Patents Examined by Catherine S Hibbert
  • Patent number: 11969401
    Abstract: The disclosure provides methods for treating or limiting development age-related macular degeneration, comprising (a) a GPR143 receptor agonist, including but not limited to L-DOPA, L-DOPA analogues, or a pharmaceutically acceptable salt thereof, and (b) melatonin, a melatonin analogue, or a pharmaceutically acceptable salt thereof, and related compositions.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: April 30, 2024
    Inventors: Robert Snyder, Brian McKay
  • Patent number: 11959127
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: April 16, 2024
    Assignee: California Institute of Technology
    Inventors: Mikhail G. Shapiro, Dan Piraner, Mohamad H. Abedi, Brittany Moser, Audrey Lee-Gosselin
  • Patent number: 11951151
    Abstract: A method of treating or preventing a microbial infection in a patient is provided, along with a wound irrigation system and a composition in the form of an irrigation liquid for reducing microbial load or preventing microbial infection in a wound.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: April 9, 2024
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kenneth Urish, Jonathan Brendan Mandell
  • Patent number: 11952408
    Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 9, 2024
    Assignees: Juno Therapeutics, Inc., Editas Medicine, Inc.
    Inventors: Cameron Brandt, Brian Belmont, Christopher Borges, Stephen Michael Burleigh, Alexandra Croft, Stephen Jacob Goldfless, David Jeffrey Huss, Yue Jiang, Timothy G. Johnstone, David Koppstein, Hieu Nguyen, Christopher Heath Nye, Haley Peper, Blythe D. Sather, Sonia Timberlake, Dean Y. Toy, Queenie Vong, Gordon Grant Welstead, James Sissons
  • Patent number: 11946101
    Abstract: The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: April 2, 2024
    Assignee: Natera, Inc.
    Inventors: Huseyin Eser Kirkizlar, Raheleh Salari, Styrmir Sigurjonsson, Bernhard Zimmermann, Allison Ryan, Naresh Vankayalapati
  • Patent number: 11939585
    Abstract: Systems and methods are provided for transfecting immune competent cells with RNA at high efficiency and viability.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: March 26, 2024
    Assignee: NantBio, Inc.
    Inventors: Marcos Sixto, Kayvan Niazi, Ting Wu, Chihwei Chang
  • Patent number: 11940452
    Abstract: Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: March 26, 2024
    Assignee: Cleveland Heartlab, Inc.
    Inventors: Cory Bystrom, Timothy Collier
  • Patent number: 11939579
    Abstract: The present invention relates to a tissue-specific promoter system for expressing microRNA (miRNA) for RNA interference-based methods of gene therapy. In these systems, the miRNA will inhibit gene expression or replace natural miRNA expression using microRNA.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: March 26, 2024
    Inventor: Scott Quenton Harper
  • Patent number: 11905521
    Abstract: The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: February 20, 2024
    Assignee: The Chinese University of Hong Kong
    Inventors: Bo Feng, Xiangjun He
  • Patent number: 11891623
    Abstract: Provided herein are isolated neural stem cells and methods of making neural stem cells from human trophoblast stem cells. The isolated neural stem cells can be immune privileged and express one or more protein(s). Also provided are methods for treatment of neurodegenerative diseases using suitable preparations comprising the isolated neural stem cells.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: February 6, 2024
    Assignee: Accelerated BioSciences Corp.
    Inventors: Jau-Nan Lee, Tony Tung-Ying Lee, Yuta Lee, Eing-Mei Tsai
  • Patent number: 11859179
    Abstract: Aspects of the disclosure relate to recombinant gene editing complexes comprising a recombinant gene editing protein and guide RNA (gRNA) that specifically hybridizes to a region of a C90RF72 gene (e.g., a region flanking a G4C2 repeat or within a exonic region of the gene).
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: January 2, 2024
    Assignee: University of Massachusetts
    Inventors: Christian Mueller, Abbas Abdallah
  • Patent number: 11834519
    Abstract: The ?c-family cytokines, Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), Interleukin-15 (IL-15), and Interleukin-21 (IL-21), are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (GvHD). Thus, inhibitors of ?c-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Peptide and/or peptide derivative antagonists based on the consensus ?c-subunit binding site to inhibit ?c-cytokine activity are described. Also described are peptide and/or peptide derivative antagonists exhibiting Simul-Block activity, and inhibiting the activity of multiple ?c-cytokine family members.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: December 5, 2023
    Inventors: Yutaka Tagaya, Nazli Azimi
  • Patent number: 11810646
    Abstract: Methods for design of genetic circuits are provided.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: November 7, 2023
    Assignee: The Regents of the University of California
    Inventors: Chunbo Lou, Tae Seok Moon, Virgil Rhodius, Brynne Stanton, Alvin Tasmir, Karsten Temme, Chris Voigt
  • Patent number: 11793857
    Abstract: Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin ?v?3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: October 24, 2023
    Assignee: ORTHOTROPHIX, INC.
    Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
  • Patent number: 11767563
    Abstract: The present invention relates to methods, devices, combinations, kits, and systems for predicting and treating clinically significant prostate cancer in a urine sample of an individual suspected of suffering from prostate cancer based on expression analysis of normalised prostate tumour markers. The present methods, devices, combinations, kits, and systems are especially suitable for predicting and treating prostate cancer with a Gleason score of seven or more in individuals with a serum prostate-specific antigen (sPSA) level lower than 15 ng/ml.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: September 26, 2023
    Assignee: MDxHealth SA
    Inventors: Daphne Hessels, Franciscus Petrus Smit, Jack A. Schalken
  • Patent number: 11760788
    Abstract: Compositions and methods for the treatment of neurological disorders whereby vectors contain codon-optimized nucleic acids for expression in humans, encoding a human dopamine receptor D1 protein, a human 5-Hydroxytryptamine receptor 4 protein, and a human G-protein coupled receptor 139).
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: September 19, 2023
    Assignee: Pathways Neuro Pharma, Inc.
    Inventors: Warren C. Lau, Brad Thompson
  • Patent number: 11732273
    Abstract: Disclosed are methods and compositions for in situ germline genome engineering. The disclosed methods and compositions may be utilized for germline genome engineering in a subject having a reproductive organ containing a fertilized zygote, via: (i) isolating or obtaining the reproductive organ from the subject after a time period following insemination of the subject; (ii) introducing a reagent composition into the reproductive organ, the reagent composition comprising a nuclease system and/or an exogeneous polynucleotide; and (iii) electroporating the reproductive organ.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: August 22, 2023
    Assignees: Board of Regents of the University of Nebraska, Tokai University Educational System
    Inventors: Channabasavaiah Gurumurthy, Masato Ohtsuka, Masahiro Sato
  • Patent number: 11731982
    Abstract: Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: August 22, 2023
    Inventors: Lai-Qiang Ying, Bruce Branchaud, Yu-Zhong Zhang, Stephen Yue
  • Patent number: 11732258
    Abstract: A functional engineered guide RNA sequence is provided including a spacer sequence and a scaffold sequence, wherein the scaffold sequence includes a primer binding site for reverse transcription.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: August 22, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Reza Kalhor, Prashant G. Mali, George M. Church
  • Patent number: 11725211
    Abstract: Disclosed herein are vectors and components for a nucleic acid cloning system, and methods of use of the vectors and components in cloning nucleic acid fragments of interest. The cloning system includes two families of destination vectors which can be used in alternating form to systematically combine nucleic acid fragments of interest.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: August 15, 2023
    Assignee: UT-Battelle, LLC
    Inventors: Gerald A. Tuskan, Xiaohan Yang, Henrique Cestari De Paoli