Abstract: Methods and apparatus for delivering prostheses to body lumens, such as stents and grafts to blood vessels, utilize a delivery device which carries one or more linearized elements. The linearized elements assume non-linear configurations, particularly helical configurations, when advanced and released from the delivery device. By selectively controlling the length and/or number of elements delivered from the delivery device, extended and disseminated disease within the body lumens may be effectively treated.

Abstract: The invention is a system, apparatus, and method for treating, and/or repairing an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a prosthesis assembly for establishing a fluid flow path between an upstream portion of an artery and at least one bifurcated downstream portion of the artery.

Abstract: An intervention is performed on a target anatomic structure of a patient body by first altering the configuration of the diaphragm through displacement or puncturing of the latter, in order to create a passageway leading into the thoracic cavity. An implement is introduced into the thoracic cavity through the passageway. The implement is then used while extending through the passageway to alter a biological tissue of the target structure or manipulate the latter. Optionally, a separating component having a peripheral wall encompassing a component channel is introduced into the passageway for receiving the implement and separating the latter from the non-target anatomic structure.

Abstract: An accommodating intraocular lens is provided having optical parameters that are altered in-situ, wherein an optic portion of the lens includes a lens piston that alters the shape of a lens element of the lens to alter the optical power of the lens, responsive to forces applied to a haptic portion to the lens by contraction of the ciliary muscles. Forces applied to the haptic portion are concentrated by the lens piston to provide a greater dynamic range, and may be further augmented by the use of haptic pistons disposed in the haptic portion of the lens.

Abstract: There is described a prosthetic valve to be inserted into a body lumen, the valve having leaflets that are spread apart during forward flow of fluid to create an orifice, and the leaflets coming into contact with each other during reverse flow of fluid, thereby impeding the reverse flow of fluid, the valve comprising: a hollow, cylindrical stent having an inner surface and an outer surface, and having a first and a second open end; and valve means formed from a single tubular membrane, the membrane mounted to the stent, the membrane having a graft portion internally folded and bonded to itself at a plurality of points to form pouches such that the leaflets extend from the pouches, and a sleeve portion on an outer surface of the stent to secure the membrane thereto.

Abstract: A method and device for reducing mitral regurgitation. An elongated body is positioned in a coronary sinus of a patient in a vicinity of a heart mitral valve posterior leaflet. The body is adapted to straighten a natural curvature of at least a portion of the coronary sinus in the vicinity of the posterior leaflet to move a posterior annulus anteriorly, which in turn moves the posterior leaflet anteriorly, thereby to improve leaflet coaptation.

Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant comprising collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.

Abstract: A stent for use in animals including humans is disclosed which includes unprotected and protected regions, each protected regions including a bioactive or biopenetrating agent containing therein where the protected regions are protected by the unprotected regions when the stent is in its undeployed state which has a smaller cross-sectional dimension than the stent in its deployed state. And when the stent is in its deployed state the bioactive or biopenetrating agent(s) are brought into direct and intimate contact with a tissue or interior of a blood vessel of an animal including a human.

Abstract: A method for making a bioprosthetic heart valve includes providing a non-contact cutting apparatus and a layer of tissue. The non-contact cutting apparatus may include a laser cutting system or high pressure water jet system. A leaflet is cut from the layer of tissue using a predefined template, and a plurality of alignment holes in the leaflet are created in the leaflet, e.g., along a peripheral edge. A support structure is provided having a plurality of alignment holes corresponding to alignment holes in the leaflet. The leaflet is secured to the support structure by securing one or more sutures through corresponding alignment holes in the leaflet and the support structure to provide a leaflet subassembly. A bioprosthetic heart valve is made by securing a set of leaflet subassemblies to a frame.

Abstract: The present invention comprises a securement member to improve securement of a stent upon an expandable balloon and delivery catheter, and to constrain portions of the stent before and during stent deployment. Generally, the securement member comprises a securement connector arranged to engage a catheter, at least one flexible connecting member coupled to the securement connector, and a locking member arranged to engage a portion of a stent.

Abstract: An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.

Abstract: A skin topographical method for quantifying pharmacodynamic parameters of a paralytic effect of a Clostridial toxin, such as a botulinum toxin upon a muscle, such as a frontalis muscle.

Abstract: An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.

Abstract: The instant invention proposes an artificial intervertebral disc providing for angular displacements between adjacent vertebrae wherein these displacements are accommodated by internal shear in an elastomeric layered element residing between the upper and lower bases attached, respectively, to the upper and lower adjacent vertebrae, without sliding.

Abstract: A canister rack system for a microdermabrasion machine has a base with bores. The base has conduits for crystal passage through the canister rack. The canisters are mountable upon the canister rack and include supply and storage canisters. The supply canister has a feeding conduit for the exit of crystal from the supply canister and the storage canister has a return conduit and a filtered conduit. The canister rack bores are formed at the base so that the conduits from the storage canister and supply canister meet with their respective conduits to form an airtight seal. A Horizontal locking pin protrudes from each canister and locks into a pair of horizontal slots formed in the canister rack. A vertical locking pin protrudes from the base of the canister rack and locks into a slot formed in each canister. A latch attaches each canister to the canister rack.

Abstract: A knee prosthesis includes a femoral prosthetic part which forms a pair of condylar gliding surfaces, a tibial part that has tibial gliding surfaces cooperating with the condylar gliding surfaces and a coupling part that connects the femoral and tibial parts so that they can rotate about a rotational axis that is approximately parallel to the axis of the tibia. If the femoral and tibial parts have the same anteroposterior alignment, an applied load is borne by a central region of the tibial gliding surfaces. The tibial gliding surface slopes upwardly relative to the prosthesis both in front of and behind the central region of the tibial gliding surface so that when the femoral and tibial parts rotate against one another, each of the condylar gliding surfaces remains in contact with its corresponding tibial gliding surface.

Abstract: Medical implants containing a temporary plasticizer, methods of producing such implants, and methods of using the implants in treating a disease, or ameliorating one or more symptoms thereof, in a subject are provided.

Abstract: A medical device for treating a defective heart valve. The medical device comprises a delivery sheath and an implantable device moveably disposed within the delivery sheath. The implantable device further comprises a distal expandable basket, a proximal expandable basket, and a connecting member coupling at a first end to the distal expandable basket and at a second end to the proximal expandable basket. Each of the distal expandable basket and proximal expandable basket is in a collapsed state during delivery and an expanded state after deployment. An actuator is releasably coupled to the implantable device. When coupled to the implantable device, the actuator can move the implantable device in a way to allow for positioning of the distal and proximal expandable baskets.

Abstract: A prosthetic foot incorporate a foot keel and a calf shank connected to the foot keel to form an ankle joint area of the prosthetic foot. The foot keel has forefoot and hindfoot portions and a relatively long midfoot portion extending between and upwardly arched from the forefoot and midfoot portions. The calf shank includes a downward convexly curved lower end which is attached at a portion thereof to the keel midfoot portion by way of an adjustable fastener arrangement. The foot has biplanar motion capability and, in a preferred form, also has high low dynamic response characteristics. The adjustable fastener arrangement permits adjustment of the alignment of the calf shank and the foot keel with respect to one another in the longitudinal direction of the foot keel for tuning the performance of the prosthetic foot.

Abstract: A system for cutting the cornea of an eye includes a moveable member with a cutting blade at one end, a pivot element disposed thereon, a cutting guide restraint disposed thereon, a mechanism for oscillating the moveable member around the pivot element, and a cutting guide configured to engage the cutting guide restraint on the moveable member to thereby limit the degree of angular movement of the cutting blade as the moveable member oscillates about the pivot element. A pocket can be cut in the cornea by advancing and oscillating the moveable member.