Abstract: A drug delivery device for reducing the likelihood of stent thrombosis following implantation in a subject is provided. A stent is provided including a body having a plurality of struts and one or more coatings applied to the body including at least one polymer, a therapeutic agent for inhibiting restenosis, a loading dose of a first antiplatelet agent and a maintenance dose of the first antiplatelet agent, and a loading dose of a second antiplatelet agent and a maintenance dose of the second antiplatelet agent.

Abstract: A provisional femoral component, in one embodiment, including at least one first visual indicator and at least one second visual indicator, the first and second visual indicators providing indicating means for simultaneously visually representing a first profile of a first femoral prosthesis and a second profile of a second femoral prosthesis. In another embodiment, a provisional femoral component including a patellofemoral flange having two sulci and a central ridge between the two sulci. In this manner, the provisional femoral component can be positioned on a resected distal femur surface of both a right and left knee joint.

Abstract: A method of forming a bone cutting block includes: forming a plurality of saw slot plates and two side plates, the plurality of saw slot plates each including a plurality of ends opposing one another, each of the plurality of ends including a locating feature, the side plates including a plurality of locating features; and supporting the plurality of saw slot plates using the side plates, each locating feature of the plurality of saw slot plates being connected with a respective one of the plurality of locating features of the side plates and the side plates thereby opposing one another, the plurality of saw slot plates defining at least one slot therebetween which is configured for receiving a bone saw blade therethrough to make a predefined cut in a bone.

Abstract: This invention is the method of treating an ailment associated with the cervical portion of the spine by performing an intravertebral corpectomy that includes the steps of removing the vertebral corpus to define a working channel for the surgeon to gain access to the epidural space so as to attend to and perform a procedure on the pathology. This method obviates the problems incidental to more radical cervical spine operations such as discectomy or corpectomy which requires removal of a portion of the vertebra and adjacent intervertebral discs for decompression of the cervical spinal cord and spinal nerves and using a bone graft with or without a metal plate and screws to reconstruct the spine and provide stability. Prior to terminating the surgery, the opening formed by the removed vertebral corpus is fitted and/or filled with a suitable implant.

Abstract: Disclosed herein are systems, devices, and methods for guiding placement, orientation, and fixation of an orthopedic implant. Examples include a surgical guide having a first surface structured to fit within a prosthetic cup, at least one guide hole through the first surface, and an alignment structure having a contour formed from data indicative of the patient anatomy. The contour of the alignment surface is complementary to a portion of the patient anatomy in a unique orientation that aligns the guide hole with tissue suitable for receiving a fastener. The alignment structure preferably includes an arm with a first end coupled to a rim of the guide and a second end coupled to the contour. In certain implementations, the guide includes a plurality of alignment structures. Further disclosed are methods of making and using a surgical guide for aligning an orthopedic implant.

Abstract: A compression plate kit that allows for manual compression of a bone discontinuity includes a bone plate, two or more reduction screws, and a compression clamp. The compression clamp can include engagement members configured to engage the reduction screws, thereby allowing a practitioner to compress a bone discontinuity by manually closing the compression clamp. One or more implementations of a kit of the present invention can provide a practitioner with physical or tactile feedback during the compression of a bone discontinuity, and thus, provide the practitioner with the ability to better control the compression and spacing of bone portions during a reduction.

Abstract: The invention relates to an articulating joint spacer for temporary replacement of a joint, whereby the joint spacer comprises two spacer parts which each comprise one sliding surface on which the spacer parts, in the patient-inserted state, touch against each other in mobile manner and roll off on each other, and the remaining spacer parts are made, at least in part, of a second bone cement that contains at least one water-soluble antibiotic. The invention also relates to a method for producing a two-part articulating joint spacer, in which a sliding surface is formed in both spacer parts from a low-abrasion first bone cement and at least the surfaces of the remaining spacer parts, at least 50% thereof, are formed with a second bone cement that contains at least one water-soluble antibiotic.

Abstract: A method includes inserting a stem into a bone, positioning a solid articulating portion of a mounting element within a tapered bore so that the mounting element is substantially free to pivot in multiple degrees of freedom relative to the stem while maintaining substantially contiguous engagement between the solid articulating portion and a portion of a surface of the tapered bore defining a circle, engaging the joint component to the mounting element, manipulating the mounting element to vary an angular position of the joint component with the mounting element positioned in the tapered bore while maintaining the substantially contiguous engagement, and mechanically locking the solid articulating portion in the tapered bore to fix a position of the mounting element relative to the stem after manipulating the mounting element by forcing the solid articulating portion toward a bottom of the tapered bore.

Abstract: A flexible chain implant for insertion into an interior volume of a vertebral body. The implant may be implanted in an insertion position for sliding through a cannula and is flexible for packing into the interior volume in an implanted configuration. The implant randomly separates in the implanted configuration. The implant includes a top member and a bottom member, wherein the top and bottom members are coupled to one another at a coupled portion. The top and bottom members preferably each include an inner surface such that the inner surfaces include a plurality of alternating projections and recesses so that the projections are received within the recesses in an insertion position. Alternatively, the implant may include a plurality of substantially non-flexible bodies and a plurality of substantially flexible links interconnecting the bodies. The non-flexible bodies include a plurality of facets and/or abutment surfaces.

Abstract: A femoral prosthesis. The femoral prosthesis includes an implant body having a proximal end and a distal end and a shoulder at the proximal end, the shoulder being structured and dimensioned for a tight press fit into the neck of a femur. The implant body includes a trunk at the distal end, the trunk having a wedge formed by a tapered portion extending in the direction of the distal end of the implant, body. The implant, body also includes a medial column extending from the shoulder toward the distal end and a lateral column extending from the shoulder toward the distal end. The wedge, the medial column, and the lateral column to provide multi-planar stability for the implant body and surface area for fixation of the implant body.

Abstract: A bone fixation plate includes a first opening formed in a plate that is configured to receive a first fastener; a second opening formed in the plate that is configured to receives a second fastener, and a retention member that extends into a third opening formed in the plate between the first opening and the second opening, wherein the retention member is elastically deformable between at least three positions.

Abstract: Improved methods and apparatuses for vertebral body distraction and fusion in accordance with various embodiments employ mechanisms for stabilizing a device so that the device can stay in the body and stably support the disc space during vertebral fusion following distraction of the adjacent vertebra by operation of the device. The device is inserted into the disc space and distracted from a compressed configuration to an expanded configuration to distract the disc space. Mechanisms for stabilizing the device in the expanded configuration constrain the device to zero degrees of freedom of movement to allow the device to stably support the disc space. A bone growth stimulant for promoting vertebral fusion can be inserted into an open space defined by the device, which continues to stably support the disc space during vertebral fusion.

Abstract: A vertebral body spacer of the present invention is used by being inserted between a vertebral body and a vertebral body (intervertebral space). The vertebral body spacer has a block body constituted of titanium or a titanium alloy as a main component thereof, and provided with a pair of contact surfaces to be made contact with the vertebral body and the vertebral body. The block body includes a frame-shaped dense part and a porous part provided inside the dense part, and a porosity of at least a surface of the porous part is larger than a porosity of the dense part. According to the present invention, it is possible to maintain an appropriate size between the vertebral bodies (intervertebral space).

Abstract: A kit for use in performing joint arthroplasty on a head of a long bone is disclosed. The kit includes: a first implant including a first implant articulating surface and an opposed first implant mounting surface having a first implant location feature; and an instrument for preparing a cavity in the head of the long bone. The instrument includes a body and a punch extending from the body. The punch includes a portion thereof having a shape similar to the first implant location surface of the implant. A method for providing joint arthroplasty is also disclosed.

Abstract: In one embodiment, the present invention includes an intramedullary osteosynthesis or arthrodesis implant including a central body, a first pair of legs extending from the central body to a pair of leg tips, and a second pair of legs extending from the central body, in a direction opposite the first pair of legs, to a pair of leg tips such that the central body, first pair of legs and second pair of legs are positioned alongside a longitudinal axis.

Abstract: A medical device for implantation in a hip joint of a patient is provided. The medical device is adapted to be fixated to the femoral bone of the patient. The medical device comprises an inner and an outer surface, wherein a contacting portion of said inner surface is spherical and adapted to face the center of the hip joint when said medical device is implanted, and wherein said medical device is adapted to receive a prosthetic replacement for the caput femur fixated to the pelvic bone having a spherical portion. The medical device comprises at least one extending portion, extending said contacting portion of said inner surface such that said at least one extending portion clasps said spherical portion of said prosthetic replacement for the caput femur, such that said spherical portion is restrained in said medical device.

Abstract: The present invention comprises a highly conformable stent graft with an optional portal for a side branch device. Said stent graft comprises a graft being supported by a stent, wherein said stent comprises undulations each which comprise apices in opposing first and second directions and a tape member attached to said stent and to said graft such that the tape member edge is aligned to the edge of the apices in the first direction of the each of the undulations, thus confining the apices in the first direction of the undulations to the graft and wherein the apices in the second direction of the undulation are not confined relative to the graft; wherein said graft forms unidirectional pleats where longitudinally compressed and wherein said apices in the first direction of said undulation is positioned under an adjacent pleat when compressed. The invention also discloses and claims methods of making and using said highly conformable stent graft and method of making the optional portal.

Abstract: An instrumented linkage system (100) to facilitate accuracy and efficiency of a surgical procedure is disclosed. The linkage system may be directly attached to a bone and used to register the bone to a computer. The linkage system may also be used to verify the accuracy and alignment of planned resections relative to the bone.

Abstract: Devices and methods are provided for positioning and forming bone tunnels. In one embodiment, a surgical drill guide apparatus is provided. The apparatus can include a first guide member having a longitudinal passageway extending therethrough for aiming a first guide pin along a first path to form a first bone tunnel. The apparatus can also include a second guide member having a longitudinal passageway extending therethrough for aiming a second guide pin along a second path to form a second bone tunnel. The first and second guide members can extend at an angle relative to one another and they can be offset such that axes of the guide members do not intersect.

Abstract: A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.