Abstract: Diaryl and substituted diaryl carbonates are formed by a series of steps, the first step involving the production of a dialkyl carbonate from an alkanol, carbon monoxide and oxygen; and the second step involving the reaction of the dialkyl carbonate with a phenyl ester or substituted phenyl ester in the presence of a dialkyl tin compound to produce a mixture of diaryl carbonate, alkyl aryl carbonate, and an alkyl ester. The alkyl ester can be heated to reform the alkanol and form ketene; in turn the ketene can be reacted with the phenol or substituted phenol to form the phenyl ester or substituted phenyl ester used in the second step above.

Abstract: (Hydrocarbylthio)phenols containing at least two hydrocarbylthio groups on a phenolic ring are prepared by reacting phenolic compounds with an excess of hydrocarbyl disulfide in the presence of catalytic amounts of an aluminum phenoxide. Novel and useful (hydrocarbylthio)phenols containing at least two hydrocarbylthio groups on a phenolic ring can be prepared by this process. (Hydrocarbylthio)phenols containing at least two hydrocarbylthio groups on a phenolic ring are effective antioxidants for organic material normally susceptible to oxidative deterioration, such as mineral oil.

Abstract: Substituted triazolo[4,3-c]pyrimidines which are bronchodilators. The pharmacological use of these compounds, and synthetic intermediates for the preparation of these compounds are also described.

Abstract: Substituted triazolo[1,5-c]pyrimidines which are bronchodilators. The pharmacological use of these compounds and pharmaceutical compositions containing these compounds are also described.

Abstract: Described are 1-hydroxymethyl-2-acyl cyclopropane derivatives having one of the structures: ##STR1## and utilities thereof for their organoleptic properties.

Abstract: Described are organic peroxycarbonates of the graphic formula: ##STR1## in which R.sub.1 is a C.sub.1 -C.sub.14 alkyl, phenyl or benzyl group, R.sub.2 and R.sub.3 are each selected from the group C.sub.1 -C.sub.4 alkyl, C.sub.5 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.4 alkyl substituted C.sub.5 -.sub.7 cycloalkyl or participate in a cycloalkyl group of from 5 to 7 carbon atoms, provided that when one of R.sub.2 and R.sub.3 is a cycloalkyl group, the other is an alkyl group, A is cyano or alkoxycarbonyl, i.e., ##STR2## wherein R is a C.sub.1 -C.sub.8 alkyl or cyclohexyl group. Preferably R.sub.2 and R.sub.3 are each a C.sub.1 -C.sub.2 alkyl group or participate to form a cyclohexyl group, R.sub.1 is a C.sub.1 -C.sub.3 alkyl or phenyl and R is a C.sub.1 -C.sub.4 alkyl.The compounds can be used as initiators for the polymerization and copolymerization of ethylenically unsaturated monomers.

Abstract: 4-Hydroxy-2-quinolone derivatives are useful for their anti-inflammatory, anti-allergenic, antitussive and expectorant activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

Abstract: 7,8,9,10-Tetrahydrobenzo[h]quinolin-9-amine derivatives of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is hydrogen or lower alkyl, or R.sup.1 and R.sup.2 together form a chain of the formula --(CH.sub.2).sub.n -- where n is the integer 4, 5 or 6, are useful for treating depression.

Abstract: This invention relates to compounds which may be described as the unnatural enantiomers of morphine agonists and antagonists, which are useful as antitussives. The synthesis utilized is capable of producing all of the unnatural enantiomers of medically important opium derivatives of the morphinan type, including thebaine.

Abstract: Compounds of the formula (1) ##STR1## wherein n is 1 or 2;R.sub.1 represents a hydrogen or a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a --CN group, a --CONH.sub.2 group or a --COOR.sub.8 group, wherein R.sub.8 represents hydrogen or a C.sub.1 -C.sub.6 alkyl group, unsubstituted or substituted by di(C.sub.1 -C.sub.4) - alkylamino;each of R.sub.2, R.sub.3 and R.sub.4 independently represents a hydrogen or a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group or a C.sub.3 -C.sub.4 alkenyloxy group;A completes a bond, thereby providing a double bond or, when R.sub.1 is --COOR.sub.8 wherein R.sub.8 is as defined above, A may represent also a --CH.sub.2 -- group, thereby providing a cyclopropane ring fused to the pyrido ring;R is (a) furyl, thienyl or pyridyl; or(b) a group of formula ##STR2## wherein each of R.sub.5, R.sub.6 and R.sub.7 represents, independently, a hydrogen or a halogen atom, hydroxy, formyloxy, C.sub.2 -C.sub.8 alkanoyloxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.

Abstract: New 5- and/or 7-substituted camptothecin-1-oxide derivatives possessing anti-tumor activity with slight toxicity, represented by the general formula: ##STR1## wherein R is a hydrogen atom, an alkyl group, a hydroxyl group, an alkoxy group or an acyloxy group and R' is a hydrogen atom, an alkyl group, an aralkyl group, a hydroxymethyl group, an acyloxymethyl group or a carboxymethyl group, with the proviso that both of R and R' should not be hydrogen atoms. These 5- and/or 7-substituted camptothecin-1-oxide derivatives are prepared by treating the corresponding 5- and/or 7-substituted camptothecins with a peroxidant as an N-oxidizing reagent.

Abstract: The application relates to a process for synthesizing unsaturated carbonic acid esters from polyhydric alcohols, which are reacted with alkyl carbonates and unsaturated alcohols in the presence of a basic catalyst, which can be chosen from sodium hydroxide, sodium carbonate, sodium alcoholate, organic bases and basic ion exchange resins.

Abstract: Novel pyrimidines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of --OH, cation of metals and organic bases, alkoxy of 1 to 5 carbon atoms, hydrazino and 1H-tetrazol-5-yl-amino, A is selected from the group consisting of ##STR2## R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 5 carbon atoms with the proviso that when R.sub.1 is alkoxy of 1 to 5 carbon atoms, R.sub.2 is not hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic properties.

Abstract: There are prepared compounds of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SH,R is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immuno-modulating activity.

Abstract: The application relates to a process for synthesizing carbonic allyl esters from polyhydric alcohols, which are reacted with diallyl carbonate in the presence of a basic catalyst, which can be chosen from sodium hydroxide, sodium carbonate, sodium alcoholate, organic bases or basic ion exchange resins.The final products obtained differ according to the ratio of the components of the starting mixture. Thus, in the case of diols with a diallyl carbonate/diol ratio greater than or equal to 10, the resultant product is constituted by the bis allyl carbonate of the diol together with a quantity of less than or equal to 10% of oligomers represented mainly by dimers. If the ratio is less than 10, the percentage of oligomers rises until, in the case of an approximately stoichiometric ratio, it reaches a value close to 70% of the reaction product.

Abstract: The novel anthranilic acid derivatives having the structural formula (I): ##STR1## wherein n is 0, 1 or 2, one of R.sub.1 and R.sub.2 is chloro or trifluoromethyl and the other is hydrogen, and R is 2-oxo-3-oxolanyl or 2-oxo-3-oxazolidinyl, are effective analgesics and anti-inflammatories.

Abstract: A process for preparing compounds of the formula ##STR1## wherein X is sulfur or oxygen; and R.sup.1 and R.sup.2 are independently selected from the group consisting of H and an alkyl group containing 1 to about 4 carbon atoms, or R.sup.1 and R.sup.2 are fused to form a benzene ring which is optionally substituted by one or more substituents independently selected from the group consisting of an alkyl group containing 1 to about 4 carbon atoms, an alkoxy group containing 1 to about 4 carbon atoms, and halogen. The process involves reacting together a 2-aminooxazole, 2-aminobenzoxazole, 2-aminothiazole or 2-aminobenzothiazole, an alkyl tetrazol-5-ylacetate, and a trialkyl orthoformate and cyclizing the resulting intermediate.

Abstract: N.sub.1 -acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds active on the cardiocirculatory system, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the new compounds and some intermediates useful in the preparation of the new tetrahydroquinoline compounds.Process for preparing the new tetrahydroquinoline compounds and some intermediates useful in the preparation thereof.

Abstract: Isoxazolo[3,4-d]pyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, respectively, are lower alkyl; R.sup.3 is lower alkyl or acyl; and R.sup.4 is hydrogen, lower alkyl, or acyl have antiflammatory, analgesic and antipyretic activities in mammals and low acute and subacute toxicities, as well. The compounds are particularly useful as an antiinflammatory, analgesic and antipyretic drug.

Abstract: Novel 20,21-dinoreburnamenines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and .dbd.CH.sub.2, the wavy line connecting to the E ring being a single bond when R is hydrogen or alkyl of 1 to 4 carbon atoms or a double bond when R is .dbd.CH.sub.2 and the dotted line being possibly an endo carbon-carbon bond when R is hydrogen or alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts in all their possible isomers forms, racemic mixtures and optical isomers having oxygenating and cerebral vasoregulating activity of great value and a novel process and intermediates for their preparation.