Patents Examined by Deborah Lambkin
  • Patent number: 5389685
    Abstract: The color-stability of disinfectant formulations comprising bacteriocidal quaternary amine compounds, a non-ionic surfactant, and water is enhanced significantly by adding color-stabilizing amounts of an alkali bicarbonate. An alkali bicarbonate can be used in lieu of the art-accepted EDTA/NaOH builder in quaternary amine-based disinfectant formulations to enhance color stability without sacrificing the bacteriocidal efficacy of the formulations.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: February 14, 1995
    Assignee: Huntington Laboratories, Inc.
    Inventors: Kim Smith, Fred Boyd
  • Patent number: 5380925
    Abstract: Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cyclic amino acid is treated with (-)cinchonidine and the resulting salt resolved into the desired enantiomers, as well as derivatives thereof and valuable intermediates used in the process.
    Type: Grant
    Filed: August 20, 1993
    Date of Patent: January 10, 1995
    Assignee: Warner-Lambert Company
    Inventors: Vladimir Beylin, Huai G. Chen, Om P. Goel, Mark E. Marlatt, John G. Topliss
  • Patent number: 5380878
    Abstract: This invention relates to a process for producing a compound represented by formula (6a) or (6b): ##STR1## wherein R.sup.2 represents a hydrogen atom or a hydroxyl-protecting group and R.sup.4 and R.sup.5, which may be the same or different, represents lower alkyl groups, using a compound represented by formula (2a) or (2b) obtained by preferential crystallization: ##STR2## and also to a compound represented by the following formula (7) which is an intermediate useful for producing the compound of formula (6a) or (6b): ##STR3## wherein R.sup.1 represents a group represented by formula (8): ##STR4## wherein R.sup.2 and R.sup.3 is as defined above and R.sup.3 represents a hydrogen atom, a group or a carboxyl protecting group represented by formula (9): ##STR5## or a group represented by formula (10): ##STR6## wherein R.sup.2 is as defined above.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: January 10, 1995
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Joji Nakano, Nobuhisa Taya, Hisaaki Chaki, Tetsuo Yamafuji, Kaishu Momonoi
  • Patent number: 5380452
    Abstract: A cleaning composition which comprises approximately by weight 2 to 35% of at least one unsaturated fatty acid having about 8 to 24 carbon atoms; 0.01 to 1.5% of a trialkanolamine; 0.01 to 1.5% of an alkanol having about 1 to about 5 carbon atoms; 1 to 5.0% of an alkali metal hydroxide; 0.02 to 2.0% of an amine oxide; 0.02 to 2.0% of a sultaine; and the balance being water.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: January 10, 1995
    Assignee: Colgate Palmolive Co.
    Inventors: Claude Blanvalet, Mary C. Brauchli, Jolanta Dautas, Constance A. Marchese
  • Patent number: 5380749
    Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: January 10, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Theodore C. Miller, Joseph C. Collins, Kenneth C. Mattes, Mark P. Wentland, Robert B. Perni, Thomas H. Corbett, Joseph W. Guiles
  • Patent number: 5374607
    Abstract: Phytopharmaceutical wettable powder comprising at least one phytopharmaceutical active substance which is solid at ambient temperature and at least one pulverulent inert filler, characterized by the fact that the constitutive particles of the filler constitute a support or carrier for the active substance comprised within a liquid composition, said active substance being selected from the group comprising:the esters of the family of the parahydroxybenzonitriles of the group comprising bromoxynil octanoate, bromoxynil heptanoate, bromoxynil butyrate, ioxynil octanoate, ioxynil heptanoate, ioxynil butyrate,the triazines of the group comprising simazine, atrazine and ametryne,the dinitroanilines of the group comprising butraline, pendimethaline, trifluraline, orizaline,the substituted ureas of the group comprising diuron, isoproturon, ethidimuron,the sulphonylureas of the group comprising especially chlorsulfuron.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: December 20, 1994
    Assignee: C F P I
    Inventors: Joseph Schapira, Jacques Schild, Jacques Pecheur, Ange C. Guerin, Dominique Ambrosi, Jean-Jacques Fuchs, Bernard Guyenet
  • Patent number: 5371240
    Abstract: 3-substituted thiophene compounds contaminating the analogous 2-substituted thiophene compounds, e.g. 3-acetylthiophene contaminating 2-acetyl thiophene, are removed by a selective electrophilic substitution process, e.g. bromination, followed by fractional distillation. It has been found that electrophilic substitution as exemplified by bromination is highly selective towards the 3-substituted thiophenes, yielding compounds of significantly higher molecular weights for separation purposes, to give high purity 2-substituted thiophene compounds.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: December 6, 1994
    Assignee: Torcan Chemical Ltd.
    Inventor: Clarke Slemon
  • Patent number: 5364830
    Abstract: Pressure or heat sensitive record materials with color-former sublimation problems reduced or eliminated whilst not reducing the color forming capability per unit weight of color former by providing what are in effect dimers of vinyl carbinols, with the vinyl carbinol residues, linked through the aryl groups of a diaryl amine.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: November 15, 1994
    Assignee: The Wiggins Teape Group Limited
    Inventors: Ivan Sheiham, Margaret P. Templey
  • Patent number: 5363593
    Abstract: The present invention discloses a synthetic cultivation medium comprised of fibrous glomerates and a method for manufacturing the same. Absent a soil component, the synthetic cultivation medium is manufactured from scrap, man-made textiles, chiefly those made from polyacrylonitrile or polyester fibers. In manufacturing the cultivation medium, scrap textiles are shredded into short fibers and chemically refined and bleached. Prior or subsequent to the chemical refinement and bleaching, the short fibers are agitated into glomerates of intertwined fibers.
    Type: Grant
    Filed: August 12, 1992
    Date of Patent: November 15, 1994
    Inventor: Glint Hsh
  • Patent number: 5360934
    Abstract: This invention relates to an improved hydrogenation process wherein aromatic amines are hydrogenated to their ring hydrogenated counterparts. These aromatic amines are presented by the formulas: ##STR1## wherein R is hydrogen or C.sub.1-6 aliphatic, R1 and R2 are hydrogen or C.sub.1-6 aliphatic, A is C.sub.1-4 or NH; n is 0-2, x is 1-3 and y is 1 to 2 except the sum of the y groups in Formula I may be 1. The improvement resides in the utilization of a catalyst comprising rhodium carried on a support of kappa, theta or delta alumina.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: November 1, 1994
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Gamini A. Vedage, John N. Armor
  • Patent number: 5356621
    Abstract: A method of attracting flies of the Muscidae or Muscinae families comprising providing in a locus where the flies exist a fly attractant composition which contains as an active ingredient a composition extracted from a bamboo with an extractive solvent such as water or C.sub.1 -C.sub.4 alcohol.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: October 18, 1994
    Assignee: Sankyo Company, Limited
    Inventors: Yuichiro Tabaru, Akio Saito
  • Patent number: 5350748
    Abstract: 3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described.The same benzo[b]thiophene and benzofuran-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected mammals.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: September 27, 1994
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, James B. Kramer, Paul C. Unangst
  • Patent number: 5346917
    Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: September 13, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Theodore C. Miller, Joseph C. Collins, Kenneth C. Mattes, Mark P. Wentland, Robert B. Perni, Thomas H. Corbett, Joseph W. Guiles
  • Patent number: 5334628
    Abstract: Amine derivatives having the general formula (I): ##STR1## wherein X is selected from the group consisting of ##STR2## wherein Q is oxygen, sulfur or nitrogen atom, and ##STR3## wherein Q is as above; Y is selected from the group consisting of ##STR4## R.sup.1 is hydrogen atom or an alkyl group; R.sup.2 is hydrogen atom or an alkyl group; R.sup.3 is hydrogen atom, a halogen atom or an alkyl group; R.sup.4 hydrogen atom, an alkyl group, a cycloalkyl group, a halogenated alkyl group or a halogen atom; R.sup.5 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro group or hydroxy group; R.sup.5 is attached to an arbitrary position of X, and R.sup.3 or R.sup.4 is attached to an arbitrary position of Y.The amine derivatives (I) are useful as fungicides.
    Type: Grant
    Filed: December 31, 1992
    Date of Patent: August 2, 1994
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Tetsuya Maeda, Toshiyuki Yamamoto, Mituo Takase, Kazuya Sasaki, Tadashi Arika, Mamoru Yokoo, Rieko Hashimoto, Kouji Amemiya, Sakae Koshikawa
  • Patent number: 5331007
    Abstract: There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano;R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl;R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ;R.sub.3 represents hydrogen or C1 to 6 alkyl;in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl;or a pharmaceutically acceptable salt thereof.Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: July 19, 1994
    Assignee: Fisons Corporation
    Inventors: Ronald C. Griffith, James J. Napier
  • Patent number: 5314910
    Abstract: 2-Heteroaromatic alkanoate esters which are useful as inhibitors of human leukocyate or neutrophil elastase.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: May 24, 1994
    Assignee: Cortech Inc.
    Inventors: Gary P. Kirschenheuter, Raymond T. Cunningham, John C. Cheronis
  • Patent number: 5312798
    Abstract: There is disclosed a herbicidal composition comprising as active ingredients a herbicidally effective amount of (a) an iminothiazoline compound of the formula: ##STR1## wherein R.sup.1 is halogen, halo(C.sub.1 -C.sub.2)alkyl, halo(C.sub.1 -C.sub.2)alkoxy or halo(C.sub.1 -C.sub.2)alkylthio; R.sup.2 is C.sub.1 -c.sub.2 alkyl, chroline, bromine or iodine; R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.3 -C.sub.6 cycloalkoxy or C.sub.1 -C.sub.6 alkoxy, all of which are optionally substituted with at least one substituent selected from halogen, C.sub.1 -C.sub.2 alkyl and C.sub.1 -C.sub.2 alkoxy; R.sup.4 is hydrogen or halogen; and (b) at least one of herbicidal triazine compounds, herbicidal uracil compounds, herbicidal urea compounds, herbicidal dinitro aniline compounds, norflurazon, dimethazon, imazaquin and imazethapyr. Also disclosed is a method for controlling undesired weeds by use of the herbicidal composition.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: May 17, 1994
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Shinichi Kawamura, Izumi,Keiichi, Junichi Sato, Yuzuru Sanemitsu, Ryo Sato, Tatsuhiro Hamada, Hideyuki Shibata
  • Patent number: 5310763
    Abstract: Compounds of general formula I: ##STR1## wherein: R.sup.1 represents a C.sub.1 -C.sub.6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, heterocyclyl, (C.sub.1 -C.sub.6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R.sup.1 represents SR.sup.x, wherein R.sup.x represents a group: ##STR2## R.sup.2 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, phenyl(C.sub.1 -C.sub.6)alkyl, cycloalkyl(C.sub.1 -C.sub.6)alkyl or cycloalkenyl(C.sub.1 -C.sub.6)alkyl group;R.sup.3 represents an amino acid residue with R or S stereochemistry or a C.sub.1 -C.sub.6 alkyl, benzyl, (C.sub.1 -C.sub.6 alkoxy)benzyl or benzyloxy(C.sub.1 -C.sub.6 alkyl) group;R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group;R.sup.5 represents a hydrogen atom or a methyl group;n is an integer having the value 0, 1 or 2; andA represents a C.sub.1 -C.sub.6 hydrocarbon chain, optionaly substituted with one or more C.sub.1 -C.sub.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: May 10, 1994
    Assignee: British Bio-technology Limited
    Inventors: Colin Campion, Alan H. Davidson, Jonathan P. Dickens, Michael J. Crimmin
  • Patent number: 5303503
    Abstract: A fertilization and irrigation system including a hollow tubular fiber conduit having a liquid permeable wall for nitrogen fertilizing and irrigating soil. The conduit or length of this tubular material is placed within the soil generally in the vicinity of the root level of plants to be irrigated. For nitrogen fertilization, ammonium hydroxide (NH.sub.4 OH) is introduced into the conduit, the ammonia (NH.sub.3) then allowed to permeate through the conduit wall into the soil. The presence of ammonium hydroxide may be by circulation or held statically under a varying amount of static head pressure. The ammonium hydroxide interacts to dissolve plasticizer within the hollow fiber conduit so that the plasticizer will thereafter go into colloidal suspension within water and carried away. By removal of plasticizer in this manner, both fertilization efficiency and the water permeability of the conduit for subsequent irrigation of the plants and soil are increased significantly.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: April 19, 1994
    Inventor: James A. Patterson
  • Patent number: 5300688
    Abstract: This invention relates to the preparation of hydrazide or hydrazine compounds. More particularly, this invention relates to an efficient method for the preparation of substituted hydrazides, hydrazines, and intermediates therefor, from urea starting products. Such hydrazide and hydrazine compounds are useful as insecticides.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: April 5, 1994
    Assignee: American Cyanamid Company
    Inventor: Kenneth A. M. Kremer