Patents Examined by Casey Hagopian
  • Patent number: 9894895
    Abstract: Embodiments of the present disclosure relate to organo-silica based composite materials, methods of making the organo-silica based composite material, methods of using the organo-silica based composite material, and the like.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: February 20, 2018
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Swadeshmukul Santra, Mikaeel Young
  • Patent number: 9889090
    Abstract: A method for treating a periodontal disease affecting a periodontal pocket of a patient. The method comprises inserting an oral delivery device into the periodontal pocket at a frequency of about once every 4 days to about once every 6 weeks. The oral delivery device is a controlled release solid unit dosage form suitable for insertion into a periodontal pocket of a patient, comprising a therapeutically effective amount of at least one anti-inflammatory agent, at least one antibacterial agent, or the combination of at least one anti-inflammatory agent and at least one antibacterial agent.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: February 13, 2018
    Assignee: Dexcel Pharma Technologies Ltd.
    Inventors: Avi Avramoff, Eyal Shoshani, Adel Penhasi, Dan Oren
  • Patent number: 9861647
    Abstract: Calcium glycerophosphate is found to be effective in treating and preventing a disease, disorder and/or condition of the respiratory system. The disease, disorder and/or condition is related to an obstructive or a restrictive condition of the respiratory airway.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: January 9, 2018
    Assignee: Prelief, Inc.
    Inventors: Alan E. Kligerman, Margaret T. Weis
  • Patent number: 9855256
    Abstract: Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 2, 2018
    Assignee: Omeros Corporation
    Inventors: Gregory A. Demopulos, Jeffrey M. Herz, Wayne R. Gombotz, Hui-rong Shen
  • Patent number: 9849215
    Abstract: Methods for forming implantable compositions are provided. In some embodiments, the methods include (i) providing a gel base, (ii) adding water and a hydrating agent to the gel base to form a mixture, (iii) reducing the water content of the mixture; and (iv) adding a delivered material before, during, and/or after step (ii) or (iii). The water content is reduced to about 5% or less by weight of the implantable composition.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: December 26, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Christina Mossaad, Lawrence A. Shimp, Guobao Wei, John Winterbottom
  • Patent number: 9808526
    Abstract: The present invention provides a pharmaceutical kit, methods for cancer treatment and for preparing a metal nanoparticle-antibody fragment conjugate, which can reduce the recurrence rate of cancer and provide a safer and less invasive therapeutic method for cancer treatment.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: November 7, 2017
    Inventor: Chieh Hsiao Chen
  • Patent number: 9810687
    Abstract: A nanoagent includes at least one nanocomposite. The nanocomposite includes at least one gold nanorod, a silver layer coated on an outer surface of the gold nanorod, a Raman reporter molecule layer coated on the silver layer, a pegylated layer coated on the Raman reporter molecule layer, an active layer conjugated to the pegylated layer. the active layer includes at least one of a targeting molecule configured to bind to a target of interest, and a functional molecule configured to interact with the target of interest. The silver layer has silver nanoparticles. The Raman reporter molecule layer has Raman reporter molecules that are detectable by surface enhanced Raman spectroscopy (SERS). The pegylated layer has at least one of thiolated polyethylene glycol (HS-PEG), thiolated polyethylene glycol acid (HS-PEG-COOH) and HS-PEG-NHx.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: November 7, 2017
    Inventors: Alexandru S. Biris, Andrew G. Kumpuris, Zeid Nima
  • Patent number: 9801946
    Abstract: Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: October 31, 2017
    Assignee: Vanderbilt University
    Inventors: Scott A. Guelcher, Jerald Dumas, Edna M. Prieto, Anne Talley, Andrew Harmata, Katarzyna Zienkiewicz
  • Patent number: 9796792
    Abstract: Compositions comprising metal ions or clusters such as ferrous and/or ferric iron compounds or magnesium, zinc, lanthanum and other metal ion compounds and fiber components such as gum Arabic in a complex, methods for preparing such compositions of matter, and the use thereof for treatment of adsorbing certain accessible targets in the gastrointestinal tract and in an extracorporeal system, are provided herein.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: October 24, 2017
    Assignee: Vidasym, Inc.
    Inventor: Jinshyun Ruth Wu-Wong
  • Patent number: 9784737
    Abstract: A nanoagent for surface enhanced Raman spectroscopy (SERS) detection of a target of interest, includes one or more nanocomposites. The target of interest may include at least one tumor cell or at least one pathogen. Each nanocomposite includes at least one gold nanorod, a silver layer coated on a surface of the gold nanorod and having silver nanoparticles, a Raman reporter molecule layer assembled on the silver layer and having Raman reporter molecules, a pegylated layer coated on the Raman reporter molecule layer, and an antibody layer conjugated to the pegylated layer. The different nanocomposites of the nanoagent can be represented by different colors when SERS images are collected upon the nanoagent.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: October 10, 2017
    Inventors: Alexandru S. Biris, Zeid Nima, Yang Xu
  • Patent number: 9775798
    Abstract: Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 3, 2017
    Inventors: Henk Van Wyk, Mariette Van Wyk, Trace Krebs, Peter Lange, Brian Denomme, Michael A. Volk
  • Patent number: 9724345
    Abstract: There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous composition that comprises a lipophilic pharmaceutical agent, and an amphiphilic polymeric solvent such as PEG400 but essentially free of organic solvents and non-solubilized particles. The composition may be further diluted with a desired aqueous diluent such as an infusion fluid for parenteral administration to a subject such as a human. The compositions may be useful for the treatment for diseases or conditions that are sensitive to lipophilic agents, such as infectious diseases, malignant or autoimmune diseases.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: August 8, 2017
    Assignee: Platform Brightworks Two, Ltd.
    Inventors: Borje S. Andersson, Benigno C. Valdez, Jeffrey Tarrand
  • Patent number: 9713590
    Abstract: The present invention relates to a method for the treatment of pain and inflammation. In particular, the present invention relates to a method for the treatment of musculo-skeletal and connective tissue pain/inflammations. Further, the invention relates to reducing the incidence and seventy of adverse events resulting from administration of diclofenac. The method comprises administration of a topical pharmaceutical composition of diclofenac or its salts.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: July 25, 2017
    Inventors: Ravindra Mittal, Sunilendu Bhushan Roy, Jay Shantilal Kothari, Shafiq Sheikh
  • Patent number: 9700544
    Abstract: Oral preparations of microcapsules and nanoparticles including an inhibitor of the mammalian target of rapamycin. The preparations are intended to assist with the treatment and prevention of cancer neurocognitive dysfunction, genetically predisposed disorders, and age-related disorders. The embodiments discussed address the present need for alternative preparations or manufacturing processes that ensure efficacy while improving other performance characteristics such as storage stability, biodistribution, dosage cost, etc.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: July 11, 2017
    Inventors: Neal K Vail, Dana M Vaughn
  • Patent number: 9693947
    Abstract: The present invention provides cosmetic formulations for improving the appearance of the skin, including the facial area. The compositions of the invention provide multiple enhanced technologies that work synergistically to enhance hydration and appearance of the skin. Anti-aging peptides and tissue respiratory factor work together in an HA rich environment to enhance collagen and elastin while beneficial antioxidants protect HA in the skin from damaging exposure.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: July 4, 2017
    Assignee: Jan Marini Skin Research
    Inventors: Jan L. Marini, Subhash J. Saxena
  • Patent number: 9675572
    Abstract: The invention encompasses intravenous pharmaceutical compositions containing omega-3 fatty acids and methods of treating traumatic brain injury, traumatic spinal cord injury and/or stroke using these pharmaceutical compositions.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: June 13, 2017
    Inventor: Michael Lewis
  • Patent number: 9668978
    Abstract: Method for producing enteric microcapsules without coating, containing diclofenac or one of the salts thereof with satisfactory anti-inflammatory activity and low gastric aggressiveness; and a pharmaceutical composition containing them. The method comprises a) preparing a mixture in water-ethanol with an alginate salt, adding diclofenac or one of the salts thereof previously diluted with a surfactant and sodium bicarbonate; b) adding the previous solution to a solution with a calcium salt; c) resuspending the microcapsules obtained and isolated in an aqueous solution of the alginate salt; and d) isolating, drying and sieving through 1000 and 250 micron meshes the microcapsules obtained; and selecting the fraction comprised between both meshes. The pharmaceutical composition can be an oral composition, tablets, chewable tablets, or a powder for suspension in water.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: June 6, 2017
    Assignees: Laboratorios Bago S.A., Eastbrand Holding GmbH
    Inventor: Mario Atilio Los
  • Patent number: 9655851
    Abstract: A granular material which has a mean particle diameter of 150 to 800 micrometers; and an unsettled bulk density of 0.1 to 0.35 g/cm3 and/or a compactibility which results in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa; and wherein the main component of the granular material is a cellulose derivative or an alkylene oxide homo- or copolymer or a blend thereof is useful for preparing dosage forms with a controlled release profile.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 23, 2017
    Assignee: Dow Global Technologies LLC
    Inventors: Tim D. Cabelka, Akshay Bellare, Ka Chun A. Chan, Tina P. Dasbach, Kacee B. Ender, Karl V. Jacob, Robert E. Scheid, Jr.
  • Patent number: 9655836
    Abstract: Disclosed herein are sprayable compositions comprising: a complex of (A) at least one charged (or pseudo-charged) polymer having a molecular weight of about 125,000 amu or more; and (B) a least one oppositely charged, rheology modifying, crosslinked polymer having at least one carboxylic functional group. The composition may provide a spray with a median particle size of less than about 175 ?m. Also disclosed are methods for preparing the compositions as well as creating the spray. The invention enables the spray of the high molecular weight charged (or pseudo-charged) polymer in any number of uses including personal care and performance chemicals application.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: May 23, 2017
    Inventor: David C. Streuli
  • Patent number: 9636360
    Abstract: An orally administered composition that includes least one alkaline agent with a pH of at least 9.0 to 12.0, mixed in an aqueous vehicle with relatively high surface tension, high viscosity and lateral adhesion properties. When mixed, a low water soluble emulsion is formed that evenly coats and partially adheres to the lower section of the esophagus and the LES and forms a relatively long acting, protective barrier and partially neutralizes gastric acid. In one embodiment, the alkaline agent is potassium hydroxide and the aqueous vehicle is made of hydroxypropyl methyl cellulose, polyethylene glycol or ethylene glycol and additional thickener agents capable of withstanding high pH environments, such as xanthan gum, croscarmellose sodium, and microcrystalline cellulose. Additional organoleptic agents, such as gum Arabic and polyethylene glycol, flavorings, such as sodium chloride, acesulfame potassium, sodium saccharine, and mint, and stabilizers such as colloidal silica made be added.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: May 2, 2017
    Inventors: Ismail Gurol, Robert Burns, Steven Loyd