Patents Examined by Carlos A. Azpuru
  • Anticoagulant compounds and methods and devices for their use
    Patent number: 11654036
    Abstract: Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and/or inhibit cell proliferation.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: May 23, 2023
    Assignee: Elixir Medical Corporation
    Inventors: Motasim Sirhan, Xiaoxia Zheng, Vinayak D. Bhat, John Yan
  • Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
    Patent number: 11648241
    Abstract: Provided herein are pharmaceutical formularions comprising a 1,2-HOPO chelating agent and/or 3,2-HOPO chelating agent.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: May 16, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rebecca J. Abergel, Taylor A. Choi, Kenneth N. Raymond, David K. Shuh
  • Compositions and methods for delivery of RNA
    Patent number: 11648322
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: May 16, 2023
    Assignee: HDT BIO CORP.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Compositions and methods for delivery of RNA
    Patent number: 11648321
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: May 16, 2023
    Assignee: HDT BIO CORP.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Method of selecting skin treatment regimens, ingredients and compositions
    Patent number: 11642300
    Abstract: A method of selecting skin treatment regimens, ingredients and compositions that includes measuring the levels of particular small molecule metabolites on skin both before and after product application and testing for a change in small molecule metabolite levels is disclosed.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: May 9, 2023
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Kimberly Capone, Janeta Nikolovski, Lorena Telofski, Georgios Stamatas
  • Biodegradable bone glue
    Patent number: 11642436
    Abstract: The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 9, 2023
    Assignee: Evonik Operations GmbH
    Inventors: Teng Xue, Gianluigi Luppi, Natalia Ruggeri Savietto, Howard K. Bowman, III, Paul Joseph Spencer, Andreas Karau, Jian-Feng Zhang, Rosario Lizio, Marshall Scott Jones
  • Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
    Patent number: 11628207
    Abstract: Methods are disclosed for the reduction or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms using compositions comprising thermolysin.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: April 18, 2023
    Assignee: SMITH & NEPHEW, INC.
    Inventors: Lei Shi, Catherine Van Der Kar, Aleksa Jovanovic, Eric Roche
  • Methods of treating ocular diseases using polyalkylene glycol intracameral implants with polyactide travoprost particles
    Patent number: 11622935
    Abstract: The present invention relates to the treatment of ocular diseases in a human subject In particular, the invention relates to an intracameral administration of a sustained release biodegradable intracameral implant.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: April 11, 2023
    Assignee: OCULAR THERAPEUTIX, INC.
    Inventors: Charles D. Blizzard, Ankita Desai, Arthur Driscoll, Michael Goldstein
  • Re-oiled and hyper-oiled lecithin carrier vehicles
    Patent number: 11622556
    Abstract: A liposome composition having a lipid bilayer membrane, made of a crude or de-oiled lecithin, at least one triglyceride, a non-triglyceride active agent, and conditioned water. The liposome composition may be utilized for purposes and treatments including increased plant growth, insecticide or insect repellant, inhibiting fruit decay, forensic labeling of plants, wound treatment, and cosmetic applications.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: April 11, 2023
    Assignee: BIO-UP MIMETIC TECHNOLOGIES, INC.
    Inventor: Crispin G. S. Eley
  • Methods, compositions and kits for surgical repair
    Patent number: 11623030
    Abstract: In some aspects, the present invention provides surgical procedures that comprise applying compositions into and/or onto tissue, including supporting tissues (e.g., ligaments, connective tissue, muscles, etc.) for pelvic organs, among other tissues. In other aspects, the present disclosure pertains to compositions that are useful for performing such procedures. In still other aspects, the present disclosure pertains to kits that are useful for performing such procedures.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: April 11, 2023
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Sandra Nagale, Mark W. Boden, Andrew Dolan
  • Systems and methods for reconstruction of nerve defects
    Patent number: 11623022
    Abstract: Composite nerve guides for nerve regeneration are provided, wherein the composite guide comprise a nerve graft and a nerve conduit continuing an active agent that promote axon regeneration. The devices can provide structural supports to guide nerve regeneration and locally deliver an active agent (e.g., glial cell-line derived neurotrophic factor (GDNF) and/or glial growth factor 2 (GGF2) to injured nervous system tissue upon implantation in a subject. Methods of treatment using such devices are also provided.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: April 11, 2023
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Kacey Gribbin Marra, Jacqueline Wittmer
  • Process for preparing pitolisant hydrochloride and solid-state forms thereof
    Patent number: 11623920
    Abstract: The present disclosure relates to a process for preparing pitolisant hydrochloride of Formula-(I) and solid-state forms thereof.
    Type: Grant
    Filed: May 24, 2022
    Date of Patent: April 11, 2023
    Assignee: Nuray Chemicals Private Limited
    Inventors: Ramasamy Venkatragavan, Erugu Balaiah, Paramanandam Senthilkumaran, Guttha Jayaprasad, Manniyam Kailasam Selvam, Noti Krishnareddy, Sorakka Pichandi Parthipan, Murugan Arunkumar, Palaniswamy Premkumar, Salamuthu Kaliraj, Shanmugam Arumugam, Singavarapu Ajay Madhukar, Raman Silambarasan, Saminathan Karthick, Kudumudi Jayaraman Parthiban, Ravi Silambarasan
  • Methods of treatment comprising administering polymer particles configured for intravascular delivery of pharmaceutical agents
    Patent number: 11617814
    Abstract: Described herein are polymeric particles configured for intravascular delivery of pharmaceutical agents, e.g., to a diseased site, and methods of forming and using same. Preparation of these polymer particles is also described.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: April 4, 2023
    Assignee: Terumo Corporation
    Inventors: Gregory M. Cruise, Xinping Wu, Gloria Hincapie, Yue Wu
  • Liquid composition containing pradofloxacin
    Patent number: 11617792
    Abstract: The invention relates to pharmaceutical compositions in liquid form comprising pradofloxacin in an aqueous solution and citric acid or thioglycerol as antioxidants.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: April 4, 2023
    Assignee: Bayer Animal Health GmbH
    Inventors: Iris Heep, Patrick Billian
  • Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
    Patent number: 11617743
    Abstract: Provided herein are pharmaceutical formularions comprising a 1,2-HOPO chelating agent and/or 3,2-HOPO chelating agent.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: April 4, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rebecca J. Abergel, Taylor A. Choi, Kenneth N. Raymond, David K. Shuh
  • Drug-loaded microbead compositions, embolization compositions and associated methods
    Patent number: 11607388
    Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy. Methods for preparing the drug-loaded microbead compositions and the embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: March 21, 2023
    Assignee: C.R. Bard, Inc.
    Inventors: Hiep Do, Michael Randall
  • Bamboo extract anti-caking and flow agents for dry powdered foods, food ingredients, pharmaceuticals and nutraceuticals
    Patent number: 11602565
    Abstract: An anti-caking or flow agent is provided herein. The anti-caking or flow agent may include a bamboo extract that may include silica and carbohydrate. The bamboo extract may have a loose density (g/ml) of from about 0.14 g/ml to about 0.18 g/ml or a tapped density (g/ml) of from about 0.18 g/ml to about 0.22 g/ml. The bamboo extract may also include particles of the silica and the carbohydrate, wherein the particles have a size (Dv50) of from about 35 ?m to about 55 ?m. This anti-caking or flow agent may facilitate the manufacture, packaging, or storage of dry powdered food ingredients and food products such as spices, flavorings, and powdered food mixes as well as pharmaceuticals and nutraceuticals.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: March 14, 2023
    Assignee: Griffith Foods International, Inc.
    Inventors: Gregory J. Meyers, Samantha L. Amos
  • Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
    Patent number: 11590080
    Abstract: Drug-loaded microbead compositions include microbeads of a biodegradable material and vesicular agents located within or associated with the biodegradable material of the microbeads. The vesicular agents include a lipid bilayer and comprise liposomes or ethosomes. The drug-loaded microbeads include a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: February 28, 2023
    Assignee: C.R. Bard, Inc.
    Inventors: Elena Afonina, Hiep Do, Emily Goel, Oleg Guryev, Cyal Lecy, Majid Mehrpouyan, Michael Randall, Marybeth Sharkey, Jeffrey Wang
  • Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
    Patent number: 11583510
    Abstract: Provided herein are methods of administering a once-nightly dosage of gamma-hydroxybutyrate after a high-fat meal.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: February 21, 2023
    Assignee: Flamel Ireland Limited
    Inventors: Julien Grassot, David Monteith, Hervé Guillard, Claire Mégret, Jean-François Dubuisson
  • Treating progressive familial intrahepatic cholestasis (PFIC) with IBAT inhibitors
    Patent number: 11583539
    Abstract: Provided herein are methods for treating progressive familial intrahepatic cholestasis (PFIC) with an ileal bile acid transport (IBAT) inhibitor such as odevixibat, or a pharmaceutically acceptable salt thereof. Such methods can include reducing mean pruritus score, mean serum bile acid concentration, increasing height, normalizing weight, improving sleep, and improving liver parameters.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: February 21, 2023
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Jan Mattsson, Pat Horn, Paresh Soni