Abstract: The present invention relates to a visualization system disposed in a human body, including, a nanobot configured to be disposed within the human body, the nanobot having at least one embedded biosensor, the biosensor which operates in real-time to continuously obtain data from within the human body; a visualization device configured to be integrated and/or embedded within the nanobot to provide real-time visualization data in the human body; a transmitter/receiver disposed on the nanobot which transmits data from the nanobot to an external transmitter/receiver, the transmitted data including the data from the biosensor and the data from the visualization device; and a processor configured to receive the data from the external transmitter/receiver of the nanobot and analyze the visualization data to determine the anatomic localization of the nanobot at a specific anatomic position within the human body.

Abstract: A near-infrared spectroscopy system comprises a substrate, a light source emitting a set of wavelengths, an optical detector detecting the set of wavelengths, a processor in electronic communication with the light source bank and/or the optical detector, and a memory device in electronic communication with the processor. The light source bank, optical detector, processor, and memory device are mounted on the substrate, and a battery is in electronic communication with at least one of these components. Program instructions direct the processor to calculate an oxygenation level, compare that oxygenation level to a predetermined threshold, and optionally, activate a feedback device. A method of detecting an oxygenation level comprises mounting the system in a wearable article, calculating a baseline oxygenation level, regularly executing the program instructions to calculate the oxygenation level, and activating the feedback device.

Abstract: An apparatus for detecting a body component according to an example embodiment includes: a sensor configured to detect a bio-signal of an object according to a contact pressure that gradually changes between the object and the sensor; and a processor configured to determine a time point, at which an amplitude of an alternating current (AC) component of the bio-signal is maximum or a slope of a direct current (DC) component of the bio-signal is maximum, and to detect a body component of the object based on the determined time point.

Abstract: The present invention relates to a sampling unit, a measurement system and method for transcutaneous blood gas measurements. In particular the invention relates to a sampling unit and system adapted for rapid measuring and monitoring of blood gases in a continuous gas flow. The sampling unit is provided with an ambient air inlet and a blood gas extraction and mixing chamber wherein air is mixed with extracted blood gases. The method of continuous transcutaneous measurement of carbon dioxide in the blood utilizes a pulsed heating to minimize the detrimental effects of the heating.

Abstract: A flexible oximeter device for measuring pulse and blood oxygen saturation in tissue includes a first array of first light emitting elements that emit red light, a second array of second light emitting elements that emit green light or near-infrared (NIR) light and an array of sensor elements arranged on at least one flexible substrate. Each sensor element is configured to detect red and green or NIR light, and to output a signal representing an amount of red or green or NIR light detected. The first and second arrays and the array of sensor elements form a plurality of interleaved measurement pixels, each pixel comprising one of the first light emitting elements and a corresponding sensor element, and one of the second light emitting elements and a different corresponding sensor element.

Abstract: A ring-type wearable device is disclosed. The disclosed ring-type wearable device comprises: an outer ring member; an inner ring member separably inserted into the outer ring member; a sensor unit disposed in the outer ring member; and a control unit disposed in the outer ring member so as to be electrically connected to the sensor unit, wherein the sensor unit can maintain constant sensitivity in correspondence to the thickness of the inner ring member.

Abstract: An oximeter device has an ergonomically shaped enclosure that allows a user to comfortably grip and use the device during handheld operation. A sensor tip can be easily placed evenly on the tissue surface, so that all sources and detectors are directly on the tissue with even pressure. This allows for more consistent and accurate results. The user can easily move the device from one position to another and take numerous measurements. The user will have a wide, unobstructed view of the tissue because of the tip's small size, angle of display, and the grip and fingers are positioned away from the tip. Components housed by the enclosure are arranged to give the device a balanced weighting while in the hand. The device can be used for long periods at a time without fatigue.

Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

Abstract: An optical apparatus for non-invasively measuring a bio-signal is provided. The optical apparatus may include an interface housing including: a guide part defined by an interior space of the interface housing and configured to guide an object to a measurement position; and a pressurizing part configured to induce congestion of a second portion of the object by pressing a first portion of the object when the object is disposed within the guide part; and a measurer including: a light source provided on an upper side of the interface housing and configured to emit light to the second portion of the object when the object is at the measurement position; and a detector configured to measure a bio-signal from the second portion by detecting light scattered or reflected from the second portion.

Abstract: A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values.

Abstract: A device for transmitting and sensing signals comprises a non-conductive substrate adherable to a skin of a subject, two or more electrical contacts printed on the substrate, and a disposable connector, connectable to a compatible cable connector of a cable which receives signals from the contacts via the disposable connector. The disposable connector has a symmetric shape such that mating between the disposable connector and the compatible cable connector is established at either one of two flipped orientations.

Abstract: A patient monitor can noninvasively measure a physiological parameter using sensor data from a nose sensor configured to be secured to a nose of the patient. The nose sensor can include an emitter and a detector. The detector is configured to generate a signal when detecting light attenuated by the nose tissue of the patient. An output measurement of the physiological parameter can be determined based on the signals generated by the detector. The nose sensor can include a diffuser configured to disseminate light exiting from the emitter into or around a portion of the patient's body. The nose sensor can also include a lens configured to focus light into the detector.

Abstract: A method for non-invasively determining a physiological state of interest in a subject is described. The method involves, placing a body part in contact with a receptor, and directing a source of electromagnetic radiation (EMR) over a range of wavelengths onto body part so that the EMR reaches the blood and interstitial fluid within the body part. The EMR that is absorbed by, reflected by, or transmitted through, the blood and interstitial fluid of the body part is measured, and a spectrum over the range of wavelengths obtained. The spectrum is analyzed to determine an amount of two or more than two analytes within the blood and interstitial fluid of the body part and a biochemical profile is derived. The biochemical profile is used to determine the physiological state of interest in the subject.

Abstract: A method of non-invasively monitoring hemoglobin concentration includes providing incident light to patient tissue at a first excitation wavelength. The method further includes monitoring a first emission response at a first emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response, and monitoring a second emission response at a second emission wavelength, wherein the second emission wavelength is selected to correspond with a minimum of the emission response. A hemoglobin concentration is calculated based on a ratio of the first emission response to the second emission response.

Abstract: A light irradiation unit configured to irradiate a measurement part with a light beam that has a wavelength absorbed by glucose and a detection unit configured to detect a photoacoustic signal generated from the measurement part irradiated with the light beam emitted from the light irradiation unit are included. The light irradiation unit irradiates the measurement part by scanning the light beam 2-dimensionally. The measurement part is irradiated with the light beam through raster scanning. For example, the light beam has a beam diameter of about 100 ?m and is scanned at a scanning speed of about 100 ?m/10 ms.

Abstract: A method for detecting a respiratory event of a subject comprises: receiving a bio-impedance measurement signal (S2) dependent on respiratory action from the subject; extracting (306) at least one time-sequence of the bio-impedance measurement signal (S2); and for each extracted time-sequence: comparing (308) the bio-impedance measurement signal (S2) with each of a plurality of machine learning models in an ensemble of machine learning models to form a set of predictions of occurrence of a respiratory event, wherein each prediction is based on comparing the bio-impedance measurement signal (S2) with one machine learning model, wherein each model correlates features of time-sequences of a bio-impedance measurement signal (S2) with presence of a respiratory event and wherein each model is trained on a unique data set of training time-sequences; deciding (310) whether a respiratory event occurs in the extracted time-sequence based on the set of predictions.

Abstract: A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

Abstract: An enhanced SPO2 measuring device which includes an optical SPO2 measurement subsystem, an RF SPO2 measurement subsystem, and an integration module that provides at least one of the following functions: a fusion module in which the optical data and RF data are fused to create new SPO2 data: a machine learning module that enhances the final SPO2 measurements; or an accuracy module that provides more accurate SPO2 data.

Abstract: A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.