Patents Examined by Christopher Low
  • Patent number: 7910523
    Abstract: The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-?B, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: March 22, 2011
    Assignee: Board of Regents, The University of Texas System
    Inventors: David G. Gorenstein, Bruce A. Luxon, James Leary
  • Patent number: 7897758
    Abstract: The present invention discloses novel methods for the synthesis of oligonucleotides and nucleoside phosphoramidites. The methods are based on employing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups on the aromatic ring as activators. In one aspect the novel activators are used in the synthesis of oligonucleotides via the phosphoramidite approach. In this aspect the activators are highly efficient and can be applied with very short coupling times. In a further aspect, the activators of the invention are used in the synthesis of phosphoramidites through the reaction of nucleosides comprising a free hydroxyl group with phosphitylating agents. In this aspect the activators provide very pure phosphoramidites under mild conditions. The activators of the invention are further characterized by being highly soluble, non-hygroscopic and non-hazardous.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: March 1, 2011
    Assignee: Sigma-Aldrich Co.
    Inventors: Andreas Wolter, Michael Leuck
  • Patent number: 7888465
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 15, 2011
    Assignee: The Invention Science Fund, I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7879974
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 1, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7879975
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: February 1, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7879973
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 1, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7867391
    Abstract: The present disclosure provides a cucurbituril derivative-bonded solid substrate in which cucurbituril derivatives of Formula 1 are covalently bonded to a modified solid substrate of Formula 2. The cucurbituril derivative provides functional groups which can be used to link biomaterials to the substrate. Protein chips, gene chips, and sensors for biomaterial assays having the cucurbituril derivative-bonded solid substrate are also provided.
    Type: Grant
    Filed: July 5, 2004
    Date of Patent: January 11, 2011
    Assignee: Postech Foundation
    Inventors: Kimoon Kim, Jin Koo Kang, Woo Seong Jeon, Sang Yong Jon, Selvapalam Narayanan, Dong Hyun Oh, Kangkyun Baek
  • Patent number: 7858323
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods and compositions for phage microarray profiling of cancer (e.g., prostate, lung, or breast cancer). The present invention further provides novel markers useful for the diagnosis, characterization, and treatment of cancers.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: December 28, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Arul Chinnaiyan, Xiaoju Wang
  • Patent number: 7846875
    Abstract: The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to the solid supports functionalised by said compounds and to the use of same for the immobilisation of biological molecules of interest, such as nucleic acid molecules.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: December 7, 2010
    Assignees: Commissariat A l 'Energie Atomique, Universite Joseph Fourier
    Inventors: Antoine Hoang, Françoise Vinet, Eric Defrancq, Pascal Dumy
  • Patent number: 7838504
    Abstract: Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: November 23, 2010
    Assignee: The Board of Trustees of the Leland Standford Junior University
    Inventors: Peter Sarnow, Catherine L. Jopling, Alissa M. Lancaster
  • Patent number: 7838261
    Abstract: A method for biochemical analysis uses a micro-reaction array with at least two reaction chambers for materials which react together chemically or biochemically. The reaction chambers are smaller than 1 ?l, the reaction chambers are filled together by throughflow, the chemical or biochemical reactions of the substances retained therein then occurs in the individual isolated reaction chambers, thus preventing an interference between the reactions in the individual reaction chambers and the reaction products remain enclosed in the relevant reaction chambers. In the system the planar array has at least two reaction chambers for substances, whereby the reaction chambers are closed with the goal of preventing an exchange of substances.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: November 23, 2010
    Assignee: Siemens Aktiengesellschaft
    Inventors: Walter Gumbrecht, Rainer Hintsche, Konrad Mund, Manfred Stanzel
  • Patent number: 7795182
    Abstract: A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: September 14, 2010
    Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite de Nantes, University of Florida
    Inventors: Charles Tellier, Muriel Pipelier, Didier Dubreuil, Bruno Bujoli, Daniel Talham
  • Patent number: 7790037
    Abstract: A method of separating compounds, includes: a. tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; b. tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound, the first tagging moiety and the second tagging moiety including at least one of a common repeat unit, but having a different number of the repeat units therein, the greater the number of repeat units, the greater the polarity of the tagging moiety; and c. separating the first tagged compound from a mixture including at least the second tagged compound using a chromatographic separation technique based upon differences in the number of repeat units between the first tagging moiety and the second tagging moiety.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: September 7, 2010
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Craig S. Wilcox, Dennis P. Curran
  • Patent number: 7777002
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: August 17, 2010
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7772159
    Abstract: The invention provides a new process for the preparation of polypyrrolinones (I) of various sizes which have found to be useful peptidomimetics. One aspect of the invention is a new process utilizing ?-amino-?-substituted-valerolactones as synthons. A second aspect of the invention is a process for the synthesis of polypyrrolinones using solid-phase techniques.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: August 10, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Amos B. Smith, III, Hu Liu, Hiroyuki Ikumura, Ralph F. Hirschmann
  • Patent number: 7754854
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: July 13, 2010
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7754646
    Abstract: Highly functionalized, porous organosilica particles and methods of their synthesis are described that employ high amounts of functional silane such as 3-mercaptopropyl trimethoxysilane. Silane particle diameters are controlled from less than 1 ?m to over 100 ?m. The particles have a high surface area due to their advantageous internal structures, which consist of large pores, typically up to 10 ?m that are linked by small channels of typically about 20 nm diameter. Isothiocyanate modified fluorescent dyes can enter and react with thiol groups inside the pores. The invention also provides clear silica shells of controlled thicknesses to protect fluorescent signals and provide an independent parameter for distinguishing particle types based on light scattering off different sized particles. The particles are stable and useful for many purposes, particularly for optical bar coding in combinatorial synthesis of polymers such as nucleic acid, polypeptide, and other synthesized molecules.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: July 13, 2010
    Assignee: Nanomics Biosystems Pty Ltd
    Inventors: Mathias Trau, Angus Johnston
  • Patent number: 7749940
    Abstract: A novel tagged triazine library is provided in which three building blocks are prepared separately and assembled orthogonally to yield 1536 highly pure compounds. Each library compound contains a variety of a triethyleneglycol (TG) linker at one of the diversity sites of the triazine scaffold.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: July 6, 2010
    Assignee: New York University
    Inventor: Young-Tae Chang
  • Patent number: 7737088
    Abstract: The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: June 15, 2010
    Assignee: Febit Holding GmbH
    Inventors: Cord F. Stähler, Peer F. Stähler, Manfred Müller, Fritz Stähler, Hans Lindner
  • Patent number: 7737089
    Abstract: The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: June 15, 2010
    Assignee: Febit Holding GmbH
    Inventors: Ramon Güimil, Matthias Scheffler, Barbro Beijer