Abstract: An implant for occluding a left atrial appendage may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration, wherein the expandable framework includes an attachment point configured to secure the expandable framework to a delivery device, and an occlusive element disposed on a proximal portion of the expandable framework, wherein the occlusive element covers the attachment point.

Abstract: An extraction device can include a delivery shaft having a lumen and a distal end, a first wire forming a first arc and being positionable distal to the distal end of the delivery shaft while ends of the first arc are at a distalmost end of the delivery shaft, and a second wire forming a second arc and being positionable distal to the distal end of the delivery shaft while ends of the second arc are at the distalmost end of the delivery shaft. A distalmost extent of the first wire is distal to a distalmost extent of the second wire. The first wire and the second wire are separately retractable relative to the delivery shaft.

Abstract: Methods and systems for rotationally aligning a commissure of a prosthetic heart valve with a commissure of a native valve are disclosed. In some examples, a delivery apparatus can include a first shaft configured to rotate around a central longitudinal axis of the delivery apparatus, a second shaft extending through the first shaft and having a distal end portion extending distally beyond a distal end portion of the first shaft, an inflatable balloon coupled to the distal end portion of the first shaft, and a third shaft surrounding the first shaft. The first shaft is configured to rotate within the third shaft and translate axially relative to the third shaft, and the third shaft includes a distal tip portion including a plurality of internal helical expansion grooves and a plurality of external helical expansion grooves that are configured to allow the distal tip portion to flex radially outward.

Abstract: A navigable probe system and method of use is provided. The system may include a handle assembly having a locking mechanism enclosed and a stylus, a cannula, and a tracking device extending from the handle assembly. The stylus may include undercuts for receiving pins of the locking mechanism. A cam of the handle assembly may rotate such that in a first position, the pins of the locking mechanism may be engaged with the undercuts and in a second position, the pins of the locking mechanism may be disengaged from the undercuts releasing the stylus from the locking mechanism. The stylus may be slidably engaged with an inner diameter of the cannula. In some arrangements, the handle assembly may include a quick connect system that in a first position attaches the cannula to the handle assembly and in a second position releases the handle assembly and thus stylus from the cannula.

Abstract: Systems, methods, and apparatuses for inserting an intraocular lens (IOL) into an eye, are provided. The apparatus comprises an IOL cartridge comprising a nozzle, a compartment, a plunger, and a plunger case. The nozzle is in fluid communication with the compartment, and the plunger case is in fluid communication with the compartment. The plunger is disposed within the plunger case. The plunger case includes flexible members extending from an outer surface of the plunger case. The IOL cartridge is configured to removably attach to a handpiece.

Abstract: A device having one or more adjustable loops or coils associated with an implant body for use in soft tissue reconstructions is provided. One exemplary embodiment of a device includes a body and a suture filament, with the filament being used to form a self-locking sliding knot disposed on a top side of the body and a plurality of adjustable coils that are substantially disposed on the body's bottom side. Terminal ends of the filament located above the body's top side can be passed through an opening of a Lark's Head knot from opposite sides, thus forming a self-locking sliding knot, and then the terminal ends can be tensioned to adjust a circumference of the coils. Changing a coil's circumference changes a location of a ligament graft disposed on the coil. Other configurations of devices and systems, as well as methods for performing ACL repairs, are also provided.

Abstract: Methods and systems for vibration induced membrane rupture include an epiretinal membrane (ERM) treatment method that includes providing a vibrational device that includes an interface configured for engaging a closed eyelid of an eye of a patient, where the eye of the patient includes an ERM disposed on an epiretinal surface of a retina of the eye. The interface of the vibrational device engages with the closed eyelid and an instance of vibrational force is applied, via the vibrational device while the interface is engaged with the closed eyelid, to the eyelid, where the vibrational force is capable of propagating through the closed eyelid to the retina of the eye. Further, the instance of vibrational force is applied at predetermined frequency (s) and predetermined intensity(s) for predetermined period(s) of time.

Abstract: An extravascular access system includes a tubular stent configured to be deployed in a blood vessel, the stent having a sidewall and a proximal end opening and an internal scaffolding comprising one or more structural members, and an elongate access catheter having a distal end portion configured to access the blood vessel wherein when the stent is deployed in the blood vessel, and the distal end portion of the catheter is inserted into the proximal end opening of the stent, the one or more internal structural members of the stent deflect the distal end portion of the catheter towards a wall of the blood vessel.

Abstract: An embolic implantation system configured to deliver an embolic implant intravascularly to a treatment site includes an elongated delivery tube to which the embolic implant is detachably attached by a flexible loop extending through a retaining ring or opening on the embolic implant and an elongated detachment member or pull wire extending through the delivery tube and flexible loop. The pull wire has a bump near its distal end that inhibits the pull wire from moving further distally when the bump presses distally against the flexible loop and/or retaining ring. The flexible loop and retaining ring thereby serve as a distal obstruction obstructing distal movement of the bump and thereby distal movement of the pull wire into the implant.

Abstract: A delivery apparatus for a prosthetic heart valve includes a shaft, an inner balloon, and an outer balloon. The shaft has a lumen extending from a proximal end portion to a distal end portion and a plurality of openings formed in the distal end portion. The shaft is configured such that a fluid can flow through the lumen and the openings. The inner balloon has end portions and a center portion disposed between the end portions. The inner balloon is mounted on the distal end portion of the shaft and is in fluid communication with the openings of the shaft. When the inner balloon is inflated with the fluid, the end portions expand farther radially outwardly than the center portion. The outer balloon is mounted to the shaft and disposed over the inner balloon. The outer balloon is configured to fully expand after the inner balloon at least partially expands.

Abstract: The present invention relates to a method of implanting a blood clot removal device in a patient's body, by cutting the skin of the patient's body, dissecting an area of the patient's vascular system, placing the blot clot removal device at the dissected area, and connecting a blood flow passageway of the blood clot removal device to the patient's vascular system to allow circulation of the patient's blood through the blood flow passageway.

Abstract: Detachment of a medical device from a delivery assembly can utilize features of electrolytic detachment and features of mechanical detachment. Detachment zones can facilitate mechanical retention of the medical device as well as electrolytic corrosion of portions of the delivery assembly to allow mechanical release of the medical device. Such a delivery system, can include an implant comprising a hub, the hub defining an aperture having an aperture cross-sectional dimension; and a delivery wire comprising (i) a core member extending through the aperture and (ii) a stopper positioned distal to the aperture, the stopper having a first cross-sectional dimension larger than the aperture cross-sectional dimension, and the stopper being electrolytically corrodible to reduce the first cross-sectional dimension to a second cross-sectional dimension smaller than the aperture cross-sectional dimension.

Abstract: The invention relates to an injector assembly having: a folding chamber which is designed to receive an intraocular lens which has an optical body and two haptic elements; a holder; a folding wedge which is attached to the holder and is designed to be introduced into the folding chamber via a folding chamber opening, thereby folding the intraocular lens; and a first slider and a second slider which are each designed to push one of the two haptic elements onto the optical body by means of a displacement of the respective slider from a starting position to an end position, the holder being designed to drive the first slider and/or the second slider from the starting position to the end position by means of a movement of the holder towards the folding chamber.

Abstract: Systems, methods, and apparatuses for removably attaching a drive mechanism handpiece to an intraocular lens (IOL) cartridge that folds the IOL upon retraction of a cap, are provided. The IOL cartridge comprises a nozzle and a compartment configured to receive an IOL. The nozzle is in fluid communication with the compartment. The IOL cartridge also includes a retractable cap that covers the nozzle and the compartment. The retractable cap is configured to expose the nozzle and fold the IOL upon retraction of the retractable cap. The IOL cartridge may also include a plunger case that is in fluid communication with the compartment, wherein a plunger is movably disposed within the plunger case.

Abstract: A flat embolic braid having a first side comprising a first side surface, and a second side comprising a second side surface facing in an opposite direction than the first side surface, the braid having an elongated constrained configuration for being deployed through a delivery catheter, and a three-dimensional unconstrained configuration, wherein in the three-dimensional unconstrained configuration, the braid assumes a plurality of successive loops in which the braid is at least partially twisted between successive loops of the plurality, so that the first side surface faces externally of each loop, and the second side surface faces an interior of each loop, respectively, regardless of a change in direction and/or orientation of the braid.

Abstract: Systems, methods, and devices for inserting an intraocular lens (IOL) into an eye may be provided. In an exemplary aspect, the present disclosure is directed to a haptic optic management system. The haptic management system may include a housing that includes a bore and a cavity disposed in a first surface of the housing. The cavity may include a first end portion, a second end portion, and a central portion, wherein the cavity provides access to the bore through the first surface of the housing. The haptic management system may include arms coupled to the housing. The haptic management system may include edge rollers coupled to the housing.

Abstract: The invention relates to an injector assembly comprising a folding chamber which is designed to receive an intraocular lens having a lens body and two haptics, and comprising a holder, a folding wedge which is attached to the holder and is designed to be introduced into the folding chamber in an insertion direction via a folding chamber opening and to thereby fold the intraocular lens, and two sliders which are each designed to shift one of the two haptics onto the lens body via a shifting of the respective slider out of an initial position and into an end position, wherein at least one of the two sliders has a stop which is designed to abut a component attached to the holder in the initial position of the at least one slider, whereby a movement of the component is blocked and the folding wedge is thereby not permitted to fold the intraocular lens, and said stop is designed to permit the movement of the component in the end position of the at least one slider and the folding wedge is thereby permitted to fold

Abstract: A left atrial appendage (LAA) closure device that includes an anchor portion having a first segment and a second segment that are connected in spaced-apart manner by a first connector, a sealing portion, and a second connector that connects the anchor portion and the second segment sealing portion. The first segment is adapted to be positioned outside the LAA and in the pericardial sac after deployment of the closure device, and the second segment is positioned between the first segment and the sealing portion inside the LAA.

Abstract: A method of performing a surgical procedure with a surgical tool assembly includes inserting a surgical tool into a passage of a patient. The surgical tool can include a main unit and a first rigid sheath. The main unit includes an inner tube that is received within an outer tube. The first rigid sheath removably receives the main unit. The surgical tool can be removed from the passage of the patient, and the first rigid sheath can be completely removed from the main unit. A second rigid sheath having a different shape from the shape of the first rigid sheath can then be removably attached to the main unit instead of the first rigid sheath.

Abstract: Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.