Patents Examined by Diana G. Rivers
  • Patent number: 4496740
    Abstract: It is disclosed that the properties of epoxy resins may be improved by incorporating therein at least one metal selected from the group consisting of boron, molybdenum, rhenium, tungsten and zirconium. The selection of a particular metal atom for incorporation into the epoxy resin or a combination of these metals will depend on the specific resin properties desired.
    Type: Grant
    Filed: May 9, 1983
    Date of Patent: January 29, 1985
    Assignee: Hitco
    Inventor: P. Anthony Hinman
  • Patent number: 4496727
    Abstract: The invention relates to a simplified process for the manufacture of 1:1 metal complexes of isoindoline azines of the formula ##STR1## wherein R is hydrogen, alkyl or aryl, Q contains an isocyclic or heterocyclic radical, acyl, carbamoyl or thiocarbamoyl, and Y is the radical of an active methylene group or aromatic amine, which comprises reacting a compound HQ or a hydrazone with an ortho ester or amidine in the presence of a metal donor at elevated temperature in a polar solvent. Pigments made by this process are lightfast and are useful in coloring plastics.
    Type: Grant
    Filed: September 24, 1982
    Date of Patent: January 29, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Abul Iqbal, Paul Lienhard
  • Patent number: 4496570
    Abstract: Compounds the structural formula ##STR1## or their pharmaceutically acceptable salts, wherein X is H or CH.sub.3, Z is NH.sub.2 or OR.sub.6, R.sub.1 is a C.sub.1-8 alkyl, C.sub.3-6 -cycloalkylmethyl, or phenyl-C.sub.1-2 alkyl group,R.sub.2 is hydrogen, hydroxy, chloro or fluoro,R.sub.3 is hydrogen, hydroxy, methoxy, --OCO--(C.sub.1-6 -alkyl) or morpholinoethoxy,R.sub.4 and R.sub.5 may be the same or different and are H or C.sub.1-6 alkyl,R.sub.6 is H, C.sub.1-4 alkyl, C.sub.3-5 alkenyl, C.sub.3-7 cycloalkyl phenyl, or phenyl substituted by one to three alkyl groups with a total of 4 carbon atoms are useful opiod antagonists.
    Type: Grant
    Filed: March 21, 1983
    Date of Patent: January 29, 1985
    Assignee: Key Pharmaceuticals, Inc.
    Inventor: Nicholas S. Bodor
  • Patent number: 4495190
    Abstract: Novel antiviral compounds of the formula ##STR1## wherein each of R.sub.1 and R.sub.2, which are the same or different is hydrogen, hydroxy or fluoro; provided that R.sub.1 or R.sub.2 is hydrogen when R.sub.1 and R.sub.2 are different, and provided that R.sub.1 and R.sub.2 are hydroxy or fluoro when R.sub.1 and R.sub.2 are the same; or a physiologically acceptable salt or an optical isomer thereof, methods for their preparation, pharmaceutical preparations containing the compounds, and methods for the treatment of virus infections and other diseases caused by viruses.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: January 22, 1985
    Assignee: Astra Lakemedel Aktiebolag
    Inventors: Curt-Erik Hagberg, Karl N. Johansson, Zsuzsanna M. I. Kovacs, Goran B. Stening
  • Patent number: 4493929
    Abstract: 2-Alkylpyrimidines are obtained in a one step reaction which comprises the dehydrogenation of a 2-alkyltetrahydropyrimidine over a supported noble metal catalyst under conditions which do not generate water and in which no water is added.
    Type: Grant
    Filed: January 18, 1983
    Date of Patent: January 15, 1985
    Assignee: The Dow Chemical Company
    Inventor: Richard G. Pews
  • Patent number: 4490378
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a --CH.sub.2 --O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl, provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl,R.sup.4 is other than ethyl.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: December 25, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor cs, Csaba Szantay, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Zsuzsanna Relle nee Somfa, Janos Sugar
  • Patent number: 4489068
    Abstract: The insecticidal activity of certain pyridinyl phosphorus compounds is enhanced by the admixture therewith of certain 2,5,6-trisubstituted-4-pyrimidinyl phosphoramidates or phosphoramidothioates.
    Type: Grant
    Filed: April 28, 1983
    Date of Patent: December 18, 1984
    Assignee: The Dow Chemical Company
    Inventors: Donald H. De Vries, Walter Reifschneider, Mark J. Costales
  • Patent number: 4486424
    Abstract: Triorganotin hydantoin compounds of the formula ##STR1## wherein R is C.sub.1 -C.sub.8 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl, phenyl or ##STR2## R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.8 -alkyl, phenyl, hydroxyphenyl, or together they are C.sub.5 -C.sub.7 -alkylene or oxygen,X is oxygen or sulfur, andY is hydrogen or --Sn--(R).sub.3, as well as a process for producing these compounds, and the use thereof for combating pests are described.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: December 4, 1984
    Assignee: Ciga-Geigy Corporation
    Inventors: Wolfgang Wehner, Peter Ackermann
  • Patent number: 4486437
    Abstract: 13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo (3,2,1-de)pyrido (3,2,1-ij) (1,5) naphthiridin-12-phthalidile carboxylate, having the formula given below, and a procedure for its preparation, are described. ##STR1## The compound lends itself to the prevention and treatment of cerebrovascular affections and organic and functional syndromes caused by a deterioration of cerebral circulation.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: December 4, 1984
    Assignee: Ausonia Farmaceutici s.r.l.
    Inventor: Leonardo De Vincentiis
  • Patent number: 4486422
    Abstract: Phosphorus derivatives of 5-pyrimidinols which possess insecticidal properties and especially both systemic and foliar activity for plants against insect pests.
    Type: Grant
    Filed: November 22, 1982
    Date of Patent: December 4, 1984
    Assignee: The Dow Chemical Company
    Inventors: Mark J. Costales, Walter Reifschneider, Doris L. Paroonagian
  • Patent number: 4486421
    Abstract: Phosphorus derivatives of 4-pyrimidinols which possess insecticidal properties and especially both systemic and foliar activity for plants against insect pests.
    Type: Grant
    Filed: November 22, 1982
    Date of Patent: December 4, 1984
    Assignee: The Dow Chemical Company
    Inventors: Mark J. Costales, Doris L. Paroonagian, Walter Reifschneider
  • Patent number: 4486221
    Abstract: Thiazolo[2,3-b]quinazolones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the description, are used for influencing plant growth and for controlling undesirable plant growth.
    Type: Grant
    Filed: October 20, 1982
    Date of Patent: December 4, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Guenther Seybold, Bruno Wuerzer
  • Patent number: 4482560
    Abstract: Novel carbostyril derivatives and their salts having antihistaminic effects and are useful as antihistaminic agents, represented by the general formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkenyl group, a lower alkynyl group or a lower alkyl group which may have phenyl group(s) as the substituted group(s); R.sup.2 is a hydrogen atom, a lower alkyl group or a phenyl group; R.sup.3 is a lower alkyl group having phenyl group(s) as the substituted group(s), or a phenyl group which may have 1 to 3 substituted groups selected from the group consisting of halogen atoms, lower alkyl groups and lower alkoxy groups; R.sup.4 is a hydrogen atom, a hydroxyl group or a lower alkanoyl group; X is a halogen atom; Y is a lower alkylene group which may have hydroxyl group(s) as the substituent(s); n is 0, 1 or 2; the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or double bond; provided that when R.sup.
    Type: Grant
    Filed: March 12, 1982
    Date of Patent: November 13, 1984
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Kazuo Banno, Takafumi Fujioka, Yasuo Oshiro, Kazuyuki Nakagawa
  • Patent number: 4482561
    Abstract: The N-substituted-4-(optionally substituted)-2-, 3- or 4-piperidyl N-(7- or 8-substituted-4-quinolyl)-anthraniloyloxyalkanoates having the structural formula (I): ##STR1## in which R is a straight or branched chain alkyl radical having from 1 to 4 carbon atoms; an alkenyl or alkynyl radical having from 2 to 6 carbon atoms; a benzyl, phenethyl, 4-nitrophenethyl or 4-aminophenethyl radical; or a phenacyl, benzoylethyl, .beta.-hydroxyphenethyl or .alpha.-hydroxyphenylpropyl radical, optionally substituted on the phenyl ring by one or more halogen atom, trifluoromethyl, nitro or amino substituents, or an alkyl substituent having from 1 to 4 carbon atoms or an alkoxy substituent having from 1 to 4 carbon atoms; R.sub.1 is a hydrogen atom or a phenyl radical; each of R.sub.2 and R.sub.3 is independently a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms; one of R.sub.4 and R.sub.5 is a chlorine atom or a trifluoromethyl radical and the other of R.sub.4 and R.sub.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: November 13, 1984
    Assignee: Recordati, S. A., Chemical & Pharmaceutical Co.
    Inventors: Dante Nardi, Gianni Motta, Rodolfo Testa, Gabriele Graziani
  • Patent number: 4479946
    Abstract: Novel phosphorus esters of amidoximes and methods of preparing same. This invention is also directed to pesticidal compositions comprising an acceptable carrier and a pesticidally effective amount of a compound of this invention, as well as to a method of controlling pests which comprises subjecting the pests to a pesticidally effective amount of a compound of this invention.
    Type: Grant
    Filed: June 17, 1982
    Date of Patent: October 30, 1984
    Assignee: Union Carbide Corporation
    Inventors: Leonard E. Hodakowski, Dean F. Bushey
  • Patent number: 4479004
    Abstract: A description is given of new compounds of the formula defined herein: ##STR1## which display valuable microbicidal properties. The compounds can be used for combatting microorganisms harmful to plants, especially phytopathogenic fungi. The compounds of formula I thus possess a curative, systemic, and preventive action very useful for practical requirements for the protection of cultivated plants, without causing these to suffer any undesirable side effects. In practice, the compounds can be used by themselves or in the form of pesticides.
    Type: Grant
    Filed: September 24, 1982
    Date of Patent: October 23, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Adolf Hubele, Peter Riebli
  • Patent number: 4477456
    Abstract: Novel bridged benzofuroisoquinoline compounds having analgesic, narcotic antagonist and anorexigenic properties.
    Type: Grant
    Filed: April 22, 1982
    Date of Patent: October 16, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Engelbert Ciganek
  • Patent number: 4476304
    Abstract: A process for the purification of riboflavine-5'-monophosphate comprising subjecting crude riboflavine-5'-monophosphate to chromatography using a column packed with a weakly basic anion-exchange resin having a skeleton of a crosslinked polyacrylic acid ester or polymethacrylic acid ester in which at least a part of the ester linkages thereof are converted into amide linkages represented by the following formula (1): ##STR1## to obtain a fraction of riboflavine-5'-monophosphate containing a reduced amount of impurities from an eluate of the column is disclosed.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: October 9, 1984
    Assignees: Mitsubishi Chemical Industries Limited, Wakamoto Pharmaceutical Co., Ltd.
    Inventors: Kenji Yokota, Hiroshi Kusano, Ryuichi Sugimoto
  • Patent number: 4476132
    Abstract: Quinolinone derivatives of the formula (I) ##STR1## in which X represents oxy or a direct bond, R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical or hydrogen, Ph represents an optionally additionally substituted 1,2-phenylene radical containing the group R.sub.1 --X--C(O)--, and one of the radicals R.sub.2 and R.sub.3 represents an optionally esterified or amidated carboxy group R.sub.4 and the other represents hydrogen or an aliphatic radical or, in the case of a radical R.sub.3, hydroxy, and in which either R.sub.A and R.sub.B together represent oxo, R.sub.C and R.sub.D together represent an additional bond, or, when R.sub.2 represents a radical R.sub.4, R.sub.C is hydrogen and R.sub.3 and R.sub.D together represent oxo, and R.sub.E represents a radical R.sub.5 which represents hydrogen or an aliphatic, cycloaliphatic, araliphatic heterocyclic-aliphatic radical, or R.sub.A represents an optionally etherified hydroxy group and R.sub.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: October 9, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Richard Goschke, Pier G. Ferrini, Alfred Sallmann
  • Patent number: 4476130
    Abstract: 3-(1H-tetrazole-5-yl)-4H-pyrimido[2,1-b]-benzoxazol-4-ones are disclosed as anti-allergic compounds. Pharmaceutically acceptable salts, pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
    Type: Grant
    Filed: September 9, 1982
    Date of Patent: October 9, 1984
    Assignee: Riker Laboratories, Inc.
    Inventor: James J. Wade