Patents Examined by Dennis White
  • Patent number: 11612356
    Abstract: An on-diaper body fluid screening device (100), comprising a stack of the following sheets: a surface sheet (110) permeable to body fluid, a collection sheet (120) impervious to body fluid, a testing sheet (130), which is body fluid absorbent and provided with colorimetric assay reaction pads (131), and which is provided with a body fluid barrier network (132) forming body fluid channels (134) between an inlet section (135) and the colorimetric assay reaction pads (131), a protection sheet (140) impervious to body fluid, and a transparent readout sheet (150), through which the assay reaction pads (131) are visible. The protection sheet (140) comprises pad receiving openings (142). The collection sheet (120) comprises an inlet hole (125) which is arranged over the inlet section (135). A swelling component (702) is arranged in association with the inlet hole (125) and an inlet hole closing member (601).
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: March 28, 2023
    Assignees: University College of Southeast Norway, Sensovann AS
    Inventors: Tao Dong, Nuno Miguel Matos Pires, Zhaochu Yang, Chaohao Chen, Kai Dong, Torill Lønningdal, Haakon Karlsen
  • Patent number: 11612340
    Abstract: A system for verifying a sample volume includes a sample reservoir and a volumetric verification device. The sample reservoir defines an inner volume and is configured to receive a volume of bodily fluid. The inner volume of the sample reservoir contains an additive. The volumetric verification device includes a first indicator and a second indicator. The volumetric verification device is configured to selectively engage the sample reservoir to (1) place the first indicator in a first position along a length of the sample reservoir such that the first indicator is substantially aligned with a surface and/or meniscus of the additive and (2) place the second indicator in a second position along the length of the sample reservoir such that the second indicator is substantially aligned with a predetermined fill volume when bodily fluid is transferred to the inner volume.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: March 28, 2023
    Assignee: Magnolia Medical Technologies, Inc.
    Inventors: Gregory J. Bullington, Shan E. Gaw, Jay M. Miazga, Shannon E. Eubanks
  • Patent number: 11583850
    Abstract: The application discloses a test strip and a method for manufacturing the test strip. The test strip comprises a base layer; an intermediate layer overlaid on the base layer; a blood retaining layer comprising a slit and a blood retaining region fluidly commuted with the slit and overlaid on the intermediate layer; an upper layer overlaid on the blood retaining layer; a reagent disposed on a surface of the intermediate layer and exposed to the slit, wherein there are an expectedly predetermined depth and a measured depth from an interface between the slit and the upper layer to an upper surface of the intermediate layer; and a classification mark representing a compensation factor and disposed on an upper surface of the upper layer or a lower surface of the base layer; wherein the compensation factor is the product of a difference between the predetermined depth and the measured depth and a reciprocal of the predetermined depth.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: February 21, 2023
    Inventor: Wen-Guay Lin
  • Patent number: 11576596
    Abstract: A hand-held applicator (10) for collecting, mixing, diluting and discharging a sample liquid, comprising a main body (20) having an inlet-aperture (24), an outlet-aperture (26) and a chamber (22) for storing a liquid solution, wherein the chamber is connected to the inlet-aperture and the outlet-aperture, a lid (12) for covering the inlet-aperture and a tube (40), moveably supported in the inlet-aperture when the lid is covering the upper portion of the main body, wherein the tube (40) is moveable between a predetermined position outside the chamber and a position, in which the tube is at least partly located in the chamber.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: February 14, 2023
    Inventors: Lukas Steiner, Cédric Wernli, Gregor Naef, Daniel Gygax, Jakob Weber
  • Patent number: 11572417
    Abstract: The invention provides a mild procedure for the functionalization of cellulose and other substrates with a detection reagent such as N-(1-naphthyl)ethylenediamine and is able to achieve much higher functionalization density than previously reported. A paper-based device created using cellulose functionalized according to the invention allowed for much lower detection limits for nitrite in various kinds of water samples than have been seen using paper-based devices. In addition, grafting of N-(1-naphthyl)ethylenediamine to cellulose improved the stability of the N-(1-naphthyl)ethylenediamine in the presence of moisture and light.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: February 7, 2023
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Teresa L. Mako, Mindy Levine, Jason Dwyer
  • Patent number: 11566213
    Abstract: A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: January 31, 2023
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nancy L. Allbritton, Yuli Wang, Christopher Sims
  • Patent number: 11555801
    Abstract: An assembly is provided for interfacing with a microfluidic chip having at least one microscopic channel configured to receive a liquid sample for analysis. The assembly includes a chip carrier, an electronics module, an optical module, and a mechanical module. The chip carrier includes a base and a cover defining a cavity to receive the microfluidic chip. The electronics module includes a signal generator which applies at least one electrokinetic signal electrode(s) of the chip. The optical module includes an excitation radiation source which causes excitation radiation to impinge on the sample, and an emission radiation detector which detects radiation emitted from the sample. The mechanical module includes a chip-carrier receiving structure, relatable with respect to the optical module for focus and at least one degree of translational freedom.
    Type: Grant
    Filed: September 21, 2019
    Date of Patent: January 17, 2023
    Assignee: International Business Machines Corporation
    Inventors: Jaione T. Azpiroz, Emmanuel Delamarche, Claudius Feger, Ricardo L. Ohta, Mathias B. Steiner, Yuksel Temiz
  • Patent number: 11548194
    Abstract: A fluid device composite member includes: a silicone member that includes a body part which is made of silicone and which has a flow-path-defining section for defining a flow path on one surface of the body part, and that includes barrier layer having hydrophilicity or hydrophobicity disposed in at least a portion of the flow-path-defining section; and a resin substrate disposed on another surface of the body part opposite to the one surface. This method for manufacturing the fluid device composite member includes a layered body manufacturing step in which a liquid silicone material is placed on a surface of the resin substrate, and the liquid silicone material is cured at a temperature of 100° C. or less to obtain a layered body in which a silicone cured product is bonded to the resin substrate.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: January 10, 2023
    Assignee: Sumitomo Riko Company Limited
    Inventors: Katsumi Okashita, Shota Hayashi
  • Patent number: 11525801
    Abstract: A strip structure for measuring potassium ions includes: a strip having an inner space for receiving a solution therein and being formed in a plate shape; an inlet formed in the strip and capable of injecting a solution into the inner space of the strip; a potassium ion selective membrane arranged in the inner space and capable of permeating potassium ions of the solution; and a first working electrode extending in a strip shape, wherein one side of the first working electrode is arranged inside the potassium ion selective membrane and the other side of the first working electrode is on a surface of the strip.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: December 13, 2022
    Assignee: THEDONEE INC.
    Inventors: Kang Won Lee, Kyung Hwan Moon, Sun Mi Lee
  • Patent number: 11524288
    Abstract: A device for analysing a sample comprising a nucleic acid to be captured and detected using a test strip are described. The device comprises a resilient biasing member disposed in an analysis chamber containing the test strip. The resilient biasing member exerts a force against the test strip sufficient to urge it into the sample chamber when it is in communication with the analysis chamber. This ensures that the test strip is reliably introduced into the sample chamber when it is in communication with the analysis chamber. In one embodiment, the sample chamber comprises guide members for guiding the test strip into the sample chamber. A free end of each guide member is shaped to prevent significant rotation of the test strip, so that the test strip is in correct alignment in the sample chamber for automatic reading of the test result, for example by a camera or optical reader.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: December 13, 2022
    Assignee: Diagnostics for the Real World, LTD.
    Inventors: Philip Stankus, Ivan Hin-Kwan Chew
  • Patent number: 11511273
    Abstract: The present invention relates to a method for determining an analyte using surface enhanced RAMAN spectroscopy and to a device which is suitable for this purpose.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: November 29, 2022
    Inventors: Torsten Stadthagen, Markus Fremmer
  • Patent number: 11513117
    Abstract: A system for detecting a target material in a sample. The system includes a sensor, a light source, an image-capturing device, two linear-crossed polarizers including a first polarizer and a second polarizer, and a processing unit. The sensor is configured to place the sample thereon and includes a fabric impregnated with liquid crystals (LCs). The light source is configured to transmit a beam of light through a path passing from the first polarizer, the sensor, and the second polarizer. The image-capturing device is configured to capture an image of a surface of the second polarizer. The image contains a pattern formed by orientations of LCs corresponding to the sample. The processing unit is configured to detect a presence of the target material in the sample by analyzing the captured image.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: November 29, 2022
    Inventors: Mohammad Mohammadimasoudi, Mohamadreza Gholaminezhadshemirani, Ali Goudarzi, mahboubeh Esmaeilpour, Hosein Shahsavarani, Ezeddin Mohajerani, ALi Poorkhalil
  • Patent number: 11514609
    Abstract: A detection system method of color balancing an image includes receiving an image of a test area of a pad which includes a color of a reaction between a test substance and at least one reagent on the test area of the pad, an alignment code having detection system identification information, at least one color calibration block indicia for aligning with a camera as the image is being captured, and test identification information for analyzing the test substance during a colorimetric analysis. The method further includes collecting an array of pixels of RGB values for each pixel in the image, evaluating a captured color of the at least one color calibration block in the image, and performing the colorimetric analysis on the reaction between the test substance and the at least one reagent.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: November 29, 2022
    Assignee: DETECTACHEM, INC.
    Inventors: Travis Kisner, Aaron Sanders
  • Patent number: 11513129
    Abstract: The present application relates to a method for detecting and monitoring the level of thyroid hormones in an individual and a device for carrying out the same.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: November 29, 2022
    Inventors: Eshan Shriniwas Sane, Anoop Tej Patta, Krish Kalyan Nathan
  • Patent number: 11513097
    Abstract: Methods and techniques are described for analyzing test fluids to determine presence, absence, or concentration of analytes in the test fluids. The methods may correspond to diagnostic testing, such as quickly (within 5 minutes) identifying whether or not an individual may have a particular disease or condition, such as infection by SARS-CoV-2 or a SARS-CoV-2 variant or vaccine-induced immunity or natural immunity to infection by SARS-CoV-2 or a SARS-CoV-2 variant, or whether an individual would benefit from a vaccine booster. The test results can be used for a variety of applications including facilitating or controlling access at events, venues, or transportation systems, or generating exposure notifications.
    Type: Grant
    Filed: December 31, 2021
    Date of Patent: November 29, 2022
    Assignee: PERSOWN, INC.
    Inventors: Devi Kalyan Karumanchi, Michelle Kelly, William D. Meadow
  • Patent number: 11504099
    Abstract: Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: November 22, 2022
    Assignee: Invoy Holdings Inc.
    Inventors: Zachary B. Smith, Marcus Goudie, Lubna M. Ahmad
  • Patent number: 11506659
    Abstract: A lateral flow assay (LFA) device includes a capillary pad and a sample port that holds the sample fluid before a hole is made in a cavity surface of the sample port. The LFA device includes a breaker with a tip to make a hole in the cavity wall of the sample port causing the sample fluid held inside the compartment to be applied to the capillary pad after the start of a test.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: November 22, 2022
    Inventors: Mehdi Hatamian, Mehrtash Ghalebi
  • Patent number: 11506658
    Abstract: A system for analyzing a wound fluid. The system includes a transparent layer, a membrane layer, and an indicator layer that contains a colorimetric or fluorescent indicator reagent for detecting pH, a nitrite, an enzyme, a reactive oxygen species, a reactive nitrogen species, a nucleic acid, or a combination thereof. The membrane layer is impermeable to blood clots and cellular debris and is permeable to wound fluid. Also provided are methods for analyzing a wound fluid and for detecting biological fluid on biomedical instruments and waste materials using the system.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: November 22, 2022
    Assignee: Progenitec, Inc.
    Inventors: Wenjing Hu, Hong Vu, Ashwin Nair, Liping Tang
  • Patent number: 11498074
    Abstract: A module for processing fluids includes one or more collapsible fluid chambers supported on a substrate, a compression element supported on the substrate and configured to be movable with respect to the one or more chambers, and an actuating element coupled to the compression element and configured to effect movement of the compression element relative to the one or more fluid chambers to collapse each fluid chamber by compressing the fluid chamber between the compression element and the substrate as the compression element moves over the fluid chamber.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: November 15, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventor: David Walter Wright
  • Patent number: 11493509
    Abstract: A lateral flow assay device includes a test strip that is configured to receive a sample fluid and detect a presence of antibodies to one or more of a plurality of proteins of the target pathogen. The lateral flow assay device includes a conjugate pad and a membrane. The conjugate pad contains a plurality of the proteins of the target pathogen, each conjugated with a label. If the sample fluid contains antibodies that are specific to the target pathogen through any of the target pathogen's proteins, a binding takes place between those antibodies and the corresponding tagged protein. The membrane may include a plurality of test lines. Each test line may contain the immobilized binding reagent to one antibody class, resulting in the concentration of all the molecules of that antibody class on the test line.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: November 8, 2022
    Assignee: 2Pi-Sigma Corp.
    Inventor: Mehdi Hatamian