Abstract: There is provided herein a method and an apparatus for producing an isocyanatoorganosilane which method includes feeding a carbamatoorganosilane to a cracking device where it is thermally dissociated into a reaction product mixture comprising isocyanatoorganosilane, alcohol, and heavies, followed by separating the mixture in a distillation column of two parts and collecting the isocyanatoorganosilane from the distillation column via a side stream having a predetermined location between the top and bottom parts of the column; and wherein the distillation column is configured to have a ratio of the length of the bottom part of the distillation column to the length of the top part of the distillation column which is effective to provide a side stream having a high purity and high weight percent of isocyanatoorganosilane.
Abstract: A polycyclic compound is represented by Formula 1: where X1, R1 to R11, L1, L2, and n1 to n4 are further defined. An organic electroluminescence device includes the polycyclic compound.
Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
Type:
Grant
Filed:
August 11, 2021
Date of Patent:
May 16, 2023
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Feng Xu, Zhuqing Liu, Richard Desmond, Jeonghan Park, Alexei Kalinin, Birgit Kosjek, Hallena Strotman, Hongmei Li, Johannah Moncecchi
Abstract: Metal-organic frameworks (MOFs) comprising amines on the organic linker can be used for cell targeting. In particular, primary amine groups represent one of the most versatile chemical moieties for conjugation to biologically relevant molecules, including antibodies and enzymes. Different chemical conjugation schemes can be used to conjugate biological molecules to the amino functionality on the organic linker. For example, carbodiimide chemistry can be used to link a primary amine to available carboxyl groups on the protein. For example, sulfhydryl crosslinking chemistry can be used via Traut's reagent scheme. As a demonstration of the invention, the ability of EpCAM antibody-targeted MOFs to bind to a human epithelial cell line (A549), a common target for imaging studies, was confirmed with confocal microscopy.
Type:
Grant
Filed:
April 28, 2021
Date of Patent:
May 9, 2023
Assignee:
National Technology & Engineering Solutions of Sandia, LLC
Abstract: Disclosed herein are methods of purifying compounds useful for the deposition of high purity tin oxide and high purity compounds purified by those methods. Such compounds are those of the Formula as follows Rx—Sn-A4-x, wherein: A is selected from the group consisting of (YaR?z) and a 3- to 7-membered N-containing heterocyclic group; each R group is independently selected from the group consisting of an alkyl or aryl group having from 1 to 10 carbon atoms; each R? group is independently selected from the group consisting of an alkyl, acyl or aryl group having from 1 to 10 carbon atoms; x is an integer from 0 to 4; a is an integer from 0 to 1; Y is selected from the group consisting of N, O, S, and P; and z is 1 when Y is O, S or when Y is absent and z is 2 when Y is N or P.
Abstract: A hypergolic metal organic framework material for producing a hypergol when combined with an oxidizer, comprising a general structure M1-L-M2, wherein L is an aromatic organic linker comprising one or more unsaturated substituents, and wherein M1 and M2 are same or different metal cations.
Type:
Grant
Filed:
September 13, 2019
Date of Patent:
May 9, 2023
Inventors:
Tomislav Fri{hacek over (s)}{hacek over (c)}ić, Robin D. Rogers, Mihails Arhangelskis, Hatem Titi, Dayaker Gandrath, Joseph M. Marrett
Abstract: A group 5 metal compound according to an embodiment of the present disclosure is represented by any one of the following <Chemical Formula 1> and <Chemical Formula 2>: In <Chemical Formula 1> and <Chemical Formula 2>, M is any one selected from group 5 metal elements, n is any one selected from an integer of 1 to 5, R1 is any one selected from a linear alkyl group having 3 to 6 carbon atoms and a branched alkyl group having 3 to 6 carbon atoms, and R2 and R3 are each independently any one selected from hydrogen, a linear alkyl group having 1 to 4 carbon atoms, and a branched alkyl group having 1 to 4 carbon atoms.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
April 25, 2023
Assignee:
EGTM Co., Ltd.
Inventors:
Tae Young Lee, Sung Jun Ji, Sun Young Baik
Abstract: The present invention provides nanostructure compositions and methods of producing nanostructure compositions. The nanostructure compositions comprise a population of nanostructures comprising charge-transporting ligands. The present invention also provides nanostructure films comprising the nanostructure compositions and methods of making nanostructure films using the nanostructure compositions.
Type:
Grant
Filed:
August 21, 2019
Date of Patent:
April 25, 2023
Assignee:
Nanosys, Inc.
Inventors:
Christian Ippen, Daekyoung Kim, Emma Rose Dohner, Jesse Manders, David Olmeijer, Ruiqing Ma
Abstract: Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.
Type:
Grant
Filed:
January 27, 2021
Date of Patent:
April 25, 2023
Assignee:
ZOGENIX INTERNATIONAL LIMITED
Inventors:
Derek J. Londesbrough, Marc W. Andersen
Abstract: Provided is a method for producing a cyclic polysilane compound from a silane monomer compound in one-pot approach. The method for producing a cyclic polysilane compound according to an embodiment of the present invention includes a first step of adding and reacting a silane monomer compound in a liquid mixture of a sodium dispersion and a solvent; and a second step of adding an aromatic hydrocarbon to a reaction solution of the first step and heating and refluxing.
Abstract: A hydrolysis method for tert-butyl ester in gadolinium-based contrast agent comprises hydrolyzing the tert-butyl ester with a catalyst. The preparation method of the catalyst comprises the following steps: subjecting zirconia and titanium tetrachloride to reaction in the presence of sulfuric acid and water at 60° C. to 90° C. until solids are dissolved, adding silica to perform reaction for 1 to 5 h, filtering to obtain solids, washing and calcining the solids. This hydrolysis method does not introduce other substances that are difficult to remove, such as acids, and provides high hydrolysis efficiency and high purity of the obtained product.
Abstract: A compound represented by a combination of Chemical Formula 1 and Chemical Formula 2 bonded together, a composition including the compound, an organic optoelectronic device, and a display device are disclosed. In Chemical Formula 1 and Chemical Formula 2, each substituent is the same as described in the specification.
Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.
Type:
Grant
Filed:
January 22, 2021
Date of Patent:
March 28, 2023
Assignee:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors:
Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
Abstract: Methods are described that include contacting an alkyl ammonium metal halide film with an alkyl ammonium halide, where the alkyl ammonium metal halide film includes a first halogen and a metal, the alkyl ammonium halide includes a second halogen, such that the contacting forms an alkyl ammonium metal mixed-halide film that interfaces with the alkyl ammonium metal halide film, where the alkyl ammonium metal mixed-halide film includes the first halogen, the second halogen, and the metal.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
March 28, 2023
Assignee:
Alliance for Sustainable Energy, LLC
Inventors:
Kai Zhu, Yixin Zhao, Mengjin Yang, Taiyang Zhang
Abstract: The present invention relates to a specific azole silane compound, an oligomer thereof, a mixture comprising said compound and/or said oligomer, as well as a respective storage and working solution. Furthermore, the present invention relates to a synthesis method for said specific azole silane compound, and the use of said working solution as a surface treatment solution.
Type:
Grant
Filed:
June 14, 2019
Date of Patent:
March 14, 2023
Assignee:
Atotech Deutschland GmbH
Inventors:
Fabian Michalik, Stefanie Ackermann, Marco Haryono, Michael Merschky, Thomas Thomas, Markku Lager
Abstract: In some embodiments, the present disclosure pertains to a method for capturing alkenes that includes: associating the alkenes with metal-organic frameworks, where the metal-organic frameworks includes one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and oxidizing the metal-organic frameworks, where the oxidizing results in a capturing of the alkenes by the metal-organic frameworks. Additional embodiments of the present disclosure pertain to a system for capturing alkenes that includes: metal-organic frameworks, where the metal-organic frameworks include one or more metals and one or more ligands coordinated with the one or more metals, and where the metal-organic frameworks are conductive; and an alkene feed source associated with the metal-organic frameworks, where the alkene feed source is configured to deliver an alkene feed to the system.
Type:
Grant
Filed:
August 9, 2018
Date of Patent:
March 7, 2023
Assignee:
Trustees of Dartmouth College
Inventors:
Katherine A. Mirica, Xiaoping Zhang, Lukasz K. Mendecki, Zheng Meng, Michael Ko
Abstract: The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization.
Abstract: Molybdenum(0) coordination complexes comprising an arene ligand and one or more neutral ligands which coordinate to the metal center by carbon, nitrogen or phosphorous are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
Type:
Grant
Filed:
January 12, 2021
Date of Patent:
February 21, 2023
Assignee:
APPLIED MATERIALS, INC.
Inventors:
Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
Abstract: An organic electroluminescence device of an embodiment includes a first electrode, a second electrode, and an emission layer disposed between the first electrode and the second electrode, and the emission layer includes a polycyclic compound represented by Formula 1.
Type:
Grant
Filed:
August 20, 2020
Date of Patent:
February 14, 2023
Assignee:
Samsung Display Co., Ltd.
Inventors:
Chanseok Oh, Seokhwan Hwang, Junha Park, Hankyu Pak, Mun-Ki Sim, Hyoyoung Lee, Minjung Jung