Abstract: An alkaline animal feed, in granular or solid form, with a pH greater than or equal to 7.5, comprising Dunder, dunder and molasses, or dunder and molasses by-products mixed with sorptive materials, including bentonite and zeolite. Hydrated lime may be added as a source of calcium, to improve pellet quality, for moisture absorbency and for pH control. Cereal grains, trace elements, bypass proteins and other additives may be included in the mix to tailor the animal feed to the user's requirements.

Abstract: The present invention provides a material for promoting health and curing bruises, etc., which is able to widely exert favorable influences on symptoms such as contusions, sprains, stiffness of the shoulders, and myosalgia and to cure the same in a short time, wherein a kneaded substance 2 is laminated on one side of base material 1 such as unwoven fabric and the kneaded substance is applied to an affected part. The kneaded substance is produced by kneading a titanium based material 4 and topicum for compress in a gelling agent. The electromagnetic and electric actions which the titanium based material has, and actions of pain killing, sedation, improvement of the blood circulation, and promotion of metabolism are simultaneously made effective, and it is possible to apply the same in a wide range of symptoms and to cure them in a short time.

Abstract: Transdermal therapeutic systems that contain sex steroids and optionally penetration-enhancers and crystallization inhibitors are described, which are characterized in that they contain dimethyl isosorbide, with the exception of systems that contain active ingredient-containing, non-free-flowing gel phases or 3-keto-desogestrel.

Abstract: A transdermal system in the form of a patch that comprises a tamoxifen derivative and an absorption-promoting additive for systemic administration.

Abstract: Drug-delivery devices and methods of their use are disclosed, which devices consist of at least a semi-interpenetrating network (semi-IPN) hydrogel comprising a first, cationic polymer such as chitosan and a second high molecular weight neutral polymer such as polyethylene oxide, the semi-IPN having been freeze-dried after formation of the semi-IPN, and a drug composition. A therapeutic method of treating gastric disease is also disclosed comprising the step(s) of introducing to a gastric area to be treated a drug-delivery device according to the disclosure, whereupon the device releases the drug or therapeutic agent contained in the device. The hydrogels of the disclosure are advantageously used for site-specific drug delivery in the gastro-intestinal tract where there is a range of pH from 1.0 to 1.5 in the stomach to about 7.5 in the small intestine.

Abstract: A hydrogel wound dressing is provided which is clear, non greasy, water soluble and odor free. The wound dressing additionally does not exhibit any thickening properties and is of a viscosity such that it will adhere to the wound bed to facilitate natural healing yet will also be easily removable with water and will not stick to the wound or gauze, allowing for removal of bandages without tearing of delicate regenerated skin. The wound dressing also contains humectant properties such that the wound is kept hydrated to prevent any scabbing or drying out so that the wound is allowed to heal from the inside out.

Abstract: A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination, the oxybutynin to be administered, in a therapeutically effective amount; and a permeation-enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters; present in specific concentrations.

Abstract: A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.

Abstract: A drug for the release of active substances to the skin, which has an increased deuterium portion as compared to the natural isotope distribution.

Abstract: Pharmaceutical formulation in the form of a gel suitable for the transdermal administration of an active agent of the class of estrogens or of progestin class or of a mixture of both, comprising:as permeation enhancers of the above said active agents a combination consisting substantially of an aliphatic alcohol having general formula CH3(CH2)nCH20H wherein n=8-16 and of a monoalkylether of diethylene glycol;as a vehicle or carrier, a combination of an alkanol of 2.div.4 C atoms, a glycol and water;as gelling agent a polymer or copolymer of acrylic acid;a tertiary amine as a thickening and neutralizing agent.

Abstract: Alcoholic addiction is treated by administering pyridine nucleotide phosphate derivatives having the formula represented by Formula 1: ##STR1## where y can be a second NAD group or an adenosine group and x can be 1, 2, or 3.

Abstract: A make-up cosmetic product, which enhances the appearance of complexion, is evaluated by irradiating lights having a wavelength range of visible light onto a surface on which the make-up cosmetic product is applied, from at least two directions with different incident angles, measuring a plurality of spectra of reflected lights obtained from the irradiated lights, respectively, and comparing the spectrum patterns with each other. This clarifies the optical theory by which the skin looks beautiful and provides a method for evaluating a make-up cosmetic product making the skin look beautiful.

Abstract: An active substance-containing patch for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens, comprising a backing layer, an active substance-containing reservoir which is bonded thereto and produced by using pressure-sensitive adhesives, and a removable protective layer, is characterized by the fact that the pressure-sensitive adhesive comprises ethylcellulose, esters of non-hydrogenated and/or hydrogenated colophony, and lauric acid.

Abstract: The present invention provides a percutaneous absorption preparation which has excellent pressure-sensitive adhesive characteristics and exerts excellent percutaneous absorption property. A crosslinking agent is added to a solution of an acrylic copolymer prepared by copolymerizing a (meth)acrylic acid alkyl ester with a functional monomer, and the acrylic copolymer is partially crosslinked. A composition containing the crosslinked acrylic copolymer is pulverized to prepare a pressure-sensitive adhesive solution comprised of the acrylic copolymer containing crosslinked acrylic copolymer particles. Thereafter, a drug for percutaneous absorption use, a percutaneous penetration enhancer are added to the pressure-sensitive adhesive solution, thereby producing the percutaneous absorption preparation.

Abstract: A transdermal therapeutic system (TTS) comprises compounds releasing carbon monoxide in organisms to increase the CO-concentration in the organism.

Abstract: Controlled delivery of a beneficial agent in a dispersion is provided using (i) a compressed core which contains the beneficial agent, a polymer which forms gelatinous microscopic particles upon hydration, and if desired, an agent to modulate the hydration; and (ii) a water insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of the dispersion. The release rate of the beneficial agent is a function of the number and size of the apertures in the coating.

Abstract: The invention relates to a composition which makes it possible, in particular, to combat photo-induced ageing of the skin and/or to combat skin blemishes, this composition containing, in a cosmetically and/or dermatologically acceptable medium, at least one saccharide ester of ascorbic acid and at least one saccharide ester of rutin, the phase of this medium having a pH of from 4 to 6.

Abstract: Solubilization enhancer compositions are provided which facilitate transdermal administration of basic drugs from transdermal systems composed of nonpolar adhesive materials. Preferred solubilization enhancer compositions are comprised of liquid, isomeric acid mixtures such as oleic acid dimer. The invention also relates to novel transdermal systems, drug reservoirs, formulations, and methods of drug administration, in which the disclosed solubilization enhancer compositions are used.

Abstract: A controlled-release pharmaceutical composition for oral administration comprising a multitude of granules made by dissolving or dispersing a drug and a water-insoluble polymer in a molten carrier, solidifying the resultant material, and grinding the resultant solid into granules.

Abstract: The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant.