Patents Examined by Chukwuma O. Nwaonicha
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Patent number: 8030529Abstract: The present invention provides a process for the production of intermediate compounds of formula (I), wherein the substituents are as defined herein. The process comprises reacting a substituted aniline with aqueous HX, followed by removal of water by azeotropic distillation and diazotization and pyrolysis with an organic nitrite at elevated temperatures in the absence of a copper catalyst. Alternatively, gaseous HX can be used to substitute aqueous HX in the process. Consequently, a step of water removal by azeotropic distillation can be eliminated. The intermediate compounds of formula I are suitable as intermediates in the preparation of herbicidally active 3-hydroxy-4-aryl-5-oxopyrazoline derivatives.Type: GrantFiled: February 7, 2006Date of Patent: October 4, 2011Assignee: Syngenta Crop Protection, Inc.Inventors: Linhua Wang, Kristine Anderson Dolbeare, Frankie Lee Odom
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Patent number: 7939626Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: September 19, 2006Date of Patent: May 10, 2011Assignee: The Regents of the University of CaliforniaInventors: Eliana Saxon, Carolyn R. Bertozzi
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Patent number: 7932419Abstract: This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols.Type: GrantFiled: August 16, 2004Date of Patent: April 26, 2011Assignee: Monsanto Technology LLCInventors: Fuchen Liu, Juan Arhancet, James P. Coleman, Martin P. McGrath
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Patent number: 7932242Abstract: Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.Type: GrantFiled: March 15, 2005Date of Patent: April 26, 2011Assignees: Temple University - Of The Commonwealth System of Higher Education, Onconova Therapeutics Inc.Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stanley C. Bell
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Patent number: 7928266Abstract: The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and ?-carotene by the use of the above novel compound are disclosed. The syntheses of lycopene and ?-carotene are characterized by the processes of the coupling reaction between two equivalents of geranyl sulfone or cyclic geranyl sulfone and the above C dialdehyde, the functional group transformation reactions of the diol in the resulting C 40 coupling products to X's (either halogens or ethers), and the double elimination reactions of the functional groups of the benzenesulfonyl and X to produce the fully conjugated polyene chain of the carotenoids.Type: GrantFiled: May 23, 2007Date of Patent: April 19, 2011Assignee: Myongji University Industry and Academia CooperationInventors: Sang Ho Koo, Eun Ho Choi
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Patent number: 7923199Abstract: The invention provides a photosensitive composition for use in the production process of a semiconductor such as IC, in the production of a circuit substrate of liquid crystal, thermal head and the like or in other photofabrication processes, a pattern forming method using the photosensitive composition, and a specific organic acid, which are: a photosensitive composition comprising a compound having a proton acceptor functional group and producing a sulfonic acid group upon irradiation with actinic rays or radiation to reduce or lose the acceptor property or change the proton acceptor functional group to be acidic, or a compound capable of generating a specific organic acid upon irradiation with actinic rays or radiation; a pattern forming method using the photosensitive composition; and a specific organic acid.Type: GrantFiled: January 24, 2006Date of Patent: April 12, 2011Assignee: FUJIFILM CorporationInventor: Kenji Wada
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Patent number: 7919117Abstract: The invention relates to a device for transdermally administering a compound of formula (I), wherein A represents hydrogen or deuterium, R represents a group selected among C1-4alkyl, C3-10cycloalkyl, or phenyl, each of which can be substituted by C1-3alkoxy, fluoride, chlorine, bromine, iodine, nitro, amino, hydroxy, oxo, mercapto, or deuterium, the C atom marked by * (asterisk) being provided in the R configuration. The invention is characterized in that the compound of general formula (I) is provided in a polymer matrix and is released at a dose of 0.5 to 20 mg per day through human skin. The invention further relates to the use of said compounds of formula (I) for producing transdermal medicaments.Type: GrantFiled: April 2, 2009Date of Patent: April 5, 2011Assignee: UCB Pharma GmbHInventors: Armin Breitenbach, Claus Meese, Hans-Michael Wolff, Roland Drews
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Patent number: 7919635Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: GrantFiled: February 6, 2009Date of Patent: April 5, 2011Assignee: UBE Industries, Ltd.Inventor: Teruo Umemoto
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Patent number: 7914759Abstract: Bisphosphines are prepared by reacting a phosphine with a dihalide in the presence of an acid; characteristically, bisphosphonium compounds are initially formed and then converted into the bisphosphines.Type: GrantFiled: July 20, 2006Date of Patent: March 29, 2011Assignee: Rhodia UK LimitedInventors: Gordon Docherty, Graham Good, Sheena Jackson
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Patent number: 7915439Abstract: A method for making a silylalkoxymethyl halide at good yield represented by the formula: R1R2R3Si—R4—O—CH2X wherein R1, R2, and R3 are an alkyl, cycloalkyl, aryl group, or a halogen atom, R4 is a divalent hydrocarbyl group having 1 to 10 carbon atoms, and X is a halogen atom, by reacting: (a) a silyl alcohol compound with the formula R1R2R3Si—R4—OH wherein R1, R2, R3 and R4 are defined as above, with (b) formaldehyde or a polymer thereof, and (c) a halosilane.Type: GrantFiled: September 28, 2005Date of Patent: March 29, 2011Assignee: Dow Corning Toray Company, Ltd.Inventor: Keiji Wakita
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Patent number: 7910762Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or s configuration, and the triol is represented by the following formula: wherein, Y is divalent hydrocarbon and R1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons.Type: GrantFiled: September 28, 2009Date of Patent: March 22, 2011Assignee: Japan Science and Technology AgencyInventors: Shu Kobayashi, Haruro Ishitani, Yasuhiro Yamashita
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Patent number: 7910731Abstract: The present invention relates methods for treating disease conditions selected from the list consisting of benign or malignant tumors, diseases of the airways and lungs, diseases of the gastrointestinal tract, the bile duct and the gall bladder by administration to a patient in need thereof of a therapeutically effective amount of a bicyclic heterocyclic groups of general formula wherein said substituents are as defined herein.Type: GrantFiled: February 26, 2008Date of Patent: March 22, 2011Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Frank Himmelsbach, Birgit Jung, Flavio Solca
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Patent number: 7906644Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.Type: GrantFiled: October 5, 2006Date of Patent: March 15, 2011Assignee: Rigel Pharmaceuticals, Inc.Inventors: Rajinder Singh, Ankush Argade, Jeffrey Clough, Holger Keim, Somasekhar Bhamidipati, Catherine Sylvain, Hui Li
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Patent number: 7906683Abstract: The mercaptans R—SH contained in a hydrocarbon stream are oxidized to the corresponding (di)sulfides by means of a redox system which comprises trivalent iron and a heteropolyacid which allows the complete reoxidation of the reduced iron also with air.Type: GrantFiled: February 15, 2006Date of Patent: March 15, 2011Assignee: ENI S.p.A.Inventors: Alberto De Angelis, Paolo Pollesel
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Patent number: 7906670Abstract: A phosphorylcholine group-containing chemical compound represented by the following formula (1). In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group. R is one of the structures in the following formulas (2)-(4) (the chemical compound of formula (1) in the structures of the following formulas (2)-(4) is expressed as A-R—B). In formulas (2)-(4), L is 1-6, P is 1-3. Also a surface modifier consisting of the aforementioned phosphorylcholine group-containing chemical compound, modified powder treated with said surface modifier, a chromatography packing consisting of a modified carrier treated with said surface modifier, a filter treated with said surface modifier, and a glass device treated with said surface modifier.Type: GrantFiled: December 1, 2004Date of Patent: March 15, 2011Assignee: Shiseido Co., Ltd.Inventors: Yousuke Toujo, Kazuyuki Miyazawa, Taketoshi Kanda, Hiroshi Kutsuna, Kenichi Sakuma, Masayoshi Wada, Yukimitsu Suda
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Patent number: 7906538Abstract: Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo or ex vivo.Type: GrantFiled: October 31, 2007Date of Patent: March 15, 2011Assignee: Schering-Plough Animal Health CorporationInventors: Adam Gerhardt Meyer, Kevin Norman Winzenberg, David G. Sawutz, Andris Juris Liepa
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Patent number: 7906548Abstract: This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.Type: GrantFiled: August 11, 2009Date of Patent: March 15, 2011Assignee: Wyeth LLCInventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark L. Behnke, Baihua Hu, James D. Clark, Wei Li, Valerie Clerin, Suzana Marusic, Kevin Pong
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Patent number: 7902411Abstract: The present invention relates to a catalyst composition for the oxychlorination of ethylene, comprising a mixture of metal salts on a support, where said metal salts are applied to the support in such ratios that the catalyst composition comprises a) from 3 to 12% by weight of copper as copper salt, b) from 0 to 3% by weight of an alkaline earth metal as alkaline earth metal salt, c) from 0 to 3% by weight of an alkaline metal as alkaline metal salt, d) from 0.001 to 0.1% by weight, preferably from 0.005 to 0.05% by weight, of at least one metal selected from the group consisting of ruthenium, rhodium, palladium, osmium, iridium and platinum, and/or from 0.0001 to 0.1% by weight, preferably from 0.001 to 0.05% by weight, of gold, as corresponding metal salt or tetrachloroauric acid, where all percentages by weight are based on the total weight of the catalyst including support material.Type: GrantFiled: August 7, 2006Date of Patent: March 8, 2011Assignee: BASF Catalysts LLCInventors: Christian Kuhrs, Ruprecht Meissner
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Patent number: 7902392Abstract: Organosilicon compounds bearing carboxylic acid groups are easily and economically replaced in high yield by oxidation of a carbinol-functional organosilicon compound with an oxidizer in the presence of a moderator at a pH?3. Carboxyl-functional organopolysiloxanes highly useful as textile softeners may be obtained by this method.Type: GrantFiled: April 11, 2005Date of Patent: March 8, 2011Assignee: Wacker Chemie AGInventors: Christian Ochs, Elke Fritz-Langhals
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Patent number: 7902403Abstract: The present invention relates to oligomeric or polymer dithiophosphate di- or poly-sulfides and their utility in rubbers. Another aspect of the invention is a method for making oligomeric or polymeric dithiophosphates by reacting phosphorous pentasulfide with a di- or polyol and a mono alcohol to produce a dithiophosphoric acid, and then oxidizing the dithiophosphoric acid with an oxidizing agent to produce an oligomeric or polymeric dithiophosphate.Type: GrantFiled: January 31, 2008Date of Patent: March 8, 2011Assignee: R.T. Vanderbilt Company, Inc.Inventors: Thomas J. Karol, Ronald J. Tepper