Abstract: The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.
Type:
Grant
Filed:
October 18, 2011
Date of Patent:
September 12, 2017
Assignee:
NOVALIQ GMBH
Inventors:
Bastian Theisinger, Sonja Theisinger, Bernhard Günther
Abstract: Disclosed are compositions that include treated biodiesel glycerin. The disclosed compositions may be utilized as soil-amendments for controlling pests, weeds and for enhancing growth of plants. The biodiesel glycerin utilized in the disclosed compositions may be treated by one or more steps including neutralization, heating, refluxing, condensing, and distilling.
Type:
Grant
Filed:
September 21, 2016
Date of Patent:
September 12, 2017
Assignee:
Auburn University
Inventors:
Rodrigo Rodriguez-Kabana, Robert H. Walker
Abstract: Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders.
Type:
Grant
Filed:
January 9, 2012
Date of Patent:
September 12, 2017
Assignee:
Celgene Corporation
Inventors:
Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
Abstract: A process of preparing a glass comprising: (a) heating a mixture of precursor chemicals to a melt temperature to form a melt, the melt being characterized in that quenching the melt at or above a threshold temperature results in a spinodal phase separation, and quenching the melt below the threshold temperature results in a droplet phase separation; and (b) quenching the melt at or above the threshold temperature in a preheated mold to form the glass composition having the spinodal phase separation.
Type:
Grant
Filed:
October 19, 2016
Date of Patent:
September 12, 2017
Assignee:
Lehigh Universtiy
Inventors:
Himanshu Jain, Roman Holovchak, Matthias M. Falk
Abstract: The invention provides novel compositions of bioactive polypeptides and proteins with improved stability and shelf-life. The compositions are based on liquid vehicles selected from semifluorinated alkanes. These vehicles are remarkably effective in protecting polypeptides and proteins from degradation and/or aggregation. The compositions are useful for topical administration, e.g. into an eye, or by parenteral injection, e.g. via the subcutaneous or intramuscular route.
Type:
Grant
Filed:
January 22, 2013
Date of Patent:
September 12, 2017
Assignee:
NOVALIQ GMBH
Inventors:
Bernhard Günther, Bastian Theisinger, Sonja Theisinger, Dieter Scherer, Clive Wilson, Anthony Pettigrew, Annette Hüttig
Abstract: A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.
Type:
Grant
Filed:
April 21, 2017
Date of Patent:
September 5, 2017
Assignee:
The University of Toledo
Inventors:
E. Ishmael Parsai, Diana Shvydka, Gregory Warrell
Abstract: The invention provides compositions for the inhibition of bacterial adhesion. The composition can include nanocrystalline cellulose (NCC) and a water-soluble polymer, which form an NCC hydrogel in water. The NCC hydrogel can be used to treat or coat devices such as a catheter, whereby the NCC hydrogel inhibits bacterial adhesion to the catheter surface to thereby inhibit biofilm formation and growth of bacteria on the catheter surface. The compositions and devices can thus be useful for inhibiting or preventing conditions such as urinary tract infections.
Type:
Grant
Filed:
June 20, 2014
Date of Patent:
August 29, 2017
Assignee:
The Governors of the University of Alberta
Abstract: An object of the present invention is to provide a bone regeneration material suitable for bone (in particular, alveolar bone) regeneration. The present invention provides a non-woven fabric containing a bone prosthetic material wherein the bone prosthetic material is included between biocompatible fibers that constitute the non-woven fabric. The non-woven fabric may be suitably used as a bone regeneration material (in particular, a dental bone regeneration material).
Abstract: Compositions for the transdermal delivery of methylphenidate in a flexible, finite form are described. The compositions comprise a polymer matrix that includes methylphenidate or a pharmaceutically acceptable salt and at least one acrylic polymer that is non-reactive with methylphenidate. Methods using the compositions to achieve transdermal delivery of methylphenidate or for treating Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD), postural orthostatic tachycardia syndrome, or narcolepsy also are described.
Abstract: A process of treatment of textile materials containing microcapsules of active ingredients, the fibers and/or textile materials resulting from this process and their cosmetic or pharmaceutical use and/or their use as a repellent.
Abstract: A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties.
Abstract: The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
Type:
Grant
Filed:
June 13, 2016
Date of Patent:
May 30, 2017
Assignee:
University of Virginia Patent Foundation
Inventors:
Robert Hendel, William B. Stilley, Shannon P. Williams
Abstract: An apparatus and method for preparing a pharmaceutical for transient application includes a tray having a sealed compartment, a vial of an ophthalmic formulation of mitomycin-C, a diluent carrier containing sterilized water, and a syringe that are all contained together in a single package. The component parts of the apparatus are used together to reconstitute the contents of the vial with the water in the diluent carrier, and then draw the reconstituted drug into the sealed compartment of the tray by a suction force produced by the syringe. In the tray compartment, the reconstituted drug is absorbed in at least one absorbent pad. The absorbent pads may come in multiple shapes and or/sizes. The tray is opened to remove the pad and the absorbed drug from the tray compartment for use of the pad in transient application of the drug.
Abstract: Disclosed are compositions that include treated biodiesel glycerin. The disclosed compositions may be utilized as soil-amendments for controlling pests, weeds and for enhancing growth of plants. The biodiesel glycerin utilized in the disclosed compositions may be treated by one or more steps including neutralization, heating, refluxing, condensing, and distilling.
Type:
Grant
Filed:
October 19, 2015
Date of Patent:
September 27, 2016
Assignee:
Auburn University
Inventors:
Rodrigo Rodriguez-Kabana, Robert H. Walker
Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
September 27, 2016
Assignee:
New Jersey Institute of Technology
Inventors:
Ecevit Bilgili, Rajesh Dave, Anagha Bhakay, Mohammad Azad
Abstract: The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.
Type:
Grant
Filed:
December 11, 2013
Date of Patent:
August 16, 2016
Assignee:
University of Virginia Patent Foundation
Inventors:
Robert Hendel, William B. Stilley, Shannon P. Williams
Abstract: The present invention relates to a pharmaceutical composition for treating hepatitis B virus infection comprising crystalline entecavir as the pharmaceutically active ingredient and one or more pharmaceutically acceptable excipients. The tablet and capsule of the pharmaceutical composition have improved stability compared to that of amorphous entecavir under the conditions of light, high temperature and high humidity.
Type:
Grant
Filed:
April 4, 2014
Date of Patent:
August 9, 2016
Assignee:
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
Abstract: Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
July 5, 2016
Assignee:
PROSIDYAN, INC.
Inventors:
Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
Abstract: Compositions and methods for delivering bioactive agents, such as vitamins, hormones, nutrients and drugs, by stabilizing and or solubilizing these agents in a polymer matrix. The carrier polymers can be used in drug delivery and are useful for delivery of small molecules. The carrier polymers also can be used in scaffolds for regenerative medicine.
Type:
Grant
Filed:
April 19, 2012
Date of Patent:
June 21, 2016
Assignee:
New York University
Inventors:
Jin Kim Montclare, Man Xia Lee, Jennifer Haghpanah
Abstract: Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition.