Patents Examined by David E Gallis
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Patent number: 8088916Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.Type: GrantFiled: March 4, 2005Date of Patent: January 3, 2012Assignee: Denki Kagaku Kogyo Kabushiki KaishaInventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi
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Patent number: 7955824Abstract: The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the intermediates and products.Type: GrantFiled: May 9, 2008Date of Patent: June 7, 2011Assignee: Kosan Biosciences IncorporatedInventors: John R. Carney, Yong Li, Hugo Menzella, Ralph C. Reid
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Patent number: 7915434Abstract: A method for producing propylene oxide comprising a step of reacting hydrogen peroxide with propylene in the presence of an epoxidation catalyst in a liquid phase to produce propylene oxide and a step of recovering a recyclable constituent in a vent gas generated in the above step by absorbing the recyclable constituent in a solvent containing a nitrile.Type: GrantFiled: April 26, 2007Date of Patent: March 29, 2011Assignee: Sumitomo Chemical Company, LimitedInventors: Tateo Seo, Hiroaki Abekawa
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Patent number: 7902381Abstract: The invention relates to preparing derivatives of formula (1), wherein, in particular R1 and R2, identical or different, represent a hydrogen, flourine or chlorine atom, a hydroxy group, an alkyl radical and an alkoxy radical, R3 is an alkyl radical, a hydroxy group, or a methoxy radical, R4 is a hydrogen atom or a methyl radical and R5 and R6, identical or different, represent a hydrogen atom, an alkyl radical, an alkoxy radical, an alkylthio radical, and an alkylamino radical. The inventive method consists in reducing an amid of formula (9).Type: GrantFiled: April 8, 2005Date of Patent: March 8, 2011Assignee: Pierre Fabre MedicamentInventors: Bernard Vacher, Yves Brunel, Florence Castan-Cuisiat
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Patent number: 7888517Abstract: The present invention relates to a process for producing glycidol from glycerol carbonate as a raw material with a high yield. The process for producing glycidol according to the present invention includes the steps of (1) reducing a content of a salt having a weak acidity in glycerol carbonate to 1500 ppm by mass or less; and (2) obtaining the glycidol from the glycerol carbonate.Type: GrantFiled: June 14, 2007Date of Patent: February 15, 2011Assignee: Kao CorporationInventors: Mitsuru Uno, Munehisa Okutsu
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Patent number: 7880023Abstract: A synthesis of an energetic prepolymer used as a high-energy binder for an insensitive and high performance explosive is disclosed. More specifically, provided are a novel compound 2-nitratoethyl oxirane expressed by formula III, a novel compound poly(2-nitratoethyl oxirane) expressed by formula IV, obtained by polymerization of 2-nitratoethyl oxirane used as a monomer and a preparation method thereof. The compound, used as an energetic prepolymer and a monomer for preparation thereof can substitute for existing poly(glycidyl nitrate) (PGN) which has been known to be a promising one having the best performance among existing energetic prepolymers, but which has a problem to be self-decomposed after synthesis of polyurethane elastomer, to solve this problem.Type: GrantFiled: April 28, 2009Date of Patent: February 1, 2011Assignee: Agency for Defense Development A Non Profit Korean OrganizationInventors: Jin Seuk Kim, Jin Rai Cho, Keun Deuk Lee, Jeong-Kook Kim
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Patent number: 7879878Abstract: A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.Type: GrantFiled: December 31, 2008Date of Patent: February 1, 2011Assignee: Astellas Pharma Inc.Inventors: Susumu Watanuki, Yuji Koga, Hiroyuki Moritomo, Issei Tsukamoto, Daisuke Kaga, Takao Okuda, Fukushi Hirayama, Yumiko Moritani, Jun Takasaki
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Patent number: 7880011Abstract: A method of making a compound of formula II comprising the reaction of a compound of formula RCONH2 with a compound of formula III R being a moiety having between 1 and 15 carbon atoms and optionally from 1 to 5 heteroatoms independently selected from oxygen, nitrogen and sulfur, and X and Y being independently selected front the group consisting of H, methyl, ethyl, OMe, OEt, and mixtures thereof; the reaction being performed in a solvent in the presence of a base. The method is useful for the inexpensive manufacture of certain commercially-valuable compounds, including some that have desirable cooling properties.Type: GrantFiled: July 15, 2008Date of Patent: February 1, 2011Assignee: Givandan, S.A.Inventors: Stefan Michael Furrer, David C. Bom, David Max Dastrup, Ioana Maria Ungureanu
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Patent number: 7875570Abstract: A process for producing a titanium-containing silicon oxide catalyst, which comprises the following steps A and B; a catalyst obtainable by the process; and a process for producing an olefin oxide using the catalyst.Type: GrantFiled: November 30, 2005Date of Patent: January 25, 2011Assignee: Sumitomo Chemical Company, LimitedInventor: Jun Yamamoto
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Patent number: 7868191Abstract: The present invention relates to methods for the preparation and purification of mupirocin calcium. The process comprises adsorbing mupirocin to a hydrophobic adsorbent resin, exposing the bound mupirocin to a calcium-containing solution, washing impurities from the resin and eluting purified mupirocin calcium from the resin.Type: GrantFiled: August 29, 2007Date of Patent: January 11, 2011Assignee: Xellia Pharmaceuticals ApSInventor: Lene Aassveen
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Patent number: 7868192Abstract: The present invention relates to a process for producing glycidol from glycerol carbonate by subjecting the glycerol carbonate to decarboxylation reaction in the presence of a solvent containing no active hydrogen. In the process, glycidol can be produced from glycerol carbonate as a raw material of the glycidol with a high selectivity.Type: GrantFiled: July 15, 2009Date of Patent: January 11, 2011Assignee: KAO CorporationInventors: Yuichiro Seki, Tomoaki Sasa, Hiroki Takeuchi, Mitsuru Uno, Masanori Namba
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Patent number: 7863469Abstract: The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure trans-cyclopropane carboxylic acid derivatives, processes for preparing the carboxylic acid derivatives and their use in preparing pharmaceuticals.Type: GrantFiled: August 3, 2007Date of Patent: January 4, 2011Assignee: AstraZeneca ABInventors: Jean-Paul Dejonghe, Koen Peeters, Marc Renard
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Patent number: 7863453Abstract: A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition containing the salt, and a method of treating Gaucher disease.Type: GrantFiled: February 23, 2009Date of Patent: January 4, 2011Assignee: Amicus Therapeutics, Inc.Inventors: Benjamin Mugrage, Kamlesh A. Sheth, David Palling, Philip Rybczynski
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Patent number: 7863468Abstract: The present invention relates to a process for producing propylene oxide comprising (I) reacting propene with hydrogen peroxide in the presence of a catalyst to give a mixture (GI) comprising propylene oxide, unreacted propene, and oxygen; (II) separating propylene oxide from mixture (GI) to give a mixture (GII) comprising propene and oxygen; (III) reducing the oxygen comprised in mixture (GII) at least partially by reaction with hydrogen in the presence of a catalyst comprising Sn and at least one noble metal.Type: GrantFiled: June 20, 2006Date of Patent: January 4, 2011Assignees: BASF Aktiengesellschaft, The Dow Chemical CompanyInventors: Goetz-Peter Schindler, Christian Walsdorff, Reinhard Koerner, Hans-Georg Goebbel
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Patent number: 7863467Abstract: The present invention relates to a method for producing propylene oxide, characterized in that peroxide is reacted with propylene in the presence of a titanosilicate catalyst which has an X-ray diffraction pattern of the values indicated below and is represented by the formula. xTiO2·(1?x)SiO2 (In the formula, x denotes a numerical value of 0.0001 to 0.1.) X-ray diffraction patterns (interplanar spacing of lattice d/?) 13.2±0.6 12.3±0.3 11.0±0.3 9.0±0.3 6.8±0.3 3.9±0.2 3.5±0.1 3.4±0.1.Type: GrantFiled: March 18, 2005Date of Patent: January 4, 2011Assignee: Sumitomo Chemical Company, LimitedInventors: Masaru Ishino, Hiroaki Abekawa
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Patent number: 7863463Abstract: Disclosed herein is a method for purification of dianhydrides comprising a substantial amount (10000 ppm or more) of at least one metal salt. In one aspect the method is useful for the purification of dianhydrides prepared by the reaction of a halophthalic anhydride with a metal carbonate and may be optionally catalyzed by a phase transfer catalyst. The purification of the dianhydrides may be accomplished by hydrolyzing the dianhydride metal salt mixture directly to a tetraacid with an inorganic acid, followed by separating the impurities from an aqueous phase, and subsequently heating the tetraacid to effect ring closure to form a purified dianhydride having less than 50 parts per million metal halide and lower levels of other residual impurities. In one aspect the method is highly effective in removing phase transfer catalyst impurities such as hexalkylguanidinium halides initially present in the dianhydride undergoing purification.Type: GrantFiled: November 22, 2005Date of Patent: January 4, 2011Assignee: Sabic Innovative Plastics IP B.V.Inventors: Eric James Pressman, Albert Santo Stella, Beatriz Peñalver Bernabe, Lioba Maria Kloppenburg, Lee Harris Bergman
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Patent number: 7851633Abstract: Cosmetic or dermatological compositions which comprise at least one piperidinium salt, preferably a 4-[(2-cyclopentyl-2-hydroxyphenylacetyl)oxy]-1,1-dimethyl-piperidinium salt, and the use thereof, particularly as antiperspirants. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.Type: GrantFiled: June 9, 2006Date of Patent: December 14, 2010Assignee: Beiersdorf AGInventors: Michael Woehrmann, Lara Terstegen, Annette Martin, Melanie Sulzberger
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Patent number: 7842809Abstract: The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.Type: GrantFiled: January 23, 2006Date of Patent: November 30, 2010Assignee: Bayer Schering Pharma AGInventors: Wolfgang Schwede, Hans Briem, Hermann Kuenzer, Manfred Husemann, Georg Kettschau, Martina Schaefer, Antonius Ter Laak, Karl-Heinz Thierauch, Stuart James Ince
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Patent number: 7838553Abstract: The present invention is directed to novel benzopyran derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.Type: GrantFiled: August 30, 2006Date of Patent: November 23, 2010Assignee: Janssen Pharmaceutica NVInventors: Xuqing Zhang, Xiaojie Li, Zhihua Sui
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Patent number: 7838695Abstract: The invention relates to a neuroactive substance which is characterised in that it has formula (O), wherein R1, R2, R3 and R4 are identical or different and are methyl or ethyl radicals. Preferably, the neuroactive substance comprises 6S-acetyl-4R,5R-dimethyl-1R(10S)-epoxy-2R-hy-droxy-7R-acetoxydecahydro naphthalene which can be isolated from Rhytisma fulvum cnidaria. The inventive neuroactive substance can be used as a pharmacological reagent in research work and is also suitable for use in the fields of industry (insecticides) and health.Type: GrantFiled: November 25, 2004Date of Patent: November 23, 2010Assignee: Universite de NantesInventors: Karina-Ethel Petit, Jean-Francois Biard, Bruno Lapied, Francoise Grolleau, Alain Hamon