Patents Examined by Christopher L. Chin
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Patent number: 11761958Abstract: Devices, systems, and methods are provided for magnetic focus enhanced lateral flow assays. The devices and systems are ultrasensitive and provide for the visual detection of the presence or absence of one or more target analytes—which may include pathogens, proteins, or even molecules smaller than the foregoing—even when such analytes are only present in very limited amounts. The devices and systems include an immunostrip with a magnet positioned adjacent thereto, and magnetic probes specific to a target analyte that bind to the target analyte with specificity if present within a fluid sample to be tested. Methods are also provided for detecting one or more target analytes using magnetic focus, such methods including a step of controlling movement of a target analyte complex on an immunostrip incorporating a magnetic field, where such control slows a flow of the target analyte complex through a capture area on the immunostrip.Type: GrantFiled: July 12, 2017Date of Patent: September 19, 2023Assignee: Purdue Research FoundationInventors: Joseph M K Irudayaraj, Wen Ren
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Patent number: 11754554Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.Type: GrantFiled: January 11, 2017Date of Patent: September 12, 2023Assignee: Labrador Diagnostics LLCInventors: Shaunak Roy, Melissa Takahashi, Ian Gibbons, Edmond Ku, Thanh Dang, Tammy Burd, Adam Vollmer, Elizabeth A. Holmes
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Patent number: 11747279Abstract: An optical biomodule for detecting a disease specific biomarker, utilizing an enhanced light emission due to integration of one or more three-dimensional (3-D) protruded structures in a fluidic container (which includes one or more materials), upon chemical binding of a disease specific biomarker binder (which includes a first segment coupled with a first fluorophore and a second segment coupled with a second fluorophore) with its corresponding disease specific biomarker is disclosed. Furthermore, the disease specific biomarker binder may include a synthetic biological logic circuit/gate. Furthermore, the three-dimensional (3-D) protruded structure can be coupled with a photonic crystal or a metamaterial (hyperbolic metamaterial/metamaterial of Epsilon-Near-Zero (ENZ)) of a suitable wavelength range.Type: GrantFiled: January 6, 2020Date of Patent: September 5, 2023Inventor: Mohammad A. Mazed
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Patent number: 11740202Abstract: The presence of biomarkers or other analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.Type: GrantFiled: August 31, 2018Date of Patent: August 29, 2023Assignee: ADVANCED TEAR DIAGNOSTICS, LLC.Inventors: Andrew Douglas Penman, Marcus Willard Smith, Catalina Valencia, Sergei A Svarovsky
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Patent number: 11740205Abstract: Sensors, as well as systems and methods of using the same are provided. Aspects of the sensors include a piezoelectric base, a plurality of surface-associated compositions that are stably associated with the piezoelectric base, and a plurality of crosslinking compositions that are configured to crosslink one or more surface-associated compositions in the presence of an analyte. The sensors, systems and methods described herein find use in a variety of applications, including the detection of an analyte in a sample.Type: GrantFiled: April 15, 2020Date of Patent: August 29, 2023Assignee: MODOC TECHNOLOGIES, LLCInventors: David H. Sierra, Andrew Korey
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Patent number: 11719707Abstract: The present invention relates to methods of detecting CD200L in a female subject from a secretory phase biological sample. Increased levels of CD200L have been determined to be associated with endometriosis. CD200L is therefore a useful biomarker for the diagnosis of endometriosis and a useful target for therapeutic intervention.Type: GrantFiled: April 30, 2020Date of Patent: August 8, 2023Assignee: McMaster UniversityInventors: David Alexander Clark, Warren George Foster
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Patent number: 11719643Abstract: A method for detecting dust mite antigens includes the steps of collecting a dust sample, applying an extraction and cleanup procedure for dust mite antigens from the dust sample in order to obtain a sample solution ready for measurement, and placing the sample solution on a SERS chip without immunological modification and under a Raman spectrometer for SERS detection in order to identify whether any dust mite antigens exist in the sample solution.Type: GrantFiled: May 24, 2019Date of Patent: August 8, 2023Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Chun-Yu Chuang, Pin-Hsuan Yeh, Chao-Ming Tsen, Ching-Wei Yu, Wei-Chung Chao, Yung-Hsiang Wang, Cheng-Chien Li
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Patent number: 11719624Abstract: The present invention relates to a liquid immersion micro-channel measurement device and measurement method which are based on trapezoidal incident structure prism incident-type silicon, and according to one embodiment of the present invention, the liquid immersion micro-channel measurement device based on trapezoidal incident structure prism incident-type silicon comprises: a micro-channel structure including a support and at least one micro-channel, which is formed on the support and has a sample detection layer to which a first bioadhesive material for detecting a first sample is fixed; a quadrangular pyramid-shaped prism formed on the upper part of the micro-channel structure; a sample injection unit for injecting, into the micro-channel, a buffer solution containing the first sample; a polarized light generation unit for emitting incident light polarized through the prism on the micro-channel at an incident angle that satisfies a p-wave non-reflection condition; and a polarized light detection unit for dType: GrantFiled: December 15, 2016Date of Patent: August 8, 2023Assignee: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Hyun Mo Cho, Yong Jai Cho, Won Chegal
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Patent number: 11703513Abstract: A system for determining a concentration of hemoglobin A1C includes a first electrochemical test strip, the first electrochemical test strip providing for an HbA1C concentration; and a second electrochemical test strip, the second electrochemical test strip providing for the total amount of hemoglobin.Type: GrantFiled: August 7, 2017Date of Patent: July 18, 2023Assignee: Polymer Technology Systems, Inc.Inventors: Gary Hughes, Ryan Jesswein, Brittney Werner, Aniruddha Patwardhan
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Patent number: 11649263Abstract: Some embodiments described herein relate to a method that includes separating an analyte-containing sample via electrophoresis in a capillary. The capillary is loaded with a chemiluminescence agent, such as luminol, that is configured to react with the analyte (e.g., HRP-conjugated proteins) to produce a signal indicative of a concentration and/or quantity of analyte at each location along the length of the capillary. A first image of the capillary containing the analytes and the chemiluminescence agent is captured over a first period of time. A second image of the capillary containing the analytes and the chemiluminescence agent is captured over a second, longer, period of time. A concentration and/or quantity of a first population of analytes at a first location is determined using the first image, and a concentration and/or quantity of a second population of analytes at a second location is determined using the second image.Type: GrantFiled: May 28, 2019Date of Patent: May 16, 2023Assignee: ProteinSimpleInventors: Hui Xu, Kenneth Swartz
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Patent number: 11639926Abstract: A detection device, the device comprising a sample liquid bearing device (300), test strips (200), a test strips bearing plate (100) and a signal acquisition positioning assisting device, wherein the sample liquid bearing device (300) comprises two or more samples cells (320) used for containing sample liquid, each of the test strips (200) at least comprises an identity information bearing part (250), a developing part (220) and a capillary part (210), the test strip bearing plate (100) is used for placing the test strips (200) in the same circular ring in a circumferential array radial manner, and the signal acquisition positioning assisting device is arranged on the test strip bearing plate and is used for positioning the test strips.Type: GrantFiled: May 13, 2022Date of Patent: May 2, 2023Assignee: Institute of Quality Standard and Testing Technology for Agro-Products, CAASInventors: Jing Wang, Zhen Cao, Hui Li
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Patent number: 11619628Abstract: The present disclosure relates to a device including a reagent portion in which a chemiluminescent indicator and a chemiluminescent substrate for the indicator are disposed, and a base on which the reagent portion is formed. The chemiluminescent indicator and the chemiluminescent substrate are disposed independently from each other in the reagent portion in such a manner that the chemiluminescent indicator and the chemiluminescent substrate can react with each other when a sample is supplied to the reagent portion. The present disclosure also relates to a remote diagnosis system including an imaging terminal for detecting a luminescent signal generated when a reagent is supplied to the device and an information processing unit for processing luminescent signal data obtained by the imaging terminal. The imaging terminal and the information processing unit can bi-directionally communicate with each other via a network.Type: GrantFiled: January 26, 2018Date of Patent: April 4, 2023Assignee: Osaka UniversityInventors: Takeharu Nagai, Yoshiyuki Arai, Megumi Iwano
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Patent number: 11619584Abstract: A time-resolved fluorescence immunochromatographic test paper card for testing clothianidin. A binding pad includes a detection microsphere and a quality control microsphere thereon, wherein the detection microsphere is a fluorescent microsphere coated with a clothianidin monoclonal antibody on the surface thereof, the quality control microsphere is a fluorescent microsphere coated with a rabbit anti-tag protein on the surface thereof. An NC film is provided with a detection line and a control line. The lengths of the detection line and the control line are the same as the width of the NC film. A first clamping part is arranged at one end of the sample pad. A second clamping part and a third clamping part are respectively arranged at two ends of the binding pad. A fourth clamping part is arranged at one end of the NC film, the other end of the NC film is joined with an absorption pad.Type: GrantFiled: July 9, 2020Date of Patent: April 4, 2023Assignee: TOBACCO RESEARCH INSTITUTE OF CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Xiuguo Wang, Xiao Zhang, Qing Guo
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Patent number: 11598775Abstract: A rapid immunoassay method and apparatus for detecting foot and mouth disease virus are disclosed. The method and test device permit pen-side testing of animals and provide test results within a relatively short time period. In a preferred embodiment, the method and apparatus provide a means for differentiating between FMDV-infected and FMDV-vaccinated animals.Type: GrantFiled: July 9, 2018Date of Patent: March 7, 2023Assignee: Princeton BioMeditech CorporationInventors: Jemo Kang, Ki-Yong Jang
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Patent number: 11577248Abstract: A biosensor detector device is disclosed suitable for use in measuring membrane fluidity or membrane permeability. The biosensor detector device is formed of a solid substrate having a lipid bilayer compatible surface, a multi-lamellar lipid membrane structure derived from a biological cell and localized on the lipid bilayer compatible surface, an aqueous layer interposed between each lipid bilayer of the multi-lamellar lipid membrane structure. The biological membrane is derived from human red blood cells and localized on the lipid bilayer compatible surface. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the multi-lamellar lipid membrane structure and hemolytic activity in a test sample.Type: GrantFiled: December 21, 2018Date of Patent: February 14, 2023Assignee: McMaster UniversityInventors: Maikel Rheinstadter, Sebastian Himbert, Richard Alsop, Jose Moran-Mirabal, Sokunthearath Saem, Dawn Bowdish
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Patent number: 11579145Abstract: A method for image analysis of medical test results, comprising receiving, at a server, information from a mobile device regarding test results from a test performed using a testing device, wherein the testing device includes an alignment target disposed on the testing device and a plurality of immunoassay test strips, receiving at the server an image of the testing device from the mobile device, determining by the server RGB values for a plurality of pixels of the image, normalizing by the server the RGB values into a single value, comparing by the server the single value to a control value stored on the server, and providing by the server a risk indicator, wherein the risk indicator indicates a likelihood of a presence of a medical condition.Type: GrantFiled: November 6, 2017Date of Patent: February 14, 2023Assignee: RELIANT IMMUNE DIAGNOSTICS, INC.Inventors: Jovan Hutton Pulitzer, Henry Joseph Legere, III
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Patent number: 11573225Abstract: Various aspects of the system and methods described herein rely upon the operation of lateral flow assays specially configured to evaluate a bodily fluid for at least the presence or absence of pregnanediol glucuronide at a threshold selected from the range inclusive of 1 ?g/mL-10 ?g/mL. The results from the lateral flow assays are optionally interpreted in association with an application operating upon a mobile device or a system for the collection, interpretation and storage of results. The interpretations are useful in accordance with facilitating diagnoses and treatments associated with medical conditions related to the generated interpretations of the lateral flow assays.Type: GrantFiled: May 11, 2021Date of Patent: February 7, 2023Assignee: MFB Fertility, Inc.Inventor: Amy Beckley
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Patent number: 11567066Abstract: Among other things, the present disclosure is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly a homogeneous assay that does not use a wash step and that is fast (e.g., 60 seconds from dropping a sample to displaying results). The present disclosure is related to both competitive and non-competitive homogeneous assays.Type: GrantFiled: September 17, 2021Date of Patent: January 31, 2023Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
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Patent number: 11549943Abstract: A multiplexed lateral flow assay device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir and divides a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable paper top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays. The housing element includes an impermeable bottom cover and a spacer element arranged between the top and bottom covers and, provides a gap between the lateral flow assays and the impermeable paper top cover.Type: GrantFiled: May 31, 2019Date of Patent: January 10, 2023Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, FUNDACAO OSWALDO CRUZInventors: Jaione Tirapu Azpiroz, Ademir Ferreira da Silva, Matheus Esteves Ferreira, Ricardo Luis Ohta, Mathias B. Steiner, Nara Mazarakis Rubim, Pedro Paulo Ferreira Ribeiro, Edimilson Domingos da Silva, Antonio Gomez Pinto Ferreira
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Patent number: 11543410Abstract: A sensing device includes a sample loading chamber configured to receive a sample, a detection antibody drying or lyophilization chamber configured to receive a first portion of the sample, one or more substrate drying or lyophilization chambers configured to receive a second portion of the sample, and one or more reaction chambers connected to the detection antibody drying or lyophilization chamber and the one or more substrate drying or lyophilization chambers. The detection antibody drying or lyophilization chamber and one or more substrate drying or lyophilization chambers are placed in parallel between the sample loading chamber and the one or more reaction chambers.Type: GrantFiled: August 31, 2018Date of Patent: January 3, 2023Assignee: University of CincinnatiInventors: Chong H. Ahn, Sthitodhi Ghosh, Atreyee Chakraborty