Patents Examined by Deborah Lambkin
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Patent number: 5389685Abstract: The color-stability of disinfectant formulations comprising bacteriocidal quaternary amine compounds, a non-ionic surfactant, and water is enhanced significantly by adding color-stabilizing amounts of an alkali bicarbonate. An alkali bicarbonate can be used in lieu of the art-accepted EDTA/NaOH builder in quaternary amine-based disinfectant formulations to enhance color stability without sacrificing the bacteriocidal efficacy of the formulations.Type: GrantFiled: June 10, 1993Date of Patent: February 14, 1995Assignee: Huntington Laboratories, Inc.Inventors: Kim Smith, Fred Boyd
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Patent number: 5380925Abstract: Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cyclic amino acid is treated with (-)cinchonidine and the resulting salt resolved into the desired enantiomers, as well as derivatives thereof and valuable intermediates used in the process.Type: GrantFiled: August 20, 1993Date of Patent: January 10, 1995Assignee: Warner-Lambert CompanyInventors: Vladimir Beylin, Huai G. Chen, Om P. Goel, Mark E. Marlatt, John G. Topliss
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Patent number: 5380878Abstract: This invention relates to a process for producing a compound represented by formula (6a) or (6b): ##STR1## wherein R.sup.2 represents a hydrogen atom or a hydroxyl-protecting group and R.sup.4 and R.sup.5, which may be the same or different, represents lower alkyl groups, using a compound represented by formula (2a) or (2b) obtained by preferential crystallization: ##STR2## and also to a compound represented by the following formula (7) which is an intermediate useful for producing the compound of formula (6a) or (6b): ##STR3## wherein R.sup.1 represents a group represented by formula (8): ##STR4## wherein R.sup.2 and R.sup.3 is as defined above and R.sup.3 represents a hydrogen atom, a group or a carboxyl protecting group represented by formula (9): ##STR5## or a group represented by formula (10): ##STR6## wherein R.sup.2 is as defined above.Type: GrantFiled: March 29, 1994Date of Patent: January 10, 1995Assignee: Toyama Chemical Co., Ltd.Inventors: Joji Nakano, Nobuhisa Taya, Hisaaki Chaki, Tetsuo Yamafuji, Kaishu Momonoi
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Patent number: 5380452Abstract: A cleaning composition which comprises approximately by weight 2 to 35% of at least one unsaturated fatty acid having about 8 to 24 carbon atoms; 0.01 to 1.5% of a trialkanolamine; 0.01 to 1.5% of an alkanol having about 1 to about 5 carbon atoms; 1 to 5.0% of an alkali metal hydroxide; 0.02 to 2.0% of an amine oxide; 0.02 to 2.0% of a sultaine; and the balance being water.Type: GrantFiled: November 15, 1993Date of Patent: January 10, 1995Assignee: Colgate Palmolive Co.Inventors: Claude Blanvalet, Mary C. Brauchli, Jolanta Dautas, Constance A. Marchese
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Patent number: 5380749Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.Type: GrantFiled: March 23, 1994Date of Patent: January 10, 1995Assignee: Sterling Winthrop Inc.Inventors: Theodore C. Miller, Joseph C. Collins, Kenneth C. Mattes, Mark P. Wentland, Robert B. Perni, Thomas H. Corbett, Joseph W. Guiles
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Patent number: 5374607Abstract: Phytopharmaceutical wettable powder comprising at least one phytopharmaceutical active substance which is solid at ambient temperature and at least one pulverulent inert filler, characterized by the fact that the constitutive particles of the filler constitute a support or carrier for the active substance comprised within a liquid composition, said active substance being selected from the group comprising:the esters of the family of the parahydroxybenzonitriles of the group comprising bromoxynil octanoate, bromoxynil heptanoate, bromoxynil butyrate, ioxynil octanoate, ioxynil heptanoate, ioxynil butyrate,the triazines of the group comprising simazine, atrazine and ametryne,the dinitroanilines of the group comprising butraline, pendimethaline, trifluraline, orizaline,the substituted ureas of the group comprising diuron, isoproturon, ethidimuron,the sulphonylureas of the group comprising especially chlorsulfuron.Type: GrantFiled: January 3, 1994Date of Patent: December 20, 1994Assignee: C F P IInventors: Joseph Schapira, Jacques Schild, Jacques Pecheur, Ange C. Guerin, Dominique Ambrosi, Jean-Jacques Fuchs, Bernard Guyenet
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Patent number: 5371240Abstract: 3-substituted thiophene compounds contaminating the analogous 2-substituted thiophene compounds, e.g. 3-acetylthiophene contaminating 2-acetyl thiophene, are removed by a selective electrophilic substitution process, e.g. bromination, followed by fractional distillation. It has been found that electrophilic substitution as exemplified by bromination is highly selective towards the 3-substituted thiophenes, yielding compounds of significantly higher molecular weights for separation purposes, to give high purity 2-substituted thiophene compounds.Type: GrantFiled: November 30, 1992Date of Patent: December 6, 1994Assignee: Torcan Chemical Ltd.Inventor: Clarke Slemon
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Patent number: 5364830Abstract: Pressure or heat sensitive record materials with color-former sublimation problems reduced or eliminated whilst not reducing the color forming capability per unit weight of color former by providing what are in effect dimers of vinyl carbinols, with the vinyl carbinol residues, linked through the aryl groups of a diaryl amine.Type: GrantFiled: March 19, 1993Date of Patent: November 15, 1994Assignee: The Wiggins Teape Group LimitedInventors: Ivan Sheiham, Margaret P. Templey
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Patent number: 5363593Abstract: The present invention discloses a synthetic cultivation medium comprised of fibrous glomerates and a method for manufacturing the same. Absent a soil component, the synthetic cultivation medium is manufactured from scrap, man-made textiles, chiefly those made from polyacrylonitrile or polyester fibers. In manufacturing the cultivation medium, scrap textiles are shredded into short fibers and chemically refined and bleached. Prior or subsequent to the chemical refinement and bleaching, the short fibers are agitated into glomerates of intertwined fibers.Type: GrantFiled: August 12, 1992Date of Patent: November 15, 1994Inventor: Glint Hsh
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Patent number: 5360934Abstract: This invention relates to an improved hydrogenation process wherein aromatic amines are hydrogenated to their ring hydrogenated counterparts. These aromatic amines are presented by the formulas: ##STR1## wherein R is hydrogen or C.sub.1-6 aliphatic, R1 and R2 are hydrogen or C.sub.1-6 aliphatic, A is C.sub.1-4 or NH; n is 0-2, x is 1-3 and y is 1 to 2 except the sum of the y groups in Formula I may be 1. The improvement resides in the utilization of a catalyst comprising rhodium carried on a support of kappa, theta or delta alumina.Type: GrantFiled: June 25, 1993Date of Patent: November 1, 1994Assignee: Air Products and Chemicals, Inc.Inventors: Gamini A. Vedage, John N. Armor
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Patent number: 5356621Abstract: A method of attracting flies of the Muscidae or Muscinae families comprising providing in a locus where the flies exist a fly attractant composition which contains as an active ingredient a composition extracted from a bamboo with an extractive solvent such as water or C.sub.1 -C.sub.4 alcohol.Type: GrantFiled: February 10, 1993Date of Patent: October 18, 1994Assignee: Sankyo Company, LimitedInventors: Yuichiro Tabaru, Akio Saito
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Patent number: 5350748Abstract: 3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described.The same benzo[b]thiophene and benzofuran-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected mammals.Type: GrantFiled: August 18, 1993Date of Patent: September 27, 1994Assignee: Warner-Lambert CompanyInventors: Diane H. Boschelli, David T. Connor, James B. Kramer, Paul C. Unangst
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Patent number: 5346917Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.Type: GrantFiled: April 8, 1993Date of Patent: September 13, 1994Assignee: Sterling Winthrop Inc.Inventors: Theodore C. Miller, Joseph C. Collins, Kenneth C. Mattes, Mark P. Wentland, Robert B. Perni, Thomas H. Corbett, Joseph W. Guiles
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Patent number: 5334628Abstract: Amine derivatives having the general formula (I): ##STR1## wherein X is selected from the group consisting of ##STR2## wherein Q is oxygen, sulfur or nitrogen atom, and ##STR3## wherein Q is as above; Y is selected from the group consisting of ##STR4## R.sup.1 is hydrogen atom or an alkyl group; R.sup.2 is hydrogen atom or an alkyl group; R.sup.3 is hydrogen atom, a halogen atom or an alkyl group; R.sup.4 hydrogen atom, an alkyl group, a cycloalkyl group, a halogenated alkyl group or a halogen atom; R.sup.5 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro group or hydroxy group; R.sup.5 is attached to an arbitrary position of X, and R.sup.3 or R.sup.4 is attached to an arbitrary position of Y.The amine derivatives (I) are useful as fungicides.Type: GrantFiled: December 31, 1992Date of Patent: August 2, 1994Assignee: Kaken Pharmaceutical Co., Ltd.Inventors: Tetsuya Maeda, Toshiyuki Yamamoto, Mituo Takase, Kazuya Sasaki, Tadashi Arika, Mamoru Yokoo, Rieko Hashimoto, Kouji Amemiya, Sakae Koshikawa
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Patent number: 5331007Abstract: There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano;R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl;R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ;R.sub.3 represents hydrogen or C1 to 6 alkyl;in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl;or a pharmaceutically acceptable salt thereof.Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.Type: GrantFiled: July 20, 1992Date of Patent: July 19, 1994Assignee: Fisons CorporationInventors: Ronald C. Griffith, James J. Napier
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Patent number: 5314910Abstract: 2-Heteroaromatic alkanoate esters which are useful as inhibitors of human leukocyate or neutrophil elastase.Type: GrantFiled: January 19, 1993Date of Patent: May 24, 1994Assignee: Cortech Inc.Inventors: Gary P. Kirschenheuter, Raymond T. Cunningham, John C. Cheronis
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Patent number: 5312798Abstract: There is disclosed a herbicidal composition comprising as active ingredients a herbicidally effective amount of (a) an iminothiazoline compound of the formula: ##STR1## wherein R.sup.1 is halogen, halo(C.sub.1 -C.sub.2)alkyl, halo(C.sub.1 -C.sub.2)alkoxy or halo(C.sub.1 -C.sub.2)alkylthio; R.sup.2 is C.sub.1 -c.sub.2 alkyl, chroline, bromine or iodine; R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.3 -C.sub.6 cycloalkoxy or C.sub.1 -C.sub.6 alkoxy, all of which are optionally substituted with at least one substituent selected from halogen, C.sub.1 -C.sub.2 alkyl and C.sub.1 -C.sub.2 alkoxy; R.sup.4 is hydrogen or halogen; and (b) at least one of herbicidal triazine compounds, herbicidal uracil compounds, herbicidal urea compounds, herbicidal dinitro aniline compounds, norflurazon, dimethazon, imazaquin and imazethapyr. Also disclosed is a method for controlling undesired weeds by use of the herbicidal composition.Type: GrantFiled: September 11, 1992Date of Patent: May 17, 1994Assignee: Sumitomo Chemical Company, LimitedInventors: Shinichi Kawamura, Izumi,Keiichi, Junichi Sato, Yuzuru Sanemitsu, Ryo Sato, Tatsuhiro Hamada, Hideyuki Shibata
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Patent number: 5310763Abstract: Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a C.sub.1 -C.sub.6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl, (C.sub.1 -C.sub.6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R.sup.1 represents SR.sup.x, wherein R.sup.x represents a group: ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl(C.sub.1 -C.sub.6)alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl or cycloalkenyl(C.sub.1 -C.sub.6)alkyl group;R.sup.3 represents an amino acid residue with R or S stereochemistry or a C.sub.1 -C.sub.6 alkyl, benzyl, (C.sub.1 -C.sub.6 alkoxy)benzyl or benzyloxy(C.sub.1 -C.sub.6 alkyl) group;R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group;R.sup.5 represents a hydrogen atom or a methyl group;n is an integer having the value 0, 1 or 2; andA represents a C.sub.1 -C.sub.6 hydrocarbon chain, optionaly substituted with one or more C.sub.1 -C.sub.Type: GrantFiled: April 14, 1993Date of Patent: May 10, 1994Assignee: British Bio-technology LimitedInventors: Colin Campion, Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
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Patent number: 5303503Abstract: A fertilization and irrigation system including a hollow tubular fiber conduit having a liquid permeable wall for nitrogen fertilizing and irrigating soil. The conduit or length of this tubular material is placed within the soil generally in the vicinity of the root level of plants to be irrigated. For nitrogen fertilization, ammonium hydroxide (NH.sub.4 OH) is introduced into the conduit, the ammonia (NH.sub.3) then allowed to permeate through the conduit wall into the soil. The presence of ammonium hydroxide may be by circulation or held statically under a varying amount of static head pressure. The ammonium hydroxide interacts to dissolve plasticizer within the hollow fiber conduit so that the plasticizer will thereafter go into colloidal suspension within water and carried away. By removal of plasticizer in this manner, both fertilization efficiency and the water permeability of the conduit for subsequent irrigation of the plants and soil are increased significantly.Type: GrantFiled: October 22, 1993Date of Patent: April 19, 1994Inventor: James A. Patterson
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Patent number: 5300688Abstract: This invention relates to the preparation of hydrazide or hydrazine compounds. More particularly, this invention relates to an efficient method for the preparation of substituted hydrazides, hydrazines, and intermediates therefor, from urea starting products. Such hydrazide and hydrazine compounds are useful as insecticides.Type: GrantFiled: November 16, 1992Date of Patent: April 5, 1994Assignee: American Cyanamid CompanyInventor: Kenneth A. M. Kremer