Patents Examined by Christopher M. Gross
  • Patent number: 11067582
    Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: July 20, 2021
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Neal Woodbury, Stephen Johnston, Phillip Stafford
  • Patent number: 11017882
    Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: May 25, 2021
    Assignees: Immunocore Limited, Adaptimmune Limited
    Inventors: Brian John Cameron, Annelise Brigitte Vuidepot, Bent Karsten Jakobsen
  • Patent number: 11014957
    Abstract: Disclosed herein are methods and compositions for the detection of small RNAs in a sample. The methods and compositions disclosed herein may be used for preparing sequencing libraries of the small RNAs, fragments of RNAs and DNAs.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: May 25, 2021
    Assignee: REALSEQ BIOSCIENCES, INC.
    Inventors: Sergei A. Kazakov, Sergio Barberan-Soler, Anne Dallas, Brian H. Johnston
  • Patent number: 11001640
    Abstract: The present invention provides a method for generating bispecific shark variable antibody domains (vNAR domains) and uses thereof. The present invention further provides fusion proteins comprising the inventive bispecific vNAR domains as well as polynucleotide libraries for use in the generation of the inventive bi-specific vNARs. Furthermore, the invention provides pharmaceutical compositions comprising the inventive bispecific vNARs or fusion proteins comprising bi-specific vNAR domains for use in the treatment of pathological conditions in an individual. The invention also provides kits of parts comprising the bispecific vNAR domains or fusion proteins.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: May 11, 2021
    Assignee: Merck Patent GmbH
    Inventors: Stefan Becker, Bjoern Hock, Stefan Zielonka, Harald Kolmar, Martin Empting
  • Patent number: 11002735
    Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: May 11, 2021
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Francisco Javier Quintana, Guy Hed, Gad Getz
  • Patent number: 11004539
    Abstract: Provided are drug-transport metabolomics profile assessments and therapies.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 11, 2021
    Assignee: The Regents of the University of California
    Inventors: Sanjay K. Nigam, Henry C. Liu
  • Patent number: 10995424
    Abstract: The present disclosure provides shuttle vectors for editing exogenous polynucleotides in heterologous live cells, as well as automated methods, modules, and multi-module cell editing instruments and systems for performing the editing methods.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: May 4, 2021
    Assignee: Inscripta, Inc.
    Inventors: Richard Fox, Daniel Held
  • Patent number: 10987648
    Abstract: Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis. Provided herein are processes which include use of lamps, lasers, and/or microcontact printing to add functional groups to surfaces for the efficient and uniform synthesis of oligonucleic acids.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: April 27, 2021
    Assignee: Twist Bioscience Corporation
    Inventors: Bill James Peck, Pierre Indermuhle, Eugene P. Marsh, Andres Fernandez, David Stern
  • Patent number: 10954542
    Abstract: This disclosure provides, among other things, a method for making a cDNA library. In some embodiments the method may comprise adding a polyA tail to the longer RNA fragments but not the shorter RNA fragments in a sample by incubating the population of RNA fragments with a polyA polymerase, wherein the reaction conditions used preferentially tail only the longer fragments but not the shorter fragments.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: March 23, 2021
    Assignee: BIOO SCIENTIFIC CORPORATION
    Inventor: Kevin Allen
  • Patent number: 10937524
    Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: March 2, 2021
    Assignees: Immunocore Limited, Adaptimmune Limited
    Inventors: Brian John Cameron, Annelise Brigitte Vuidepot, Bent Karsten Jakobsen
  • Patent number: 10935544
    Abstract: The invention relates to linkers and methods for generating arrays with linkers. The invention also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for epitope identification, drug discovery and as analytical tools. The invention provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing cancer.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: March 2, 2021
    Assignee: OBI PHARMA, INC.
    Inventors: Peiwen Yu, Wei-Chien Tang, Shu-Yi Lin, Cheng-Chi Wang
  • Patent number: 10927370
    Abstract: Methods and systems for sample preparation techniques that allow amplification (e.g., whole genome amplification) and sequencing of chromatin accessible regions of single cells are provided. The methods and systems generally operate by forming or providing partitions (e.g., droplets) including a single biological particle and a single bead comprising a barcoded oligonucleotide. The preparation of barcoded next-generation sequencing libraries prepared from a single cell is facilitated by the transposon-mediated transposition and fragmentation of a target nucleic acid sequence. The methods and systems may be configured to allow the implementation of single-operation or multi-operation chemical and/or biochemical processing within the partitions.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: February 23, 2021
    Assignee: 10X GENOMICS, INC.
    Inventors: Zahra Kamila Belhocine, Geoffrey McDermott, Francesca Meschi, Xinying Zheng
  • Patent number: 10919759
    Abstract: A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film. In many respects, the device functions as a Field Effect Transistor (FET) with the bodily source, e.g., blood, acting as a polyelectrolyte liquid gate electrode to create a varying electrostatic charge or capacitance in the thin film based upon the binding of cellular targets in the source to the antibodies present on the biofunctional pad.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: February 16, 2021
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventor: Balaji Panchapakesan
  • Patent number: 10920217
    Abstract: Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: February 16, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Srivatsan Raman, Noah D. Taylor, George M. Church
  • Patent number: 10913944
    Abstract: Methods, systems, kits and compositions are described for quality control and quantitation of nucleic acid libraries of double stranded nucleic acid libraries prior to massively parallel sequencing. Electrophoretic separation within a channel using a detectably labeled single stranded sizing ladder may be used to define the molecular weight range and amount of the double stranded nucleic acids.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: February 9, 2021
    Assignee: Life Technologies Corporation
    Inventors: Stephan Berosik, Jianbo Gao, Shiaw-Min Chen, H. Michael Wenz
  • Patent number: 10900975
    Abstract: Methods for antibody profiling and epitope mapping are provided herein. More particularly, methods for screening and mapping epitopes of candidate antibodies and protein target identification are provided herein.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: January 26, 2021
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventor: Stephen Albert Johnston
  • Patent number: 10883136
    Abstract: Provided is a method of isolating biochemical molecules on a microarray substrate, the method including providing a microarray substrate to which clusters of different kinds of biochemical molecules being classified by individual spot units are attached, the individual spots being regularly arranged thereon; obtaining location information of the individual spot in which a desired cluster among clusters of the biochemical molecules locates; locating an extraction tool for applying energy to isolate the desired cluster according to the location information; and isolating the desired cluster from the microarray substrate by applying energy in a contact or non-contact manner using the extraction tool.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: January 5, 2021
    Assignee: SNU R&DB FOUNDATION
    Inventors: Sunghoon Kwon, Taehoon Ryu, Yeongjae Choi, Yushin Jung, Hyoki Kim, Howon Lee
  • Patent number: 10870925
    Abstract: Protein arrays and their use to assay, in a parallel fashion, the protein products of highly homologous or related DNA coding sequences and described. By highly homologous or related it is meant those DNA coding sequences which share a common sequence and which differ only by one or more naturally occurring mutations such as single nucleotide polymorphisms, deletions or insertions, or those sequences which are considered to be haplotypes. Such highly homologous or related DNA coding sequences are generally naturally occurring variants of the same gene. Arrays according to the invention have two or more individual proteins deposited in a spatially defined pattern on a surface in a form whereby a property such as an activity or function of the proteins can be investigated or assayed in parallel by interrogation of the array.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: December 22, 2020
    Assignee: SENGENICS CORPORATION PTE LTD
    Inventors: Jonathan Mark Boutell, Benjamin Leslie James Godber, Darren James Hart, Jonathan Michael Blackburn
  • Patent number: 10859585
    Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: December 8, 2020
    Assignee: The Scripps Research Institute
    Inventors: Benjamin F. Cravatt, Micah J. Niphakis, Kenneth Lum, Bruno Correia, Armand Cognetta, Jonathan Hulce
  • Patent number: 10858761
    Abstract: The present disclosure provides shuttle vectors for editing exogenous polynucleotides in heterologous live cells, as well as automated methods, modules, and multi-module cell editing instruments and systems for performing the editing methods.
    Type: Grant
    Filed: February 22, 2020
    Date of Patent: December 8, 2020
    Assignee: Inscripta, Inc.
    Inventors: Richard Fox, Daniel Held