Abstract: Tungstoniobate compounds containing an ion of general formulaA.sub.x W.sub.y Nb.sub.a O.sub.b !.sup.p- Iwhere A=P, Si, Ge, x=0 or an integer from 1 to 10, y is an integer from 1 to 10, y is an integer from 1 to 40, a is an integer from 1 to 8, b is an integer from 15 to 150, and p is an integer dependent upon the nature and oxidation state of element A, have been found to be active against viruses including especially HIV and Herpes Simplex. Pharmaceutical compositions and methods of treatment are disclosed.
Type:
Grant
Filed:
August 26, 1993
Date of Patent:
April 30, 1996
Inventors:
Michael J. Abrams, Gerald E. Bossard, Craig L. Hill, Raymond F. Schinazi, Brian R. C. Theobald
Abstract: A process for removing sulfur dioxide in a fluid such as, for example, sulfolene or sulfolane, comprises circulating the fluid in a loop under conditions sufficient to effect the removal of sulfur dioxide from the fluid wherein the loop comprises at least one spraying device such as, for example, a spray nozzle.
Abstract: The invention relates to a process for the preparation of 3-substituted thiophenes in which the substituent is a C.sub.4 -C.sub.18 -alkyl group. According to the invention, the preparation is carried out by allowing an alkali metal salt of a C.sub.4 -C.sub.18 -alkyl-succinic acid to react with a compound of sulfur and phosphorus, e.g. tetraphosphorus decasulfide, in an organic solvent at a temperature of 100.degree.-180.degree. C., the product obtained being 3-(C.sub.4 -C.sub.18 -alkyl)thiophene. The said reaction may be the last step in a process in which the initial material is maleic acid anhydride with which .alpha.-C.sub.4 -C.sub.18 -alkene is combined so that C.sub.4 -C.sub.18 -alkenylsuccinic acid anhydride is obtained, whereafter this is hydrogenated catalytically to produce C.sub.4 -C.sub.18 -alkylsuccinic acid anhydride. This is thereafter reacted with an alkali metal hydroxide so that an alkali salt of the C.sub.4 -C.sub.
Abstract: Improved concentrated liquid pharmaceutical compositions containing acetaminophen wherein said acetaminophen is formed by adding a Beckman rearrangement catalyst to 4-hydroxyacetophenone oxime.
Abstract: There are provided perfluoroalkanoyl aminonitrile intermediates and their use in a facile and efficient synthesis of 2-perfluoroalkyl-3-oxazolin-5-one. Said oxazolinone is a key intermediate in the preparation of insecticidal, acaricidal and nematocidal pyrrole compounds.
Abstract: There are disclosed compounds of the formula: ##STR1## wherein R.sup.1 is ##STR2## X is O, or S; Y is O or NOR.sup.2 ;R.sup.2 is alkyl, alkenyl, phenyl, --CH.sub.2 CO.sub.2 R.sup.3, --CH.sub.2 Ph, --CH.sub.2 C.sub.6 F.sub.5, or ##STR3## R.sup.3 is hydrogen, alkyl, phenyl, or phenylalkyl; R.sup.4, R.sup.5, and R.sup.6 are each, independently, hydrogen, alkyl, --OH, alkoxy, --CO.sub.2 R.sup.3, halogen, --NH.sub.2, alkylamino, dialkylamino, or --NO.sub.2 ;m=0-20; andn=0-10or a pharmacologically acceptable salt thereof which are useful as anti-inflammatory agents.
Abstract: A composition for stimulating hair growth is described. The composition comprises as an effective ingredient a 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin I.sub.2 derivative of the formula (I) or a pharmaceutically acceptable salt thereof.
Abstract: Novel trisarylaminobenzene derivatives are represented by the formula: ##STR1## wherein .PHI..sub.11, .PHI..sub.21, and .PHI..sub.31 are independently divalent aromatic ring residues, R.sub.11, R.sub.21, and R.sub.31 are independently groups represented by --N.PHI..sub.01 .PHI..sub.02, --NH.PHI..sub.01, --NR.sub.01 .PHI..sub.01, --.PHI..sub.01, --O.PHI..sub.01 or --S.PHI..sub.01 wherein each of .PHI..sub.01 and .PHI..sub.02 is a monovalent aromatic ring residue, and R.sub.01 is an alkyl group, at least one of R.sub.11, R.sub.21, and R.sub.31 being a group represented by --N.PHI..sub.01 .PHI..sub.02, --NH.PHI..sub.01 or --NR.sub.01 .PHI..sub.01, and A.sub.12, A.sub.22, and A.sub.32 are independently aromatic residues, alkyl groups or hydrogen. An organic electroluminescent element which uses the compound in an organic compound layer, especially in a hole injection transport layer provides uniform plane light emission and is durable enough to maintain luminance.
Abstract: 17.beta.-hydroxywortmannin and certain of its analogs are inhibitors of phosphatidylinositol 3-kinase. The compounds are particularly useful for inhibiting phosphatidylinositol 3-kinase in mammals and for treating phosphatidylinositol 3-kinase-dependent conditions, especially neoplasms, in mammals.
Type:
Grant
Filed:
August 25, 1993
Date of Patent:
April 2, 1996
Assignee:
Eli Lilly and Company
Inventors:
Rosanne Bonjouklian, Jeffrey A. Dodge, Chris J. Vlahos
Abstract: Methods of preventing or inhibiting ischemia-reperfusion injury in an organ by administration of a composition containing a selective A.sub.1 adenosine receptor antagonist are provided.
Type:
Grant
Filed:
March 30, 1994
Date of Patent:
April 2, 1996
Assignee:
Trustees of the University of Pennsylvania
Abstract: N-Phenylsulfonyl-N'-pyrimidinyl-,-N'-triazinyl- and-N'-triazolylureas and -thioureas of formula I ##STR1## in which X is oxygen, sulfur, SO or SO.sub.2 ; W is oxygen or sulfur, R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen, fluorine, chlorine, bromine, iodine, (X).sub.n R.sub.3, NO.sub.2, NR.sub.4 R.sub.5, --C.tbd.CR.sub.6, ##STR2## or cyano; n is the number 0 or 1; R.sub.3 is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkyl which is substituted by 1-4 halogen atoms, C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 alkylthio; or C.sub.2 -C.sub.4 alkenyl or C.sub.2 -C.sub.4 alkenyl which is substituted by 1-4 halogen atoms; R.sub.4 is hydrogen, CH.sub.3 O, CH.sub.3 CH.sub.2 O or C.sub.1 -C.sub.3 alkyl; R.sub.5 is hydrogen or C.sub.1 -C.sub.3 alkyl; R.sub.6 is hydrogen, methyl or ethyl; R.sub.7 is hydrogen or methyl; Z is ##STR3## E is methine or nitrogen; R.sub.8 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkylthio, C.sub.
Abstract: A cellulosic composition 42 is provided which may be used as a charcoal briquette replacement, germination medium, oil and animal excretion absorbent, or as a source of nourishment.
Abstract: This invention relates to 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophenecarboxamide, a method for the control of Take-All disease (Gaeumannomyces species) in plants by the use of this compound, and to fungicidal compostions for carrying out the method.
Type:
Grant
Filed:
December 15, 1994
Date of Patent:
January 23, 1996
Assignee:
Monsanto Company
Inventors:
Dennis Phillion, Sai C. Wong, Barry Shortt
Abstract: The invention is antiobesity/antidiabetes beta-3 agonists of the formula: ##STR1## wherein Ar, X, R.sub.2, R.sub.3, Y and n are as defined in the specification.
Type:
Grant
Filed:
December 13, 1993
Date of Patent:
January 2, 1996
Assignee:
American Cyanamid Company
Inventors:
Joseph W. Epstein, Gary H. Birnberg, Minu D. Dutia, Thomas H. Claus, Elwood E. Largis
Abstract: The use of nicotinic anilide derivatives of the general formula ##STR1## where the substituents have the following meanings: R.sup.1 halogen, methyl, trifluoromethyl, methoxy, methylthio, methylsulfinyl, methylsulfonylR.sup.2 unsubstituted or halogen-substituted alkyl, unsubstituted or halogen-substituted alkenyl, alkynyl, unsubstituted or halogen-substituted alkoxy, unsubstituted or halogen-substituted alkenyloxy, alkynyloxy, cycloalkyl, cycloalkenyl, cycloalkyloxy, cycloalkenyloxyfor combating Botrytis, and nicotinic anilides of the formula I.
Type:
Grant
Filed:
March 21, 1994
Date of Patent:
January 2, 1996
Assignee:
BASF Aktiengesellschaft
Inventors:
Karl Eicken, Norbert Goetz, Albrecht Harreus, Eberhard Ammermann, Gisela Lorenz, Harald Rang
Abstract: Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.
Type:
Grant
Filed:
May 3, 1993
Date of Patent:
January 2, 1996
Assignee:
Arch Development Corporation
Inventors:
Shutsung Liao, John Pataki, Ronald G. Harvey
Abstract: A photoresist stripping liquid composition comprising an alkanol amine compound, a sulfone compound or sulfoxide compound, and a hydroxy compound. The composition is excellent in its photoresist stripping performance, safety and working efficiency, and does not cause corrosion on a substrate possessing a metal film.
Abstract: Cyclohexanedione derivatives of the formula (I), ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.6 alkyl group, R.sup.2 is a C.sub.1 -C.sub.4 alkyl group, each of R.sup.3, R.sup.4 and R.sup.5 is independently hydrogen or a C.sub.1 -C.sub.4 alkyl group, and n is an integer of 0 to 2, or salts thereof exhibit high selectivity for corn, wheat and barley, and can control gramineous weeds and broad-leaved weeds at low dosages.
Abstract: Farnesyl derivatives, particularly farnesyl acetate, are used to lower the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in cells, thereby reducing cholesterol biosynthesis. The compounds may be administered to hypercholesterolemia patients to reduce the overall level of serum cholesterol, either alone or in conjunction with other drugs conventionally used for the treatment of hypercholesterolemia.
Type:
Grant
Filed:
July 8, 1993
Date of Patent:
December 12, 1995
Assignee:
The Board of Trustees of the Leland Stanford Junior University