Patents Examined by Chu Chuan Liu
  • Patent number: 11154224
    Abstract: A method of non-invasively monitoring hematocrit levels includes monitoring a first emission response to the light provided at the first excitation wavelength, wherein the first emission response is monitored at a first wavelength and monitoring a second emission response to the light provided at the first excitation wavelength, wherein the second emission response is monitored at a second wavelength. A ratiometric value is calculated based on a ratio of the first emission response to the second emission response, wherein the ratiometric value corresponds with hematocrit level of the patient.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: October 26, 2021
    Assignee: Medtronic Monitoring, Inc.
    Inventor: Rodolphe Katra
  • Patent number: 11154226
    Abstract: A medical sensor is described. In an example, the medical sensor includes a nanoscale tapered waveguide attached to a substrate. The nanoscale tapered waveguide includes a nanoscale channel that receives fluid and an excitation light and that outputs a response light. The excitation light propagates through the fluid. A receiving channel of the nanoscale channel is configured as a waveguide that receives and guides the excitation to a linearly tapered channel of the nanoscale channel. The linearly tapered channel has three dimensional linear tapering that focuses the excitation light guided from the receiving channel into an optical response channel of the nanoscale channel. In turn, the optical response channel is configured as a waveguide that outputs a response light in response to the excitation light focused from the linearly tapered channel. The response light corresponds to a response of an analyte of the fluid present in the optical response channel.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: October 26, 2021
    Assignees: California Institute of Technology, University of Southern California, Doheny Eye institute
    Inventors: Yu-Chong Tai, Hyuck Choo, Ramiro Magalhaes Ribeiro, Mark S. Humayun
  • Patent number: 11141082
    Abstract: Embodiments of the present methods measure a concentration of a substance, such as glucose, in a body. The described embodiments change the temperature of the surface of a body from a first temperature to a second temperature, then change the temperature of the surface of the body from the second temperature back to the first temperature, and measure a first amount of infrared (“IR”) radiation absorbed or emitted from the surface of the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the surface of the body in a second wavelength band at predetermined time intervals during the time period that the temperature of the surface of the body changes from the second temperature back to the first temperature. The described embodiments also measure a temperature at the surface of the body and an ambient temperature.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: October 12, 2021
    Assignee: GlucoVista Inc.
    Inventors: Yonatan Gerlitz, Alexander Ostritsky
  • Patent number: 11141111
    Abstract: A vaginal ring sensor device adapted to be placed within the vaginal vault of a user, the device including a ring body, at least one through hole that passes through the ring body, and at least one biosensor structured and arranged to sense and/or measure a parameter of vaginal fluid as such fluid passes through the at least one through hole.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: October 12, 2021
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Richard J. Fougere, Ming Dong
  • Patent number: 11141075
    Abstract: An integrated circuit device includes an insulating body provided with a number of electrically conductive leads and having a surface provided with a red LED aperture, an IR LED aperture and a photodetector aperture. The insulating body also includes an optical isolator optically separating the photodetector aperture from the red LED aperture and the IR LED aperture. A red LED is aligned with the red LED aperture, an IR LED is aligned with the IR LED aperture, and a photodetector is aligned with the photodetector aperture.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: October 12, 2021
    Assignee: Maxim Integrated Products, Inc.
    Inventors: Arpit Mehta, Richard I. Olsen, Daniel S. Christman
  • Patent number: 11134857
    Abstract: The invention provides a body-worn system that continuously measures pulse oximetry and blood pressure, along with motion, posture, and activity level, from an ambulatory patient. The system features an oximetry probe that comfortably clips to the base of the patient's thumb, thereby freeing up their fingers for conventional activities in a hospital, such as reading and eating. The probe secures to the thumb and measures time-dependent signals corresponding to LEDs operating near 660 and 905 nm. Analog versions of these signals pass through a low-profile cable to a wrist-worn transceiver that encloses a processing unit. Also within the wrist-worn transceiver is an accelerometer, a wireless system that sends information through a network to a remote receiver, e.g. a computer located in a central nursing station.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: October 5, 2021
    Assignee: SOTERA WIRELESS, INC.
    Inventors: Jim Moon, Devin McCombie, Marshal Dhillon, Matthew Banet
  • Patent number: 11129553
    Abstract: A motion capture system includes a motion sensor having a flexible body and a fiber bragg gratings (FBG) sensor inserted into the body, a fixture configured to fix the motion sensor to a human body of a user, a light source configured to irradiate light to the motion sensor, and a measurer configured to analyze a reflected light output from the motion sensor, wherein the FBG sensor includes an optical fiber extending along a longitudinal direction of the body and a sensing unit formed in a partial region of the optical fiber and having a plurality of gratings, and wherein a change of a wavelength spectrum of the reflected light, caused by the change of an interval of the gratings due to a motion of the user, is detected to measure a motion state of the user.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: September 28, 2021
    Assignees: Korea Institute of Science and Technology, Center of Human-Centered Interaction for Coexistence
    Inventors: Jinseok Kim, Hyun Joon Shin, Bum-Jae You, Sungwook Yang, Minsu Jang, Jun Sik Kim
  • Patent number: 11129544
    Abstract: A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: September 28, 2021
    Assignees: BAR ILAN UNIVERSITY, UNIVERSITAT DE VALENCIA
    Inventors: Zeev Zalevsky, Javier Garcia, Vicente Mico, Michael Belkin, Yevgeny Beiderman, Israel Margalit
  • Patent number: 11129565
    Abstract: A non-invasive method of detecting anomalous tissue, such as cancerous or injured tissue, in a patient. At least two hemoglobin signal components of hemoglobin levels in at least one segment of tissue of the patient are non-invasively measured over time. Time varying changes of at least a first of the hemoglobin signal components are measured with respect to at least time varying changes of a second of the hemoglobin signal components. A co-varying coordinate system of the time varying changes is generated. Any anomalous tissue in the measured segment of tissue is detected from a signature of the measured segment of tissue in the co-varying coordinate system which differs from a signature of non-anomalous tissue in the co-varying coordinate system. Preferably, five hemoglobin signal components are measured: oxyHb, deoxyHb, total Hb (totalHb=oxyHb+deoxy Hb), Hb oxygen saturation (HbO2Sat=(oxyHb/totalHb)*100), and tissue-hemoglobin oxygen exchange HbO2Exc (deoxyHb?oxyHb).
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: September 28, 2021
    Assignees: Photon Migration Technologies Corp., SLB Innovations Group, LLC
    Inventors: Randall L. Barbour, Harry L. Graber, San-Lian S. Barbour
  • Patent number: 11122979
    Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 21, 2021
    Assignee: MediBeacon Inc.
    Inventors: Ralf Heinrich, Johannes Pill, Sabine Neudecker, Daniel Schock-Kusch, Juergen Guenther, Stefan Koenig, Jochen Friedemann
  • Patent number: 11116429
    Abstract: A subcutaneous sensor system includes a sensor, a plurality of reservoirs, a plurality of pumps, a mixer provided with a plurality of mixer inlets and a mixer outlet, and a controller having an input coupled to the sensor output and a plurality of control outputs coupled to the plurality of pumps and the mixer. In certain embodiments, the system further includes an enclosure for the reservoirs, the pumps, the mixer and the controller, e.g. in the form of a skin patch or in the form of an implantable enclosure. In certain embodiments, the sensor is external to the enclosure and implanted beneath the skin tissue.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: September 14, 2021
    Assignee: Maxim Integrated Products, Inc.
    Inventor: John F. Di Cristina
  • Patent number: 11109782
    Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: September 7, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
  • Patent number: 11103148
    Abstract: The invention provides a body-worn system that continuously measures pulse oximetry and blood pressure, along with motion, posture, and activity level, from an ambulatory patient. The system features an oximetry probe that comfortably clips to the base of the patient's thumb, thereby freeing up their fingers for conventional activities in a hospital, such as reading and eating. The probe secures to the thumb and measures time-dependent signals corresponding to LEDs operating near 660 and 905 nm. Analog versions of these signals pass through a low-profile cable to a wrist-worn transceiver that encloses a processing unit. Also within the wrist-worn transceiver is an accelerometer, a wireless system that sends information through a network to a remote receiver, e.g. a computer located in a central nursing station.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: August 31, 2021
    Assignee: SOTERA WIRELESS, INC.
    Inventors: Jim Moon, Devin McCombie, Marshal Dhillon, Matthew Banet
  • Patent number: 11096620
    Abstract: An optical measurement system includes a wearable module assembly configured to be worn on a body of a user. The wearable module assembly includes a plurality of wearable modules and a connecting assembly. Each wearable module includes a light source configured to emit a light pulse toward a target within the body of the user and a plurality of detectors configured to receive photons included in the light pulse after the photons are scattered by the target. The connecting assembly physically and flexibly connects the plurality of wearable modules such that the wearable module assembly is conformable to a three-dimensional (3D) surface of the body of the user when the wearable module assembly is worn on the body of the user.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: August 24, 2021
    Assignee: HI LLC
    Inventors: Scott Jeremy Seidman, Ryan Field, Husam Katnani, Katherine Perdue, Isai Olvera, Alan Millman, Zachary Phillip Sheldon
  • Patent number: 11096592
    Abstract: A sensor module includes a light emitter that emits light beams including near-infrared light beams towards a subject; a light receiver that receives light beams having passed through the subject; and a controller that estimates biological information based on signals output from the light receiver. The light emitter includes a plurality of light emitting elements that emit near-infrared light beams having central wavelengths different from each other. The light emitter produces sets of light emissions by causing the plurality of light emitting elements to sequentially and intermittently emit the near-infrared light beams. In given two consecutive sets of light emissions produced by the light emitter, a second non-light-emission period of time T4 is longer than a first non-light-emission period of time T2. The controller estimates the biological information in a processing period of time T41 that is set in correspondence with the second non-light-emission period of time T4.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 24, 2021
    Assignees: ALPS ALPINE CO., LTD., Genial Light CO., LTD.
    Inventors: Yukio Otaki, Toshio Kawano, Naoki Ito, Ryo Shimokita
  • Patent number: 11090004
    Abstract: A wearable gear (100) for holding a physiological sensor for monitoring a subject, such as a pulse oximeter. Said wearable gear being configured to automatically adjust the maximal length such that the predefined tension is obtained regardless of the size of the body part of the subject. The wearable gear comprises a tensioning element (102) having a maximal length, a holding unit for holding the physiological sensor, the wearable gear further comprises a tension mechanism for tensioning the tensioning element to a predefined tension when at least partially around a body part of the subject, wherein the tension mechanism comprises i) a first part comprising a resilient material, and ii) a second part comprising a non-resilient material, and wherein the first part and the second part mechanically cooperate with each other to automatically adjust the maximal length such that the predefined tension is obtained regardless of the size of the body part.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: August 17, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wouter Herman Peeters, Pavankumar Murli Dadlani Mahtani, Ernest Roderick Laman, Ceren Bagatar, Tom Kassenaar, Sandra Liliana Ramirez Herrera
  • Patent number: 11071457
    Abstract: Disclosed are an apparatus and a method for removing strands of hair from a near-infrared spectroscopy. The apparatus for removing strands of hair from a near-infrared spectroscopy may comprise: an arch-shaped main body worn on the head of a user, having a plurality of protrusions formed at an inner side part of the arch-shaped main body, and configured to expose a portion of scalp by arranging the strands of hair; a probe configured to come into close contact with the scalp; and a sensor configured to be accommodated inside the probe and receive light.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: July 27, 2021
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Hyeon Min Bae, Jae Myoung Kim, Jong Kwan Choi, Min Gyu Choi, Gun Pil Hwang
  • Patent number: 11071479
    Abstract: A handheld device measures all vital signs and some hemodynamic parameters from the human body and transmits measured information wirelessly to a web-based system, where the information can be analyzed by a clinician to help diagnose a patient. The system utilizes our discovery that bio-impedance signals used to determine vital signs and hemodynamic parameters can be measured over a conduction pathway extending from the patient's wrist to a location on their thoracic cavity, e.g. their chest or navel. The device's form factor can include re-usable electrode materials to reduce costs. Measurements made by the handheld device, which use the belly button as a ‘fiducial’ marker, facilitate consistent, daily measurements, thereby reducing positioning errors that reduce accuracy of standard impedance measurements. In this and other ways, the handheld device provides an effective tool for characterizing patients with chronic diseases, such as heart failure, renal disease, and hypertension.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: July 27, 2021
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Matthew Banet, Marshal Singh Dhillon, Susan Meeks Pede, Lauren Nicole Miller Hayward, Arthur Deptala, Jonas Dean Cochran
  • Patent number: 11058330
    Abstract: Sensors and methods for measurement of an analyte in a medium within a living animal are described. The sensor may include an inductive element that may receive power from an external device. The sensor may also include a charge storage device (CSD) and a memory. The sensor may perform analyte measurements initiated by the external device using power received from the external device and convey the analyte measurements to the external device using the inductive element. The sensor also may perform autonomous analyte measurements using the on board charge device's power and store the autonomous analyte measurements in the memory. The sensor may convey one or more stored analyte measurements to the external device using the inductive element using power received from the external device. The sensor may include a CSD-powered clock and a CSD-powered measurement scheduler that initiate the autonomous analyte measurements.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: July 13, 2021
    Assignee: Senseonics, Incorporated
    Inventors: Andrew DeHennis, Szymon Tankiewicz, Todd Whitehurst
  • Patent number: 11058331
    Abstract: An analyte sensor includes a detector array having at least two detector elements, for example antennas or light emitting diodes, that transmit electromagnetic energy. Any one or more of the detector elements in the detector array can be selectively controlled to function as a transmit detector element that functions to transmit a generated transmit signal in a radio or microwave or visible light frequency range of the electromagnetic spectrum into a target containing an analyte of interest. In addition, any one or more of the detector elements in the detector array can be selectively controlled to function as a receive detector element that functions to detect a response resulting from transmission of the transmit signal by the transmit detector element into the target. A scan routine can be implemented that includes a plurality of scans, where each scan uses a different combination of the detector elements to transmit a signal and detect a response.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: July 13, 2021
    Assignee: KNOW LABS, INC.
    Inventor: Phillip Bosua