Abstract: A disposable guarded surgical scalpel includes a handle with a blade fixed to it and a slidably mounted guard. The guard can be moved using a single hand. When the scalpel is in use the guard is moved to a retracted position where the blade is exposed; the guard locks in this position to prevent any unintentional movement. When the scalpel is not in use, the guard is moved to an extended position where the blade is covered. When the scalpel has been used on a patient the guard is moved to a disposal position beyond the extended position thus exposing a visual indicia on the handle that indicates that the scalpel should not be reused. The guard also has grooves on the outer surface so as to provide better grip to a surgeon during operation.

Abstract: An intracorporeal device, such as an endovascular graft, having a tubular section with circumferential or helical radial support members. The radial support members may be inflatable channels which support the tubular structure of the graft and which are appropriately sized and longitudinally spaced to prevent or reduce kinking of the tubular structure upon bending of the tubular structure.

Abstract: An expandable stent having a covering which exhibits the characteristic of upon being activated by applying an agent to the covering, dissolving to expose a portion of the underlying stent. The stent may be placed across the neck of an aneurysm to seal the aneurysm and thereafter a selected region of the covering may be dissolved by an activating agent to permit blood to flow to adjacent vessels.

Abstract: A medical device comprises a catheter having a catheter shaft and a balloon located at the distal end of the catheter shaft, and a bifurcated stent. The bifurcated stent comprises a trunk and at least two joined cylindrical parts extending from the trunk. A first part is capable of radially self-expanding and a second part is radially expandable only by means of a force applied thereto. At least a portion of the second part is disposed about the balloon prior to being radially expanded.

Abstract: The present invention provides a system for treating a vascular condition, including a catheter, a stent coupled to the catheter, a drug-polymer coating on the stent including a polymeric blend of a phenoxy polymer and a styrenic block copolymer, and a bioactive drug dispersed within the drug-polymer coating.

Abstract: A prosthetic orthopaedic head has a fluid chamber defined therein. A fluid filter is positioned in the fluid chamber. In response to a load being exerted on the prosthetic head, synovial fluid is advanced through a filter thereby removing debris from the synovial fluid. A method of operating a prosthesis is also disclosed.

Abstract: A new approach for reconstructing a ligament, the new approach comprising: creating a bone tunnel within a host bone, the bone tunnel having a proximal end and a distal end, and defining a central axis extending from the proximal end to the distal end; creating an intervening layer of bone between the central axis of the bone tunnel and a rigid portion of the host bone, the intervening layer having a first side and a second side in opposition to one another, the first side of the intervening layer facing toward the central axis of the bone tunnel and the second side of the intervening layer facing toward the rigid portion of the surrounding host bone; and compressing the intervening layer of bone against a graft ligament positioned within the bone tunnel.

Abstract: An endovascular prosthesis comprising a first end section, a second end section and a midsection. The midsection has a diameter less than the diameter of the first end section and the second end section. At least the first end section and the second end section have lateral support preferably in the form of a stent which may also act as anchoring. The reduced diameter midsection is provided with at least one side port which is adapted to be connected to a branch endograft to provide a connection between the side port and the native branch artery. The side ports are arranged to correspond with the native branch arteries and are provided with radiographic markers at their proximal and distal ends. The side ports with the radiographic markers provide an effective means of making the connection to the native branch by a branch endograft without having to align the side ports exactly to the branch arteries and without kinking of the side ports.

Abstract: A hair implantation instrument herein employs a simple means for capturing a hair graft in a needle in a position for implantation into a scalp and an escapement mechanism for withdrawing the needle in a manner to leave the graft in the scalp. The needle is moved with respect to a rod which positions an implanted graft properly when the needle is withdrawn. The apparatus also defines a sheath over the needle for properly positioning a graft during a graft capture operation. The escapement mechanism is vacuum controlled in one embodiment and spring controlled in a second embodiment.

Abstract: The invention is directed toward a bone block, a bone-tendon-bone assembly and method of tendon reconstruction in which at least one tendon replacement is extended between two bone blocks and fixed within each of two bone tunnels in the bones of a joint using interference screws. Each bone block has a central through going bore and at least one substantially parallel channel longitudinally cut in the exterior of the bone block body in which the ligament replacements are seated. One end of each bone block has a rounded recess leading from the central bore to the exterior parallel channel.

Abstract: Skin topographical methods for quantifying pharmacodynamic parameters of a paralytic effect of a Clostridial toxin, such as a botulinum toxin upon a muscle, such as a frontalis muscle. The methods are effective in determining the potency of a Clostridial toxin, and in comparing toxins. For example, wrinkle reduction effects caused by one or more neurotoxins may be monitored, and differences in effects correspond to differences of neurotoxins.

Abstract: A method for controlling a vision prosthesis having an optical system in optical communication with the retina, the method including detecting a polarization state of light reflected from a retina; and at least in part on the basis of the polarization state, generating a control signal for causing a change to an optical property of the optical system.

Abstract: Devices and methods utilized in performing transmyocardial coronary bypass include retractors used to engage and support myocardial tissue, and mechanisms for supporting coronary vessels so as to allow precise entry into a vessel lumen. In addition, various conduits are provided having a configuration that permits their positioning in a heart wall to place a coronary vessel in communication with a heart chamber.

Abstract: The invention is directed toward a bone block, a bone-tendon-bone assembly and method of tendon reconstruction in which at least one tendon replacement is extended between two bone blocks and fixed within each of two bone tunnels in the bones of a joint using interference screws. Each bone block has a central through going bore and at least one substantially parallel channel longitudinally cut in the exterior of the bone block body in which the ligament replacements are seated. One end of each bone block has a rounded recess leading from the central bore to the exterior parallel channel.

Abstract: Polymeric fibers were microbraided around a mandrel to make a tubular guide tube for nerve regeneration. The polymer used for the fibers was one of poly(L-lactide-co-glycolide) (10:90 PLGA) and chitosan. These polymers are biodegradable and biocompatible. The tubes were studied for their surface morphology and swelling behavior. Biological performance of the tubes was examined in the rat sciatic nerve model with a 12 mm gap. One month after implantation nine out of ten rats showed successful nerve regeneration. Morphometric analysis of regenerated nerves confirmed the quality of the regeneration compatible with those offered by other types of biodegradable nerve guide tubes. The tubes were flexible, permeable and showed no swelling.

Abstract: The present invention provides a two-part telescopic intramedullary orthopedic device comprising a first section inserted into the medullary cavity of one of the fractured or severed bone ends, and secured thereto, and a second section inserted into the medullary cavity of the other fractured or severed bone end and secured thereto, wherein the first section is telescoped within the internal space of the second section, and wherein one of the sections comprises a ferromagnetic material and the other section is either constructed entirely of a non-magnetic material or comprises a ferromagnetic material, wherein the ferromagnetic section(s) are actuable by an external axially directed magnetic field, such that one section may be caused to move axially (either bidirectional or essentially unidirectional) in relation to the other section. In addition, the invention encompasses a method for changing bone length as well as a method for enhancing bone fracture healing.

Abstract: Stents having struts with narrowed portions are described. The narrowed portions have a coating disposed thereon for the local delivery of a drug.

Abstract: A lancing device according to the present invention includes: a housing; a moving body movable relatively to the housing for forward movement of a needle; a driving mechanism for forward movement of the moving body; a hollow pressing portion at a front end of the housing for contact with a part where a puncture is to be made; and a pump mechanism capable of causing a vacuum to act inside the pressing portion. The pump mechanism is capable of adjusting the vacuum. The pump mechanism includes for example: a moving portion capable of reciprocating in a first direction and a second direction away from the first direction. Preferably, the adjustment of the vacuum is made by changing the number of reciprocations of the moving part in the first and the second directions.

Abstract: An artificial urinary diversion device containing a urinary bladder is provided including first, second and third portions having respective cross-sectional surfaces such that the second portion is disposed between the first and third portions, and the first and second cross-sectional surfaces are smaller than the third cross-sectional surfaces, and a dislocator for sensing or controlling the artificial urinary diversion device.

Abstract: Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.