Patents Examined by Dirk R Bass
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Patent number: 11925736Abstract: Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.Type: GrantFiled: November 12, 2020Date of Patent: March 12, 2024Assignees: Fresenius Medical Care Deutschland GmbH, Fresenius Medical Care Holdings, Inc.Inventors: Massimo Earl Fini, Lynn E. Jensen, Alexander Heide, Dejan Nikolic, Arne Peters, Christoph Wiktor, Marina Wenke, Tommy Huang, Dacey John Ryan, Stefan Kreber, Lothar Leick, Dzhuney Terzi, Hendrik Therre, Manfred Weis, Alain Veneroni, Reinhold Reiter, Michele Marini, Davide Maria Benelli, Brad Yang, Jiunn Teo
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Patent number: 11925741Abstract: In a blood transfusion system (a blood transfusion kit, a blood transfusion kit for emergency blood transfusion, or a method of using a blood transfusion kit), a flow path through which blood flows is formed using a tube having a channel therein. The flow path includes: a first path that connects an upstream path and a downstream path and has a leukocyte removal filter removing leukocytes at an intermediate position of the channel and a second path that connects the upstream path and the downstream path and bypasses the leukocyte removal filter.Type: GrantFiled: September 27, 2018Date of Patent: March 12, 2024Assignee: TERUMO KABUSHIKI KAISHAInventor: Masatsugu Igarashi
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Patent number: 11918728Abstract: A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.Type: GrantFiled: November 6, 2020Date of Patent: March 5, 2024Assignee: Immutrix Therapeutics, Inc.Inventors: Carol A. Rae, Jan Simoni, Grace Simoni, John F. Moeller, Jose A. Diaz-Aunon
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Patent number: 11918717Abstract: A blood purification device includes a device body and a cassette. The cassette includes: a casing that accommodates a removal water receptacle; and pump tube. The device body includes fingers, a driving unit, and a housing. The cassette can be attached to and removed from the housing of the device body so that the pump tubes are positioned between the plurality of fingers and the outer surfaces of the casing.Type: GrantFiled: August 27, 2019Date of Patent: March 5, 2024Assignee: NIKKISO CO., LTD.Inventors: Takayoshi Yokoyama, Masato Fujiwara, Hiroshi Nimura
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Patent number: 11904083Abstract: The present disclosure relates to various aspects of a procedure for reducing the carbon dioxide content in blood during the treatment of patients. A first aspect of the present disclosure relates to a buffer solution for use in reducing the carbon dioxide content in the blood when treating a patient suffering from pulmonary insufficiency or the complete failure of lung function, wherein the fluid is in gas exchange with a portion of the patient's blood conducted through an extracorporeal circuit. The first aspect of the present disclosure further relates to an apparatus for the extracorporeal reduction of the carbon dioxide content in the blood using said buffer solution. A second aspect of the present disclosure relates to a system for extracorporeal blood treatment, likewise using said buffer solution and the apparatus, and furthermore to a treatment apparatus for extracorporeal blood treatment comprising the aforementioned system.Type: GrantFiled: December 21, 2018Date of Patent: February 20, 2024Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventors: Petra Abel, Jurgen Klewinghaus, Rolf Zander
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Patent number: 11896752Abstract: A dialysis machine configured to carry out a method and a method for draining an extracorporeal fluid circuit utilizing a dialysis machine, wherein the dialysis machine is connected to a dialyzer and said extracorporeal fluid circuit, said extracorporeal fluid circuit comprising an arterial line connectable to a patient, for drawing blood from the patient and a venous line connectable to the patient for returning blood to the patient, the method comprising: after treatment termination from said extracorporeal fluid circuit draining remaining fluid from said extracorporeal fluid circuit through the dialyzer.Type: GrantFiled: October 25, 2018Date of Patent: February 13, 2024Assignee: Gambro Lundia ABInventors: Sture Hobro, Roger Nilsson, Olof Jansson, Björn Ericson
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Patent number: 11896749Abstract: Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.Type: GrantFiled: November 9, 2020Date of Patent: February 13, 2024Assignees: Fresenius Medical Care Deutschland GmbH, Fresenius Medical Care Holdings, Inc.Inventors: Massimo Earl Fini, Lynn E. Jensen, Dacey John Ryan, Alexander Heide, Dejan Nikolic, Arne Peters
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Patent number: 11890577Abstract: A system for cleaning feed water of variable quality, the system comprising an inlet for selectively delivering feed water to one or other of at least two feed chambers, each feed chamber having a delivery pipe for delivering feed water to a reverse osmosis or nanofiltration; a pump to deliver the feed water from one of the chambers through its associated delivery pipe to the reverse osmosis or nanofiltration to create a concentrated feed stream and a product water stream; return pipes for selectively returning the concentrated feed stream to one or other of the at least two feed chambers; a product water outlet for removal of the product water; and means for switching the delivery of the concentrated feed stream between the selectable return pipes upon detection of a predetermined reduction in efficiency within one or another of the feed chambers.Type: GrantFiled: June 15, 2021Date of Patent: February 6, 2024Assignee: IDE WATER TECHNOLOGIES LTD.Inventors: Alex Drak, Tomer Efrat, Roi Zaken
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Patent number: 11884703Abstract: Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.Type: GrantFiled: February 19, 2021Date of Patent: January 30, 2024Assignee: Genzyme CorporationInventors: Tarl Vetter, Michael Coolbaugh, Veena Warikoo, Konstantin Konstantinov
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Patent number: 11883572Abstract: The present invention relates to a dialysis machine that is configured to be equipped with an extracorporeal blood system comprising a dialysis solution system that is configured to be equipped with a dialyzer, wherein a mixing region, in particular a mixing chamber, is provided in which the fresh dialysis solution or a component thereof is located in the operation of the dialysis machine, with a concentrate line being in fluid communication with the mixing region, through which concentrate line concentrate can be conducted from a concentrate container into the mixing region, wherein at least two electrically conductive elements are arranged spaced apart from one another in or at the concentrate line or lines; that a measuring device is provided which is electrically connected to the conductive elements and which is configured to measure the conductance or a value correlated therewith between them; and that a control unit is provided which is configured to compare the measured value with a desired value, withType: GrantFiled: March 26, 2019Date of Patent: January 30, 2024Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventors: Tobias Irrgang, Tilman Stäblein, Alfred Gagel, Peter Klöffel
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Patent number: 11884701Abstract: Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.Type: GrantFiled: March 16, 2021Date of Patent: January 30, 2024Assignee: Merck Millipore Ltd.Inventors: Damian Brellisford, Donna Lisa Crossley, Greg McIntosh, Robert Ruman, John Rydall, Christopher S. Shields
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Patent number: 11878101Abstract: A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: the concentrations of Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Rb, Sr, Y, Zr, Mo, Ru, Ag, Cd, Sn, Cs, La, Pr, Sm, Gd, Tb, Ta, Au, Tl, Co, In, and Bi are each 0.1 ppb or less and the concentrations of Ba, Nd, Pb, And Ce are each 1 ppb or less in a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device; and the number of fine particles having a size of 10 ?m or more is 25 or less and the number of fine particles having a size of 25 ?m or more is 3 or less in 1 mL of the physiological saline solution for injection.Type: GrantFiled: March 29, 2019Date of Patent: January 23, 2024Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko Oishi, Makoto Ozeki, Keitaro Matsuyama, Naoki Morita, Hiroshi Tajima, Toshinori Koizumi
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Patent number: 11878284Abstract: A process for the efficient transfer of molecules between phases employing mesoporous poly (aryl ether ketone) hollow fiber membranes is provided. The method addresses the controlled transfer of reactants into and removal of reaction products from a reaction media and the removal and separation of target molecules from process streams by membrane-assisted liquid-liquid extraction. A number of possible modes of liquid-liquid extraction are possible according to the invention by utilizing porous poly (aryl ether ketone) hollow fiber membranes of Janus-like structure that exhibit a combination of hydrophilic and hydrophobic surface characteristics. The method of the present invention can address the continuous manufacture of chemicals in membrane reactors and is useful for a broad range of separation applications, including separation and recovery of active pharmaceutical ingredients.Type: GrantFiled: March 21, 2023Date of Patent: January 23, 2024Assignee: Avanpore LLCInventor: Benjamin Bikson
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Patent number: 11866358Abstract: The invention relates to a household appliance for the implementation of a method enabling the instant production of mineral water with a selected composition and flavour, upon request, from tap water. The tap water circulates through a filtering unit, a demineralisation unit and a remineralisation unit comprising at least one secondary input, connected to a fluidic microfeeding device, downstream from which a portion of the circuit is a static mixer. An inlet valve and the outlet valve are arranged to operate in parallel and simultaneously.Type: GrantFiled: March 28, 2018Date of Patent: January 9, 2024Assignee: AQVITA SRL.Inventor: Philippe Tob
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Systems and methods for monitoring and controlling fluid balance during a biological fluid procedure
Patent number: 11857714Abstract: Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.Type: GrantFiled: January 23, 2023Date of Patent: January 2, 2024Assignee: Fenwal, Inc.Inventors: Zahra R Ali, Lan T. Nguyen -
Patent number: 11844889Abstract: An extracorporeal blood treatment device is provided that includes a hydraulic system having a plurality of flow paths. A control unit provides an operating mode for disinfecting the hydraulic system with a liquid supplied via one of the flow paths. A method for operating the extracorporeal blood treatment device is also provided. The hydraulic system has a valve device that provides several switching positions. The valve device has an inlet for a liquid for disinfecting the hydraulic system, and a plurality of outlets. In a first switching position, the inlet is connected to one of the outlets. In another switching position, the inlet is connected to a plurality of the outlets. The inlet of the valve device is in fluid communication with a first flow path and the outlets are in fluid communication with another flow path. Disinfecting liquid can simultaneously be supplied to the individual flow paths.Type: GrantFiled: November 18, 2022Date of Patent: December 19, 2023Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventor: Tobias Irrgang
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Patent number: 11839710Abstract: A dialysis machine has a balancing system with a balancing chamber for a volumetrically exact supply and removal of dialysis solution to and from a dialyzer fluidically connected to the balancing system in operation; a water inlet system connected to the balancing system for the supply of fresh dialysis liquid, with the water inlet system having an apparatus for degassing water that is connected to an air separator of the dialysis machine, with a first subsection of the air separator serving as a mixing chamber and being connectable to at least one concentrate source via at least one concentrate line and being in fluid communication with the balancing system via at least one dialysate line, wherein the filling volume of a balancing chamber corresponds to or exceeds the sum of the volume of the mixing chamber and the inner volume of the dialysate line.Type: GrantFiled: April 2, 2019Date of Patent: December 12, 2023Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventors: Peter Klöffel, Tilman Stäblein, Andreas Syfonios, Dirk Hümmer, Tobias Irrgang, Benedict Glaser
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Patent number: 11835123Abstract: An oil strainer is arranged between an oil pan configured to close a lower opening of a transmission case and a control valve body which is installed in the lower opening. The control valve body has a discharge hole of oil in a portion opposing the oil strainer. The oil strainer has an oil suction port in a portion opposing the oil pan, and has a rib projecting on the control valve body side on a surface of a portion opposing the control valve body. When seen from the oil pan side, the oil suction port and the discharge hole are provided so that positions are not matched from each other. When seen from the oil pan side, the rib is provided to cross a straight line passing through the oil suction port and the discharge hole in a region between the oil suction port and the discharge hole.Type: GrantFiled: July 19, 2019Date of Patent: December 5, 2023Assignees: JATCO LTD, NISSAN MOTOR CO., LTD.Inventor: Isao Yabuzaki
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Patent number: 11833284Abstract: Methods, sorbent cartridges and cleaning devices are disclosed for refurbishing sorbent materials. In one implementation among multiple implementations, a medical fluid delivery method includes: providing a sorbent cartridge including H+ZP within a casing for a treatment; and after the treatment, refurbishing the H+ZP while maintained within the casing via (i) regenerating the non-disinfected H+ZP by flowing an acid solution through the casing, (ii) rinsing the regenerated H+ZP while maintained within the casing, (iii) disinfecting the regenerated and rinsed H+ZP by flowing a disinfecting agent through the casing, and (iv) rinsing the regenerated and disinfected H+ZP while maintained within the casing. Multiple batch sorbent refubishing implementations are also disclosed.Type: GrantFiled: April 15, 2021Date of Patent: December 5, 2023Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Yuanpang Samuel Ding, Rosa Hung-Chen Yeh, Cristian Adolfo Menzel Bueno, Ieng Kin Lao
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Patent number: 11835513Abstract: A method for separating particles in a biofluid includes pretreating the biofluid by introducing an additive, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel. A system for microfluidic separation, capable of separating target particles from non-target particles in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic particle separation includes a microfluidic separation channel connected to an acoustic transducer, a source of an additive, and instructions for use.Type: GrantFiled: February 9, 2021Date of Patent: December 5, 2023Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Jason O. Fiering, Kenneth T. Kotz