Patents Examined by David J. Steadman
  • Patent number: 10093937
    Abstract: The invention relates to a recombinant yeast cell, in particular a transgenic yeast cell, functionally expressing one or more recombinant, in particular heterologous, nucleic acid sequences encoding ribulose-1,5-biphosphate carboxylase oxygenase (Rubisco) and phosphoribulokinase (PRK). The invention further relates to the use of carbon dioxide as an electron acceptor in a recombinant chemotrophic micro-organism, in particular a eukaryotic micro-organism.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: October 9, 2018
    Assignee: TECHNISCHE UNIVERSITEIT DELFT
    Inventors: Antonius Jeroen Adriaan Van Maris, Jacobus Thomas Pronk, Victor Gabriel Guadalupe Medina, Hendrik Wouter Wisselink
  • Patent number: 10066251
    Abstract: The present invention relates to isolated polypeptides having catalase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: September 4, 2018
    Assignee: Novozymes Inc.
    Inventors: Ye Liu, Junxin Duan, Yu Zhang, Lan Tang
  • Patent number: 10059932
    Abstract: An object is to provide a mutant of a cellulase-producing microorganism which produces a cellulase capable of preferentially producing a cello-oligosaccharide during the selective production of the cello-oligosaccharide through enzymolysis of a cellulosic material in the presence of the cellulase, a method for producing the cellulase and a method for producing a cello-oligosaccharide using the cellulase. The present invention relates to a mutant of a cellulase-producing microorganism, in which cellobiohydrolase and ?-glucosidase genes are disrupted.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 28, 2018
    Assignees: NAGAOKA UNIVERSITY OF TECHNOLOGY, INPEX CORPORATION
    Inventors: Wataru Ogasawara, Takashi Yamaguchi, Yosuke Shida, Yoshiro Ishii, Tatsuki Wakayama, Yoshiro Konda
  • Patent number: 9827205
    Abstract: The invention provides a composition comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose. The invention further provides methods for treating wounds by administering the novel microparticle composition.
    Type: Grant
    Filed: December 12, 2009
    Date of Patent: November 28, 2017
    Assignees: Mallinckrodt Pharma IP Trading D.A.C., Quadrant Drug Delivery Limited
    Inventors: Nicola Whitfield, Jaap Koopman, Jos Grimbergen
  • Patent number: 9828613
    Abstract: An acyl-ACP thioesterase consisting of an amino acid sequence of the 72nd to 233rd amino acids set forth in SEQ ID NO: 1, an acyl-ACP thioesterase gene encoding the protein, a transformant having the gene, and a method of producing a lipid using the transformant.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: November 28, 2017
    Assignee: Kao Corporation
    Inventor: Tatsuro Ozaki
  • Patent number: 9822350
    Abstract: The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: November 21, 2017
    Assignee: Novozymes Inc.
    Inventor: Nikolaj Spodsberg
  • Patent number: 9814764
    Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: November 14, 2017
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Michael F. Concino, Pericles Calias, Jing Pan, Kevin Holmes, Paolo Martini, Alla Romashko, Muthuraman Meiyappan, Bohong Zhang, Andrea Iskenderian, Dianna Lundberg, Angela Norton, Bettina Strack-Logue, Huang Yan, Mary Alessandrini, Richard Pfeifer
  • Patent number: 9802993
    Abstract: The present invention provides a cell capable of high-yield production of polypeptides and a method for producing the same. The present invention relates to a method for producing a cell capable of high-yield production of a desired polypeptide, wherein a strongly taurine transporter-expressing cell into which DNA encoding the desired polypeptide has been introduced is cultured in the presence of a high concentration of methotrexate and a cell capable of high-yield production of the desired polypeptide is selected from among surviving cells.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: October 31, 2017
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hisahiro Tabuchi, Tomoya Sugiyama
  • Patent number: 9803182
    Abstract: The present invention provides ionic liquid-tolerant cellulases and method of producing and using such cellulases. The cellulases of the invention are useful in saccharification reactions using ionic liquid treated biomass.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: October 31, 2017
    Assignees: The Regents of the University of California, Sandia Corporation
    Inventors: John Gladden, Joshua Park, Steven Singer, Blake Simmons, Ken Sale
  • Patent number: 9796994
    Abstract: A method for producing a nuclease of a gram negative bacterium or a nuclease preparation containing a nuclease of a gram negative bacterium including expression of the nuclease in a gram positive bacterium and subsequent secretion of the nuclease, as well as a nuclease or a nuclease preparation that can be obtained by this method.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: October 24, 2017
    Assignee: c-LEcta GmbH
    Inventors: Thomas Greiner-Stoeffele, Stefan Schoenert
  • Patent number: 9783789
    Abstract: This invention relates generally to the discovery of novel recombinant forms of ?-hexosyl-transferases (BHT) and uses thereof to produce galacto-ligosaccharides (GOS) or as food additives.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: October 10, 2017
    Assignee: North Carolina State University
    Inventors: Jose M. Bruno-Barcena, Suzanne Dagher, Maria Azcarate-Peril
  • Patent number: 9771604
    Abstract: A genetically engineered yeast cell with enhanced activity of an EDC protein compared to that of a parent cell and capability of producing lactate, a method of producing the yeast cell, and a method of producing lactate by using the yeast cell.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: September 26, 2017
    Assignee: SAMSUN ELECTRONICS CO., LTD.
    Inventors: Wooyong Lee, Soyoung Lee, Jiyoon Song, Kwangmyung Cho
  • Patent number: 9765409
    Abstract: The present invention relates to isolated polypeptides having dextranaseactivity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: September 19, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Sara Landvik, Lorena G. Palmen, Thiago O. Basso, Eduardo Alberto Borges Da Silva
  • Patent number: 9765104
    Abstract: Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five ?-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D3, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: September 19, 2017
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Venkata Sai Prakash Chaturvedula, Oliver Yu
  • Patent number: 9752132
    Abstract: Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: September 5, 2017
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver
  • Patent number: 9752136
    Abstract: The present invention relates to novel polypeptides derived from endolysins from a bacteriophage of Clostridium perfringens and to nucleic acid molecules encoding the same, as well as compositions thereof. The invention also provides uses of such polypeptides and nucleic acid molecules in the diagnosis and treatment of conditions and diseases associated with microbial cells such as Clostridium perfringens. In particular, the invention provides a polypeptide having endolysin activity derived from bacteriophage ?CP51 of Clostridium perfringens and uses thereof.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: September 5, 2017
    Assignee: PLANT BIOSCIENCE LIMITED
    Inventors: Melinda Mayer, Arjan Narbad
  • Patent number: 9745603
    Abstract: Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: August 29, 2017
    Assignee: Intrexon Corporation
    Inventors: William J. Coleman, Genevieve M. Vidanes, Guillaume Cottarel, Sheela Muley, Roy Kamimura, Akbar F. Javan, Jianping Sun, Eli S. Groban
  • Patent number: 9725707
    Abstract: A protein comprising a polypeptide sequence having at least 70% sequence identity to SEQ ID NO:6, SEQ ID NO:2 or SEQ ID NO:4. The protein has ketose 3-epimerase activity.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: August 8, 2017
    Assignee: TATE & LYLE INGREDIENTS AMERICAS LLC
    Inventors: Ryan David Woodyer, Richard W. Armentrout
  • Patent number: 9719112
    Abstract: The present invention relates to beta-glucosidase that is mutated to have enhanced activity, and a method for producing bioethanol using the same. More particularly, the present invention relates to a polynucleotide encoding beta-glucosidase that is mutated to have enhanced activity, beta-glucosidase expressed from the polynucleotide, an expression vector including the polynucleotide, a transformant that is transformed with the expression vector, a method for producing the mutated beta-glucosidase using the transformant, and a method for producing bioethanol using the transformant. The mutant beta-glucosidase of the present invention increases production of glucose much more than the conventional beta-glucosidase, and thus it can be widely used for economic production of bioethanol.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: August 1, 2017
    Assignee: KOREA RESEARCH INSITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Jung Hoon Sohn, Hyun Jin Kim, Chul Ho Kim, Ji Hun Seomoon, Bong Hyun Sung, Kwang Mook Lim, Mi Jin Kim, Jong Hyun Kim
  • Patent number: 9708587
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: July 18, 2017
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore