Patents Examined by Celeste A Roney
  • Polymer-based lipid nanodiscs and macrodiscs
    Patent number: 11092605
    Abstract: The disclosure provides a lipid nanodisc including a lipid bilayer having two opposing hydrophilic faces and a hydrophobic edge between the hydrophilic faces, and a copolymer encircling the hydrophobic edge of the lipid bilayer, the copolymer including a first monomeric unit including a pendant aromatic group, and a second monomeric unit including a pendant hydrophilic group, wherein the first monomeric unit and the second monomeric unit are present in the copolymer is a molar ratio ranging from 1:1 to 3:1 for the first monomeric unit:the second monomeric unit. The disclosure further provides a method of making the polymer-based lipid nanodiscs of the disclosure and methods of characterizing membrane proteins using the polymer-based lipid nanodiscs of the disclosure.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: August 17, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ayyalusamy Ramamoorthy, Thirupathi Ravula, Nathaniel Z. Hardin, Sarah J. Cox
  • Oral care compositions
    Patent number: 11090241
    Abstract: An oral care composition, including a non-aqueous dispersant and a fatty acid structure-building agent.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: August 17, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Shaotang Yuan, Guofeng Xu, Robert DiCosimo, Sharon L. Haynie
  • Methods for making compositions containing multiple populations of microcapsules
    Patent number: 11085008
    Abstract: A method of making a consumer product providing multiple blooms of fragrance, the multiple blooms being provided for by different populations of microcapsules.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 10, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Jiten Odhavji Dihora, Marc Adam Flickinger, Jianjun Justin Li, Johan Smets
  • Phytonadione compositions and related methods
    Patent number: 11077071
    Abstract: Stable Phytonadione compositions for parenteral administration are provided which comprise (E) isomer of phytonadione at or greater than 97% w/w as the active ingredient, and is substantially free of (Z) isomer. Said compositions are stable, sterile, and particulate-free. Further, said compositions reduce or avoid allergic reactions to benzyl alcohol and polysorbate. In some aspects, the compositions are free or substantially free of benzyl alcohol and/or reduced amounts of polysorbate. Methods of manufacture and methods of administration also provided.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: August 3, 2021
    Assignee: Exela Holdings, Inc.
    Inventors: Phanesh Koneru, Sreerarama Murthy Mallipeddi, Jonathan E. Sterling
  • Use of bile acids and bile salts as anti bacterial agents for inhibition of bacterial conjugation and horizontal gene transfer
    Patent number: 11077123
    Abstract: Methods of inhibiting bacterial conjugation, bacterial horizontal gene transfer or bacterial growth are disclosed. The methods comprise contacting bacteria with an effective amount of a bile acid or a bile salt, wherein the effective amount does not affect viability of the bacteria. A method of increasing susceptibility of bacteria to antibiotic treatment is also disclosed as well as methods of decontaminating a farm animal housing or a medical surface and methods of treating water. Also disclosed are compositions effective in inhibiting bacterial conjugation, bacterial horizontal gene transfer and bacterial growth.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: August 3, 2021
    Assignee: Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Ohad Gal-Mor, Galia Rahav
  • Chitin-glucan complex, its preparation, and uses
    Patent number: 11077060
    Abstract: A biocomposite powder comprising 20-95% (w/w) chitin-glucan complex (CGC), and up to 50% (w/w) mannose-containing polysaccharides, wherein the biocomposite powder has a bulk density of 0.5 to 1.0 g/cm3, and wherein greater than 60% (w/w) of the particles of the biocomposite powder have a size below 212 ?m.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: August 3, 2021
    Assignee: PHARMA73, S. A.
    Inventors: Maria Filomena Andrade De Freitas, Fernando Miguel Da Silva Cruz, Maria D'Ascensão Carvalho Fernandes de Miranda Reis, Inês Da Silva Farinha
  • Atropine pharmaceutical compositions
    Patent number: 11071732
    Abstract: The inventive subject matter is directed to compositions and methods for sterile and storage stable low-dose atropine formulations with improved stability. Most preferably, the compositions presented herein are substantially preservative free and exhibit less than 0.35% tropic acid from degradation of atropine. Advantageously, contemplated formulations are also substantially free of preservatives.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: July 27, 2021
    Assignee: NEVAKAR INC.
    Inventors: Navneet Puri, Prem Sagar Akasapu, Irfan A. Mohammed, Kumaresh Soppimath, Iouri V. Ilitchev
  • Core stabilized microcapsules, method of their preparation and uses thereof
    Patent number: 11071878
    Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: July 27, 2021
    Assignee: Sol-Gel Technologies Ltd.
    Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
  • Nanotechnology-based nostril drops for relief of respiratory ailments
    Patent number: 11052041
    Abstract: The invention pertains to liposomes containing an oil-in-water emulsion of a selected combination of at least ten different essential plant oils produced with phospholipids found in human membranes and methods for treating respiratory diseases, disorders or conditions by administering the liposomes into the nose and respiratory system.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: July 6, 2021
    Assignee: King Abdulaziz University
    Inventors: Taha Kumosani, Elie Barbour, Werner Krull, Soonham Yaghmoor
  • Compositions with natural oils for providing a protective barrier
    Patent number: 11039993
    Abstract: A composition provides a protective barrier and includes glyceryl dibehenate, tribehenin, and glyceryl behenate, a surfactant that includes glyceryl stearate, hydrogenated vegetable oil, one or more additional fatty compounds, and one or more triglyceride. The composition optionally includes wax, a hydrating agent, and may be essentially free of or is devoid of one or more of petrolatum, mineral oil and water. The composition provides occlusivity and hydration effects that are comparable to compositions that include one or more of petrolatum, mineral oil and lanolin.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: June 22, 2021
    Assignee: L'OREAL
    Inventors: Zachary Maron, Paul Pierre Bonvallet, Susan Halpern Chirch
  • Reinforced bone scaffold
    Patent number: 11026794
    Abstract: Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: June 8, 2021
    Assignee: Marquette University
    Inventors: Lobat Tayebi, Morteza Rasoulianboroujeni
  • Composition for suppressing or preventing abnormality in intestinal environment
    Patent number: 11026967
    Abstract: This application provides a composition comprising hydrogen gas or dissolved hydrogen as an active ingredient for suppressing or preventing abnormality in the intestinal environment of a subject, wherein the abnormality is selected from the group consisting of bacterial translocation and bacterial species composition abnormality of intestinal flora.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: June 8, 2021
    Assignees: MIZ COMPANY LIMITED, OSAKA UNIVERSITY
    Inventors: Mitsunori Ikeda, Kentaro Shimizu, Hiroshi Ogura, Shinichi Hirano, Ryosuke Kurokawa
  • Auricular cleaning composition
    Patent number: 11020344
    Abstract: An auricular cleaning composition includes isopropylic alcohol and/or diethylene glycol monoethyl ether as ceruminolytic agent(s), optionally in combination with caprylocaproyl polyoxyl-8 glyceride.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: June 1, 2021
    Assignee: VETOQUINOL SA
    Inventors: Marinette Moreau, Aurelie Brevet, Elodie Lego
  • Cosmetic water-in-oil microemulsion
    Patent number: 11020328
    Abstract: A cosmetic water-in-oil microemulsion having advantageous rheological properties comprising: i) 20-40% w/w of oil phase ingredients with spreadability value of above 1700 mm2/10 min, ii) 15-35% w/w of oil phase ingredients with spreadability value between 1000 and 1700 mm2/10 min, iii) 1-15% w/w of oil phase ingredients with spreadability value between 500 and 999 mm2/10 min, iv) 0-10% w/w of oil phase ingredients with spreadability value of below 500 mm2/10 min, v) 5-30% w/w of fatty acid ester(s) of glycerol or fatty acid ester(s) of polyglycerol, vi) 5-20% w/w of water, co-surfactant(s) and optionally co-solvent(s), cosmetic active ingredient(s), skin care ingredient(s), water-soluble extract(s) of plant material and cosmetic auxiliary ingredient(s).
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: June 1, 2021
    Assignee: IONIA AZURÉ AG
    Inventor: Georgios Ionidis
  • Edaravone dosage form
    Patent number: 11020375
    Abstract: Disclosed is an Edaravone dosage form and a use thereof in preparing a drug used for treating diseases related to oxidative stress, the dosage form being selected from a lipid-based delivery system, a solid dispersion, micelles and a co-solvent based formulation.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: June 1, 2021
    Assignee: SUZHOU AUZONE BIOLOGICAL TECHNOLOGY CO., LTD.
    Inventors: Xinfu Zhou, Ankit Parikh, Sanjay Garg
  • Insect control system
    Patent number: 11019814
    Abstract: A system for controlling insects, comprising a first lure module for attracting insects to eat a toxicant and a second cooling module for lowing environmental temperature to a temperature lethal to insects but above the ice crystallization of fruit. The lure comprises: wax; oil; ethyl methyl eugenol or other suitable attractant; and spinosad or other suitable toxicant.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: June 1, 2021
    Inventor: Morton Edward Bassan, Jr.
  • Corticotropin releasing factor receptor antagonists
    Patent number: 11007201
    Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: May 18, 2021
    Assignee: SPRUCE BIOSCIENCES, INC.
    Inventors: Alexis Howerton, Hal Gerber, Michael Huang
  • Methods for diagnosing and treating a heart condition in a patient
    Patent number: 11000484
    Abstract: Various methods for diagnosing and treating heart conditions are disclosed herein. According to one method, nitric oxide is delivered to a patient's lungs when the patient has one or more symptoms of a heart condition. The patient is diagnosed as suffering from a heart condition when a symptom of a heart condition subsides after nitric oxide delivery.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: May 11, 2021
    Assignee: Vero Biotech LLC
    Inventor: David H. Fine
  • Stable oxaliplatin-encapsulating liposome aqueous dispersion and method for stabilizing same
    Patent number: 10993913
    Abstract: An object of the present invention is to provide an oxaliplatin-encapsulating liposome aqueous dispersion that has excellent long-term storage stability. The present invention provides an aqueous dispersion of liposomes encapsulating oxaliplatin, the oxaliplatin-encapsulating liposome aqueous dispersion containing 2-morpholinoethanesulfonic acid in an external aqueous phase.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: May 4, 2021
    Assignees: Taiho Pharmaceutical Co., Ltd, University of Tokushima
    Inventors: Yusuke Doi, Tatsuhiro Ishida
  • Deep-sea water concentrate skin application kit and use thereof
    Patent number: 10987288
    Abstract: A deep-sea water concentrate skin application kit of deep-sea active concentrate and skincare formula is provided. The deep-sea water concentrate skin application kit has the following properties of micronizing the skincare formulas immediately, and decreasing the surface tension of the deep-sea active concentrate immediately; furthermore, the deep-sea active concentrate can become a driving force for the permeability of the micronized skincare formulas. Therefore, the deep-sea water concentrate skin application kit can be more easily absorbed into the skin (dermis). A manufacturing method of the deep-sea water concentrate skin application kit is also provided to improve skin appearance.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: April 27, 2021
    Inventors: Yin-Ming Lo, Jane-Yi Su