Abstract: An apparatus for non-invasively estimating blood pressure is provided. The apparatus for estimating blood pressure may include a bio-signal measurer configured to measure a bio-signal from a user and a processor configured to estimate blood pressure using the measured bio-signal. The processor may extract a first feature and a second feature from the bio-signal at an extraction time, estimate changes in the first feature and the second feature which have occurred during a time period from a calibration time at which the first feature and the second feature are calibrated to the extraction time at which the first feature and the second feature are extracted, and estimate a blood pressure based on the changes in the first feature and the second feature.

Abstract: Various systems and devices are provided for determining a weaning readiness for weaning a patient from a thermoregulated microenvironment. In one example, a method includes receiving current patient parameters of the patient and applying a weaning model to the current patient parameters to calculate a weaning index representing a likelihood that the patient can be successfully weaned from the microenvironment. The method also includes outputting the weaning index for display on a display device or for storage in a medical record of the patient and upon outputting the weaning index, receiving one or more subsequent patient outcomes, the one or more subsequent patient outcomes comprising whether the patient developed any complications within the duration since being weaned from the microenvironment. The method also includes updating the weaning model based on the one or more received subsequent patient outcomes.

Abstract: A transcutaneous magnetic stimulation (tMS) device is provided for modulating nerve function and chronic pain management, and includes a tMS stimulator, a control module in wired and powered communication with the tMS stimulator, and a portable electronic device in wireless communication with the control module to receive, generate and transmit feedback and control settings relating to a treatment session. The tMS stimulator may be a flexible figure-of-eight coil configured in different sizes and shapes to provide varying pulse and magnetic field strengths for mobile, home, or clinical uses, and also include guidance tools and measurement sensors to aid in positioning and directing the tMS stimulator to a target area for treatment.

Abstract: Ultrasound-guided rete testis injection/aspiration devices and methods are described. Some methods include inserting a needle into the rete testis space of a patient and injecting a therapeutic medium through the needle into the rete testis space and seminiferous tubules of the testis. The therapeutic medium can help to treat infertility. In some examples, the method can include monitoring intra-testicular pressure of the patient. In some examples, the therapeutic medium can include stem cells. In some examples, the therapeutic medium can include gene therapy vectors. In some examples, the method can include flushing the rete testis space and seminiferous tubules with a saline solution through the needle. Exemplary devices can include a dual lumen needle, a collection tube, a dual function pump, and flexible tubing. The dual function pump can include a dual syringe pump and a vacuum pump.

Abstract: The invention describes method for delivering and positioning radio-isotopes. The method uses encapsulating free flowing medicament into a leak proof vehicle and positioning the vehicle into the body. Also provided is a system for delivering and positioning radio-isotopes into the body, the system comprising fluid radio-isotope encapsulated in a leak proof material and/or absorbable material.

Abstract: The disclosure generally relates to determining a breathing rate and a heart rate from cardiopulmonary signal. Conventional systems use additional hardware to improve signal quality or different signal processing techniques to calculate the heart rate from the cardiopulmonary signal. However accurately determining the heart rate is always a continuous area of an improvement. The present methods and systems solve the problem of determining the heart rate accurately, from the cardiopulmonary signals, by determining the signal quality of the cardiopulmonary signal and the signal associated with the heart rate, comprised in the cardiopulmonary signal. A signal processing technique that best performs, out of a set of signal processing techniques is identified based on the signal quality to determine the heart rate. A long-term and an effective health monitoring of healthy as well as patient and infant subjects is achieved by the present disclosure.

Abstract: A system is disclosed. The system includes an accessory control module, comprising computer-executable code stored in non-volatile memory, a processor, an accessory of a user, and a terminal device. The accessory control module, the processor, the accessory, and the terminal device are configured to determine a distance between the terminal device and either the accessory or a user device of the user, and control the accessory to perform a predetermined action for sexually stimulating the user based on the distance.

Abstract: A hydrotherapy cup includes a hydrotherapy cup shell; a fixed cover disposed on a top of the hydrotherapy cup shell; a power compartment disposed in the fixed cover and including an intake pipe, an exhaust pipe, a water pump connected to the exhaust pipe, and a battery pack electrically connected to the water pump; a control panel disposed on the fixed cover and electrically connected to the battery pack; a connecting pipe extending outward from a lower portion of the hydrotherapy cup shell; and a control element including a hose connected to the connecting pipe and a limiting valve disposed on the hose. The water pump may move fluids through the exhaust pipe to create a negative pressure in both the hydrotherapy cup shell and the power compartment.

Abstract: Provided herein are systems, devices, assemblies, and methods for localization of a tag in a tissue of a patient. For example, provided herein are systems, devices, and methods employing a detection component that is attached to or integrated with a surgical device, where the detection component detects a signal from a tag in a patient, where the tag is activated by remote introduction of a magnetic field.

Abstract: An implantable magnetic neurostimulation probe includes at least one electrical conductor disposed on a substrate and arranged in at least one planar loop. At least one planar magnetic core comprising a magnetic material is disposed on the substrate and within the planar loop. A biocompatible coating is disposed over the substrate, electrically conductive trace, and magnetic core.

Abstract: Described herein are wearable sensory stimulation and monitoring devices that can be worn around the back of the neck along and in contact with the spine. Apparatuses described herein stimulate one or more senses including auditory, tactile or olfactory. Apparatuses are also described that allow for sensing and monitoring of physiologic parameters such as heart rate, blood pressure and movement. The device also has features that allow for easy attachment or integration to articles worn on the head such as augmented reality and virtual reality accessories to provide visual stimulation and entertainment.

Abstract: A newborn support device for supporting a newborn in close proximity to the mother is provided. The newborn support device has a support platform for receiving thereon the newborn in an almost fully supported manner. The platform is provided with an elongated slit which is accessible from a side of the platform and extends through the platform from the top surface to a bottom surface of the platform. The slit enables resuscitation of the newborn on the platform with delayed cord clamping. In another aspect the invention relates to a resuscitation device having resuscitation means connected to such a support device.

Abstract: Methods, systems and devices are provided to stimulate the vestibular system in such a way as to excite the neurological components of the circadian rhythm system and induce sleep. A device with one or more electrodes placed over a subject's scalp provides vestibular nerve stimulation (VeNS) to the vestibular nerve, which is then carried into the vestibular nucleus in the brainstem and thereafter transmitted to the neurological components of the circadian rhythm system to excite the areas that promote sleep, allowing the body to enter the sleep state. The characteristics of the stimulation signal and duration of the treatment are configured to allow the treatment to be delivered in advance of the subject's desired sleep time so that the device does not need to be worn in bed.

Abstract: Systems and methods for clinical neuronavigation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a brain stimulation target, including obtaining functional magnetic resonance imaging (fMRI) image data of a patient's brain, where brain imaging data describes neuronal activations within the patient's brain, determining a brain stimulation target by mapping at least one region of interest to the patient's brain, locating functional subregions within the at least one region of interest based on the fMRI image data, determining functional relationships between at least two brain regions of interest, generating parameters for each functional subregion, generating a target quality score for each functional subregion based on the parameters and selecting a brain stimulation target based on its target quality score and the patient's neurological condition.

Abstract: An apparatus includes a support, including an outer surface and configured for insertion into a body of a subject. The apparatus further includes multiple atoms of a radionuclide, which radioactively decays to produce a daughter radionuclide, coupled to the outer surface, and a layer of a polymer, which covers the atoms so as to protect the atoms from being washed away, yet allows diffusion of the daughter radionuclide through the layer. Other embodiments are also described.

Abstract: The invention provides methods of treating metastatic or unresectable pancreatic cancer through the administration of a combination of an immune modulator and radiation therapy.

Abstract: A baby bottle device (100) is provided which comprises at least one 100 movement sensor (140, 150) for detecting a movement of the baby bottle device (100). The movement data from the movement sensor (140, 150) is analyzed in an analyzer (200) to perform a suck-swallow-breathe analysis during a drinking phase of the baby based on the movement data from the movement sensor (140, 150). Thus, a drinking behavior of a baby can be efficiently analyzed.

Abstract: A method of treating dysautonomia in a human via transcranial magnetic stimulation is provided. The method includes positioning an induction device in proximity to a head region adjacent a prefrontal cortical brain region of the human and delivering magnetic stimulation to the prefrontal cortical region of the human by applying current to the induction device at a frequency that promotes inhibition (e.g., a frequency of about 5 Hertz or less, or certain types of theta bursts). The transcranial magnetic stimulation can introduce variability and/or have a modulatory or a disinhibitory effect on an autonomic nervous system of the human. For instance, the transcranial magnetic stimulation can increase a level of heart rate variability in the human by having a positive modulatory effect on the autonomic nervous system in which autonomic balance is achieved or restored as a result of the stimulation.

Abstract: An apparatus for neural stimulation, the apparatus comprising a head device configured to be worn on a head of a user, the head device comprising a light-emitting device configured to provide photic entertainment to the user, and a control module connected to the light-emitting device and configured to operate the light-emitting device through receipt of one or more stimulatory commands, and a computing device communicatively connected to the head device, the computing device comprising a processor, and a memory communicatively connected to the processor, the memory containing instructions configuring the processor to receive user data, wherein the user data comprises information relating to a neural state of a user, generate the one or more stimulatory commands as a function of the user data wherein generating or more stimulatory commands includes determining the neural state of the user, and transmit one or more stimulatory commands to the head device.

Abstract: According to an aspect, a medical device includes an elongate member, a first arm extending from the elongate member, a second arm extending from the elongate member, the second arm being configured to move with respect to the first arm, and a needle coupled to the elongate member, the needle being configured to move with respect to the elongate member.