Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.

Abstract: An assembly for holding a liquid sample, the assembly comprising a cup for holding a liquid and a chamber assembly, The chamber assembly comprises: a cap configured to be removably joined to the cup and to close the cup when joined to the cup; a chamber joined to the cap and having an open top end above the cap, the chamber traversing the cap and extending from the open top end to a bottom end below the cap, such that when the cap is joined to the cup, the bottom end of chamber is located inside the cup, the first chamber having at least one perforation at or near the bottom end; a chamber cap configured to be joined to the open top end of the chamber and to close the chamber when joined to the chamber.

Abstract: The present disclosure provides a microfluidic device, including a bottom substrate, an electrowetting-on-dielectric (EWOD) chip, a circuit board, a dielectric film, and a motor. The EWOD chip is disposed on the bottom substrate, and the circuit board is arranged on the EWOD chip. The circuit board includes a circuit area that is electrically connected to the EWOD chip, and the empty area is adjacent to the circuit area and the EWOD chip is exposed. The dielectric film is disposed on the empty area of the circuit board and covers the exposed EWOD chip. The motor is disposed under the bottom substrate, and one end of the motor has a magnetic structure, so that the magnetic structure can move closer to or away from the bottom substrate.

Abstract: The present technology relates to an analytical device for quantitative or qualitative analysis of one or more analytes in a sample. The analytical device comprises a reaction component and a capping component. The reaction component is capable of performing an analysis on a sample placed within an inner reaction chamber that is connected to an output end and conduit that eliminates the air or liquid component of the sample. Once the output end is sealed, the inner reaction chamber may be used as an extraction, reaction and analysis chamber with an optically clear path for interrogation of the sample. The analytical device may also feature a sealing device that seals the inner reaction chamber during analysis. The sealing device may also have an inner chamber for accommodating lyophilized reagents that can be added at any point during the procedure.

Abstract: Disclosed is a testing apparatus comprising a disposal container body comprising: a first opening portion that faces upward to receive a used test piece dropped by a test piece transfer part of the testing apparatus, wherein the test piece transfer part is configured to transfer the used test piece to the first opening portion; and a second opening portion that faces laterally to receive a liquid waste and to which an end of a discharge pipe of the testing apparatus is inserted, wherein the discharge pipe is configured to transfer the liquid waste to the second opening portion.

Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Abstract: Provided are a method and a device for acquiring a temperature and a computer-readable storage medium. The method for acquiring a temperature includes: building a temperature acquisition model, wherein the temperature acquisition model is configured to acquire, based on an operating parameter of the radioactive substance treatment system input to the temperature acquisition model, a temperature of different parts of the radioactive reactant in the radioactive substance treatment system under a condition of the parameter; inputting a current operating parameter of the radioactive substance treatment system into the temperature acquisition model during the treatment for the radioactive substance; and acquiring a current temperature of different parts of the radioactive reactant in the radioactive substance treatment system output by the temperature acquisition model.

Abstract: A system for urine analysis and personal health monitoring includes a testing box, including a testing chamber, a camera aperture, a visual check aperture, and a test slot, an interchangeable color pattern chart, including a bar code, a base color calibration strip, a test result area, and a test lookup area; a diagnostic analysis server, and a diagnostic analysis device, including a processor, a diagnostic manager, a camera manager, an image analyzer, a camera calibrator, and a camera; such that the diagnostic analysis device captures an original image of the testing chamber interior with a test strip inserted, and analyzes a diagnostic portion of the original image and calculates a test result. Also disclosed is a method for diagnostic analysis, including installing interchangeable color pattern chart, depositing sample, inserting test strip, capturing image, performing color calibration, reading bar code, extracting test strip image, performing color conversion, and calculating test result.

Abstract: The present invention relates to devices and methods for detecting date rape drugs (DRDs) in beverages during social events. The device includes a cellphone, and further includes one or more protective covers, screen cover, stylus, or other add-ons, either individually or in combination. The device incorporates a user-friendly DRD detection system physically attached or integrated with the cellphone or any one of its accessories, ensuring uninterrupted use of the device's primary functions, wherein this physical attachment and/or integration minimizes the likelihood of users forgetting the device elsewhere and/or removing the DRD detection system, thus ensuring its immediate availability when needed. The DRD detection system's operation does not significantly impact the regular use of the cellphone or its accessories, maintaining convenience and safety in social settings.

Abstract: Disclosed are a detection chip, a preparation method and use method thereof, and a detection device. The detection chip comprises a substrate and a reservoir chamber. The reservoir chamber is configured to contain a liquid and comprises a support frame, and a first seal layer and a second seal layer for sealing the support frame. The support frame comprises a support frame body and a cavity formed in the middle of the support frame body. The second seal layer is configured to be concaved into the cavity. The substrate comprises a piercing structure.

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

Abstract: Sample filtration devices are provided. The devices can comprise a filter membrane positioned between an input and output substrate and joined using an adhesive layer. The filter assembly can be used with various sample collection and dispensing devices, such as a flexible container, a bulb pipette, a micropipette, etc. Applying pressure to the filter assembly, e.g., using a flexible container, a bulb pipette or a micropipette can force the fluid through the filter membrane and onto a test strip or cartridge.

Abstract: Described are methods and devices that can accelerate the process and quantify the parameters for bio/chemical material samples. In some embodiments, a QMAX (Q: quantification; M: magnifying; A: adding reagents; X: acceleration) device having two or more electrodes capable of accelerating the electrical measurement process of the samples. In addition, the electrical measurement technology of the QMAX device enables for extraction, separation, and purification of sample components, such as but not limited to nucleic acids. In some embodiments, the QMAX device includes a plate for hosting a small sensing chip to facilitate a bio/chemical sensing of the sensing chip.

Abstract: A test strip eject mechanism for a fluid testing device comprising an actuation button and a lever having a distal end movably engaged with the button, the lever configured to rotate about a fulcrum, wherein the lever has a proximal end movably engaged with a sled which slides to transport the test strip, the device configured such that a user's insertion of a test strip onto the sled and in an insertion direction into the device causes the sled to contact the lever arm and the lever arm to contact and move the actuation button in an outward direction of the medical device and into a position where the actuation button can be actuated by the user.

Abstract: Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.

Abstract: A system and method for treating water containing at least one contaminant. The system and method include a water treatment module such as a reverse osmosis unit. An electrochemical contaminant detection system is positioned in the waste water stream of the water treatment module. The contaminant detection system includes a contaminant sensor and a water quality sensor module. The contaminant sensor measures the concentration of the contaminant in the waste water stream and the water quality sensor module measures one or more water quality parameters of the waste water stream. A processor uses an algorithm to determine the concentration of the contaminant in the feed water based on the measurements of the contaminant sensor and water quality sensor module.

Abstract: A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.

Abstract: Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Abstract: Embodiments of a device, system and method are disclosed herein. In one embodiment, a device comprises a sample cell configured to interact a fluid sample with an ion selective substrate to modify an optical characteristic of the ion selective substrate according to an ion concentration of the fluid sample, wherein the sample cell is also configured to optically interact an illumination light with the ion selective substrate to generate a sample light; an optical element configured to interact with the sample light to provide a modified light that has a property of the fluid sample; and a detector that receives the modified light and provides an electrical signal proportional to the property of the fluid sample indicated by the modified light; and wherein the ion selective substrate comprises a membrane, the membrane configured to change an optical property in a selected wavelength range, according to the property of the fluid sample.

Abstract: A testing pad comprising a water-resistant base layer, a water-transmissive top layer coupled with said base layer, an hydrophilic intermediate layer contained between said top layer and said base layer, and a color-changing chemical reagent contained between said top layer and said base layer adapted an configured to allow an animal or person to urinate on the testing pad and the chemical reagent to present testing results related to the presence, absence and/or concentration of substances within the urine.