Abstract: The invention relates to a packaging (1) for medicines, comprising a base (4) from which two guide rails (6) extend which are arranged to house an electronic monitoring device (9), to a method for manufacturing same, and to the use thereof.

Abstract: A pharmacological method for treating the expressive language deficit in an autistic human child or adult is provided. A therapeutically effective dose of a succinimide anticonvulsant, e.g., ethosuximide, methsuximide, phensuximide, or a pharmaceutically acceptable salt thereof, is administered to a patient suffering from expressive language deficit, preferably over an extended period, e.g., six months or longer. Language gains are retained even after treatment is discontinued.

Abstract: Systems and apparatuses for detecting an amount of steering articulation of a steering system are disclosed. The systems and apparatuses may be applied to steering systems of agricultural header transport systems. The systems and apparatuses may include a first component moveable with a first steering component and a second component that is movable with a second steering component. The first component and the second component may interact to generate a notification that a selected amount of steering articulation has occurred or is about to occur. The notification may be provided to an operator, such as in the form of a visual, audible, or haptic output.

Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (TLD), or chronic kidney disease (CKD).

Abstract: There is provided a physiological detection device including a light source, a light detector, a processing unit and a display device. The light source emits light to illuminate a skin surface. The light detector receives the light from the skin surface to output detected signals. The processing unit confirms an attached state according to the detected signals and controls the display device to show an indication signal or a warning message when the attached state is confirmed not good.

Abstract: The disclosure provides methods for the acute treatment of depression and/or anxiety, for the enhancement of mTOR (e.g., mTORC1) signaling, and for the reduction of neuroinflammation, comprising administering to a patient in need thereof, a therapeutically effective amount of a 5-HT2A or 5-HT2A/D2 receptor ligand, e.g. lumateperone.

Abstract: Systems and methods of maternal and fetal monitoring include acquiring ultrasound physiological data with an ultrasound transducer. A plurality of electrodes acquire biopotential physiological data from the skin of a patient. A controller receives the ultrasound and biopotential physiological data and calculates fetal heart rate (fHR) values, maternal heart rate (mHR) values, and uterine activity (UA) values from the ultrasound and biopotential physiological data.

Abstract: The present invention relates to the use of certain ?-lactamase inhibitors in conjunction with one or more ?-lactam antibiotics for the treatment of Strenotrophomonas maltophilia, tuberculosis or Pseudomonas species infections.

Abstract: A measuring device is provided for reducing the occurrence of damage to a sensor section. The sensor section includes a substrate, a pair of comb electrodes on a first principal surface, and a pair of back-side electrodes disposed on a second principal surface and corresponding to the pair of comb electrodes, respectively. The pair of comb electrodes includes a plurality of tooth sections and connection sections that connect the tooth sections to each other, respectively. The substrate includes via-hole conductors in positions corresponding to the tooth sections inside a region surrounded by the outer tooth sections on opposite ends in a direction in which the tooth sections in the pair of comb electrodes are aligned and the connection sections. The via-hole conductors connect the comb electrodes and the back-side electrodes.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger, and plunger driver assembly comprising double-acting, telescoping lead screws that is located behind and outside of the barrel. Simultaneously and counter-rotating sleeve screw and center screw telescope out of a nested configuration of the plunger driver assembly and into the reservoir at a rate of double their individual and equal pitch and lead parameters when the sleeve screw is rotated. A threaded nut and gear anchor disposed on an end of the barrel receive the sleeve screw and the threaded nut causes the sleeve screw to translate and rotate in response to motor operation. A distal end of the center screw can be keyed to a plunger pusher for anti-rotation constraint when the motor is imparting rotation on the threaded nut and sleeve screw.

Abstract: Disclosed is a layered body comprising a polymer comprising repeating units having the general structure —CH2—CHR1—COOR2— as defined herein, to a process for producing such a layered body, to a layered body produced by that process and to the use of a layered body for electrophysical measurements.

Abstract: Generally speaking, pursuant to these various embodiments a memory stores prescribed treatment instructions for a particular patient radiation therapy. Those treatment instructions specify clinical metrics for goals pertaining to at least one treatment volume for the particular patient. Either directly or inferentially those clinical metrics are prioritized. A control circuit automatically converts those treatment instructions into resultant radiation treatment plan optimization objectives where the automatic conversion can compatibly comprise a non-convex optimization objective. The control circuit then automatically iteratively optimizes the radiation treatment plan for the particular patient radiation therapy as a function, at least in part, of the aforementioned resultant optimization objectives to thereby produce an optimized radiation treatment plan for the particular patient that a radiation treatment platform then utilizes to administer therapeutic radiation to the particular patient.

Abstract: A guide rail type shielding curtain, comprising guide rail type moving mechanism, shielding curtain frame, first stretching bearing mechanism and second stretching bearing mechanism. Guide rail type moving mechanism comprises first guide rail sliding grooves and first guide rail sliding strips, which are arranged on the inner sides of automobile side plates on two sides; curtain frame mounting holes are formed in front ends of first guide rail sliding grooves; shielding curtain frame is mounted in left and right curtain frame mounting holes; stretching limiting transverse strip is provided on the rear side of first stretching bearing mechanism; first guide rail sliding strip holes are formed on left end and right end of stretching limiting transverse strip respectively; first guide rail sliding strips are arranged in first guide rail sliding strip holes; pulleys are movably arranged at the outer ends of the first guide rail sliding strips.

Abstract: Risks of radiation-induced toxicity associated with a radiotherapy treatment of a target region of a patient are predicted. Data associated with a region of interest comprising the target region is received. The received data includes a predefined dose map of the radiotherapy treatment and pre-radiotherapy-treatment imaging data of the region of interest. A trained machine-learning algorithm is applied to the received data. The trained machine-learning algorithm generates at least one toxicity indicator based on the received data. The at least one toxicity indicator is indicative of the risks of the radiation-induced toxicity.

Abstract: The invention relates to a computer-implemented method for assessing a clearance between a tooth element to be provided with a dental restoration element and an antagonist of the tooth element. A 3D digital teeth model with 3D digital representations of the tooth element and of a surface area of the antagonist is received. The surface area is offset from the antagonist by adding an offset. The resulting offset surface area defines a limit for the tooth element. For the clearance it is checked, whether the tooth element violates one or more penetration criteria regarding the offset surface area. If the tooth element violates the one or more penetration criteria, the clearance is assessed to be insufficient for the tooth element to be provided with the dental restoration element. Else the clearance is assessed to be sufficient. The result of the assessment is output.

Abstract: A method for enhancing the accuracy of aiming while putting a golf ball with a putter is provided. A head of the putter includes a body having a first end and a second end, the second end includes a target and the first end includes an aiming member extending towards a center of the target. The method includes the steps of focusing on a pointed end of the aiming member and aligning the pointed end with a hole in the ground, executing a backswing while concentrating on moving the pointed end of the aiming member towards the center of the target, executing a forward swing towards the golf ball, and striking the golf ball to translate the golf ball along the alinement towards the hole.

Abstract: An oral health care device is activated. The oral health care device includes a fluid reservoir and a pump to provide fluid included in the fluid reservoir to a plurality of fluid nozzles. A sensed value is used to determine whether the fluid is being provided to the plurality of fluid nozzles via the pump. A motor associated with the pump is stopped based on whether the fluid is being provided to the plurality of fluid nozzles via the pump.

Abstract: A suspension includes a housing, links, a radius arm, and a radius arm bush. The radius arm bush is provided on a front end of the radius arm, couples the radius arm to a vehicle body, with an elastic body in between, and is disposed vehicle-widthwise inwardly of a wheel center contact point of the rear wheel. The radius arm bush has higher rigidity with respect to turn of the radius arm with respect to the vehicle body in a direction in which an underside of the radius arm is displaced vehicle-widthwise outwardly from an upside of the radius arm, than rigidity with respect to turn of the radius arm with respect to the vehicle body in a direction in which the underside of the radius arm is displaced vehicle-widthwise inwardly from the upside of the radius arm.

Abstract: The present disclosure relates generally to traction devices for footwear. Cleats are provided that are operable to provide preexisting articles of footwear with enhanced grip, traction and performance. The cleat includes a threaded male extension for interfacing with a preexisting shoe sole and at least one projecting gripping element for contacting or extending toward a ground surface.

Abstract: A wall module for a modular wall having a wall segment with a top, bottom, front, back, first end, and back end. A first component of a connector is preferably and extended tongue and is attached to the second end of a wall segment. The second component of a connector is preferably an extended groove in the first end of the wall segment. Preferably, a channel exists along the length of each wall segment at top. Also, preferably either a ring segment or an elongate member is in such channel and is connected to a leg. And preferably the ring segment or elongate member connects to the corresponding element on an adjacent wall segment when such adjacent wall segment has been connected to the first wall segment.