Patents Examined by Dominic Lazaro
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Patent number: 11969496Abstract: An anhydrous personal care composition, comprising: (a) 45 to 60 weight % of at least one ester, selected from (i) triglycerides, (ii) diglycerides, (iii) monoglycerides, (iv) monoesters of diols, and (v) diesters of diols; (b) a first wax having a melting point of from 35° C. to 72° C. present in an amount of 5 to 25 weight %; (c) a second wax having a melting point of 73 to 90° C. present in an amount of 0.5 to 15 weight %; and (d) at least one plant oil having a saponification value of from 150 to 275 mg KOH/g present in an amount of 5 to 35 weight.Type: GrantFiled: July 27, 2022Date of Patent: April 30, 2024Assignee: Colgate-Palmolive CompanyInventors: Ewelina Lesniak, Kathy Potechin, Lauren Decina
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Patent number: 11964120Abstract: Provided herein are gastroretentive dosage forms (GRDFs) for extended retention in a human stomach, comprising a body comprising at least two arms, the body configured to transform between a collapsed configuration for ingestion, an expanded configuration for retention within the stomach and a disassembled configuration wherein after a predetermined time period has elapsed, the GRDF disassembles into at least two parts such that each of the disassembled parts of the GRDF is sized for exiting the stomach; and, an erodible insert comprising a therapeutic agent, a diagnostic agent, an electronical device, or a combination thereof.Type: GrantFiled: November 17, 2022Date of Patent: April 23, 2024Assignee: Clexio Biosciences Ltd.Inventors: Avshalom Ben Menachem, Ilan Zalit
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Patent number: 11964018Abstract: Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.Type: GrantFiled: November 22, 2022Date of Patent: April 23, 2024Assignee: Fennec Pharmaceuticals Inc.Inventor: Alexander Smith
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Patent number: 11957853Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.Type: GrantFiled: January 18, 2023Date of Patent: April 16, 2024Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett, David Hendrickson
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Patent number: 11952435Abstract: Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.Type: GrantFiled: March 16, 2023Date of Patent: April 9, 2024Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Kyle Hyun Chang Kim, Yefim Brun, Lucia Daniela Ionescu, Juan David Londono, Jorge Mok, James Joshua Ohane, Lemuel Tong
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Patent number: 11951098Abstract: A method for suppressing obstruction of meibomian gland in a mammalian subject, the method comprising administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to an eye of the mammalian subject 1 to 2 times per day.Type: GrantFiled: February 16, 2023Date of Patent: April 9, 2024Assignee: SANTEN PHARMACEUTICAL CO., LTD.Inventors: Hideki Miyake, Tomoko Oda, Daisuke Shii
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Patent number: 11944708Abstract: The present application provides methods of treating a CNS disorder (such as glioblastoma and epilepsy) in an individual, comprising systemically (e.g., intravenously or subcutaneously) administering to the individual an effective amount of a composition comprising nanoparticles comprising an mTOR inhibitor (such as a limus drug, such as sirolimus or a derivative thereof) and an albumin, optionally further comprising administering a second agent (such as an anti-VEGF antibody, a proteasome inhibitor, or an alkylating agent).Type: GrantFiled: September 17, 2020Date of Patent: April 2, 2024Assignee: Abraxis BioScience, LLCInventors: Neil P. Desai, Shihe Hou
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Patent number: 11938287Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.Type: GrantFiled: September 14, 2022Date of Patent: March 26, 2024Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett, David Hendrickson
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Patent number: 11931357Abstract: The present invention provides long-acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of Cariprazine or salts thereof, in a depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot compositions are preferably in the form of in-situ implants suitable for subcutaneous or intramuscular administration and provide prolonged release of the Cariprazine active ingredient and/or its metabolites desmethyl Cariprazine (DCAR) and didesmethyl Cariprazine (DDCAR) for a period of at least 4 weeks following a single administration. The present invention further provides methods of use of the depot compositions for the treatment of schizophrenia, major depressive disorder, and bipolar disorder.Type: GrantFiled: February 14, 2023Date of Patent: March 19, 2024Assignee: MAPI PHARMA LTD.Inventors: Shai Rubnov, Ehud Marom, Anna Gopin
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Patent number: 11925729Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.Type: GrantFiled: October 17, 2022Date of Patent: March 12, 2024Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett, David Hendrickson
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Patent number: 11925705Abstract: Nanogels and methods of synthesizing and using these nanogels are provided. The nanogels are formed by mixing a building block (e.g., polymer), crosslinker, preferably a target (e.g., biomedical compound or molecule), and a solvent in a multi-inlet vortex mixer, so as to cause the polymer and crosslinker to react and form a chemically crosslinked polymer network. In embodiments including a target, the target will be interspersed in and among that network and can be physically embedded and/or chemically bound therein.Type: GrantFiled: September 16, 2022Date of Patent: March 12, 2024Assignee: The Curators of the University of MissouriInventors: Hu Yang, Da Huang
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Patent number: 11918653Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.Type: GrantFiled: December 21, 2018Date of Patent: March 5, 2024Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi, Martha Pastuszka
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Patent number: 11910797Abstract: The present specification discloses a composition comprising, consisting essentially of, or consisting of hypochlorous acid or free available chlorine in combination with one or more quaternary compounds or silicon quaternary compounds, one or more guanide-containing compounds, one or more alcohols, one or more metallic particles, one or more metal salts, or any combination thereof. The present specification further discloses a kit comprising, consisting essentially of, or consisting of a one or more containers including a composition disclosed herein or components which make up such compositions as well as methods and uses for such compositions and kits.Type: GrantFiled: March 14, 2022Date of Patent: February 27, 2024Assignee: Collidion, Inc.Inventors: Hojabr Alimi, Sridhar Govinda Prasad, Surya Kanta De
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Patent number: 11911524Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O—groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: GrantFiled: September 8, 2021Date of Patent: February 27, 2024Assignee: Stryker European Operations Holdings LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Patent number: 11904072Abstract: Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.Type: GrantFiled: September 23, 2022Date of Patent: February 20, 2024Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett
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Patent number: 11905338Abstract: The present invention relates to new peptides comprising an amino acid sequence LL-[X]n-LL, wherein X is selected from R, L and W, and n=10 to 12, and wherein [X]n comprises 4 R, 4 L and between 2 and 4 W, that may be used as cell-penetrating peptides. The present invention also relates to nanoparticles comprising a peptide of the invention and a cargo molecule and uses thereof.Type: GrantFiled: July 16, 2019Date of Patent: February 20, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIERInventors: Sébastien Deshayes, Karidia Konate, Eric Vives, Gudrun Aldrian, Prisca Boisguerin
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Patent number: 11903384Abstract: Hydrogels are blended with water to produce a hydrogel solution. Viscosity of the hydrogel solution is controlled by adjusting the ratio of hydrogel to water and/or by adjusting the blending conditions. The hydrogel solutions may be used to modify the rheology of agricultural compositions. The hydrogel may include lactose, which may be provided by a milk permeate waste stream from the dairy or food processing industry.Type: GrantFiled: May 26, 2022Date of Patent: February 20, 2024Assignee: WinField Solutions, LLCInventors: Danny Brown, Christine Colby, Lillian Magidow, Megan Barta
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Patent number: 11903978Abstract: A functional food including a supplement composition in which the supplement composition includes a non-winterized marine source oil.Type: GrantFiled: January 19, 2023Date of Patent: February 20, 2024Assignee: AMBO Innovations, LLCInventors: Bo Reidar Martinsen, Leif Andreas Riege
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Patent number: 11896685Abstract: The present invention relates to a core-shell network structure formed using a biocompatible biopolymer and to a composition comprising same. Said structure can be used as an alternative to synthetic chemical materials, such as polyethylene glycol (PEG), to effectively disperse an insoluble effective substance within a composition, thus addressing safety issues, and formulations can be preserved stably for a long time through said network structure. Furthermore, said structure and the composition comprising same may provide useful benefits for the skin in terms of skin barrier enhancement, skin moisturization, skin regeneration, or the like.Type: GrantFiled: October 31, 2019Date of Patent: February 13, 2024Assignee: AMOREPACIFIC CORPORATIONInventors: Eunmi Kim, Young Gyu Kang, Jaeyoung Ko, Miju Kim, Minkee Kim, Yong Jin Kim, Heungsoo Baek, Jaewon You, Yonghee Lee, Eun Soo Lee, Yuri Choi
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Patent number: 11897902Abstract: A compound 4-bromo-2-(quinolin-2-yliminomethyl)-phenol imine]-Ru(III)-phenanthroline complex, its synthesis, and its use for pharmaceutical applications.Type: GrantFiled: September 25, 2023Date of Patent: February 13, 2024Assignee: KING FAISAL UNIVERSITYInventors: Hany Mohamed Abd El-Latef Ahmed, Mai Mostafa Khalaf Ali, Tarek El-Dabea, Seraj Alzahrani, Ahmed M. Abu-Dief