Patents Examined by Carlos Azpuru
  • Patent number: 10413525
    Abstract: The present invention relates in part a to multiparticulate sprinkle dosage form comprising duloxetine or a pharmaceutically acceptable salt thereof, having higher acid resistance as compared to commercially available delayed release formulations. It further relates to various methods of administering the said multiparticulate sprinkle dosage forms.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: September 17, 2019
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Ravindra Agarwal, Tarun Singhal, Ravi Kochhar
  • Patent number: 10413493
    Abstract: Methods of making personal care compositions including microcapsules and methods of enhancing the efficacy of the microcapsules in said personal care compositions.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: September 17, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Jonathan Robert Cetti, Jiten Odhavji Dihora, Steven Edward Witt, Eric Shane Henley
  • Patent number: 10406168
    Abstract: Biocompatible intraocular implants, such as microparticles, include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the prostamide component may be encapsulated by the polymeric component. The present implants include oil-in-oil emulsified implants or microparticles. Methods of producing the present implants are also described. The implants may be placed in an eye to treat or reduce a at least one symptom of an ocular condition, such as glaucoma.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 10, 2019
    Assignee: Allergan, Inc.
    Inventors: Patrick M. Hughes, Michele Boix, Christian Sarrazin, Marina Do
  • Patent number: 10406114
    Abstract: A method for producing an antibiotic-loaded transdermal patch including preparing a polymeric adhesive solution by dissolving a polymeric mixture in a solvent, preparing a plurality of antibiotic-loaded solid lipid nanoparticles (SLNs), forming a patch formulation by mixing the plurality of antibiotic-loaded SLNs and the polymeric adhesive solution, and forming a layer of the patch formulation on a substrate.
    Type: Grant
    Filed: June 9, 2018
    Date of Patent: September 10, 2019
    Inventors: Masoumeh Nasrollahzadeh Abyazani, Fariba Ganji, Seyed Mojtaba Taghizadeh, Ebrahim Vasheghani Farahani
  • Patent number: 10406104
    Abstract: The present application relates to a method for the preparation of a nanosuspension comprising nanoparticles of at least one natural material and an extract of at least one natural material, wherein the method comprises the steps of providing particles of at least one natural material having a particle size (D100) of less than 320 ?m; providing an extract of at least one natural material; dispersing said particles of at least one natural material and said extract of at least one natural material in a solvent; and milling the dispersion to a particle size (D90) of below 1000 nm (D90<1000 nm). Furthermore, the present application also relates to a nanosuspension prepared according to said method, and the use of such nanosuspension for the preparation of a medicament and/or nutritional supplement.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: September 10, 2019
    Assignee: Apurano Life Sciences GmbH
    Inventor: Werner Brand
  • Patent number: 10398707
    Abstract: Biocompatible intraocular implants include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or reduce a at least one symptom of an ocular condition, such as glaucoma.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: September 3, 2019
    Assignee: Allergan, Inc.
    Inventor: Patrick M. Hughes
  • Patent number: 10391061
    Abstract: The present invention relates to a delayed release pharmaceutical formulation for delivering an active agent to the intestine, a method of preparing such formulation and the use of such formulation in the treatment of gastrointestinal disorders.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: August 27, 2019
    Assignee: Tillotts Pharma AG
    Inventors: Daniel Preisig, Maxim Puchkov, Joerg Huwyler, Felipe José Oliveira Varum, Roberto Carlos Bravo Gonzalez
  • Patent number: 10383939
    Abstract: The invention includes light-activated compositions and methods that are useful for promoting cell death or growth. In certain embodiments, the compositions comprise quantum dots (QD).
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 20, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Prashant Nagpal, Anushree Chatterjee, Colleen Courtney, Samuel Martin Goodman
  • Patent number: 10383817
    Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 20, 2019
    Assignee: Mati Therapeutics Inc.
    Inventors: Eugene de Juan, Jr., Stephen Boyd, Cary Reich, Alan Rapacki, Hanson S Gifford, Mark Deem
  • Patent number: 10368995
    Abstract: Bone void filler compositions and methods for preparation to provide substrates with carbonate surface coatings to promote bone growth.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: August 6, 2019
    Assignee: CaP Biomaterials, LLC
    Inventor: Lawrence A. Shimp
  • Patent number: 10369252
    Abstract: The invention relates to electrospun three-dimensional (3D) nanofibrous scaffolds (with controllable porosities as high as about 96%) and methods of preparing the same. The electrospun 3D scaffolds possess interconnected and hierarchically structured pores with sizes ranging from tens of nanometers to hundreds of micrometers. In embodiments, the 3D scaffolds can be biocompatible and/or biodegradable. In some embodiments, the 3D scaffolds can be conductive. In some embodiments, the 3D scaffolds can contain bioactive species.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: August 6, 2019
    Assignee: South Dakota Board of Regents
    Inventors: Hao Fong, Tao Xu, Yong Zhao, Todd J. Menkhaus
  • Patent number: 10369088
    Abstract: An encapsulated sunscreen composition that includes a polymeric shell material having a substantially spherical geometry. The shell material is a polymeric composition that includes a photosensitizer chemically bound to the polymeric composition. The polymeric shell material has a minimum diameter of 100 nm.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: August 6, 2019
    Assignee: International Business Machines Corporation
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jacob T. Porter, Jason T. Wertz
  • Patent number: 10370391
    Abstract: The present invention includes 4-(hydroxymethyl)phenylboronic esters, which react with hydrogen peroxide to form 4-hydroxybenzyl alcohol, which is an anti-inflammatory and/or anti-oxidant compound, as well as microparticles and compositions thereof. In certain embodiments, the compositions of the invention may be used to treat or prevent oxidative stress and/or inflammation, including ischemic disease.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: August 6, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Chonbuk National University Industrial Cooperation Foundation
    Inventors: Peter M. Kang, Dongwon Lee, Seunggyu Park, Dahee Jeong
  • Patent number: 10369539
    Abstract: The present invention broadly relates to a process for preparing products comprising active components, and in particular biological materials, wherein the active components are stabilised. The invention further relates to compositions comprising the products, and in particular compositions comprising therapeutic biological materials.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: August 6, 2019
    Assignee: BIOLINGUS IP LLC
    Inventor: Sai Ying Ko
  • Patent number: 10369089
    Abstract: The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: August 6, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Hyun Koo, Lizeng Gao, David Cormode, Pratap Naha
  • Patent number: 10363281
    Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: July 30, 2019
    Assignee: TissueGen, Inc.
    Inventors: Kevin D. Nelson, Brent B. Crow, Nickolas B. Griffin, Jennifer Seifert, Paul R. Sood, Alpeshkumar P. Patel, Paul A. Hubbard
  • Patent number: 10357461
    Abstract: A hard shell capsule includes a body and a cap cooperatively defining a hollow core hard shell capsule. Each of the body and the cap has a composition that includes a polymer forming a hard polymer structure of the body and of the cap, at least one of the body and the cap composition including a therapeutically effective amount of a drug(s) loaded throughout the body and/or cap.
    Type: Grant
    Filed: December 30, 2017
    Date of Patent: July 23, 2019
    Inventor: Hemant Narahar Joshi
  • Patent number: 10350164
    Abstract: A process for preparing a dry powder formulation for inhalation comprising a combination of an anti-cholinergic, a long-acting beta2-adrenoceptor agonist, and, optionally, an inhaled corticosteroid, is provided.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: July 16, 2019
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Alessandro Cavecchi, Cristiana Merusi, Fausto Pivetti, Francesca Schiaretti
  • Patent number: 10350198
    Abstract: The present application provides a pharmaceutical composition comprising 6-(2-chloro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridine-7-carboxamide or a pharmaceutically acceptable salt, a binder, a surface stabilizer and a dispersant, wherein the pharmaceutical composition can be dispersed in water to form a pharmaceutical suspension having a median particle size, X50, of 0.5 ?m to 4.0 ?m. Also disclosed are a preparation method thereof and the use thereof for treating cancers.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: July 16, 2019
    Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    Inventors: Xiongxiong He, Ping Dong, Jiahui Cai, Xifeng Lu, Jiao Xu, Bo Jiang, Zhenxue Deng, Shanshan Sui
  • Patent number: 10349653
    Abstract: The present disclosure relates to methods for forming an antimicrobial nanostructure and antimicrobial articles. The methods may include: providing a master template of a layout of the antimicrobial nanostructure on a silicon substrate, depositing a silicon nitride layer on a top surface of the silicon substrate, forming a patterned lithographic resist mask layer on a top surface of the silicon nitride layer, generating certain silicon pillars according to the patterned lithographic resist mask using a resist and reactive ion etching, forming certain lateral silicon nanospikes on the silicon pillars by performing metal assisted chemical etching (MacEtch), and removing the silicon nitride layer and bonding a top cover glass on the silicon pillars to form the antimicrobial nanostructure having lateral silicon nanospikes.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: July 16, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Stacey M. Gifford, Huan Hu, Pablo Meyer Rojas, Joshua T. Smith