Patents Examined by Christopher Low
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Patent number: 7910523Abstract: The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-?B, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.Type: GrantFiled: May 20, 2004Date of Patent: March 22, 2011Assignee: Board of Regents, The University of Texas SystemInventors: David G. Gorenstein, Bruce A. Luxon, James Leary
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Patent number: 7897758Abstract: The present invention discloses novel methods for the synthesis of oligonucleotides and nucleoside phosphoramidites. The methods are based on employing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups on the aromatic ring as activators. In one aspect the novel activators are used in the synthesis of oligonucleotides via the phosphoramidite approach. In this aspect the activators are highly efficient and can be applied with very short coupling times. In a further aspect, the activators of the invention are used in the synthesis of phosphoramidites through the reaction of nucleosides comprising a free hydroxyl group with phosphitylating agents. In this aspect the activators provide very pure phosphoramidites under mild conditions. The activators of the invention are further characterized by being highly soluble, non-hygroscopic and non-hazardous.Type: GrantFiled: April 26, 2006Date of Patent: March 1, 2011Assignee: Sigma-Aldrich Co.Inventors: Andreas Wolter, Michael Leuck
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Patent number: 7888465Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.Type: GrantFiled: June 29, 2006Date of Patent: February 15, 2011Assignee: The Invention Science Fund, I, LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
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Patent number: 7879974Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.Type: GrantFiled: June 29, 2006Date of Patent: February 1, 2011Assignee: The Invention Science Fund I, LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
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Patent number: 7879975Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.Type: GrantFiled: June 22, 2007Date of Patent: February 1, 2011Assignee: The Invention Science Fund I, LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
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Patent number: 7879973Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.Type: GrantFiled: June 29, 2006Date of Patent: February 1, 2011Assignee: The Invention Science Fund I, LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
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Patent number: 7867391Abstract: The present disclosure provides a cucurbituril derivative-bonded solid substrate in which cucurbituril derivatives of Formula 1 are covalently bonded to a modified solid substrate of Formula 2. The cucurbituril derivative provides functional groups which can be used to link biomaterials to the substrate. Protein chips, gene chips, and sensors for biomaterial assays having the cucurbituril derivative-bonded solid substrate are also provided.Type: GrantFiled: July 5, 2004Date of Patent: January 11, 2011Assignee: Postech FoundationInventors: Kimoon Kim, Jin Koo Kang, Woo Seong Jeon, Sang Yong Jon, Selvapalam Narayanan, Dong Hyun Oh, Kangkyun Baek
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Patent number: 7858323Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods and compositions for phage microarray profiling of cancer (e.g., prostate, lung, or breast cancer). The present invention further provides novel markers useful for the diagnosis, characterization, and treatment of cancers.Type: GrantFiled: June 6, 2005Date of Patent: December 28, 2010Assignee: The Regents of the University of MichiganInventors: Arul Chinnaiyan, Xiaoju Wang
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Patent number: 7846875Abstract: The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to the solid supports functionalised by said compounds and to the use of same for the immobilisation of biological molecules of interest, such as nucleic acid molecules.Type: GrantFiled: July 11, 2005Date of Patent: December 7, 2010Assignees: Commissariat A l 'Energie Atomique, Universite Joseph FourierInventors: Antoine Hoang, Françoise Vinet, Eric Defrancq, Pascal Dumy
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Patent number: 7838504Abstract: Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.Type: GrantFiled: December 10, 2007Date of Patent: November 23, 2010Assignee: The Board of Trustees of the Leland Standford Junior UniversityInventors: Peter Sarnow, Catherine L. Jopling, Alissa M. Lancaster
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Patent number: 7838261Abstract: A method for biochemical analysis uses a micro-reaction array with at least two reaction chambers for materials which react together chemically or biochemically. The reaction chambers are smaller than 1 ?l, the reaction chambers are filled together by throughflow, the chemical or biochemical reactions of the substances retained therein then occurs in the individual isolated reaction chambers, thus preventing an interference between the reactions in the individual reaction chambers and the reaction products remain enclosed in the relevant reaction chambers. In the system the planar array has at least two reaction chambers for substances, whereby the reaction chambers are closed with the goal of preventing an exchange of substances.Type: GrantFiled: November 26, 2001Date of Patent: November 23, 2010Assignee: Siemens AktiengesellschaftInventors: Walter Gumbrecht, Rainer Hintsche, Konrad Mund, Manfred Stanzel
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Patent number: 7795182Abstract: A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.Type: GrantFiled: July 22, 2003Date of Patent: September 14, 2010Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Universite de Nantes, University of FloridaInventors: Charles Tellier, Muriel Pipelier, Didier Dubreuil, Bruno Bujoli, Daniel Talham
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Patent number: 7790037Abstract: A method of separating compounds, includes: a. tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; b. tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound, the first tagging moiety and the second tagging moiety including at least one of a common repeat unit, but having a different number of the repeat units therein, the greater the number of repeat units, the greater the polarity of the tagging moiety; and c. separating the first tagged compound from a mixture including at least the second tagged compound using a chromatographic separation technique based upon differences in the number of repeat units between the first tagging moiety and the second tagging moiety.Type: GrantFiled: June 25, 2004Date of Patent: September 7, 2010Assignee: University of Pittsburgh—of the Commonwealth System of Higher EducationInventors: Craig S. Wilcox, Dennis P. Curran
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Patent number: 7777002Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.Type: GrantFiled: June 22, 2007Date of Patent: August 17, 2010Assignee: The Invention Science Fund I, LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
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Patent number: 7772159Abstract: The invention provides a new process for the preparation of polypyrrolinones (I) of various sizes which have found to be useful peptidomimetics. One aspect of the invention is a new process utilizing ?-amino-?-substituted-valerolactones as synthons. A second aspect of the invention is a process for the synthesis of polypyrrolinones using solid-phase techniques.Type: GrantFiled: July 20, 2004Date of Patent: August 10, 2010Assignee: The Trustees of the University of PennsylvaniaInventors: Amos B. Smith, III, Hu Liu, Hiroyuki Ikumura, Ralph F. Hirschmann
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Patent number: 7754854Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.Type: GrantFiled: June 29, 2006Date of Patent: July 13, 2010Assignee: The Invention Science Fund I, LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
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Patent number: 7754646Abstract: Highly functionalized, porous organosilica particles and methods of their synthesis are described that employ high amounts of functional silane such as 3-mercaptopropyl trimethoxysilane. Silane particle diameters are controlled from less than 1 ?m to over 100 ?m. The particles have a high surface area due to their advantageous internal structures, which consist of large pores, typically up to 10 ?m that are linked by small channels of typically about 20 nm diameter. Isothiocyanate modified fluorescent dyes can enter and react with thiol groups inside the pores. The invention also provides clear silica shells of controlled thicknesses to protect fluorescent signals and provide an independent parameter for distinguishing particle types based on light scattering off different sized particles. The particles are stable and useful for many purposes, particularly for optical bar coding in combinatorial synthesis of polymers such as nucleic acid, polypeptide, and other synthesized molecules.Type: GrantFiled: July 1, 2002Date of Patent: July 13, 2010Assignee: Nanomics Biosystems Pty LtdInventors: Mathias Trau, Angus Johnston
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Patent number: 7749940Abstract: A novel tagged triazine library is provided in which three building blocks are prepared separately and assembled orthogonally to yield 1536 highly pure compounds. Each library compound contains a variety of a triethyleneglycol (TG) linker at one of the diversity sites of the triazine scaffold.Type: GrantFiled: May 5, 2004Date of Patent: July 6, 2010Assignee: New York UniversityInventor: Young-Tae Chang
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Patent number: 7737088Abstract: The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.Type: GrantFiled: August 27, 1999Date of Patent: June 15, 2010Assignee: Febit Holding GmbHInventors: Cord F. Stähler, Peer F. Stähler, Manfred Müller, Fritz Stähler, Hans Lindner
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Patent number: 7737089Abstract: The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.Type: GrantFiled: December 23, 2003Date of Patent: June 15, 2010Assignee: Febit Holding GmbHInventors: Ramon Güimil, Matthias Scheffler, Barbro Beijer