Abstract: A clot retrieval cleaning instrument can have bristles, fluid sprays, or other techniques to liberate captured clot material from a clot retrieval device so that it can be reinserted into a patient's vasculature for successive capture attempts. The cleaning instrument can be conveniently integrated or connected to a hemostasis valve assembly so that the cleaning function can be performed without completely removing the clot retrieval device from the delivery system. Aspiration can be applied to remove the freed thrombus material. The cleaning instrument can be removable from the delivery system to facilitate the instrument's washing or disposal.

Abstract: An intravascular device is provided having a catheter tube and an expandable portion including a plurality of struts capable of being moved between an open and a closed position. An incising element and an abrasive surface are provided on at least one of the struts. The incising element has a sharpened edge for creating an incision in, and the abrasive surface is configured to abrade, atherosclerotic material located within a blood vessel when the expandable portion is in the opened position.

Abstract: Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.

Abstract: A delivery system for side-delivery of a prosthetic valve includes a compression device defining a lumen having a first perimeter at a proximal end that is larger than a second perimeter of the lumen at a distal end. A loading device is coupleable to the compression device and defines a lumen having substantially the second perimeter. A distal end of the loading device includes a first gate that is movable between an open state and a closed state to at least partially occlude the lumen of the loading device. A delivery device defines a lumen having substantially the second perimeter. A proximal end of the delivery device is coupleable to the distal end of the loading device and includes a second gate movable between an open state and a closed state to at least partially occlude the lumen of the delivery device.

Abstract: A surgical device for closing a vaginal cuff includes a handle having an elongated shaft and a plurality of needles disposed therein. Each needle includes a suture anchor at a distal end thereof having a suture engaged therewith. An anvil is disposed at a distal end of the elongated shaft. A cutting mechanism is operably associated with the handle and is configured to cut tissue upon actuation thereof. A firing mechanism is operably associated with the handle and is movable between an unactuated position wherein the plurality of needles and suture anchors remain retained within the elongated shaft, an actuated position wherein the plurality of needles and suture anchors deploy from the elongated shaft through the cervical tissue, and a reverted position wherein the plurality of needles retract leaving the plurality of suture anchors and sutures engaged with the cervical tissue for tying off the vaginal cuff.

Abstract: Systems, methods, and devices for inserting an intraocular lens (IOL) assembly into an eye may be provided. A device for delivery of the IOL into the eye may include a nozzle; a bay adjacent to the nozzle, wherein the bay is configured to contain the lens component and comprises a recess in a shape of a haptic extension; and a cam-actuated mechanism comprising a slider configured to move in a direction toward the nozzle; a side arm moveably disposed within the bay, wherein the side arm is positioned at an end of the slider, the end of the slider comprising a groove aligned with the side arm, wherein the groove extends from an outer edge of the slider into an interior portion of the slider, wherein the groove is angled to receive the side arm as the slider moves.

Abstract: An intravascular catheter device for treating atherosclerotic material located within a blood vessel includes an expandable portion is secured to a catheter tube having a centerline. The expandable portion includes a plurality of struts pivotably attached to the expandable portion for movement between a closed position where the struts extend parallel to the centerline and an opened position where the struts splay outwardly at an angle from the centerline. A sharpened edge associated with at least one of struts creates an incision in the atherosclerotic material when the expandable portion is placed in the opened position and retracted axially through the blood vessel.

Abstract: Described herein are devices and methods for creating a capsulorhexis. In some embodiments, the device includes a template with a tearing profile, which, when placed against the capsular bag, defines a perimeter of a capsulorhexis. In some embodiments, the device further includes rigid sections and bendable sections which are configured to transition the template between a first bent configuration for insertion through a corneal incision and a second unbent configuration for creation of the capsulorhexis. In some embodiments, the device further includes connecting elements which enter through the corneal incision and, when manipulated, transition the device between the first bent configuration and the second unbent configuration. In some embodiments, the connectors are configured to impart a downward force on the template and thus the capsular bag during the capsulorhexis creation.

Abstract: The present disclosure includes an endoprosthesis delivery system comprising an elongate member, such as a catheter, an endoprosthesis, a covering member disposed about the endoprosthesis, and at least one flexible element situated between the endoprosthesis and the covering member. The covering member can extend beyond an end of the endoprosthesis. In operation, as the covering member is removed, the flexible element can guide the covering member over the end of the endoprosthesis to prevent entanglement between the end of the endoprosthesis and the covering member.

Abstract: IOL injectors and associated methods are described. An IOL injector may include a collapsible portion configured to reduce the length of the IOL injector when the collapsible portion is altered from an uncollapsed configuration to a collapsed configuration. In some instances, an IOL may be advanced from a storage location to a dwell location when the collapsible portion is altered from the uncollapsed configuration to the collapsed configuration. An IOL injector may include one or more of a hydraulic damper and a ribbed damper.

Abstract: A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into a common carotid artery through the internal lumen of the arterial access sheath. The catheter has an overall length and a distal most section length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use.

Abstract: The invention generally relates to intraluminal procedures, and, more particularly, to a contra-rotating cutting assembly for use with an atherectomy device to remove occlusive material from an occluded lumen, such as a blood vessel or other body lumen. The contra-rotating cutting assembly includes a rotatable housing having a distal end, an opposing proximal end and a lumen extending between the distal and proximal ends. The housing is configured to rotate about a longitudinal axis in a first direction. The cutting assembly further includes a rotatable cutter head positioned within at least a portion of the lumen of the housing and in coaxial alignment with the housing. The cutter head is configured to rotate about the longitudinal axis in a second direction opposite the first direction.

Abstract: A prosthetic suturing device is disclosed. The prosthetic suturing device has a guide tip defining a cuff receiving area. The device also has a guide tip having at least one needle guide configured to guide at least one needle through the cuff receiving area. Another prosthetic suturing device is disclosed. The prosthetic suturing device has a guide tip defining a cuff receiving area and comprising first and second apertures for receiving a suture adapter. The prosthetic suturing device also has first and second needles, each needle having an end configured to engage a suture adapter. The prosthetic suturing device further has at least one set of needle guides configured to guide the first and second needles through the cuff receiving area. The prosthetic suturing device also has a grip pointing in a direction substantially orthogonal to the cuff receiving area.

Abstract: Methods and devices for relieving stenoses in, or otherwise improving blood flow through, body lumens. Although applicable in a variety of different body lumens, the methods and devices of this invention are specifically useable for relieving stenoses in, or otherwise improving blood flow through, veins which drain blood from the brain for treatment of multiple sclerosis or other neurodegenerative disorders that are caused, triggered or exacerbated by venous occlusion or venous insufficiency.

Abstract: The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods.

Abstract: A system for treating a bifurcation includes a first radially expandable stent and a second radially expandable stent. The first stent has a side hole and a plurality of lateral elements extending from the side hole. The second stent has a plurality of axial elements extending away from the proximal end of the second stent. The axial elements of the second stent interdigitate with the lateral elements of the first stent when both stents have been expanded.

Abstract: Described here are devices, systems, and methods for cannulating a vessel. Generally, the method may comprise advancing a stent into a first vessel and deploying the stent in the first vessel to hold open one or more valves. This may permit retrograde blood flow through the blood vessel in peripheral vasculature and aid in cannulation of the blood vessel.

Abstract: A surgical suturing instrument includes first and second jaw members each defining a hole for detachable receipt of opposite ends of a curved needle. The first jaw member is rotatable relative to the second jaw member to move and transfer the curved needle between the jaw members. A first elongate locking element is slidable within the first jaw member between non-locking and locking positions. When the first elongate locking element is in the locking position and the curved needle is disposed within the hole of the first jaw member, a portion of the first elongate locking element is received in a notch defined in an end of the curved needle to selectively secure the curved needle to the first jaw member.

Abstract: An end effector of a surgical tool may include a housing, a jaw support shaft, jaw members, an articulation member, and cam pulleys. The jaw members may be supported on the support shaft and may be pivotable about a pivot axis. The articulation member may have a slot and include articulation pins extending from it that are coupled to the jaw members. The slot may be adapted to receive the jaw support shaft to support the articulation member between the jaw members. The articulation member may be rotatable about the jaw support shaft to articulate the jaw members relative to the longitudinal axis. The cam pulleys may be mounted to the housing and coupled to the jaw members. The cam pulleys may be rotatable about the pivot axis to pivot the pair of jaw members between open and closed conditions.

Abstract: A clip applier tool for use with a robotic surgical system is disclosed. The clip applier tool comprises a housing, a shaft, an end effector, a firing chamber, a replaceable clip magazine, an articulation joint, an articulation drive configured to articulate the end effector, a rotation drive configured to rotate the shaft, and a firing drive. The housing comprises an interface for attachment to the robotic surgical system. The interface comprises rotatable inputs. The end effector comprises a crimping chamber. The replaceable clip magazine comprises a storage chamber, clips removably positioned in the storage chamber, and a biasing member configured to sequentially bias the clips from the storage chamber into the firing chamber. The firing drive is configured to advance a clip positioned in the firing chamber into the crimping chamber. The articulation drive, the rotation drive, and the firing drive are each operably coupled to different rotatable inputs.