Patents Examined by Chukwuma O. Nwaonicha
  • Patent number: 8030529
    Abstract: The present invention provides a process for the production of intermediate compounds of formula (I), wherein the substituents are as defined herein. The process comprises reacting a substituted aniline with aqueous HX, followed by removal of water by azeotropic distillation and diazotization and pyrolysis with an organic nitrite at elevated temperatures in the absence of a copper catalyst. Alternatively, gaseous HX can be used to substitute aqueous HX in the process. Consequently, a step of water removal by azeotropic distillation can be eliminated. The intermediate compounds of formula I are suitable as intermediates in the preparation of herbicidally active 3-hydroxy-4-aryl-5-oxopyrazoline derivatives.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: October 4, 2011
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Linhua Wang, Kristine Anderson Dolbeare, Frankie Lee Odom
  • Patent number: 7939626
    Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: May 10, 2011
    Assignee: The Regents of the University of California
    Inventors: Eliana Saxon, Carolyn R. Bertozzi
  • Patent number: 7932242
    Abstract: Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: April 26, 2011
    Assignees: Temple University - Of The Commonwealth System of Higher Education, Onconova Therapeutics Inc.
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stanley C. Bell
  • Patent number: 7932419
    Abstract: This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: April 26, 2011
    Assignee: Monsanto Technology LLC
    Inventors: Fuchen Liu, Juan Arhancet, James P. Coleman, Martin P. McGrath
  • Patent number: 7928266
    Abstract: The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and ?-carotene by the use of the above novel compound are disclosed. The syntheses of lycopene and ?-carotene are characterized by the processes of the coupling reaction between two equivalents of geranyl sulfone or cyclic geranyl sulfone and the above C dialdehyde, the functional group transformation reactions of the diol in the resulting C 40 coupling products to X's (either halogens or ethers), and the double elimination reactions of the functional groups of the benzenesulfonyl and X to produce the fully conjugated polyene chain of the carotenoids.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: April 19, 2011
    Assignee: Myongji University Industry and Academia Cooperation
    Inventors: Sang Ho Koo, Eun Ho Choi
  • Patent number: 7923199
    Abstract: The invention provides a photosensitive composition for use in the production process of a semiconductor such as IC, in the production of a circuit substrate of liquid crystal, thermal head and the like or in other photofabrication processes, a pattern forming method using the photosensitive composition, and a specific organic acid, which are: a photosensitive composition comprising a compound having a proton acceptor functional group and producing a sulfonic acid group upon irradiation with actinic rays or radiation to reduce or lose the acceptor property or change the proton acceptor functional group to be acidic, or a compound capable of generating a specific organic acid upon irradiation with actinic rays or radiation; a pattern forming method using the photosensitive composition; and a specific organic acid.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: April 12, 2011
    Assignee: FUJIFILM Corporation
    Inventor: Kenji Wada
  • Patent number: 7919117
    Abstract: The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-4alkyl, C3-10cycloalkyl, or phenyl, each of which can be substituted by C1-3alkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, the C atom marked by * (asterisk) being provided in the R configuration. The invention is characterized in that the compound of general formula (I) is provided in a polymer matrix and is released at a dose of 0.5 to 20 mg per day through human skin. The invention further relates to the use of said compounds of formula (I) for producing transdermal medicaments.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: April 5, 2011
    Assignee: UCB Pharma GmbH
    Inventors: Armin Breitenbach, Claus Meese, Hans-Michael Wolff, Roland Drews
  • Patent number: 7919635
    Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: April 5, 2011
    Assignee: UBE Industries, Ltd.
    Inventor: Teruo Umemoto
  • Patent number: 7914759
    Abstract: Bisphosphines are prepared by reacting a phosphine with a dihalide in the presence of an acid; characteristically, bisphosphonium compounds are initially formed and then converted into the bisphosphines.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: March 29, 2011
    Assignee: Rhodia UK Limited
    Inventors: Gordon Docherty, Graham Good, Sheena Jackson
  • Patent number: 7915439
    Abstract: A method for making a silylalkoxymethyl halide at good yield represented by the formula: R1R2R3Si—R4—O—CH2X wherein R1, R2, and R3 are an alkyl, cycloalkyl, aryl group, or a halogen atom, R4 is a divalent hydrocarbyl group having 1 to 10 carbon atoms, and X is a halogen atom, by reacting: (a) a silyl alcohol compound with the formula R1R2R3Si—R4—OH wherein R1, R2, R3 and R4 are defined as above, with (b) formaldehyde or a polymer thereof, and (c) a halosilane.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: March 29, 2011
    Assignee: Dow Corning Toray Company, Ltd.
    Inventor: Keiji Wakita
  • Patent number: 7910731
    Abstract: The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: March 22, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Frank Himmelsbach, Birgit Jung, Flavio Solca
  • Patent number: 7910762
    Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or s configuration, and the triol is represented by the following formula: wherein, Y is divalent hydrocarbon and R1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: March 22, 2011
    Assignee: Japan Science and Technology Agency
    Inventors: Shu Kobayashi, Haruro Ishitani, Yasuhiro Yamashita
  • Patent number: 7906538
    Abstract: Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: March 15, 2011
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: Adam Gerhardt Meyer, Kevin Norman Winzenberg, David G. Sawutz, Andris Juris Liepa
  • Patent number: 7906644
    Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: March 15, 2011
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Ankush Argade, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li
  • Patent number: 7906683
    Abstract: The mercaptans R—SH contained in a hydrocarbon stream are oxidized to the corresponding (di)sulfides by means of a redox system which comprises trivalent iron and a heteropolyacid which allows the complete reoxidation of the reduced iron also with air.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: March 15, 2011
    Assignee: ENI S.p.A.
    Inventors: Alberto De Angelis, Paolo Pollesel
  • Patent number: 7906548
    Abstract: This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: March 15, 2011
    Assignee: Wyeth LLC
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark L. Behnke, Baihua Hu, James D. Clark, Wei Li, Valerie Clerin, Suzana Marusic, Kevin Pong
  • Patent number: 7906670
    Abstract: A phosphorylcholine group-containing chemical compound represented by the following formula (1). In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group. R is one of the structures in the following formulas (2)-(4) (the chemical compound of formula (1) in the structures of the following formulas (2)-(4) is expressed as A-R—B). In formulas (2)-(4), L is 1-6, P is 1-3. Also a surface modifier consisting of the aforementioned phosphorylcholine group-containing chemical compound, modified powder treated with said surface modifier, a chromatography packing consisting of a modified carrier treated with said surface modifier, a filter treated with said surface modifier, and a glass device treated with said surface modifier.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: March 15, 2011
    Assignee: Shiseido Co., Ltd.
    Inventors: Yousuke Toujo, Kazuyuki Miyazawa, Taketoshi Kanda, Hiroshi Kutsuna, Kenichi Sakuma, Masayoshi Wada, Yukimitsu Suda
  • Patent number: 7902403
    Abstract: The present invention relates to oligomeric or polymer dithiophosphate di- or poly-sulfides and their utility in rubbers. Another aspect of the invention is a method for making oligomeric or polymeric dithiophosphates by reacting phosphorous pentasulfide with a di- or polyol and a mono alcohol to produce a dithiophosphoric acid, and then oxidizing the dithiophosphoric acid with an oxidizing agent to produce an oligomeric or polymeric dithiophosphate.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: March 8, 2011
    Assignee: R.T. Vanderbilt Company, Inc.
    Inventors: Thomas J. Karol, Ronald J. Tepper
  • Patent number: 7902411
    Abstract: The present invention relates to a catalyst composition for the oxychlorination of ethylene, comprising a mixture of metal salts on a support, where said metal salts are applied to the support in such ratios that the catalyst composition comprises a) from 3 to 12% by weight of copper as copper salt, b) from 0 to 3% by weight of an alkaline earth metal as alkaline earth metal salt, c) from 0 to 3% by weight of an alkaline metal as alkaline metal salt, d) from 0.001 to 0.1% by weight, preferably from 0.005 to 0.05% by weight, of at least one metal selected from the group consisting of ruthenium, rhodium, palladium, osmium, iridium and platinum, and/or from 0.0001 to 0.1% by weight, preferably from 0.001 to 0.05% by weight, of gold, as corresponding metal salt or tetrachloroauric acid, where all percentages by weight are based on the total weight of the catalyst including support material.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: March 8, 2011
    Assignee: BASF Catalysts LLC
    Inventors: Christian Kuhrs, Ruprecht Meissner
  • Patent number: 7902392
    Abstract: Organosilicon compounds bearing carboxylic acid groups are easily and economically replaced in high yield by oxidation of a carbinol-functional organosilicon compound with an oxidizer in the presence of a moderator at a pH?3. Carboxyl-functional organopolysiloxanes highly useful as textile softeners may be obtained by this method.
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: March 8, 2011
    Assignee: Wacker Chemie AG
    Inventors: Christian Ochs, Elke Fritz-Langhals