Abstract: A lubricating composition comprising a base oil in combination with molybdenum dithiocarbamate, zinc naphthenate and one or more metal dithiophosphates, and optionally one or more metal dithiocarbamates. A lubricating grease comprising such a composition in combination with a thickener, is particularly suitable for lubricating constant velocity joints.
Abstract: The present invention is related to a trandermal preparation of oxicams. In preparation, it is comprised of 0.1% to 50% of an oxicam, 0.1% to 70% of pure compositions from Chinese herbal enhancers as enhancers, as well as other necessary excipients for transdermal delivery of an active ingredient. This transdermal preparation is intended to be used for anti-inflammatory cases, but with few gastrointestinal side effects. Based on results from testing this preparation on nude mice skin, rabbit skin, and human leg skin, it was found that skin penetration of the transdermal preparation containing 20% terpineol oil was 157.6 times higher than that of the control group.
Abstract: This invention provides a prilled wax composition that can be compression-molded to a votive type candle product which has a superior combination of density and hardness properties. An invention receptacle-contained votive candle can have a burn rate between about 2 and 5 grams per hour with a standard cotton wick, and maintains a flame height between about 1-3 centimeters during combustion.
Type:
Grant
Filed:
November 25, 1997
Date of Patent:
February 1, 2000
Assignee:
S. C. Johnson & Son, Inc.
Inventors:
Luz P. Requejo, Kathryn H. Ferguson, Keith G. Patzen, Bradley Matyas
Abstract: Hydroalcoholic compositions useful for the enhancement of the transdermal delivery of a pharmaceutical agent, methods of preparation, transdermal delivery systems, and methods of delivering the pharmaceutical agent are provided. The composition includes a lower alcohol and water in a weight ratio of at least about 20:80, a pharmaceutical agent, and an emulsifier system.
Type:
Grant
Filed:
January 9, 1997
Date of Patent:
February 1, 2000
Assignee:
Minnesota Mining and Manufacturing
Inventors:
Matthew T. Scholz, Robert A. Asmus, John C. Hedenstrom
Abstract: The low temperature flow properties of wax-containing liquids are improved by adding a composition comprising (i) a polymer of a C.sub.8-20 alkyl ester of an ethyleneically unsaturated 1,2-diacid, and (ii) the reaction product of an alkanolamine with a C.sub.8-50 hydrocarbyl-substituted acylating agent.
Type:
Grant
Filed:
September 25, 1998
Date of Patent:
January 25, 2000
Assignee:
The Lubrizol Corporation
Inventors:
John S. Manka, Kim L. Ziegler, Daniel R. Nelson
Abstract: A process for producing an emulsifier which comprises hydrolysis of water-soluble hemicellulose with purified rhamnogalacturonase, and emulsified compositions prepared using the emulsifier.
Abstract: Described is a method of making a silicone in water emulsion. The method comprises mixing (I) a composition containing at least one polysiloxane, at least one organosilicon material that reacts with said polysiloxane by a chain extension reaction and a metal containing catalyst for said chain extension reaction, (II) at least one surfactant and (III) water to form a mixture. The mixture is emulsified to form an emulsion which can have a wide variety of silicone volume fractions, a broad range of mono-disperse particle sizes and a wide variety of molecular weight polymers.
Abstract: Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer and a monolithic carrier layer formed from a melt blend of an active ingredient with a thermoplastic matrix polymer without first dissolving or suspending the polymer or active ingredient in a solvent therefor, so that the carrier layer is substantially free of residual solvent, wherein the thermoplastic matrix polymer has a melt temperature between about 170.degree. C. and about 200.degree. C.
Type:
Grant
Filed:
October 21, 1997
Date of Patent:
January 4, 2000
Assignee:
Bertek, Inc.
Inventors:
John J. Wick, Ludwig J. Weimann, Wayne C. Pollock
Abstract: The present invention relates to the use in perfumery of compounds of the general formulae ##STR1## in which R.sup.1 and R.sup.2 are identical or different and represent each a methyl or ethyl group, R.sup.3 represents hydrogen or an alkyl group from C.sub.1 to C.sub.4, linear or branched, and R.sup.4 represents hydrogen, an alkyl group from C.sub.1 to C.sub.4, linear or branched, or an acyl group of formula R.sup.5 C(O)--, R.sup.5 being hydrogen or an alkyl group from C.sub.1 to C.sub.4, linear or branched. The novel odoriferous character of these compounds is the combination of woody with fruity notes. Also described is a synthesis for the preparation of the compounds of formula (I) starting from the compounds of formula (II).
Type:
Grant
Filed:
May 28, 1998
Date of Patent:
December 28, 1999
Assignee:
Firmenich SA
Inventors:
Karl-Heinrich Schulte-Elte, Herve Pamingle, Christian Vial
Abstract: Method and composition for gel formation in hydrocarbon recovery, in which an organic phosphate ester is gelled by a novel activator composition comprising iron sulfate, dibutylaminoethanol, and a phosphate surfactant.
Abstract: Composition of matter for application to a body surface or membrane to administer pergolide by permeation through the body surface or membrane, the composition comprising pergolide to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the pergolide or pergolide and enhancer composition and methods for the transdermal administration of the pergolide and pergolide/enhancer composition.
Type:
Grant
Filed:
December 18, 1996
Date of Patent:
December 14, 1999
Assignee:
Alza Corporation
Inventors:
Su I Yum, Melinda K. Nelson, Patricia S. Campbell
Abstract: The invention relates to the use of substantially fully destructurized starch for transdermal applications in humans and animals, in particular the use of solid particles such as implants. The invention further relates to the implants manufactured of substantially fully destructurized starch, in addition to methods for manufacturing the implants.
Abstract: A tracer solution suitable for use in measuring flow velocities in a borehole, includes: a) a gadolinium salt of a carboxylic acid of general formula ##STR1## where R is an alkyl of not less than four carbon atoms, typically C4 or C5 alkyl, and R.sub.1 and R.sub.2 are hydrogen or an alkyl group, typically hydrogen, methyl or ethyl; b) a free branched-chain carboxylic acid such as an excess of the acid used to form the Gd salt; and c) a non-polar solvent such as hexane or heptane. The Gd content of the solution should be not less than about 50 g/l and is best when it is as high as possible, for example greater than 100 g/l, and the viscosity should be less than 20 cP.
Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber.
Type:
Grant
Filed:
June 19, 1998
Date of Patent:
November 23, 1999
Assignee:
Alza Corporation
Inventors:
Patrick S.-L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
Abstract: The corrosion of metals in contact with an aqueous alkanolamine solution in an acid gas removal unit is inhibited by adding a corrosion inhibiting amount of an alkanemonothiol or alkanedithiol compound to the aqueous alkanolamine solution. The alkanemonothiol and alkanedithiol compounds are useful for inhibiting the corrosion of metals in both the acid gas rich and lean portions of the acid gas removal unit.
Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
Type:
Grant
Filed:
October 2, 1997
Date of Patent:
November 16, 1999
Assignee:
Alza Corporation
Inventors:
John R. Peery, Keith E. Dionne, James B. Eckenhoff, Felix A. Landrau, Scott D. Lautenbach, Judy A. Magruder, Jeremy C. Wright
Abstract: A transdermal therapeutic system (TTS) which contains as the active ingredients an oestrogen and a gestagen or a gestagen or androgen as well as an acrylate adhesive and, as resorption promoters, the two substances oleic acid and 2-(2-ethoxyethoxy)ethanol.
Type:
Grant
Filed:
January 22, 1998
Date of Patent:
November 16, 1999
Assignee:
Labtec Gesellschaft fuer techologische Forschung und Entwicklung mbH
Abstract: The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I ##STR1## in which R.sup.1 is a saturated or monounsaturated or polyunsaturated hydrocarbon residue with 12 to 20 C atoms and R.sup.2, R.sup.3 and R.sup.4 denote independently of one another hydrogen, a C.sub.1 -C.sub.5 alkys group, a C.sub.3 -C.sub.6 cycloalkyl group or a C.sub.1 -C.sub.5 hydroxyalkyl group whereby two of the residues R.sup.2, R.sup.3 and R.sup.4 can together form a C.sub.2 -C.sub.5 alkylene group which, if desired, can be substituted with an --O--, --S-- or NR.sup.5 group, in which R.sup.5 is hydrogen, a C.sub.1 -C.sub.5 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group or a C.sub.1 -C.sub.5 hydroxyalkyl group as well as, if desired the usual pharmaceutical auxiliary, diluting, carrier or/and filling substances.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
November 9, 1999
Assignee:
Max-Planck-Gesellschaft zur Forderung der Wissenschaften
Inventors:
Hansjorg Eibl, Clemens Unger, Jurgen Engel
Abstract: A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. .Iadd.In a preferred embodiment, the base layer further contains a thermoplastic resin. .Iaddend.The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.
Abstract: Perfuming ingredients which include at least one macrolide of formula ##STR1## having a double bond in one of the positions indicated by the dotted lines and wherein the symbol R represents a hydrogen atom or a methyl radical, are described. They are useful for the preparation of perfumes and perfumed consumer products to which they impart musky odors with original nuances.