Abstract: A lateral flow assay device includes a test strip that is configured to receive a sample fluid and detect a presence of antibodies to one or more of a plurality of proteins of the target pathogen. The lateral flow assay device includes a conjugate pad and a membrane. The conjugate pad contains a plurality of the proteins of the target pathogen, each conjugated with a label. If the sample fluid contains antibodies that are specific to the target pathogen through any of the target pathogen's proteins, a binding takes place between those antibodies and the corresponding tagged protein. The membrane may include a plurality of test lines. Each test line may contain the immobilized binding reagent to one antibody class, resulting in the concentration of all the molecules of that antibody class on the test line.

Abstract: A diagnostic cassette includes a substrate, to physically and electrically connect the product to a computing device, a reservoir defined within the substrate to receive a fluid sample for processing by the diagnostic cassette, a reagent to react with the fluid sample deposited in the reservoir to form a solution to enable processing of the fluid sample by the diagnostic cassette, a channel to direct the solution, and a sensor to measure a number of parameters of the solution passing through the channel. A method for measuring microfluidic samples includes receiving, in a reservoir, a fluid sample to be measured, combining the fluid sample with a reagent to create a solution, moving the solution through a channel, and measuring the solution, using sensors, as the solution passes through the channel.

Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

Abstract: A medical instrument and method thereof for performing a measurement on a biological sample using a test strip are disclosed. The medical instrument may comprise: an analytical unit for analyzing the test strip, wherein the analytical unit comprises a test strip mount which receives the test strip to perform the measurement; a test strip port which receives the test strip, wherein the test strip port is aligned with the test strip mount along an insertion direction; and a shutter movable between open and closed positions, the shutter comprises a test strip opening, wherein the test strip opening is aligned with the test strip port and the test strip mount when the shutter is in the open position, wherein the shutter comprises a shutter mechanism that rotates the shutter parallel to the insertion direction about a rotational axis to move the shutter between the open position and the closed position.

Abstract: The present disclosure provides a monitoring device comprising a test composition, a test element comprising a test portion to which the test composition is releasably adhered, a detection reagent, and a container comprising a first end with an opening and a second end opposite the first end. The test composition comprises a predetermined quantity of tracer analyte. The container is configured to receive the test portion and configured to be operationally coupled to an analytical instrument. The tracer analyte and the detection reagent each are capable of participating in one or more chemical reaction that results in the formation of a detectable product. A method of using the monitoring device to assess the efficacy of a washing process is also provided.

Abstract: Devices that include a low sensitivity bulk acoustic wave (BAW) resonator sensor including a surface to which a low recognition component is immobilized, the low recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; a high sensitivity BAW resonator sensor including a surface to which a high recognition component is immobilized, the high recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; one or more containers housing an amplification molecule, the amplification element-linked second recognition component, and optionally one or both of the tag and the analyte molecule.

Abstract: In the various illustrative embodiments herein, test devices are described with opposing sensor arrays and same side contacts.

Abstract: A device including a sample cell configured to interact a fluid sample with an ion selective substrate to modify an optical characteristic of the ion selective substrate according to an ion concentration of the fluid sample is provided. The sample cell is configured to optically interact an illumination light with the ion selective substrate to generate a sample light. The device includes an integrated computational element configured to interact with the sample light to provide a modified light that has a property indicative of the ion concentration in the fluid sample; and a detector that receives the modified light and provides an electrical signal proportional to an intensity of the modified light.

Abstract: The claimed invention provides real-time and subsequent analysis personalized user based caradiac health and wellness detection information utilizing novel cardiac health markers including Troponin as well as TMAO. Non-invasive techniques utilize saliva for body levels of cardiac wellness indicators as well as pharmaceutical ingestion which are coordinated over time. Saliva captured on sample strips are real-time indicator reviewed and subsequently analyzed using traditional analytical chemistry techniques including liquid chromatography/mass spectrometry (LC/MS) and coordinated with time of administration with optional genetic sequence analysis to confirm related cardiac disease conditions. By using P4 (Participatory, Personalized, Predictive, and Preventive) health management techniques the patient determines if the pharmaceutical is having the correct and desired effect for maximum therapeutic benefit.

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.

Abstract: The disclosure relates to a diagnosis method and diagnosis device of ecotoxicity of solid waste soil in a pesticide production site. The diagnosis method is as follows: performing multi-point distributed collection on solid waste soil of a to-be-diagnosed pesticide production site, and subsequently pretreating the connected soil sample; synchronously performing a first toxicity test, a second toxicity test and a third toxicity test on the pretreated solid waste soil by using the diagnosis device. The diagnosis device comprises a first test device, a second test device and a third test device. The method of the disclosure is used for synchronous diagnosis of ecotoxicity by utilizing multiple diagnosis methods, and therefore is high in diagnosis efficiency and high in accuracy rate.

Abstract: Optically-actuated microfluidic devices permit the use of spatially-modulated light to manipulate micro-objects such as biological cells. Systems and methods are described for providing sequences of light patterns to move and direct a plurality of micro-objects within the environment of a microfluidic device. The sequenced light patterns provide improved efficiency in directing the transport of the plurality of micro-objects. Other embodiments are described.

Abstract: Embodiments of the present invention encompass systems and methods for detecting the presence of a test pad on a test strip. Exemplary techniques involve receiving a test strip having at least one test pad, where individual test pads have a pad width with ink disposed on two ink zones at two opposing sides of the width of the pad, illuminating the at least one test pad with a light source, detecting reflected signals from the test pad, generating an image comprising of pixels of the two ink zones based on the reflected signals, detecting the presence of each of the ink zones by comparing the number of consecutive pixels against a predetermined threshold, and determining the presence of the test pad on the test strip if two ink zones are detected within the pad width.

Abstract: The present invention provides a medical device and a method for the selective separation of a biological sample of a mammal into a first portion and a second portion. It comprises a first layer comprising a first reservoir for receiving the biological sample and for retaining the first portion of the sample, and a second layer comprising a second reservoir for receiving the second portion of the sample. Between the first layer and the second layer a third layer is provided, wherein the third layer comprises a plurality of channels configured to provide a fluid communication between the first reservoir and the second reservoir. Furthermore, between the first layer and the second layer a fourth layer adjacent to the third layer is provided, wherein the fourth layer comprises and/or is configured as a separation layer.

Abstract: The present technology includes a color changeable indicator that changes color upon exposure of the indicator to high pressure and comprises at least one reagent releasing layer, a transition layer disposed on the reagent releasing layer, a color changeable layer disposed on the transition layer, and a non-porous protectant encompassing the reagent releasing layer, the transition layer and the color changeable layer. An additional reagent releasing layer can be located between the transition layer and the color changeable layer. The indicators provide simple, reliable, and cost effective detection means for detecting whether a product has been exposed to high pressure, e.g. high pressure pasteurization, and may find use in applications such as food and beverage processing and/or packaging and medical applications.

Abstract: The present invention provides an apparatus for detecting the presence or absence of an analyte in liquid sample, including: a collection chamber, including an opening for collecting a liquid sample; a testing element for testing the analyte in liquid sample; and a cover for covering the opening of the collection chamber; wherein the apparatus further includes a prompting device for prompting if the cover is covered to a specified location, and the prompting device shall at least includes a first element and a second element, the first element is in contact with the second element, wherein one element vibrates to produce a sound. In some preferred ways, the second element produces friction with the first element, to cause one of the elements to generate vibrations. The apparatus in the present invention can allow the prompting sound to be clear and loud.

Abstract: Aspects of the embodiments are directed to a microfluidic chip that includes a plurality of openings to expose a microfluidic channel. The plurality of openings are within a recessed area of the microfluidics chip, the recess defining a surface onto which a sensor die can be clamped. The surface can include a clamping bump that contacts a membrane of a solid-state chemical sensor. The surface can also include a glue stop that, in some embodiments, can act as a spacer to prevent over-compression of the sensor die as it is clamped onto the microfluidic chip. The microfluidic chip can include a rigid structure, such as a printed circuit board, that is affixed to a top surface of the microfluidic chip. The rigid structure can include contact pads that are electrically connected to sensor electrodes on the sensor die by a wire.

Abstract: A fluid analysis cartridge having an improved structure in order to increase test reliability, and a fluid analysis apparatus including the same are disclosed.

Abstract: Embodiments of the invention are generally directed to analyte detection and products facilitating the collection, separation of sample components, and analyte detection. The multilayer device that allows for a rapid, easy, accurate, and efficient test of a fluid sample for analytes of interest and methods of collecting, separating components, and testing using the multilayer device are described in various embodiments of the invention.