Patent number: 4049645
Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is wherein R.sub.1 and R.sub.2 are members selected from the class consisting of hydrogen, alkyl, aryl, alkenyl and cycloalkyl, respectively containing not more than 10 carbon atoms, and aralykyl and cycloalkylalkyl, respectively containing not more than 15 carbon atoms; and R' is a member selected from the class consisting of 5,6,7,8-tetrahydro-l-naphthyl, 5,6,7,8-tetrahydro-2-naphthyl, 1-naphthyl, 2-naphthyl, 1-naphthyl substituted with halogen, nitro, cyano, hydroxy, alkyl containing not more than 10 carbon atoms, and 2-naphthyl substituted with halogen, nitro, cyano, hydroxy, alkyl containing ot more than 10 carbon atoms.
Type:
Grant
Filed:
March 29, 1976
Date of Patent:
September 20, 1977
Assignees:
Mitsubishi Chemical Industries Limited, Shosuke Okamoto
Inventors:
Shosuke Okamoto, Ryoji Kikumoto, Kazuo Ohkubo, Shinji Tonomura, Yoshikuni Tamao, Tohru Tezuka, Akiko Hijikata