Abstract: Certain substituted 6,7-dihydro-1-oxo-1H,5H-benzo[ij]-quinolizine-2-carboxylic acids and hydrazides, esters, amides and salts thereof, intermediates therefor, and a process for their preparation are described; the compounds are active as anti-microbial agents.

Abstract: 1-Aryl-3,4-dihydro-2(1H)-isoquinolinecarbonyl chlorides, useful in the preparation of the corresponding carboxamides, are described herein. The subject compounds can be prepared by reacting an 1-aryl-3,4-dihydro-2(1H)-isoquinoline with phosgene.

Abstract: The title compound possesses pharmacological activity as an anti-inflammatory agent.

Abstract: This invention relates to new cephalosporanic acid derivatives and pharmaceutically acceptable salts thereof which possess antibacterial activity, pharmaceutical composition of the same and processes for the preparation thereof.

Abstract: 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.

Abstract: A cephalosporanic acid derivative possessing antibacterial activity and pharmaceutically acceptable salts thereof, and processes for preparing same, having the general formula ##STR1## wherein R.sub.1 is hydrogen, aryl or a heterocyclic groupR.sub.2 is pyridyl or styryl, andR.sub.3 is hydrogen, alkylthio or an unsubstituted or alkyl substituted heterocyclic group.

Abstract: Compounds of the formula ##STR1## wherein R is H, heterocyclic thio, pyridinium, carbamoyloxy or acetoxy; Y is H, Cl or Br; and pharmaceutically acceptable salts and esters thereof are effective antibacterial agents.

Abstract: Cationic dyestuffs of the formula ##STR1## IN WHICH R represents alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl or aryl,R.sub.1 represents hydrogen or an alkyl, alkenyl, alkinyl, cycloalkyl or aralkyl radical andAn.sup.- represents an anion, processes for their preparation and their use for dyeing, printing and bulk dyeing of natural and synthetic materials.

Abstract: Derivatives of 7-aminocephalosporanic acid of the formula: ##STR1## wherein the carbon atom marked with an asterisk represents an asymmetry center of the molecule, A represents an aromatic nucleus, preferably phenyl which may be substituted by alkyl having 1-4 carbon atoms, halogen, hydroxy or alkoxy having 1-4 carbon atoms, or a heterocyclic nucleus, preferably 2- or 3-thiophene which may be, for example, substituted by halogen, R represents a hydrogen atom or a straight or branched chain lower alkyl radical, R.sub.1 represents a hydrogen atom, a hydroxy group, an acetoxy or pyridinium group. The invention includes the compounds as such or in the form of separated epimers as well as the corresponding pharmaceutically acceptable salts with alkali or alkaline-earth metals, with suitable organic bases or corresponding suitable organic or inorganic acid addition salts. Also method of preparing same. The compounds have powerful antibacterial action against gram-positive and gram-negative bacteria.

Abstract: This invention discloses new chemical compositions of matter having the formula: ##STR1## wherein A is a saturated or mono unsaturated aliphatic hydrocarbon chain having from 3 to 7 carbon atoms which optionally contains a maximum of three substituents selected from the group consisting of alkyl, alkoxy and halogen; and n is an integer from 1 to 3. This invention further discloses an insecticidal and fungicidal composition which comprises an inert carrier and, as an essential active ingredient, in a quantity toxic to insects and fungi, a compound of the above description; and a method for the control of insects and fungi which comprises applying to the locus of said insects or fungi an insecticidal and fungicidal composition heretofore described.

Abstract: Compounds useful as antiamebic agents are 1-(Ac.sub.1)-5-R-6-(Ac.sub.2 O)-1,2,3,4-tetrahydroquinolines (I), where Ac.sub.1 is haloacetyl, dihaloacetyl or trihaloacetyl with halo being chloro or bromo, R is hydrogen, chloro or bromo, and Ac.sub.2 is hydrogen, Ac.sub.1, alkanoyl having from one to sixteen carbon atoms, benzoyl, 2(or 3)-thenoyl, 2(or 3)-furoyl or N-(lower-alkyl)carbamoyl. Said compounds are prepared: by reacting 1,2,3,4-tetrahydro-6-quinolinol with an acyl halide of the formula Ac.sub.1 -halogen to produce 1-(Ac.sub.1)-1,2,3,4-tetrahydro-6-quinolinol having formula I where R and Ac.sub.2 are each hydrogen, Ac.sub.1 is defined as in formula I and halide is chloride or bromide; by reacting said 1-(Ac.sub.1)-1,2,3,4-tetrahydro-6-quinolinol with a chlorinating or brominating agent to produce the corresponding 1-(Ac.sub.1)-5-chloro(or bromo)-1,2,3,4-tetrahydro-6-quinolinol where Ac.sub.1 is defined as in claim 1; and, by reacting 1-(Ac.sub.

Abstract: 3-Heterothio(formylamino)acetylamino cephalosporin derivatives of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl, furyl, pyridyl or thienyl; R.sub.2 is a five or six membered nitrogen, sulfur and/or oxygen containing heterocyclic ring system; R.sub.3 is lower alkyl, phenyl or phenyl-lower alkyl; and R.sub.4 is hydrogen or lower alkyl; are useful antibacterial agents.

Abstract: 3-Heterothio(.alpha.-thiocarbonylamino)cephalosporin derivatives of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract: Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.

Abstract: 3-Heterothio(.alpha.-thiocarbonylamino)-7.alpha.-methoxycephalosporin derivatives of the general formula ##SPC1##Wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##EQU1## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system, and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract: Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.

Abstract: New cyclopenteno-quinolone derivatives of the formula ##SPC1##WhereinR is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

Abstract: A process for producing a 2-cephem or 3-cephem derivative compound of the formula: ##SPC1##Wherein R.sub.1 represents a substituted or unsubstituted amino radical and R.sub.4 represents hydrogen or a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and the dotted line indicates the alternate bond structure providing 3-cephem or 2-cephem, which comprises:Reacting a halogenated derivative selected from the group consisting of a halogenated penam derivative having the formula: ##SPC2##A halogenated cepham derivative of the formula: ##SPC3##Wherein X represents a halogen atom, R.sub.3 represents a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and R.sub.1 is as defined above, or mixtures thereof with a dehydrohalogenoic acid reagent.

Abstract: Phenoxyacetic acids of the formula ##SPC1##Wherein R.sub.1 is H or alkyl of 1-4 carbon atoms; R.sub.2 is H, or when R.sub.4 is Q, also alkyl of 1-4 carbon atoms; R.sub.3 is methyl, phenyl or chlorophenyl; and R.sub.4 is piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1-R.sub.5 -1,2,3,4-tetrahydro-4-quinolyl, 4-piperidinophenyl, 4-piperidinophenoxy, 1-pyrryl, or Q, wherein R.sub.5 is H or alkyl of 1-4 carbon atoms; and Q is 4-oxo-1,2,3,4-tetrahydroquinolino, 4-hydroxy-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 1-phenyl-1,2,3,4-tetrahydro-4-quinolyl; and the salts thereof, possess cholesterol level-lowering activity.

Abstract: Novel 3-quinoline-carboxamides of the formula ##SPC1##Wherein R is selected from the group consisting of halogen, --CF.sub.3, --OCF.sub.3 and --SCF.sub.3 in the 7- or 8-position, R.sub.1 is selected from the group consisting of hydrogen and acyl of an aliphatic carboxylic acid of 2 to 4 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sub.2 is selected from the group consisting of thiazloyl, pyridinyl and oxazolyl and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic activity and their preparation and novel intermediates.