Patents Examined by Deborah C. Lambkin
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Patent number: 7199251Abstract: The invention relates to a novel process for the production of linear organic thiophene-phenylene oligomers represented by the following general formula (I), The process involves reacting (e.g., by means of a Suzuki coupling reaction) a compound represented by the following general formula (II), with a formula represented by the following general formula (III), The reaction may be conducted optionally in the presence of catalysts, optionally in a solution and/or optionally at elevated temperature. The linear organic thiophene-phenylene oligomers of the present invention may be used to form semi-conductive coatings.Type: GrantFiled: November 9, 2004Date of Patent: April 3, 2007Assignee: H.C. Starck GmbH & Co. KGInventors: Stephan Kirchmeyer, Sergei Ponomarenko
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Patent number: 7196207Abstract: A method for reducing a sulfur-containing compound by hydrogenation using a noble metal catalyst which method is exemplified by an industrial method for producing a 2-alkyl-3-aminothiophene derivative with high economical efficiency by hydrogenating a 2-alkenyl-3-aminothiophene derivative using the noble metal catalyst. 2-Alkyl-3-aminothiophene derivatives are useful compounds in the fields of medicine and agriculture, and in particular, useful in bactericides for agriculture or gardening, or intermediates of the bactericides. The hydrogenation reaction temperature is controlled at 150° C. to 300° C. and the method allows the used noble metal catalyst to be recovered and reused.Type: GrantFiled: July 22, 2003Date of Patent: March 27, 2007Assignee: Mitsui Chemicals, Inc.Inventors: Daisuke Ura, Hiroyuki Katsuta, Toshio Kitashima, Kenichi Sato
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Patent number: 7196103Abstract: The present invention is directed to the compound of formula I which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as for inhibiting the formation of thrombin or for therapeutically or prophylactically treating a patient suffering from, or subject to, or associated with a disease state associated with a cardiovascular disorder.Type: GrantFiled: May 19, 2004Date of Patent: March 27, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: Marc Nazare, Volkmar Wehner, Kurt Ritter, Volker Laux
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Patent number: 7196114Abstract: Substituted 3-(benzoylureido)thiophene derivatives, processes for preparing them and their use The invention relates to compounds of the formula I where the radicals are as defined, and their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.Type: GrantFiled: February 17, 2004Date of Patent: March 27, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: Karl Schoenafinger, Elisabeth Defossa, Erich Von Roedern, Dieter Kadereit, Andreas Herling, Hans-Joerg Burger, Thomas Klabunde, Karl-Ulrich Wendt
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Patent number: 7196206Abstract: The invention relates to asymmetrical linear organic oligomers represented by the following formula (I), X—R1ArnR2 ??(I) in which n is from 4 to 10, Ar is for example an optionally substituted 2,5-thienylene group, R1 is for example a C10–C20 alkylene group, R2 is for example a C1–C12 alkyl group, and X is for example a vinyl group or an alkoxysilyl group. Also described is a process for the production of such organic oligomers, and semiconductors in electronic modules that include such organic oligomers.Type: GrantFiled: November 9, 2004Date of Patent: March 27, 2007Assignee: H.C. Starck GmbH & Co. KGInventors: Stephan Kirchmeyer, Sergei Ponomarenko, Marcus Halik
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Patent number: 7192535Abstract: It is intended to provide a novel material having no absorption or low absorption intensity in the visible region and to provide an electroluminescent device excellent in hole injection characteristic by using the novel material. A novel organic material wherein two electron abundant aromatic rings inherently having a low ionization potential, such as a thiophene ring, a furan ring, and pyrrol ring, is intervened by a conjugated substituent such as a phenylene ring is provided. The electroluminescent device having an excellent hole injection characteristic is provided by using this novel organic material.Type: GrantFiled: March 12, 2004Date of Patent: March 20, 2007Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Takako Takasu, Hiroko Yamazaki, Satoshi Seo, Ryoji Nomura, Hideko Inoue
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Patent number: 7189854Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.Type: GrantFiled: May 26, 2005Date of Patent: March 13, 2007Assignee: Bristol-Myers Squibb CompanyInventors: Jagabandhu Das, Ping Chen, Derek J. Norris
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Patent number: 7186746Abstract: Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.Type: GrantFiled: August 27, 2003Date of Patent: March 6, 2007Assignee: Merck & Co., Inc.Inventors: John J. Acton, III, Sheryl D. Debenham, Kun Liu, Peter T. Meinke, Harold B. Wood, Regina M. Black
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Patent number: 7186845Abstract: Dispersion of filler(s) in polymeric compositions are improved by the use of a polymer-filler coupling compound, Q—A—B, wherein Q comprises a dipolar nitrogen-containing moiety that can form a 1,3 dipolar addition to an unsaturated carbon-carbon bond; B is an oxazoline, thiazoline, alkoxysilane or allyltin moiety, and A is a linking atom or group that forms a bridge between Q and B.Type: GrantFiled: October 20, 2004Date of Patent: March 6, 2007Assignee: Bridgestone CorporationInventors: Yasuo Fukushima, Russell W. Koch, William L. Hergenrother, Shunji Araki
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Patent number: 7186745Abstract: This invention relates to the use of compounds of Formula (I) as vascular damaging agents: wherein X is selected from: —O—, —S—, —S(O)—, —S(O2)—, —N(R5)—, —C(O)—, —C(O)N(R5)—, —N(R5)C(O)—, —S(O2)N(R5)—, or —N(R5)S(O2)—; R1 is independently selected from: amino, halo, hydroxy, —OPO3H2, C1-4alkyl, or C1-4alkoxy, wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; R2 is selected from: hydrogen or C1-4alkyl; R3 is selected from: hydrogen, halo, hydroxy, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, carboxy, carboxyC1-4alkyl, C1-4alkanoyl, C1-4alkanoylC1-4alkyl, carbamoyl, carbamoylC1-4alkyl, C1-4alkoxy, C1-4alkoxycarbonyl, C1-4alkoxycarbonylC1-4alkyl, C1-4alkoxycarbonylamino, amino, N—C1-4alkylamino, NN-diC1-4alkylamino, aminoC1-4alkyl, N—C1-4alkylaminoC1-4alkyl, NN-diC1-4alkylaminoC1-4alkyl, ureido, or C1-4alkylureyleno; R4 is independently selected from: C1-4alkyl, C1-4alkoxy or halo; R5 is selected from: hydrogen or C1-4alkyl; n is 0 or 1; p isType: GrantFiled: March 4, 2002Date of Patent: March 6, 2007Assignee: AstraZeneca ABInventor: Jean-Claude Arnould
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Patent number: 7186844Abstract: A method for producing a cyclic carbamate ester produces the cyclic carbamate ester by reacting an organic compound having at least two halogen atoms per molecule, an amine having at least two hydrogen atoms on a nitrogen atom, and carbon dioxide.Type: GrantFiled: January 3, 2005Date of Patent: March 6, 2007Assignee: Mitsubishi Gas Chemical Co., Inc.Inventor: Kazuto Ikemoto
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Patent number: 7183310Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.Type: GrantFiled: August 10, 2004Date of Patent: February 27, 2007Assignee: Allergan, Inc.Inventors: Yariv Donde, Robert M. Burk, Michael E. Garst
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Patent number: 7183419Abstract: A process for the production of 3,4-dioxythiophene compounds represented by the following formula (I), is described. In formula (I) A, B, C and D in each case independently denote a bond, optionally substituted alkylene, optionally substituted cycloalkylene, optionally substituted arylene or (O—(CR1R2)m)x, where R1 and R2 in each case mutually independently denote hydrogen or optionally substituted alkyl, m denotes an integer from 1 to 10 and x denotes an integer from 1 to 10, provided that at least one of the units A, B, C or D does not denote a bond. The process involves reacting a 3,4-dihydroxythiophene or the alkali metal salt thereof with the following compound, TosO-A-B-C-D-OTos, thus forming an intermediate 3,4-dioxythiophene diester. The intermediate 3,4-dioxythiophene diester is saponified, thus forming an intermediate 3,4-dioxythiophene dicarboxylic acid, which is then decarboxylated, thereby forming the 3,4-dioxythiophene compound represented by formula-(I).Type: GrantFiled: December 14, 2004Date of Patent: February 27, 2007Assignee: H.C. Starck GmbH & Co. KGInventors: Helmut-Werner Heuer, Rolf Wehrmann
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Patent number: 7183311Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-? phosphorylation of I?B. In yso doing these aminothiophene inhibitors block pathological activation of transcription factor NF-?B in which diseases excessive activation of NF-?B is implicated.Type: GrantFiled: April 11, 2003Date of Patent: February 27, 2007Assignee: SmithKline Beecham CorporationInventors: James F. Callahan, Yue H. Li
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Patent number: 7183324Abstract: Disclosed herein are compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein Y, A, B, J, and E are further described. Methods, compositions, and medicaments related thereto are also disclosed.Type: GrantFiled: November 23, 2004Date of Patent: February 27, 2007Assignee: Allergan, Inc.Inventors: Yariv Donde, Mark Holoboski, Mari F. Posner, Robert M. Burk, Michael E. Garst
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Patent number: 7183418Abstract: The invention relates to novel mono-, oligo and poly[2,3-b]-thienothiophenes, their use as semiconductors or charge transport materials, in optical, electro-optical or electronic devices like for example liquid crystal displays, optical films, organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in photovoltaic and sensor devices, and to a field effect transistor, light emitting device or ID tag comprising the novel polymers.Type: GrantFiled: August 30, 2004Date of Patent: February 27, 2007Assignee: Merck Patent GesellschaftInventors: Martin Heeney, Iain McCulloch, Clare Bailey
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Patent number: 7183275Abstract: The present invention relates to 2-imino-1,3-thiazine derivatives, in specific, 2-imino-1,3-thiazine derivatives having a selective antagonistic activity or agonistic activity to a cannabinoid type 2 receptor and their pharmaceutical use.Type: GrantFiled: October 26, 2004Date of Patent: February 27, 2007Assignee: Shionogi Co., Ltd.Inventors: Koji Hanasaki, Takami Murashi, Hiroyuki Kai
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Patent number: 7179836Abstract: Thiophene derivatives are described herein. The described invention also includes methods of making such thiophene derivatives as well as methods of using the same in the treatment of diseases.Type: GrantFiled: September 20, 2002Date of Patent: February 20, 2007Assignee: SmithKline Beecham CorporationInventors: Jerry Leroy Adams, Domingos J Silva
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Patent number: 7179923Abstract: Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonylaminocarbonyl group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a carbonylimino-containing connector group. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.Type: GrantFiled: November 12, 2004Date of Patent: February 20, 2007Assignee: 3M Innovative Properties CompanyInventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. I. Moore, Rahul R. Shah
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Patent number: 7169955Abstract: Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants: wherein X1 is H, halogen, formyl, optionally halogenated (C1–C6) alkyl, (C1–C6) alkylthio, or the like; X2 is H, halogen, formyl, hydroxyl, (C1–C6) alkyl, —C(?O)—R1 (wherein R1 is H, halogen, hydroxyl, (C1–C6) alkyl, or NR2R3, with R2 and R3 being each H, C1-6 alkyl, or the like), or the like; X3 is H, halogen, hydroxyl, cyano, isocyanate, hydrazino, diazo, —C(?O)—R1, —SO2—R4 (wherein R4 is halogen, hydroxyl, (C1–C6) alkyl, or NR5R6, with R5 and R6 being each H or (C1–C6) alkyl), or the like; and X4 is H, halogen, (C1–C6) alkyl, or (C1–C6) alkoxy, with publicly known compounds being excepted.Type: GrantFiled: October 22, 2004Date of Patent: January 30, 2007Assignee: Nihon Nohyaku Co., Ltd.Inventors: Masanobu Onishi, Kenichi Ikeda, Takashi Shimaoka, Masanori Yoshida