Patents Examined by Charles L. Patterson
  • Strand-specific polynucleotide nickases
    Patent number: 6867028
    Abstract: A strand-specific polynucleotide nickase comprising an endonuclease which comprises a first subunit and a second subunit and which recognises an asymmetric nucleotide recognition sequence, wherein the first subunit comprises a catalytic domain capable of cleaving one strand of a DNA duplex, and the second subunit is incapable of cleaving the other strand of the DNA duplex.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: March 15, 2005
    Assignee: Fermentas AB
    Inventors: Arvydas Janulaitis, Komelijus Stankevicius, Arvydas Lubys, Algimantas Markauskas
  • Isolated human phosphodiesterase proteins, nucleic acid molecules encoding human phosphodiesterase proteins, and uses thereof
    Patent number: 6867029
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphodiesterase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphodiesterase peptides, and methods of identifying modulators of the phosphodiesterase peptides.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: March 15, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Xin Wang, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Oncoprotein protein kinase
    Patent number: 6863888
    Abstract: An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: March 8, 2005
    Assignee: The Regents of the University of California
    Inventors: Michael Karin, Masahiko Hibi, Anning Lin, Roger Davis, Benoit Derijard
  • Human endometrial specific steroid-binding factor I, II and III
    Patent number: 6861226
    Abstract: The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: March 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz
  • Methods for producing highly phosphorylated lysosomal hydrolases
    Patent number: 6861242
    Abstract: The present invention provides highly phosphorylated lysosomal hydrolases, methods of modifying lysosomal hydrolases with the lysosomal targeting pathway enzymes GlcNAc-phosphotransferase and/or phosphodiester ?-GlcNAcase.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: March 1, 2005
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6858420
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: February 22, 2005
    Assignee: Applera Corporation
    Inventors: Chunhua Yan, Jane Abu-Threideh, Wei Shao, Gennady Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • DNA FRAGMENT CARRYING TOLUENE MONOOXYGENASE, GENE, RECOMBINANT PLASMID, TRANSFORMED MICROORGANISM, METHOD FOR DEGRADING CHLORINATED ALIPHATIC HYDROCARBON COMPOUNDS AND AROMATIC COMPOUNDS, AND METHOD FOR ENVIRONMENTAL REMEDIATION
    Patent number: 6858417
    Abstract: A recombinant DNA is constructed by using a toluene monooxygenase gene isolated from Ralstonia eutropha strain TB64 and employed to provide the transformant which can express toluene monooxygenase useful for cleaning of aqueous media such as drain and waste water containing halogenated aliphatic hydrocarbon compounds or aromatic compounds, for remediation of soil polluted with such compounds, and cleaning of air (gas phase) polluted with volatile organic chlorine compounds.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: February 22, 2005
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tetsuya Yano, Tsuyoshi Nomoto, Takeshi Imamura
  • Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses
    Patent number: 6855528
    Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens assocated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: February 15, 2005
    Assignees: University of Nebraska Board of Regents
    Inventors: Sudhir Paul, Gennady Gololobov, Larry J. Smith
  • Human protease molecules
    Patent number: 6855811
    Abstract: The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: February 15, 2005
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Jennifer L. Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
  • Covalently reactive transition state analogs and methods of use thereof
    Patent number: 6855804
    Abstract: Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: February 15, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sudhir Paul, Yasuhiro Nishiyama
  • Human RNase H1 mutants
    Patent number: 6855530
    Abstract: A human RNase H polypeptide and methods of use are provided.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: February 15, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Hongjiang Wu, Walter F. Lima, Stanley T. Crooke
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6852519
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: February 8, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady V. Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Oncoprotein protein kinase
    Patent number: 6846644
    Abstract: An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: January 25, 2005
    Assignee: The Regents of the University of California
    Inventors: Roger Davis, Benoit Derijard, Michael Karin, Masahiko Hibi, Anning Lin
  • DSP-4 dual specificity phosphatase
    Patent number: 6841369
    Abstract: Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-4, and polypeptide variants thereof that stimulate dephosphorylation of DSP-4 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-4 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: January 11, 2005
    Assignee: Ceptyr, Inc.
    Inventors: Ralf M. Luche, Bo Wei
  • Process for producing transglutaminase
    Patent number: 6833258
    Abstract: The present invention relates to a high-yield process for producing high-activity, high-purity transglutaminase by refolding denatured microorganism-derived transglutaminase by reacting denatured transglutaminase in an aqueous medium under acidic conditions and reconstituting a higher-order enzymatically active state in an aqueous medium at a neutral pH.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: December 21, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Keiichi Yokoyama, Kunio Ono, Daisuke Ejima
  • Glycosyl hydrolase genes and their use for producing enzymes for the biodegradation of carrageenans
    Patent number: 6830915
    Abstract: The present invention relates to genes which code for glycosyl hydrolases having an HCA score with the iota-carrageenase of Alteromonas fortis which is greater than or equal to 65% over the domain extending between amino acids 164 and 311 of the protein sequence SEQ ID No. 2 of said iota-carrageenase, and to genes which code for glycosyl hydrolases having an HCA score with the kappa-carrageenase of Alteromonas carrageenovora which is greater than or equal to 75% over the domain extending between amino acids 117 and 262 of the protein sequence SEQ ID No. 6 of said kappa-carrageenase.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: December 14, 2004
    Assignee: Laboratoires Goemar, S.A.
    Inventors: Tristan Barbeyron, Philippe Potin, Christophe Richard, Bernard Henrissat, Jean-Claude Yvin, Bernard Kloareg
  • Epoxide hydrolases from streptomyces
    Patent number: 6828115
    Abstract: A description is given of epoxide hydrolases from bacteria of the genus Streptomyces, a novel process for the enzymatic separation of epoxide enantiomeric mixtures, of a novel detection method for epoxide hydrolase activity, a screening method for detecting epoxide hydrolase activity and the use of bacteria of the genus Streptomyces and of the resultant epoxide hydrolases for enantioselective epoxide hydrolysis.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: December 7, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Frank Zocher, Markus Enzelberger, Rolf D. Schmid, Wolfgang Wohlleben, Bernhard Hauer
  • Recombinant vanadium haloperoxidases and their uses
    Patent number: 6828133
    Abstract: The present invention provides new recombinantly produced vanadium bromoperoxidases. The enzymes are useful in a number of industrial applications.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: December 7, 2004
    Assignee: The Regents of the University of California
    Inventors: Valerie Vreeland, Kwan L. Ng
  • Process for the preparation of allysine acetal
    Patent number: 6825014
    Abstract: The present invention relates to the preparation of compounds of formula (I): from the corresponding hydantoins by means of an enzymatic process. The L-compound is preferably formed.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: November 30, 2004
    Assignee: Degussa AG
    Inventors: Hans-Peter Krimmer, Oliver May, Ingo Klement, Karlheinz Drauz, Dietmar Reichert
  • 5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids
    Patent number: 6815195
    Abstract: The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the racemase, and processes for producing optically active amino acids.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: November 9, 2004
    Assignee: Ajinomoto Co. Inc.
    Inventors: Shunichi Suzuki, Norimasa Onishi, Kenzo Yokozeki