Patents Examined by Clinton Brooks
  • Patent number: 10981940
    Abstract: The invention is to develop a protecting group that does not solidify or insolubilize a compound in which a functional group has been protected, and facilitates separation and purification after a reaction.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: April 20, 2021
    Assignee: SEKISUl MEDICAL CO., LTD.
    Inventors: Shinya Yano, Hideki Kubota
  • Patent number: 10975010
    Abstract: Continuous processes for making ethylene glycol form aldohexose-yielding carbohydrates are disclosed which enhance the selectivity to ethylene glycol.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 13, 2021
    Assignee: Iowa Corn Promotion Board
    Inventors: David James Schreck, Ray Chrisman, Brooke Albin, Donald Bunning, Mark Nunley
  • Patent number: 10975109
    Abstract: A pure composition comprises a monoalkyltin trialkoxide compound represented by the chemical formula RSn(OR?)3 or a monoalkyl tin triamide compound represented by the chemical formula RSn(NR?2)3 and no more than 4 mole % dialkyltin compounds relative to the total tin amount, where R is a hydrocarbyl group with 1-31 carbon atoms, and wherein R? is a hydrocarbyl group with 1-10 carbon atoms. Methods are described for the formation of the pure compositions. A solid composition comprises a monoalkyl triamido tin compound represented by the chemical formula RSn—(NR?COR?)3, where R is a hydrocarbyl group with 1-31 carbon atoms, and where R? and R? are independently a hydrocarbyl group with 1-10 carbon atoms. The compositions are suitable for the formation of resist compositions suitable for EUV patterning in which the compositions have a high EUV absorption.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: April 13, 2021
    Assignee: Inpria Corporation
    Inventors: Joseph B. Edson, Thomas J. Lamkin, William Earley, Truman Wambach, Jeremy T. Anderson
  • Patent number: 10975103
    Abstract: An object of the present invention is to provide a novel complex having at least two carbon-carbon double bonds and/or carbon-carbon triple bonds. The present invention provides a complex represented by a structural formula (2): [In the structural formula (2), M1 to M4 are identical to or different from each other and represent a metal atom, R1 to R6 are identical to or different from each other and represent a hydrogen atom, an alkyl group having 1 to 24 carbon atoms, an alkenyl group having 2 to 18 carbon atoms or an alkynyl group having 2 to 18 carbon atoms, at least two of R1 to R6 are the alkenyl group having 2 to 18 carbon atoms or the alkynyl group having 2 to 18 carbon atoms, and at least one of R1 to R6 is the alkyl group having 6 to 24 carbon atoms].
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: April 13, 2021
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Hiroshi Tadaoka, Chiemi Mikura, Kazuyoshi Shiga
  • Patent number: 10960373
    Abstract: The present invention relates to a continuous flow hydrogenation process and process apparatus.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: March 30, 2021
    Assignee: Intensichem Group Limited
    Inventor: Oliver Alexander Albert Tames
  • Patent number: 10947183
    Abstract: Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: March 16, 2021
    Assignee: ZOGENIX INTERNATIONAL LIMITED
    Inventors: Derek J. Londesbrough, Marc W. Andersen
  • Patent number: 10946098
    Abstract: Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted A431 cancer cells when exposed to near infrared light excitation. Free MG2I is a pure and stable fluorogen; it is easy to synthesize and modify, and has no toxicity to cells. Unlike conventional photosensitizers, the dye and FAP itself has no photosensitizing effect until they are bound. Also unlike other activation methods, the activation step is achieved by adding the fluorogen, not the presence of the targeted molecule, requiring an ‘active’ activation instead of a ‘passive’ activation. This method offers the ability to locally switch-on and selective generation of singlet oxygen at the target site and can be used for a wide variety of molecular targets.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: March 16, 2021
    Assignee: Carnegie Mellon University
    Inventors: Marcel P. Bruchez, Jianjun He, Yi Wang
  • Patent number: 10941166
    Abstract: The present invention relates to a water-stable Titanium-based metal-organic framework (MOF) material having a high degree of condensation, i.e. an oxo to Ti ratio (or oxo to metal ratio, in the case of doped Ti-based MOFs) >1.0; a process of preparing same and uses thereof, particularly for heterogeneously catalyzed chemical reactions, for gas storage/separation/purification, for information storage, laser printing or as an oxygen indicator, or as proton conductive material (fuel cells), optoelectronic material (photovoltaic cells including Grätzel cells), as a matrix for encapsulating active principles (medicaments, cosmetics), or else as sensing material.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: March 9, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE VERSAILLES SAINT QUENTIN EN YVELINES
    Inventors: Sujing Wang, Christian Serre, Nathalie Guillou, Nathalie Steunou
  • Patent number: 10934243
    Abstract: This invention relates to a catalyst composition for a producing process of an unsaturated carboxylic acid salt and its derivatives from carbon dioxide and olefin, wherein the catalyst composition in the present invention has been proved to be effective in catalyzing the carboxylation of carbon dioxide and olefin, wherein said catalyst composition comprises: a) a palladium metal complex as shown in structure (I); wherein, R1, R2, R3, and R4 independently represents a group selected from hydrogen atom, halogen atom, alkyl group, alkyl halide group, alkoxy group, amine group, optionally from alkenyl group, alkynyl group, phenyl group, benzyl group, or cylic hydrocarbon group comprising hetero atom; R5 represents group selected from alkyl group or phenyl group; b) a ligand selected from organophosphorus compound; c) a base selected from sodium tert-butoxide, sodium isopropoxide, sodium 2,6-dimethylphenolate, sodium 2,6-difluorophenolate, sodium 2-methylphenolate, or sodium 2-fluorophenol); and d
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: March 2, 2021
    Assignee: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED
    Inventors: Phonpimon Wongmahasirikun, Sucheewin Chotchatchawankul, Khamphee Phomphrai, Sophon Kaeothip
  • Patent number: 10927067
    Abstract: The present invention specifically relates to novel salt and crystalline form of haloacetic acid and its process of preparation. The invention more particularly relates to novel crystalline form dichloroacetate tromethamine salt and its process of preparation. The present invention more specifically relates to the dichloroacetate tromethamine salt, its process and its use for the treatment of various diseases and/or disorders.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: February 23, 2021
    Inventors: Sarin Parayil, Anil Roy
  • Patent number: 10919842
    Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: February 16, 2021
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
  • Patent number: 10913705
    Abstract: The invention describes hydrosoluble iron (III) oxyhydroxide complexes prepared from different sources of iron, amino acids and carboxylic acids. The iron (III) complexes have no undesirable residual taste and can be used as supplementation forms for the prevention or treatment of iron deficiency anemia in humans or animals and pharmaceutical or food compositions containing them.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: February 9, 2021
    Assignee: NPA—NÚCLEO DE PESQUISAS APLICADAS LTDA
    Inventors: Ricardo Da Silva Sercheli, Nelson Henriques Fernandes, Nelson Henriques Fernandes Filho
  • Patent number: 10913754
    Abstract: A lanthanum compound, a method of synthesizing a thin film, and a method of manufacturing an integrated circuit device, the compound being represented by Formula 1 below, wherein, in Formula 1, R1 is a hydrogen atom or a C1-C4 linear or branched alkyl group, R2 and R3 are each independently a hydrogen atom or a C1-C5 linear or branched alkyl group, at least one of R2 and R3 being a C3-C5 branched alkyl group, and R4 is a hydrogen atom or a C1-C4 linear or branched alkyl group.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: February 9, 2021
    Assignees: SAMSUNG ELECTRONICS CO., LTD., ADEKA CORPORATION
    Inventors: Gyu-hee Park, Youn-soo Kim, Jae-soon Lim, Youn-joung Cho, Kazuki Harano, Haruyoshi Sato, Tsubasa Shiratori, Naoki Yamada
  • Patent number: 10913755
    Abstract: The present invention relates to: a novel transition metal compound; a preparation method therefor; a composition for depositing a transition metal-containing thin film, containing the same; a transition metal-containing thin film using the composition for depositing a transition metal-containing thin film; and a method for preparing a transition metal-containing thin film. The transition metal compound of the present invention has high thermal stability, high volatility, and high storage stability, and thus a transition metal-containing thin film having high-density and high-purity can be easily prepared by using the same as a precursor.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: February 9, 2021
    Assignee: DNF CO., LTD.
    Inventors: Myong Woon Kim, Sang Ick Lee, Won Mook Chae, Sang Jun Yim, Kang Yong Lee, A Ra Cho, Sang Yong Jeon, Haeng Don Lim
  • Patent number: 10906867
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L1, n and p are defined herein. The compounds of formula (X) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: February 2, 2021
    Assignee: Novartis AG
    Inventors: Luis Brito, Delai Chen, Gabriel Grant Gamber, Andrew Geall, Kevin Love, Thomas Zabawa, Frederic Zecri
  • Patent number: 10906866
    Abstract: The present invention provides a process for the preparation of N-phenoxyisopropyl ethanolamine of Formula (II) and its conversion to Phenoxybenzamine of Formula (I) or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: February 2, 2021
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Shashi Kant Tiwari, Rajesh Chennuri, Bhanuchandar Samala, Venkata Ramana Kintali, Sivakumaran Meenakshisunderam
  • Patent number: 10899779
    Abstract: A method for manufacturing an amino group-containing organosilicon compound of the following formula (1): wherein each R1 independently represents an alkyl group having 1 to 10 carbon atoms, etc., each of R2 and R3 represents a functional group of the following formula (4), etc., m represents an integer of 1 to 3, and n represents an integer of 1 to 12, wherein an asterisk * represents a bond with an adjacent atom, p represents an integer of 1 to 12, and q represents an integer of 1 to 10, the method comprising: (A) reacting an amine compound of the following formula (2): wherein R2 and R3 mean the same as above with a halogen group-containing organosilicon compound of the following formula (3): wherein X represents a chlorine atom, etc., and R1 and n mean the same as above; (B) removing an amine hydrohalide produced in the step (A), by liquid-liquid separation; and (C) neutralizing an organic layer obtained in the step (B), using a base which amounts 0.1 to 0.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: January 26, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Munenao Hirokami
  • Patent number: 10899777
    Abstract: A method of separating a metal organic framework (MOF) from a solution and associated apparatus. The method comprises: providing a MOF containing solution; contacting the MOF containing solution with an acoustic reflector surface such that, any high frequency ultrasound applied within the MOF containing solution reflects off the acoustic reflector surface; and applying a high frequency ultrasound of at least 20 kHz to the MOF containing solution. The MOF material is substantially separated from solution as aggregated sediment that settles out of solution.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: January 26, 2021
    Inventors: Marta Rubio Martinez, Pablo Juliano, Thomas Leong, Matthew Roland Hill, Kok Seng Lim
  • Patent number: 10889597
    Abstract: Provided is a desulfurizer for removing a sulfur compound contained in a fluid, comprising a desulfurization agent for removing the sulfur compound from the fluid and a housing which contains the desulfurization agent and the inside of which the fluid flows through. The desulfurization agent includes a metal organic framework. The metal organic framework has copper ions and organic ligands. The organic ligands include 1,3,5-benzenetricarboxylic acid and 1,3-benzenedicarboxylic acid.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: January 12, 2021
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventor: Masashi Morita
  • Patent number: 10888842
    Abstract: The present invention relates to a method for manufacturing a catalyst for synthesizing a fatty acid methyl or ethyl ester and a method for manufacturing a fatty acid methyl or ethyl ester using the catalyst. It provides a method for manufacturing a solid catalyst by mixing the oxides of manganese as active catalytic material and the soda lime glass as carrier wherein the content of the oxides of manganese is in the range of 0.1 w % to 70 w %, molding the mixture to spherical or cylindrical shape and sintering the molded catalyst. It also provides a method for manufacturing fatty acid methyl or ethyl ester with high purity by reacting fatty acid or a mixture of oil and fatty acid with methanol or ethanol by placing the solid catalyst in the reactor.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: January 12, 2021
    Inventor: Seong Min Yoo