Abstract: A method of characterising tremor stability in a subject is described for a subject having an involuntary tremor symptomatic of a neurological disorder. The method comprising: identifying a series of tremor cycles from measured tremor data of the subject, said tremor cycles measuring periodic variation in movement of the subject due to the tremor; determining an instantaneous frequency for each tremor cycle and collating the instantaneous frequencies; determining an instantaneous variation between the instantaneous frequencies of each pair of adjacent tremor cycles within the series; comparing the instantaneous variation to the collation of determined instantaneous frequencies to determine a distribution of instantaneous variations; and determining an index value of the distribution of the instantaneous variations, said index value defining the stability of the tremor.

Abstract: In one embodiment of the present disclosure, an ingestible medication device is a self-contained electronic device that stores an active agent, and that controls release of the active agent using an on board processor. The ingestible medication device embodies one or more ingestible device identifiers, including personal identifiers and active agent identifiers, which are compared with external device identifiers to determine whether to release the active agent. A method for managing an ingestible medication device detects proximity to a limited range, RFID-enabled patient wristband, indicating that the wristband is worn by the patient that ingested the ingestible medication device. Various methods enable a nurse to track medication information to monitor compliance with medication regimen and dosage information. Other methods track an ingestible medication device selected for filling a prescription at a pharmacy of the health care provider, including transfer to a caregiver station using a transport cart.

Abstract: Systems for determining fractional flow reserve are disclosed. An example system may include a pressure sensing guidewire for measuring a first pressure, a second pressure sensing medical device for measuring a second pressure, and a processor coupled to the pressure sensing guidewire and coupled to the second pressure sensing medical device. The processor may be designed to generate a plot of the magnitude of the second pressure over time, identify one or more time intervals of the plot that have a slope less than zero, determine a mean of the second pressure, and calculate the ratio of the first pressure to the second pressure when (a) the second pressure is less than or equal to the mean of the second pressure and (b) during the one or more time intervals when the slope of the plot is less than zero.

Abstract: An implantable intraocular physiological sensor for measuring intraocular pressure, glucose concentration in the aqueous humor, and other physiological characteristics. The implantable intraocular physiological sensor may be at least partially powered by a fuel cell, such as an electrochemical glucose fuel cell. The implantable intraocular physiological sensor may wirelessly transmit measurements to an external device. In addition, the implantable intraocular physiological sensor may incorporate aqueous drainage and/or drug delivery features.

Abstract: A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for processing sensor data, including calculating a rate of change of sensor data and/or determining an acceptability of sensor or reference data.

Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for performing intravascular data analysis and measurement of various types of data such as pressure and flow data. The disclosure relates to probes and methods suitable for determining an event in a cardiac cycle such as flow threshold such as a peak flow, a fraction thereof, other intravascular parameters or a point in time during which peak flow or a change in one of the parameters occurs. An exemplary probe includes one or more of a pressure sensor, a resistor, a flow sensor and can be used to generate diagnostic data based upon measured intravascular and other parameters. In part, the disclosure relates to methods and systems suitable for determining a coronary flow reserve value in response to one or more of intravascular pressure and flow data or data otherwise correlated therewith.

Abstract: Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk.

Abstract: Apparatus and methods are operative to probe the condition of a sensor either initially, at any point thereafter or continuously during a continuous sensor operation for measuring an analyte in a bodily fluid (such as performed by, e.g., a continuous glucose monitoring (CGM) sensor). Results of the probe may include calibration indices determined from electrical signals obtained during the probe. The calibration indices may indicate whether in-situ adjustment of the sensor's calibration should be performed either initially and/or at random check points. Probing potential modulation parameters also may be used during analyte calculations to reduce the effects of lot-to-lot sensitivity variations, sensitivity drift during monitoring, temperature, interferents, and/or the like. Other aspects are disclosed.

Abstract: The present disclosure relates to optical methods and devices based on pulsate behavior of blood and optical absorption spectroscopy to measure the level of water and/or other substances or compounds, such as an alcohol or lipid, in the blood and the tissues surrounding blood vessels and arteries.

Abstract: A bio-information measuring apparatus bio-information measuring method are provided. The bio-information measuring apparatus includes: a pulse wave obtainer configured to obtain a pulse wave signal, and a processor configured to correct a feature of the obtained pulse wave signal based on a variation in an amplitude of the obtained pulse wave signal, and to measure bio-information based on the corrected feature.

Abstract: The present disclosure relates to a method for determining a user-specific hair treatment with determination and inclusion of the degree of damage of the hair. To this end, the content of cysteic acid is firstly determined with the aid of near-infrared and/or infrared spectra of the keratin fibres of an individual and a degree of damage is derived via a calibration model. Individual treatment advice is output on the basis of the determined degree of damage.

Abstract: Method and system for providing basal profile modification in insulin therapy for use with infusion devices includes periodically monitoring the analyte levels of a patient for a predetermined period of time in order to determine, based on the monitored analyte levels, an appropriate modification factor to be incorporated into the underlying basal profile which was running at the time the periodic monitoring of the analyte levels were performed.

Abstract: A hearable comprises at least one microphone coupled with a wearable structure and a sensor processing unit disposed within the wearable structure and coupled with the microphone. A portion of the wearable structure is configured to be disposed within a user's ear. The sensor processing unit acquires audio data from the at least one microphone and head motion data from at least one motion sensor of the sensor processing unit. The head motion data describes motions of the user's head and comprises cranium motion data and mandible motion data. The sensor processing unit separates the mandible motion data from the head motion data, synchronizes the mandible motion data and the audio data into a synchronized data stream; classifies an activity of the head during a portion of the synchronized data stream; and generates a health indicator for the user based on the activity and the synchronized data stream.

Abstract: The inventive concept relates to a body composition analysis system. A body composition analysis system according to an embodiment of the inventive concept includes a sinusoidal signal generator, a synchronous detector, and a bioimpedance analyzer. The sinusoidal signal generator converts a digital sinusoidal signal having a target frequency into an analog sinusoidal signal. The synchronous detector extracts a target frequency component of a bioelectrical signal generated in response to an analog sinusoidal signal based on the digital sinusoidal signal. The bioimpedance analyzer calculates the bioimpedance based on the target frequency component of the bioelectrical signal. According to the inventive concept, it is possible to improve the selectivity for extracting the target frequency component of the bioelectrical signal and to reduce the area and variations of characteristics for the implementation of the integrated circuit.

Abstract: An implantable sensor can be used for determining a concentration of at least one analyte in a medium, particularly in a body tissue and/or a body fluid. The implantable sensor can comprise a flexible, tubular sensor element. This sensor element has a tubular body on which at least two electrode rings are mounted for electrochemical determination of the concentration of the analyte.

Abstract: Embodiments include methods, systems, and apparatus for identification, detection, and removal of cancerous cells from a patient. The apparatus includes an apparatus handle. The apparatus also includes a display including a pH measurement result. The apparatus also includes an apparatus tip including a reference electrode and a plurality of sensing surfaces, wherein each of the plurality of sensing surfaces is connected to a base of a bipolar junction transistor (BJT) device. The BJT device further includes a collector and an emitter. The apparatus also includes automation circuitry including a processing unit in communication with the apparatus tip and the display. The plurality of sensing surfaces includes a conducting material.

Abstract: A kit of two compositions comprising the same odorants in mixtures of different proportions is used for the measurement of olfactory discrimination capacity in subjects affected by a psychiatric disorder or disease involving mood disturbance, more particularly mood depression.

Abstract: A surgical system used to determine a size of a vessel within a region proximate to a working end of a surgical instrument includes at least one light emitter disposed at the working end, an array of light sensors disposed opposite the at least one light emitter, the array comprising a least one row of light sensors, individual light sensors in the row adapted to generate a signal comprising a pulsatile and a non-pulsatile component, and a controller coupled to the array, the controller comprising a splitter to separate the pulsatile component from the non-pulsatile component, and an analyzer to determine the magnitudes of the pulsatile and non-pulsatile components at the individual light sensors, to determine a first peak magnitude and a second peak magnitude of the pulsatile components, and to determine a resting outer diameter of the vessel based on the first and second peak magnitudes.

Abstract: While performing heart rate estimation of a user, if the user is in motion, a signal is measured and is likely to have noise data, which in turn affects accuracy of estimated heart rate value. Method and system for heart rate estimation when the user is in motion is disclosed. The system estimates value of a noise signal present in a measured PPG signal by performing a Principal Component Analysis (PCA) of an accelerometer signal collected along with the PPG signal. The system further estimates value of a true cardiac signal for a time window, based on value of the true cardiac signal in a pre-defined number of previous time windows. The system then estimates frequency spectrum of a clean PPG signal based on the estimated noise signal and the true cardiac signal. The system further performs heart rate estimation based on the clean PPG signal.