Patents Examined by David E Gallis
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Patent number: 7833498Abstract: Process and apparatus for the continuous preparation of a chemical compound in at least one reactor, where at least one of the reactors is a shell-and-tube reactor which has a shell and at least one internal tube located within the shell, wherein at least one of the internal tubes has, at least in part, a noncircular cross section and a helical configuration in the region in which it is surrounded by the shell.Type: GrantFiled: January 20, 2005Date of Patent: November 16, 2010Assignee: BASF AktiengesellschaftInventors: Hans-Georg Goebbel, Peter Bassler, Joaquim Henrique Teles, Peter Rudolf
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Patent number: 7834043Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.Type: GrantFiled: December 9, 2004Date of Patent: November 16, 2010Assignee: Abbott LaboratoriesInventors: David A. DeGoey, Charles A. Flentge, William J. Flosi, David J. Grampovnik, Dale J. Kempf, Larry L. Klein, Ming C. Yeung, John T. Randolph, Xiu C. Wang, Su Yu
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Patent number: 7829732Abstract: Paper, cotton, corn stover, straw, and wood are converted into furanic products in high yields (based on their cellulose content) using a simple, inexpensive process involving concurrent hydrolysis, dehydration, and substitution reactions coupled with continuous extraction into an organic phase. In a simultaneous process, the hemicellulose fraction of these substrates is converted into furfural, and together these constitute an efficient means for the total exploitation of the carbohydrate content of biomass.Type: GrantFiled: March 16, 2009Date of Patent: November 9, 2010Assignee: Regents of the University of CaliforniaInventor: Mark Mascal
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Patent number: 7825146Abstract: A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a group represented by the formula: R6 is optionally substituted aryl and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof; and a metalloproteinase inhibitor containing them.Type: GrantFiled: July 28, 2004Date of Patent: November 2, 2010Assignee: Shionogi & Co., Ltd.Inventors: Fumihiko Watanabe, Naoki Yoshikawa, Yoshinori Tamura
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Patent number: 7820840Abstract: Disclosed herein is a catalytic method of converting alkenes to epoxides. This method generally includes reacting alkenes with oxygen in the presence of a specific silver catalyst under conditions suitable to produce a yield of the epoxides. The specific silver catalyst is a silver nanocrystal having a plurality of surface planes, a substantial portion of which is defined by Miller indices of (100). The reaction is performed by charging a suitable reactor with this silver catalyst and then feeding the reactants to the reactor under conditions to carry out the reaction. The reaction may be performed in batch, or as a continuous process that employs a recycle of any unreacted alkenes. The specific silver catalyst has unexpectedly high selectivity for epoxide products. Consequently, this general method (and its various embodiments) will result in extraordinarily high epoxide yields heretofore unattainable.Type: GrantFiled: July 7, 2009Date of Patent: October 26, 2010Assignee: The Regents of the University of MichiganInventors: Suljo Linic, Phillip Christopher
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Patent number: 7816545Abstract: The present invention is directed to a process for the preparation of a diastereomerically pure dibenzoyl-L-tartrate salt of a compound of formula (III) and to products of said process.Type: GrantFiled: November 14, 2008Date of Patent: October 19, 2010Assignee: AstraZeneca ABInventors: Rhony Aufdenblatten, Martin Hans Bohlin, Laurent Ducry, Ulrika Lindblad, Mattias Magnusson
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Patent number: 7812038Abstract: A method for the inhibition of the binding of ?4?1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which ?4?1 is involved.Type: GrantFiled: June 14, 2005Date of Patent: October 12, 2010Assignee: Encysive Pharmaceuticals, Inc.Inventors: Ronald J. Biediger, Qi Chen, E. Radford Decker, George W. Holland, Jamal M. Kassir, Wen Li, Robert V. Market, Ian L. Scott, Chengde Wu, Jian Li
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Patent number: 7812184Abstract: [Problem] To provide a production method of optically active epoxy compound, and a complex used for the production method and a production method of the complex. [Means for solving the problem] The skeleton that is necessary for expressing a high catalyst activity of optically active titanium salan complex of formulae (1) and (1?) and the substituent that is useful therefor and the position of the substituent are identified, and it is found that optically active epoxy compounds can be produced with a high enantioselectivity and a high chemical yield compared with a case where the prior optically active titanium salan complex is used. The production method comprises subjecting a prochiral compound (formula (4), (5) or (6)) having carbon-carbon double bond in the molecule to asymmetric epoxidation to produce an optically active epoxy compound (formula (7), (8) or (9)). The present invention relates also to a complex used for the production method and a production method of the complex.Type: GrantFiled: November 8, 2007Date of Patent: October 12, 2010Assignee: Nissan Chemical Industries, Ltd.Inventors: Shoichi Kondo, Kazuhiro Matsumoto, Yuji Sawada, Tsutomu Katsuki
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Patent number: 7803955Abstract: The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble ?-tocopherol metabolite known under the name of ?-CEHC, which is prepared by the acid-catalyzed reaction of condensation of trimethyl hydroquinone with linalool in boiling octane, using n-toluenesulfonic acid or (+)-camphor-10-sulfonic acid as the catalyst. The reaction is carried out for 3 hours at the trimethyl hydroquinone:linalool:catalyst mole ratio of 1:1:0.1. The forming product is acetylated with acetic anhydride in pyridine at room temperature for 0.5 hour, and then ozonized in acetone in the presence of Ba(OH)2, oxidized with Jones' reagent in acetone, and isolated on silica gel column chromatography. Said compound is an acetate derivative of the main ?-tocopherol metabolite—?-CEHC, for which high efficiency has been noted in treating disorders of the central nervous system.Type: GrantFiled: June 15, 2006Date of Patent: September 28, 2010Assignee: Institut Neftekhimii I Kataliza RanInventors: Anna Yulievna Spivak, Viktor Nikolaevich Odinokov, Oxana Valerievna Knyshenko
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Patent number: 7799799Abstract: The present invention is directed to compounds of formula (I): described as novel indolizine derivatives and to a method for their preparation along with pharmaceutical compositions thereof whose substituents are as described in the specification.Type: GrantFiled: May 8, 2008Date of Patent: September 21, 2010Assignee: Sanofi-AventisInventors: Patrick Gautier, David Marchionni, Alain Roccon, Bernard Tonnerre, Jean Wagnon
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Patent number: 7799952Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.Type: GrantFiled: February 10, 2009Date of Patent: September 21, 2010Assignee: ratiopharm GmbHInventors: Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
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Patent number: 7795458Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet) 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.Type: GrantFiled: August 21, 2009Date of Patent: September 14, 2010Assignee: Nippon Chemiphar Co., LtdInventors: Atsushi Tendo, Toshihiro Takahashi, Tomio Yamakawa, Kazuki Okai, Susumu Nihashi
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Patent number: 7790908Abstract: The present invention relates to a process for preparing highly pure glyceryl carbonate by transesterifying dialkyl carbonates or cyclic carbonates in the presence of a basic catalyst.Type: GrantFiled: October 11, 2006Date of Patent: September 7, 2010Assignee: Evonik Roehm GmbHInventors: Bardo Schmitt, Joachim Knebel, Maik Caspari
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Patent number: 7786317Abstract: The present invention provides a process for the epoxidation of propene which comprises reacting propene with hydrogen peroxide in the presence of methanol as solvent and a titanium zeolite catalyst, the process further comprising separating propylene oxide from the reaction mixture to obtain a mixture comprising methanol, water, at least one carboxylic acid and at least one carbonyl compound, wherein the at least one carboxylic acid is at least partially neutralized, said process optionally comprising a hydrogenation stage.Type: GrantFiled: December 18, 2006Date of Patent: August 31, 2010Assignees: BASF Aktiengesellschaft, The Dow Chemical CompanyInventors: Hans-Georg Goebbel, Peter Bassler, Joaquim Henrique Teles, Peter Rudolf, Ulrich Mueller, Anna Forlin, Malte Schulz, Meinolf Weidenbach
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Patent number: 7786136Abstract: The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: January 15, 2008Date of Patent: August 31, 2010Assignee: Theravance, Inc.Inventors: Paul Fatheree, Roland Gendron, Adam A Goldblum, Daniel D Long, Daniel Marquess, S. Derek Turner, Seok-Ki Choi
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Patent number: 7777045Abstract: Process for the preparation of a 2-ethylaminopyridine derivative of general formula (I) or a salt thereof Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (II) or a salt thereof Intermediate of general formula (III)Type: GrantFiled: December 19, 2005Date of Patent: August 17, 2010Assignee: Bayer Cropscience S.A.Inventors: Frédéric Lhermitte, Gilles Perrin-Janet, Paul Dufour, Pierre-Yves Coqueron
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Patent number: 7772397Abstract: This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.Type: GrantFiled: July 21, 2008Date of Patent: August 10, 2010Assignee: University of British ColumbiaInventors: Raymond Andersen, John Coleman, Dilip De Silva, Fangming Kong, Edward Piers, Debra Wallace, Michel Roberge, Theresa Allen
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Patent number: 7767835Abstract: A supported catalyst and a catalyst mixture, useful for the direct epoxidation of olefins, are disclosed. The supported catalyst comprises a noble metal, lead, and a carrier that has been treated by contacting with nitric acid. The catalyst mixture comprises a titanium or vanadium zeolite and the supported catalyst. The invention also includes a process for producing an epoxide comprising reacting an olefin, hydrogen and oxygen in the presence of the catalyst mixture. The process results in significantly reduced alkane byproduct formed by the hydrogenation of olefin.Type: GrantFiled: December 18, 2008Date of Patent: August 3, 2010Assignee: Lyondell Chemical Technology, L.P.Inventor: Roger A. Grey
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Patent number: 7763756Abstract: A method for collecting an object material from a solution, which comprises the following steps: a step of adding a second solvent to a solution composed of an object material to be collected and a first solvent, then mixing therewith to form an emulsion containing the object material in a state under which the emulsion is not uniformly dissolved in the second solvent, in the second solvent; and a step of separating thus obtained emulsion from the solution.Type: GrantFiled: September 16, 2004Date of Patent: July 27, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Shigenori Shiraishi, Shigeru Goto, Masaaki Katao
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Patent number: 7759487Abstract: The present invention discloses a novel process to prepare ketone amides, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 1-(2,4-dimethylpyrimidine-5-carbonyl)-4-piperidone, 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4-piperidone and related compounds. A salient feature of the invention is the use of a three-phase reaction medium with an organic phase and a buffer salt slurry.Type: GrantFiled: January 5, 2006Date of Patent: July 20, 2010Assignee: Schering CorporationInventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Hongbiao Liao