Patents Examined by D. L. Jones
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Patent number: 11738099Abstract: A molecular probe comprising a linear peptide that includes an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 9; a contrast agent; and a non-peptide linker that covalently links the peptide to the contrast agent.Type: GrantFiled: February 23, 2021Date of Patent: August 29, 2023Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Zheng-Rong Lu, Zheng Han
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Patent number: 11730819Abstract: A compound comprising at least one looped peptide structure attached via at least one alkylamino linkage to a scaffold. Preferably the looped peptide structure is a Bicycle structure comprising two peptide loops attached to the scaffold via two alkylamino linkages and one thioether linkage, one of the linkages being common to both loops.Type: GrantFiled: December 20, 2017Date of Patent: August 22, 2023Assignee: BicycleTx LimitedInventors: Daniel Teufel, Gemma Mudd, Silvia Pavan
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Patent number: 11723948Abstract: The present invention relates to an in vitro method for determine the prognosis of the survival time of a patient suffering from a cancer comprising the steps consisting of i) determining the expression level of the couple DNMT3A/ISGF3? in a sample from said patient, ii) comparing said expression level with a predetermined reference value and iii) providing a good prognosis when the expression level is lower than the predetermined reference value and a poor prognosis when the expression level is higher than the predetermined reference value. The invention also relates a compound which is a DNMT3A/ISGF3? antagonist or a compound which is a DNMT3A/ISGF3? gene expression inhibitor for use in the treatment and prevention of cancer.Type: GrantFiled: May 21, 2020Date of Patent: August 15, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), NANTES UNIVERSITĂ, UNIVERSITE D'ANGERS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Pierre-Francois Cartron, Mathilde Cheray, Francois Valette
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Patent number: 11723992Abstract: Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.Type: GrantFiled: August 2, 2019Date of Patent: August 15, 2023Assignee: Board of Regents, The University of Texas SystemInventors: Mai Lin, Carlos E. Gonzalez-Lepera
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Patent number: 11718625Abstract: The present disclosure relates to the fields of near-infrared surgical navigation fluorescent molecules, cell marker imaging and so on, and in particular discloses an active targeting near-infrared fluorescent small molecule structure and a preparation method thereof. The present disclosure prepares the active targeting near-infrared fluorescent small molecule with pemetrexed disodium and derivatives thereof as active targeting groups by utilizing an organic total synthesis method. Such active targeting near-infrared fluorescent molecule has the advantages of high active targeting property, strong specificity, good water solubility, high fluorescence quantum yield and so on.Type: GrantFiled: November 27, 2020Date of Patent: August 8, 2023Assignee: NANJING UOYUAN MEDICAL DEVICES CO., LTDInventors: Huiming Cai, Yiqing Wang
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Patent number: 11712486Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.Type: GrantFiled: January 30, 2018Date of Patent: August 1, 2023Assignees: VECT-HORUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX-MARSEILLEInventors: CĂ©dric Malicet, Pascaline Lecorche, Jonathan Nowak, Marion David, Jamal Temsamani, Michel Khrestchatisky
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Patent number: 11712485Abstract: Metal complexes including a radionuclide and a compound of Formula I and Formula II are potent inhibitors of PSMA.Type: GrantFiled: December 21, 2020Date of Patent: August 1, 2023Assignee: Molecular Insight Pharmaceuticals, Inc.Inventors: John W. Babich, Craig Zimmerman, John L. Joyal, Genliang Lu
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Patent number: 11713305Abstract: In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.Type: GrantFiled: July 3, 2018Date of Patent: August 1, 2023Assignee: The Board of Regents of The University of Texas SystemInventors: Andre F. Martins, Sara Chirayil, Maria Veronica Clavijo Jordan, A. Dean Sherry
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Patent number: 11684681Abstract: Disclosed are methods of detecting eosinophil degranulation in the respiratory tract of subjects. Also, disclosed are methods of producing medical images of the respiratory tract of subjects. The method can include administering radiolabeled heparin to the respiratory tract of subjects, wherein the radiolabeled heparin binds to one or more eosinophil granule protein in the mucosal tissue of the respiratory tract.Type: GrantFiled: July 19, 2021Date of Patent: June 27, 2023Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Leonard F. Pease, Hedieh Saffari, Gerald J. Gleich, Kristin M. Leiferman, Kathryn A. Peterson, Russell Morris Condie
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Patent number: 11679168Abstract: Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.Type: GrantFiled: September 13, 2019Date of Patent: June 20, 2023Assignee: The Board of Trustees of Leland Stanford Junior UniversityInventors: Jianghong Rao, Yunfeng Cheng, Min Chen, Jianghang Xie, Zixin Chen
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Patent number: 11680105Abstract: The present invention relates to diagnostic and therapeutic agents comprising recombinant antibody fragments to bind a protein associated with cancer and methods of use of these diagnostic and therapeutic agents.Type: GrantFiled: January 16, 2020Date of Patent: June 20, 2023Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Jayanth Panyam, Stephen Kalscheuer, Vidhi D. Khanna
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Patent number: 11666671Abstract: A molecular imaging agent including a detectable moiety, a chelation moiety, and a carrier moiety is provided. In one embodiment, the detectable moiety is coupled to the chelation moiety and the chelation moiety is linked to the carrier moiety. In another embodiment, the detectable moiety is 99mTc; the chelation moiety includes HYNIC; and the carrier moiety includes from N-terminus to C-terminus: a His6 purification tag, a human VEGFA polybasic tag sequence, and a human Fc stabilization segment.Type: GrantFiled: May 31, 2019Date of Patent: June 6, 2023Assignee: Northwestern UniversityInventor: Jing Jin
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Patent number: 11654203Abstract: Disclosed herein are a dual-targeted carbonic anhydrase IX complex, a contrast agent comprising the same, and a synthesizing method thereof. The dual-targeted carbonic anhydrase IX complex includes a carbonic anhydrase IX (CA9) binding peptide, a sulfonamide derivative, and a metal chelating agent. The dual-targeted carbonic anhydrase IX complex has potential for use as a molecular nuclear drug.Type: GrantFiled: October 26, 2020Date of Patent: May 23, 2023Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.CInventors: Siao-Syun Guan, Tsai-Yueh Luo, Tse-Zung Liao, Cheng-Liang Peng, Kun-Liang Lin
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Patent number: 11642418Abstract: Disclosed is the use of a radiolabeled anti-nanobody in the prognosis and diagnosis of cancers. In particular, disclosed is an immunoconjugate for detecting a PD-L1 molecule. The immunoconjugate comprises the VHH chain of a specific anti-PD-L1 nanobody and a radionuclide, and can be used for non-invasive detecting of expression of the object PD-L1 to be detected. The immunoconjugate of the invention has small size and high specificity, and is suitable for systemic detection which simultaneously targets primary and metastatic tumors, and has high accuracy and low radiation dose.Type: GrantFiled: September 13, 2018Date of Patent: May 9, 2023Assignee: NANOMAB TECHNOLOGY LIMITEDInventors: Hong Hoi Ting, Chung Lim Wong
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Patent number: 11638764Abstract: Disclosed are compounds, compositions, and methods involving theranostic capture agent for a target where the capture agent is (a) a precursor that can be loaded with a detectable moiety, a therapeutic moiety, or both, (b) loaded with a detectable moiety, (c) loaded with a therapeutic moiety, or (d) loaded with both a detectable moiety and a therapeutic moiety. Also disclosed are stable peptide-based PSMA capture agents and methods of use as detection agents.Type: GrantFiled: November 8, 2019Date of Patent: May 2, 2023Assignee: INDI MOLECULAR, INC.Inventor: Heather Agnew
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Patent number: 11638763Abstract: Embodiments of the present disclosure provide a nanoparticle based platform, and nanoallergens for identifying, evaluating and studying allergen mimotopes as multiple copies of a single mimotope or various combinations on the same particle. The nanoparticle is extremely versatile and allows multivalent binding to IgEs specific to a variety of mimotopes, simulating allergen proteins. Nanoparticles can include various molecular ratios of components. For example, the nanoallergens can include about 0.1-40% mimotope-lipid conjugate and about 60-99.9% lipid. The mimotope-lipid conjugate includes a mimotope, a first linker, and lipid molecule. Nanoallergens can be used in in vitro and in vivo applications to identify a specific patient's sensitivity to a set of epitopes and predict a symptomatic clinical response, identify allergen epitopes through blind screening peptide sequences from allergen protein, and in a clinical application similar to a scratch test.Type: GrantFiled: December 18, 2020Date of Patent: May 2, 2023Assignee: University of Notre Dame du LacInventors: Zihni Basar Bilgicer, Peter Edward Deak, Tanyel Kiziltepe Bilgicer, Jared Francis Stefanick, Jonathan Darryl Ashley
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Patent number: 11633507Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: GrantFiled: December 10, 2020Date of Patent: April 25, 2023Assignees: GENERAL ELECTRIC COMPANY, AFFIBODY ABInventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Patent number: 11612667Abstract: The present invention relates to a compound that inhibits the activity of a degrading enzyme for use in combination with a therapeutic or diagnostic compound, preferably a moiety conjugated peptide, in the diagnosis and/or treatment of a disease, in particular cancer, to enhance targeting of the therapeutic or diagnostic compound to the disease site.Type: GrantFiled: October 21, 2019Date of Patent: March 28, 2023Inventors: Theodosia Maina-Nock, Berthold Artur Nock, Marion de Jong Hendriks
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Patent number: 11607465Abstract: This invention concerns various methods of using labeled HSP90 inhibitors to improve treatment of cancer patients with HSP90 inhibitors, including ex vivo and in vivo methods for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor.Type: GrantFiled: July 21, 2020Date of Patent: March 21, 2023Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Gabriela Chiosis, Naga Vara Kishore Pillarsetty, Jason S. Lewis, Steven M. Larson, Tony Taldone, Mary L. Alpaugh, Erica M. Gomes-DaGama
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Patent number: 11576987Abstract: The invention provides compositions, kits and methods to treat a hyperproliferative disorder with an agent that increases expression of MCR1 and an MCR1 ligand. The invention also provides a method of treating drug-resistant melanoma, comprising administering an MCR1 ligand to a patient in need thereof. The present invention also provides in certain embodiments a melanoma-targeting conjugate comprising Formula I: T-L-X wherein T is a MCR1 ligand, L is a linker, and X an anti-cancer composition, for the therapeutic treatment of a hyperproliferative disorder. The present invention also provides methods, kits and uses of the conjugate of Formula I.Type: GrantFiled: October 21, 2021Date of Patent: February 14, 2023Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Michael K. Schultz, Frances L. Johnson, Somya Kapoor, Dongyoul Lee, Mengshi Li, Molly Martin