Patents Examined by Danah Al-Awadi
  • Silica nanoparticle agent conjugates
    Patent number: 9028880
    Abstract: The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: May 12, 2015
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jianjun Cheng, Li Tang
  • Citrullinated fibrin-filaggrin chimeric polypeptide capable of detecting the antibodies generated in rheumatoid arthritis
    Patent number: 9012405
    Abstract: The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the ? or ? chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: April 21, 2015
    Assignees: Consejo Superior de Investigaciones Cientificas, Fundacio Clinic per a la Recerca Biomedica
    Inventors: Isabel Haro Villar, José M. Gomora Elena, Luisa M Perez Rodríguez, Raimon Sanmarti Sala
  • Catheter lock solution comprising citrate and a paraben
    Patent number: 9011897
    Abstract: This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: April 21, 2015
    Assignee: Ash Access Technology, Inc.
    Inventors: Stephen R. Ash, Janusz Steczko, Gary L. Swanson
  • Pharmaceutical compositions for oral administration in the form of stabilised aqueous suspensions
    Patent number: 8999395
    Abstract: The invention relates to a liquid pharmaceutical composition, in the form of a suspension of micronized powder of active substance in an acceptable physiological liquid medium, stabilized over time, for administration via the oral route.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: April 7, 2015
    Assignee: Ceva Sante Animale
    Inventors: Claudio Zanichelli, Simona Binacchi, Sandrine Lacoste, Cecilia Sacchetti
  • Porous electroactive hydrogels and uses thereof
    Patent number: 8999378
    Abstract: The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: April 7, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Megan O'Grady
  • Polysaccharide derivatives and dosage forms
    Patent number: 8992987
    Abstract: Polysaccharide derivatives having a median Equivalent Projected Circle Diameter (EQPC) of less than 140 micrometers and a particle size and shape distribution meeting condition A or B or both are useful for preparing dosage forms, particularly for preparing compressed sustained-release dosage forms: A. non-compacted polysaccharide derivative particles have a flowability of at least 45 g/sec through a vertically inverted cone having a vertex angle of about 40 and an outlet diameter of about 50 mm, or B. i) no more than 40 volume percent of the polysaccharide derivative particles are fine particles having a particle length LEFI of less than 40 micrometers and ii) no more than 40 volume percent of the polysaccharide derivative particles are fibrous particles, and the sum of the fine particles and the fibrous particles does not exceed 50 volume percent.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: March 31, 2015
    Assignee: Dow Global Technologies LLC
    Inventors: Jennifer L'hote-Gaston, Nicholas S. Grasman, Jorg Theuerkauf, Sjoerd A. De Vries
  • Angiogenesis regulating composition and method for regulating angiogenesis
    Patent number: 8974836
    Abstract: An angiogenesis regulating composition used to treat/prevent an angiogenic disease in a subject, that contains in an effective amount at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, and an angiogenesis regulation method administering to a subject a composition containing as an active ingredient at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, provide a composition effective in treating and preventing angiogenic diseases, that can medically control angiogenic diseases, and medically regulate angiogenesis in ophthalmologic diseases in particular, and allows treatment without inhibiting physiological neovascularization, with a limited side effect and significantly safely, and an angiogenesis regulation method using the same.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: March 10, 2015
    Assignee: Air Water, Inc.
    Inventors: Junya Fujimori, Hidekazu Baba, Toshinori Murata
  • Method of administering an injectable antibiotic to an animal
    Patent number: 8968759
    Abstract: A method of administering an antibiotic to an animal in need thereof, including the step of injecting the antibiotic subcutaneously at the junction of a pinna with the cranium of the animal, is disclosed.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: March 3, 2015
    Assignee: Zoetis P&U LLC
    Inventor: Scott A. Brown
  • Methods and compositions for bone formation
    Patent number: 8961999
    Abstract: A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: February 24, 2015
    Assignees: Baylor College of Medicine, William Marsh Rice University
    Inventors: Alan R. Davis, Elizabeth A. Davis, Kevin Moran, Ronke Olabisi, Jennifer L. West, Christy Franco
  • Composite mesh including a 3D mesh and a non porous film of oxidized cellulose from bacterial cellulose origin
    Patent number: 8962006
    Abstract: The present invention relates to a composite implant comprising: a prosthetic fabric having a first side and a second side, a non-porous film of bacterial cellulose secured to the first side of the fabric. The invention further relates to a method of making such an implant.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: February 24, 2015
    Assignee: Sofradim Production
    Inventors: Yves Bayon, Sébastien Ladet, Olivier Lefranc, Philippe Gravagna
  • Calciumphosphate-based nanoparticles as carrier-systems for photodynamic therapy
    Patent number: 8956648
    Abstract: The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic photosensitizer, nanoparticulate calcium phosphate and in certain cases auxiliary reagents such as stabilizers. The calcium phosphate-based nanoparticle formulations of the present invention provide excellent storage stability and therapeutically effective amounts of photosensitizer for intravenous or topical administration. In a preferred embodiment, tetrapyrrole derivatives such as porphyrins, chlorins and bacteriochlorins, are the preferred hydrophobic photosensitizers to be formulated in calcium phosphate nanoparticle formulations for photodynamic tumor therapy. Additionally, 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (pTPPP) is a preferred hydrophilic photosensitizer for photodynamic tumor therapy.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: February 17, 2015
    Assignee: Biolitec PharmaMarketing Ltd
    Inventors: Burkhard Gitter, Susanna Gräfe, Arno Wiehe, Volker Albrecht, Matthias Epple, Janine Schwiertz, Kathirvel Ganesan
  • Nano-structured thixotropic inorganic peeling gels
    Patent number: 8951559
    Abstract: A composition, a method, and a kit are provided for chemical skin peeling, based on nano-structured thixotropic inorganic gels, which have a higher potency and are less irritant of the conventional peeling formulations. The gels of the invention can easily be applied on the skin, where they form a stable, uniform layer, that doesn't strain. The kit comprises by a defatting gel, different types of peeling gels and a neutralizing gel. The defatting gel is characterized by a markedly enhanced defatting capacity in comparison to the conventional products, because the sebum solubilized by the solvent is strongly adsorbed on the huge surface of the nano-structured material of the gel.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: February 10, 2015
    Assignee: MSB S.R.L.
    Inventor: Mario De Rosa
  • Method of modifying dissolution rate of particles by addition of hydrophobic nanoparticles
    Patent number: 8951541
    Abstract: Method of modifying dissolution rate of a plurality of particles in an aqueous-based solvent by adding hydrophobic surface modified nanoparticles to the plurality of particles, and exposing the plurality of particles to the aqueous-based solvent.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: February 10, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., Haeen Sykora, Rebecca L. A. Everman
  • Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose
    Patent number: 8936795
    Abstract: A liquid embolic material may include a mixture of a first solution comprising between about 1.2% and about 2.5% weight per volume (w/v) carboxymethyl chitosan (CCN) in a first solvent and a second solution comprising between about 1.2% and about 2.5% w/v oxidized carboxymethyl cellulose (OCMC) in a second solvent. The liquid embolic material may be used to embolize a targeted embolization location by mixing the first solution and the second solution to form a liquid embolic material (or hydrogel precursor material), introducing the hydrogel precursor material to a targeted embolization location within a body of a patient, and allowing the CCN and the OCMC to react to form the hydrogel material and embolize the targeted embolization location.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: January 20, 2015
    Assignee: Regents of the University of Minnesota
    Inventors: Jafar Golzarian, Lihui Weng
  • Dural repair material
    Patent number: 8932619
    Abstract: Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as dural repair materials.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: January 13, 2015
    Assignee: Sofradim Production
    Inventors: Sebastien Ladet, Philippe Gravagna, Yves Bayon
  • Cosmetic or dermatological preparations with a content of one or more thiazole derivates
    Patent number: 8920785
    Abstract: Cosmetic or dermatological preparations having an effective content of one or more thiazoles of the general formula.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: December 30, 2014
    Assignee: Beiersdorf AG
    Inventors: Ludger Kolbe, Cathrin Scherner
  • Controlled release pharmaceutical compositions of milnacipran
    Patent number: 8916194
    Abstract: A controlled release pharmaceutical compositions comprising Milnacipran or pharmaceutically acceptable salts thereof is provided. The pharmaceutical composition comprises an immediate release core comprising Milnacipran or pharmaceutically acceptable salts thereof, pharmaceutically acceptable excipients and a coating on the immediate release core comprising rate controlling agents.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: December 23, 2014
    Assignee: Lupin Limited
    Inventors: Shirishkumar Kulkarni, Rajesh Kulkarni, Pandharinath Jadhav, Ashish Tiwari
  • Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
    Patent number: 8916188
    Abstract: The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: December 23, 2014
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Mikael O. Trollsas, Michael H. Ngo, Syed Hossainy, David J. Sherman
  • Polylactic acid/calcium sulfate scaffold
    Patent number: 8911762
    Abstract: The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the composite is a calcium sulfate-polylactic acid composite or porous composite and the composite can be especially used as an in situ pore forming scaffold.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: December 16, 2014
    Assignee: Taipei Medical University
    Inventors: Wei-Chung Yang, Jen-Chang Yang, Duen-Jeng Wang, Sheng-Yang Lee, Yan-Chih Chen
  • Method for preventing or treating skin tumor
    Patent number: 8911713
    Abstract: Methods, compositions and products for preventing skin tumor formation or inhibiting development of an existing skin tumor in a subject are described. The methods involve administering to the subject a composition containing an ?2 adrenergic receptor agonist, such brimonidine.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 16, 2014
    Assignee: Galderma Research & Development
    Inventors: Guy Bouvier, Matthew James Leoni, Michael Graeber