Abstract: An example of a system may include an electrode arrangement and a neuromodulation device configured to use electrodes in the electrode arrangement to generate a neuromodulation field. The neuromodulation device may include a neuromodulation generator, a neuromodulation control circuit and a storage. The storage may include a stochastically-modulated neuromodulation parameter set and the stochastically-modulated neuromodulation parameter set may include at least one stochastically-modulated parameter. The controller may be configured to control the neuromodulation generator using the stochastically-modulation parameter set to generate the neuromodulation field.

Abstract: Disclosed herein is an implantable blood pump assembly that includes a housing defining an inlet, an outlet, a flow path extending from the inlet to the outlet, and an internal compartment separated from the flow path. The blood pump assembly further includes a rotor positioned within the flow path and operable to pump blood from the inlet to the outlet, a stator positioned within the internal compartment and operable to drive the rotor, and an inlet conduit connected to the housing inlet and having a downstream end that has a reduced cross-sectional area that produces a localized region of high velocity blood flow. The blood pump assembly further includes at least one pressure sensor positioned between the inlet and the outlet and configured to detect a pressure of blood flowing through the flow path. The pressure sensor is located adjacent the downstream end of the inlet conduit.

Abstract: A hearing training device, is provided, including: a wearable device configured for being worn on the head of a user; a playing device arranged on the wearable device; an acupoint stimulation device, served as a physiotherapy device, comprising a plurality of acupoint stimulation mediums arranged on the wearable device, respectively configured for stimulating a plurality of acupoints on the head of the user and related to hearing, and arranged at the positions of the wearable device corresponding to the acupoints respectively; and a control device being in signal connection with the playing device and storing at least one music file, wherein the control device controls the playing device to play the music file, a beat is formed in an audio track of the music file, and the beat decreases with time, and is fixed until the beat is between 10 Hz and 15 Hz.

Abstract: A medical apparatus includes a probe configured for insertion into a body of a patient. The probe includes electrodes configured to contact tissue of a region within the body. The apparatus further includes a display screen, a position-tracking system configured to acquire position coordinates of the electrodes within the body, and a processor. The processor is configured to acquire electrophysiological signals from the electrodes while they are held stationary in the region, extract electrophysiological parameters from the signals, compute a measure of consistency of the parameters, and render to the display screen a three-dimensional (3D) map of the tissue while superimposing on the map, responsively to the position coordinates, a visual indication of the extracted parameters at the locations for which the measure of consistency satisfied a consistency criterion, and automatically discarding from the map the parameters for which the measure of consistency did not satisfy the consistency criterion.

Abstract: Methods and devices are provided for activating brown adipose tissue (BAT) using electrical energy. In general, the methods and devices can facilitate activation of BAT to increase thermogenesis. The BAT can be activated by applying an electrical signal thereto that can be configured to target sympathetic nerves that can directly innervate the BAT. The electrical signal can be configured to target the sympathetic nerves using fiber diameter selectivity. In other words, the electrical signal can be configured to activate nerve fibers having a first diameter without activating nerve fibers having diameters different than the first diameter. Sympathetic nerves include postganglionic unmyelinated, small diameter fibers, while parasympathetic nerves that can directly innervate BAT include preganglionic myelinated, larger diameter fibers.

Abstract: An apparatus includes implantable first circuitry configured to wirelessly receive power from a device external to the recipient's body, implantable second circuitry configured to provide stimulation signals to a portion of the recipient's body, and implantable third circuitry, at least a portion of the first circuitry and at least a portion of the third circuitry forming a series resonant tank circuit configured to capacitively couple the second circuitry to the first circuitry while galvanically isolating the second circuitry from the first circuitry, such that at least a portion of the electric power is transferred from the first circuitry to the second circuitry through the third circuitry whilst preventing stimulation currents.

Abstract: In some examples, a method including determining a chronaxie of evoked threshold motor responses from electrical stimulation delivered to a sacral nerve of a patient; and delivering, based on the determined chronaxie, electrical stimulation therapy, configured to treat a patient condition, to the sacral nerve having a pulse width at or near the identified chronaxie, wherein the delivered electrical stimulation is configured to inhibit contraction of at least one a bladder or bowel of the patient.

Abstract: The disclosure relates to an implant comprising an electronics module and an energy store, wherein the volume of the electronics module is less than 25% of the volume of the energy store.

Abstract: In an example, the disclosure describes a system with a lead having a proximal end and a distal end and an elongated lead body. The lead has one or more electrodes. A fixation member is located on the elongated lead body and is configured to secure the lead to tissue within a patient. The fixation member is located on the lead so the fixation member is closer to the proximal end than the one or more electrodes of the lead. A trialing adaptor receives the proximal end of the lead and is removable when a trialing period is completed. A sheath encloses at least a portion of the lead and covers the fixation member. The sheath is configured to remain in place over the lead during the trialing period.

Abstract: A method of detecting hypertension in a patient having an implantable blood pump, the method includes operating the implantable blood pump at a first pump set speed during a first period of time. A first flow rate minimum during a cardiac cycle of the patient is measured during the first period of time. The first pump set speed is reduced by at least 200 rpm during a second period of time after the first period of time to a second pump set speed, the second period of time being less than the first period of time. A second flow rate minimum is measured during a cardiac cycle during the second period of time. If the second flow rate minimum decreases during the second period of time at the second pump set speed by more than a predetermined amount, an alert is generated indicating a presence of hypertension.

Abstract: The present invention relates to a system of multiple implantable medical devices for an impedance measurement comprising a first implantable medical device, at least a second implantable medical device distinct from the first implantable medical device and; an analysis module comprising at least one amplifier and one envelope detector, one of the first implantable medical device or the second implantable medical device being a subcutaneous implantable cardioverter defibrillator or a subcutaneous loop recorder, and the other of the first implantable medical device or the second implantable medical device being an implantable endocardial device.

Abstract: A patient treatment unit for delivering non-invasive pulsed energy to living tissue with a probe stimulus generator circuit configured to output, as a treatment signal, a sequence of DC electrical pulses at a controlled pulse frequency of about 20 kHz and having a pulse voltage defined by a variable supply voltage of the probe stimulus generator circuit. The unit includes primary and secondary probes for contacting a body, an intensity adjustment circuit configured to control the variable supply voltage, and an electronic timer display configured to display an elapsed time in decimal numbers in minute and second format. An electrical current of the pulses is in a range of 0.1-2 mA while the probes are contacting the body. An operating output voltage across the probes while conducting the treatment signal does not exceed a maximum operating output voltage of 165 VDC while the probes are contacting the body.

Abstract: A method includes applying, by an implantable medical device (IMD), stimulation to a cranial nerve of a patient responsive to a determination that a level of synchrony between neural activity of one or more regions of an autonomic nervous system of the patient and one or more regions of a central nervous system of the patient falls below a first threshold and discontinuing the application of stimulation by the IMD when the level of synchrony exceeds a second threshold.

Abstract: The invention relates to a modular pulse source consisting of a main module and at least one additional module which are connected in series to each other in the sense of two-terminal circuits. The modules each comprise an energy storage device. The energy storage device of the main module is initially charged by a charging circuit. A stimulation coil is connected at the two ends of the series connection and as a result of a voltage pulse delivered by the chain of modules generates a magnetic field which in turn causes an induced electrical pulse or a respective electric field.

Abstract: The disclosure relates to devices and methods for the treatment of edema that uses an impeller with a balloon that may be mounted on the impeller housing. The invention provides devices and methods for treatment of edema that use an indwelling catheter with an impeller to lower pressure at an outlet of a lymphatic duct and a balloon on the impeller to guide and to restrict blood flow. The balloon restricts return flow from the jugular and guides that flow into the impeller cage. By funneling the flow into the impeller cage, a rate of flow down the vessel may be increased, resulting in a lateral pressure decrease effecting the lymphatic outlet. Because the lymphatic outlet is subject to a pressure decrease, fluids in the lymphatic system drain to the outlet and into the circulatory system.

Abstract: An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.

Abstract: The disclosure relates to an implant comprising an electrode connection device and a housing, wherein a cover for closing the housing is formed on the electrode connection device. A method for producing an implant is also disclosed.

Abstract: A subcutaneous insertable cardiac monitor (ICM) for use in performing long term electrocardiographic (ECG) monitoring is disclosed. The length of the monitoring performed by the ICM is extended, potentially for a life time of the patient, and the functionality of the ICM is enhanced, including enhancing the rate at which data can be offloaded from the ICM, by including an internal energy harvesting module in the ICM. The energy harvesting module harvests energy from outside the ICM, and provides the harvested energy for powering the circuitry of the ICM, either directly or by recharging a power cell within the ICM. As the circuitry of the ICM requires a low amount of electrical power, the harvested energy can be sufficient to support the functioning of the ICM even when the electrical power stored on the ICM at the time of implantation runs out.

Abstract: Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

Abstract: Apparatus and methods are described including a catheter, and first and second impellers configured to be inserted into a subject's body via the catheter, the first and second impellers being disposed in series with each other. A motor is configured to generate rotational motion. A rotation shaft extends from the motor to the first impeller and imparts the rotational motion from the motor to the first impeller. A gear mechanism disposed between the first and second impeller is configured to effect a change in rotational motion that is imparted from the first impeller to the second impeller, such that the second impeller rotates in a different manner from the first impeller. Other applications are also described.