Patents Examined by Dirk R Bass
  • Patent number: 11561188
    Abstract: The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: January 24, 2023
    Assignee: Icagen, LLC
    Inventors: Eva R. Birnbaum, Benjamin P. Warner, Sharon M. Baldwin, Jennifer A. Berger, Lori J. Peterson-Court, Michael N. Harris, Rebecca L. E. Miller
  • Patent number: 11529446
    Abstract: The invention relates to an extracorporeal blood treatment device comprising a hydraulic system II comprising a plurality of flow paths, the blood treatment device having a control unit 40 which provides an operating mode for disinfecting the hydraulic system with a liquid which can be supplied via one of the flow paths. Moreover, the invention relates to a method for operating an extracorporeal blood treatment device with a hydraulic system comprising a plurality of flow paths. The blood treatment device according to the invention is characterized in that the hydraulic system II has a valve device 23 which provides several switching positions. The valve device 23 has an inlet 25A for the liquid for disinfecting the hydraulic system and a plurality of outlets 26A, 27A, 28A, wherein in a switching position the inlet 25A is connected to one of the outlets 26A, 27A, 28A and in another switching position the inlet is connected to a plurality of outlets 26A, 27A, 28A.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: December 20, 2022
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Tobias Irrgang
  • Patent number: 11524101
    Abstract: A blood treatment device includes an extracorporeal blood circuit, dialyzer and dialysis fluid circuit. The blood circuit and dialysis fluid circuit are separated from each other by a membrane in the dialyzer. A weighing device measures and monitors the weight of a bag containing a fluid. A fluid pump pumps fluid out of and into the bag. A control unit interrupts fluid supply by stopping the pump when a weight variation of the bag occurs and temporarily maintains the interruption at least until the malfunction disappears, and automatically restarts the fluid supply if the bag or the weight of the bag stabilizes within a predetermined time and the weight variation does not exceed a predetermined value. The control unit generates an alarm if the bag or weight of the bag does not stabilize within a predetermined time and/or if the weight variation exceeds a predetermined value.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: December 13, 2022
    Assignee: B. Braun Avitum AG
    Inventors: István Golarits, Botond Tényi
  • Patent number: 11511025
    Abstract: A medical fluid treatment system includes a source of purified water; at least one concentrate for mixing with the water from the source to form a treatment fluid; a disposable set including a pumping portion, a concentrate line in fluid communication with the concentrate source and the pumping portion, and a patient line in fluid communication with the pumping portion, the patient line including a filter having a membrane configured to filter the treatment fluid, the filter configured such that (i) fresh treatment fluid flowing from the pumping portion towards a patient flows through the membrane and (ii) used treatment fluid flowing through the filter from the patient to the pumping portion bypasses the membrane; and a medical fluid delivery machine including a pump actuator operable with the pumping portion of the disposable set.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: November 29, 2022
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: John Norman, Edward Szpara, Karl Cazzini
  • Patent number: 11504463
    Abstract: Systems and method for verifying the timely placement of a container of biolocal cells or fluid within a treatment chamber of a biological fluid treating device are disclosed. The systems and methods utilize a sensor that detects the presence of a container at an appropriate and pre-determined time and, optionally, detects the weight of the container and cells.
    Type: Grant
    Filed: January 8, 2020
    Date of Patent: November 22, 2022
    Assignee: Fenwal, Inc.
    Inventors: Zahra R. Ali, Katherine N. Radwanski
  • Patent number: 11498049
    Abstract: A process for producing a calcium phosphate reactant, according to which: in a first step, use is made of a source of calcium and a source of phosphate ions in water, in a molar ratio that is adjusted so as to obtain a Ca/P molar ratio of between 0.5 and 1.6, and the source of calcium is reacted with the phosphate ions at a pH of between 2 and 8, in order to obtain a suspension (A) of calcium phosphate, and in a second step, added to the suspension (A) are an alkaline compound comprising hydroxide ions in order to set a pH of more than 8 and an additional source of calcium in order to obtain a suspension (B) of calcium phosphate reactant having a Ca/P molar ratio of more than 1.6. A calcium phosphate reactant obtainable by such a process.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: November 15, 2022
    Assignee: Solvay SA
    Inventors: Patrick Perrin, Olivier Jacques F. J. G. Bodson, Thierry Delplanche, Dirk Breugelmans
  • Patent number: 11497840
    Abstract: An indirect drain flush system incorporating hot water to facilitate the transport of kidney dialysis effluent to wastewater treatment facilities is provided. Heated water is discharged into a waste line through an air gap, and the heated water increases the molecular interchange of fatty substances in the dialysis effluent, decreasing the viscosity of those fatty substances and preventing them from coagulating or crystalizing on pipes and drains. An air admittance valve may prevent negative pressure from building up within the system.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: November 15, 2022
    Assignee: PHS SOLUTIONS LLC.
    Inventors: Randy J. Pentecost, Bryan S. Hall, Fred A. Sink
  • Patent number: 11491464
    Abstract: A process for the efficient transfer of molecules between phases employing mesoporous poly (aryl ether ketone) hollow fiber membranes is provided. The method addresses the controlled transfer of reactants into and removal of reaction products from a reaction media and the removal and separation of target molecules from process streams by membrane-assisted liquid-liquid extraction. A number of possible modes of liquid-liquid extraction are possible according to the invention by utilizing porous poly (aryl ether ketone) hollow fiber membranes of Janus-like structure that exhibit a combination of hydrophilic and hydrophobic surface characteristics. The method of the present invention can address the continuous manufacture of chemicals in membrane reactors and is useful for a broad range of separation applications, including separation and recovery of active pharmaceutical ingredients.
    Type: Grant
    Filed: June 9, 2022
    Date of Patent: November 8, 2022
    Assignee: Avanpore LLC
    Inventor: Benjamin Bikson
  • Patent number: 11491426
    Abstract: A purification device comprises a main body having an opening in a front-face thereof; a rotator disposed in the opening to be rotatably mounted on the main body; a manipulation structure spaced from and above the rotator and rotatably connected to a top face of the main body, the manipulation structure protruding forward of the main body; and a water-outlet including; a first cover fixed to the rotator through the opening, the first cover protruding forward of the main body, and a top of the first cover being connected to a bottom of the manipulation structure; a second cover vertically movable while being held in contact with the first cover; and a nozzle on a bottom of the second cover; wherein when the second cover rises to a highest level, a top of the second cover is located in a space between the rotator and the manipulation structure.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: November 8, 2022
    Assignee: LG ELECTRONICS INC.
    Inventors: Jewook Jeon, Soonki Jung, Minho Kim, Youngseok Kim, Hoon Jang, Jingyu Ji
  • Patent number: 11491269
    Abstract: The disclosed arterial chambers for hemodialysis may include a cap with a blood inlet port for conveying an intended patient's blood into the arterial chamber, an auxiliary port configured to provide fluid access to the arterial chamber, and a needleless access port configured to couple to a needleless syringe. The needleless access port may be configured for administering a substance to an interior of the arterial chamber from the needleless syringe and/or for withdrawing blood from the interior of the arterial chamber into the needleless syringe. Various tubing sets, hemodialysis systems, and other components, systems, and methods are also disclosed.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: November 8, 2022
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Irving Uziel Hernandez Gomez, Juan Arturo Montecillo Juárez, Diego Suarez del Real Pena
  • Patent number: 11479882
    Abstract: A fiber can be made having a structure with an axial core and a coating layer. The fiber can have a polymer core and one or two layers surrounding the core. The fine fiber can be made from a polymer material and a resinous aldehyde composition such that the general structure of the fiber has a polymer core surrounded by at least a layer of the resinous aldehyde composition.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: October 25, 2022
    Assignee: Donaldson Company, Inc.
    Inventors: Suresh L. Shenoy, Thomas M. Weik
  • Patent number: 11478579
    Abstract: A microwave therapy apparatus and method for blood cancer treatment is disclosed. The microwave therapy apparatus for blood cancer treatment includes a plurality of porous anodic aluminum oxide (AAO) filters or a plurality of porous glass filters provided in a dialyzer of a hemodialysis apparatus; a nanoflower filter provided downstream of the plurality of porous anodic aluminum oxide (AAO) filters or the plurality of porous glass filters in the blood tube; and an RF absorber provided downstream of the nanoflower filter to attract cancer cells thereto by generating a frequency of a predetermined band, wherein the blood, from which the cancer cells have been removed by an RF frequency and which includes normal blood cells that passed through the nanoflower filter, is circulated and supplied to a blood tube connected to a vein of the body of the blood cancer patient.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: October 25, 2022
    Assignee: KWANGWOON UNIVERSITY INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
    Inventors: Nam-Young Kim, Eun Seong Kim
  • Patent number: 11482347
    Abstract: A decontamination method in which tritium radiation is attenuated or eliminated from radioactive contaminated water. In the decontamination method, the following steps are executed: a step for performing an addition treatment to add a prescribed amount of a mineral powder such as a silicon dioxide ore and a nano-level carbon liquid to heated tritium-contaminated water in an addition treatment tank; a step for pumping the addition-treated water from the addition treatment tank to a mineral solid filled tank using a hydraulic pump; a step for causing the addition-treated water to collide with a mineral solid and passing the addition-treated water through the mineral solid filled tank; a step for returning the passed water to the addition treatment tank using the hydraulic pump; and a circulation process step for repeating the aforementioned steps in a prescribed period of time.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: October 25, 2022
    Assignee: KABUSHIKIKAISHA GABRIEL
    Inventor: Hikaru Takatsuka
  • Patent number: 11478755
    Abstract: A fluid processing system includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a spinning membrane separator drive coupled to the spinning membrane separator, first and second syringe pumps coupled to the first and second syringes respectively, a control cassette interface coupled to the flow control cassette, and at least one controller coupled to the spinning membrane separator drive, the first and second syringe pumps, and the control cassette interface. The controller is configured to selectively operate the drive, the first and second syringe pumps, and the interface to provide a procedure according to a protocol.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: October 25, 2022
    Assignee: Fenwal, Inc.
    Inventors: Christopher J. Wegener, Bret M. Olson, Carolyn Kos, Timothy Getschman, Mark J. Brierton, Robert A. Brown
  • Patent number: 11471576
    Abstract: An extracorporeal blood treatment apparatus comprises: a blood treatment device (2) comprising a blood chamber (3) and a fluid chamber (4) separated from one another by a semipermeable membrane (5); an extracorporeal blood circuit (17) comprising a blood withdrawal line (6) connected to an inlet port (3a) of the blood chamber (3) and a blood return line (7) connected to an outlet port (3b) of the blood chamber (3); a blood pump (21) configured to be coupled to the blood withdrawal line (6); a hydraulic circuit (100) connectable to the fluid chamber (4), wherein the hydraulic circuit (100) comprises a fluid preparation device (9) connected to a water network (14) and configured to dilute concentrates in water to prepare a treatment fluid; a control unit (12) connected to the preparation device (9) and to the blood pump (21).
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: October 18, 2022
    Assignee: Gambio Lundia AB
    Inventors: Paolo Rovatti, Katty Ferrari
  • Patent number: 11465098
    Abstract: A feed of at least one of (a) a source liquid including a solvent with a dissolved impurity and (b) a retentate of the source liquid is pumped in a substantially closed loop through a liquid-separation module. The liquid-separation module includes a membrane that passes at least partially purified solvent to a permeate side of the membrane while diverting the impurity in a retentate on the retentate side of the membrane. The purified solvent is extracted from the permeate side of the membrane; and the retentate from the liquid-separation module is pumped to or through a pressurized reservoir with a variable volume for the feed component and recirculated as a component of the feed. Over time, the volume for the feed is reduced and the pressure applied to the feed in the reservoir is increased to balance against an increasing difference in osmotic pressure across the membrane.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: October 11, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: David Elan Martin Warsinger, John H. Lienhard, Emily Winona Tow, Ronan Killian McGovern, Gregory Parker Thiel
  • Patent number: 11465100
    Abstract: There is provided a thin film composite (TFC) hollow fibre membrane comprising a porous hollow fibre support layer formed of a polymer and a selective layer, formed of a cross-linked polyamide, on an inner circumferential surface of the hollow fibre support layer, wherein the TFC hollow fibre membrane has a power density of 25-50 W/m2 at a pressure of 30 bar. There is also provided a method of forming the TFC hollow fibre membrane.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: October 11, 2022
    Assignee: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Chunfeng Wan, Tianshi Yang, Wenxiao Gai, Tai-Shung Neal Chung
  • Patent number: 11452802
    Abstract: A negative-balanced isolated pelvic perfusion method, in which a drug is administered into the closed pelvis while keeping the volume of suction from the vein larger than that of injection into the artery, does not require allogeneic blood transfusion. A perfusion device is for recovering a liquid containing a drug and/or blood from a tube connecting to the inferior vena cava and for injecting the liquid obtained into a tube connecting to the artery, provided with a unit for closing the inside of the pelvis by including a unit for blocking the artery from the heart to the pelvis, a unit for blocking the inferior vena cava from the pelvis to the heart, and a unit for blocking a blood flow from the pelvis to the lower limbs. The perfusion device is provided with a pelvic perfusion unit equipped with a reservoir, an autotransfusion unit, and a dialysis unit.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: September 27, 2022
    Assignees: KOSEI ADVANCE CO., LTD.
    Inventor: Satoru Murata
  • Patent number: 11439737
    Abstract: The invention relates to a device for extracorporeal blood treatment, having a hydraulic system B which comprises multiple lines (7), (9) for providing dialysate for a dialyser (3) and having a control system (15) which comprises multiple electrical components (17A), (17B), (17C). The invention also relates to a method for operating a device for extracorporeal blood treatment which has a hydraulic system which comprises multiple lines for providing dialysate for a dialyser and a control system which comprises multiple electrical components, wherein the dialysate is produced using a liquid supplied to the device for extracorporeal blood treatment. The extracorporeal blood treatment device is a blood treatment device which has a central connection (11) to allow a liquid, in particular permeate (pure water), to be supplied to the machine.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: September 13, 2022
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Benedict Glaser
  • Patent number: 11439736
    Abstract: A dialysis system includes a dialysis machine including at least one pump positioned and arranged to pump a dialysis fluid; and a dialysis fluid source located separate from and in fluid communication with the dialysis fluid machine, the dialysis fluid source including a purified water line for carrying purified water, a source of a first concentrate, a source of a second concentrate, a first concentrate pump positioned and arranged to pump first concentrate from the first concentrate source, and a second concentrate pump positioned and arranged to pump second concentrate from the second concentrate source, wherein dialysis fluid is prepared for delivery from the dialysis fluid source to the dialysis machine by mixing the purified water with the first concentrate pumped by the first concentrate pump and the second concentrate pumped by the second concentrate pump.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: September 13, 2022
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Justin B. Rohde, Shincy J. Maliekkal