Patents Examined by Carlos Azpuru
  • Patent number: 11365293
    Abstract: This invention belongs to the technical field of composite materials, and discloses a xylan-based dual network nanocomposite hydrogel, preparation method thereof and use therefor. The method comprises (1) adding graphite oxide powder into deionized water, ultrasonically dispersing to obtain a GO aqueous dispersion; (2) adding xylan into deionized water, heating and stirring to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO aqueous dispersion, and stirring and dispersing uniformly under an ice-bath condition, then adding an initiator, a crosslinking agent and an accelerator, stirring and mixing uniformly to obtain a mixed solution; and 4) drying and reacting the mixed solution (in the step (3) to obtain a xylan-based dual network nanocomposite hydrogel.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 21, 2022
    Inventors: Junli Ren, Weiqing Kong, Runcang Sun, Danyang Huang, Guibin Xu
  • Patent number: 11344503
    Abstract: The patent discloses long-term injectable formulations and delivery systems of cariprazine and related salts and derivatives in the prevention and treatment of various psychotic diseases, such as schizophrenia, mania, and bipolar disorder. The dosage forms are either microsphere, microparticle, nanoparticle drug delivery systems in a pharmaceutically acceptable carrier, or devices that contain long-term injectable formulation of such cariprazine and related salts and derivatives.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 31, 2022
    Assignee: HALO SCIENCE LLC
    Inventors: Yu Hui, Kevin Yuan, Tian Zhang
  • Patent number: 11331302
    Abstract: The present invention relates to pharmaceutical compositions formulated for transmucosal delivery, and in particular sublingual delivery, comprising at least one tocotrienol or derivative thereof together with one or more pharmaceutically acceptable excipients. The present further relates to the use of said compositions for treating or preventing post exercise muscle soreness, delayed onset muscle soreness, cardiac fibrosis, hypertension, inflammation, stroke, cancer, elevated cholesterol and/or triglycerides, baldness, hypertrophy, conditions resulting from radiation exposure, stabilizing and/or controlling blood glucose levels, and improving exercise endurance and capacity.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: May 17, 2022
    Inventor: Glenn Tong
  • Patent number: 11331298
    Abstract: Disclosed are powder solid dispersions including quercetin, phospholipids and a very to freely water soluble carrier. Also disclosed are a process for the preparation of the powder solid dispersions and pharmaceutical, nutraceutical and cosmetic compositions including the solid dispersions.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 17, 2022
    Assignee: INDENA S.P.A.
    Inventors: Massimo Ronchi, Elisabetta Frattini, Antonella Riva
  • Patent number: 11331288
    Abstract: Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally by applying a transdermal delivery device to a tissue surface at the treatment site in multiple discrete doses. The transdermal delivery system comprises DFO encapsulated in reverse micelles.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: May 17, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Derrick C. Wan, Geoffrey C. Gurtner, Michael T. Longaker
  • Patent number: 11324863
    Abstract: In some aspects, the present invention provides surgical procedures that comprise applying compositions into and/or onto pelvic tissue to provide support to the pelvic tissue. The injectable hydrogel composition comprises a polysaccharide. In embodiments, the polysaccharide comprises one or more of a glycosaminoglycan, chitosan, hyaluronic acid, dextran, alginic acid and hydroxyethyl starch. In other aspects, the present disclosure pertains to kits that are useful for performing such procedures.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: May 10, 2022
    Inventors: Sandra Nagale, Mark W. Boden, Andrew Dolan
  • Patent number: 11324715
    Abstract: The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: May 10, 2022
    Inventor: Brett Hugh James Baker
  • Patent number: 11324760
    Abstract: A solid dispersion of dutasteride for improving the solubility or dissolution rate of poorly soluble dutasteride, a method for preparing the solid dispersion, and a pharmaceutical composition including the solid dispersion are provided. The solid dispersion includes: a coprecipitate including dutasteride and a water-soluble polymeric carrier; and an adsorbent. The dutasteride and the water-soluble polymeric carrier are present in a weight ratio of 1:10-100 in the coprecipitate.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: May 10, 2022
    Inventors: Dae Ik Kim, Woo Cheoul Shin
  • Patent number: 11324854
    Abstract: Disclosed is a process for the preparation of hydrogels consisting of crosslinked glycosaminoglycans, which comprises: a) reacting at least one hybrid cooperative complex obtained by heating aqueous solutions of low- and high-molecular-weight glycosaminoglycans at 80-160° C. with a diepoxide as crosslinker in a ratio with the complex ranging between 0.1 and 1 equivalents, preferably between 0.2 and 0.4 equivalents, the concentration by weight of the complex in the solution ranging between 1% and 15%, preferably between 2% and 10%; b) purifying by dialysis, ultrafiltration and diafiltration.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: May 10, 2022
    Assignee: Altergon SA
    Inventors: Nicola Solimando, Maurizio Pagliuca
  • Patent number: 11318213
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: May 3, 2022
    Assignee: HDT BIO CORP.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Patent number: 11318156
    Abstract: The present invention relates to an injectable implant comprising an effective amount of a macrocyclic lactone, or a salt thereof, and a bioresorbable polymer, and its use in preventing and/or treating parasites infestations in non human mammals, especially pets.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: May 3, 2022
    Inventors: Florence Guimberteau, Patrick Forget
  • Patent number: 11311630
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MCNC)), methods of making micelles, methods of using micelles, and the like.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: April 26, 2022
    Inventors: Carlos Rinaldi, Sun Hao, Brent S. Sumerlin
  • Patent number: 11311492
    Abstract: A nanomedicine for the treatment of obesity comprising either noble metal nanoparticles having surface ligands comprising a mixture comprising (+)-catechin (2R,3S) and gingerol or particles of a carbon nanomaterial having an adsorbed mixture comprising (+)-catechin (2R,3S) and gingerol. Also provided are a method for making the noble metal nanomedicine and the carbon nanomedicine. The nanomedicine is used in a method of treating obesity.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: April 26, 2022
    Assignee: King Abdulaziz University
    Inventors: Imran Kazmi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Fahad A. Al-Abbasi, Firoz Anwar
  • Patent number: 11304999
    Abstract: Composition are described, which are dried under reduced pressure from a liquid mixture comprising an adjuvant comprising a saponin (e.g., such as QS21) in a liposomal formulation wherein the liposomes contain a neutral lipid (e.g., such as a phosphatidylcholine) and a sterol (e.g., such as cholesterol), and, a cryoprotectant that is an amorphous sugar. The adjuvant may further comprises a TLR-4 agonist. The compositions may further comprising an antigen, such as an antigen derived from Plasmodium falciparum, Mycobacterium tuberculosis, HIV, Moraxella, ntHi or Varicella Zoster Virus. The cryoprotectant is an amorphous sugar or mixture of amorphous sugars, and preferably is a combination of at least two cryoprotectants selected from sucrose, trehalose and dextran. The compositions may further comprise a buffer and/or a surfactant.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: April 19, 2022
    Inventors: Dominique Ingrid Lemoine, Nicolas Moniotte
  • Patent number: 11305039
    Abstract: The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 500-750 microns and a pore spacing of 220-250 microns.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 19, 2022
    Assignees: Vanderbilt University, Venostent, Inc.
    Inventor: Timothy C. Boire
  • Patent number: 11304974
    Abstract: A composition including metallic silver nanoparticles is supported on a carrier, wherein the carrier is in the form of particles. The carrier is selected from an inert carrier or an antibiotic. The composition further includes at least one antibiotic in the case the carrier is an inert carrier. A related nanosystem includes a composition having metallic silver nanoparticles or a mixture of silver nanoparticles and at least one antibiotic for use in the treatment of an infection caused by at least one strain of bacteria resistant to at least one antibiotic. Pharmaceutical compositions and methods for the preparation of these compositions and nanosystems are also used for the treatment of bacterial infections.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: April 19, 2022
    Inventor: Luis Jesús Lostao Camón
  • Patent number: 11285102
    Abstract: An oral gastro-retentive delivery device is provided which unfolds rapidly upon contact with gastric juice. The device is configured in a collapsed configuration for oral intake and unfolding for gastric retention for a predetermined period of time and eventually reducing in size for passage through the rest of the GI track.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: March 29, 2022
    Assignee: Clexio Biosciences Ltd.
    Inventors: Avshalom Ben Menachem, Ilan Zalit
  • Patent number: 11285109
    Abstract: The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) or polylactide (PLA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 ?m or more and 150 ?m or less, and a variation coefficient of area ratios in six regions is 0.35 or less, wherein the area ratios in six regions are calculated by (s/A)×100 (%) wherein the six regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the biologically active substance in the microsphere or a higher magnification; and dividing the electron microscope observation image into six regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the biologically active substance included in the respective divided region.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: March 29, 2022
    Assignee: M. TECHNIQUE CO., LTD.
    Inventors: Masakazu Enomura, Kaeko Araki
  • Patent number: 11286171
    Abstract: The invention is directed to a composition of metal particles and methods of manufacturing and using the composition in the treatment of microbial infections and cancer. The particles can be nanoparticles having coupled thereto at least one of a surfactant, an antibiotic, and a drug. The particles of the invention achieve enhanced stability, enhanced cytotoxicity, and enhanced antimicrobial activity through novel combinations of metals, surfactants, antibiotics, and drugs.
    Type: Grant
    Filed: October 31, 2020
    Date of Patent: March 29, 2022
    Inventors: Regina Vertelova, Nikolai Tankovich
  • Patent number: 11266617
    Abstract: The present invention provides compositions comprising ?-hydroxybutyrate, cyclic or linear ?-hydroxybutyrate oligomers, and/or ?-hydroxybutyrate ester derivatives, or pharmaceutically-acceptable salts thereof. In various embodiments, the compositions are encapsulated by nanoparticles, such as nanoparticles comprising, e.g., poly(lactic-co-glycolic acid). In additional embodiments, the invention provides methods of using such compositions to induce intestinal stem cell regeneration and/or treat radiation-induced intestinal damage in a subject.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: March 8, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Omer Yilmaz, Chia-Wei Cheng, George Eng, Fang Wang