Patents Examined by Dominic Lazaro
  • Patent number: 12251380
    Abstract: The present invention provides long-acting parenteral pharmaceutical compositions including a therapeutically effective amount of Cariprazine or salts thereof, in a depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot compositions are preferably in the form of in-situ implants suitable for subcutaneous or intramuscular administration and provide prolonged release of the Cariprazine active ingredient and/or its metabolites desmethyl Cariprazine (DCAR) and didesmethyl Cariprazine (DDCAR) for a period of at least 4 weeks following a single administration. The present invention further provides methods of use of the depot compositions for the treatment of schizophrenia, major depressive disorder, and bipolar disorder.
    Type: Grant
    Filed: February 8, 2024
    Date of Patent: March 18, 2025
    Assignee: Mapi Pharma Ltd.
    Inventors: Shai Rubnov, Ehud Marom, Anna Gopin
  • Patent number: 12251455
    Abstract: The present invention relates to the production of personal care products that have a high oil content. Specifically the use of a novel combination of starches which allows for the manufacturing of high oil compositions that maintain desirable high quality sensory characteristics. Compositions include cosmetic and personal care items such as lotions and creams.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: March 18, 2025
    Assignee: CARGILL, INCORPORATED
    Inventors: Nabila Belhaj, Jean-Noel Ollagnier
  • Patent number: 12251412
    Abstract: The present disclosure relates to a method for extracting caffeic acid and rosmarinic acid from Rosmarinus officinalis L., and more particularly, to a method for extracting caffeic acid and rosmarinic acid from Rosmarinus officinalis L., the method comprising the steps of: (S1) preparing an extraction apparatus including an extractor for passing a solution contained in a main body unit through a filtration membrane to obtain a filtered solution, and dropping the filtered solution to the lower outside through a dropping unit connected to a lower portion of the main body unit, and a receiver located in the lower part of the extractor to collect the filtered solution that is dropped from the dropping unit; (S2) putting dried Rosmarinus officinalis L. into the main body unit, and adding a solvent to the main body unit to immerse the dried Rosmarinus officinalis L. at room temperature; and (S3) dropping a solution in which the dried Rosmarinus officinalis L.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: March 18, 2025
    Assignee: UCL CO. LTD.
    Inventors: Byoung Kwon Park, Jeong Mi Kim, Ji Young Moon, Min Jeong Kim, Mi So Moon, Jin Oh Park, Ji Won Lee
  • Patent number: 12245989
    Abstract: A plunger is described, which is configured for application in a syringe-type pump for a machine for encapsulation of soft capsules, for adjusting the quantity of filler to be injected into said soft capsules, said plunger having an axially developing structure and comprising: a tip (31) and a sealing body (32) connected to the tip, adapted to penetrate into said syringe-type pump (P), a first mechanical abutment ring (33), fixedly positioned, connected to said sealing body, a plunger stopper housing (34), connected to said fixedly positioned mechanical abutment ring, a second mechanical abutment ring (35), axially adjustable, a mechanical dowel (37) protruding from said stopper housing, an adjuster nut (36) adapted to be screwed on said mechanical dowel (37) for adjusting the axial position of the second ring (35) relative to the first ring, so as to adjust the axial position of the plunger in said syringe-type pump (P).
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: March 11, 2025
    Assignee: Altergon SA
    Inventors: Giovanni D'Angelo, Marco Pontiggia, Simone Carucci, Paolo Russo
  • Patent number: 12213484
    Abstract: The present invention relates to solvent-free aqueous suspension concentrates having high active ingredient concentration, good biological efficacy and good rheological stability, and to processes for production thereof. The formulations of the invention are suitable for the field of plant protection.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: February 4, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Gorka Peris, Pierre Philippe Haas, Stefan Herrmann
  • Patent number: 12208116
    Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
    Type: Grant
    Filed: June 30, 2023
    Date of Patent: January 28, 2025
    Assignee: CytoSorbents, Inc.
    Inventors: Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
  • Patent number: 12201660
    Abstract: The present disclosure relates to a herbo-mineral kit for alleviating adverse effects of chemotherapy resulting into improved quality of life of patients. The herbo-mineral kit comprises a first container containing Padmakadi Ghrut (PDG) in a thick, viscous form; a second container containing Mouktikyukta Kamdudha Vati (MKD) in a solid dosage form; a third container containing Praval Pishti Vati (PPV) in a solid dosage form; and a fourth container containing Ananta vati in a solid dosage form. The herbo-mineral kit of the present disclosure can be used for alleviating adverse effects of chemotherapy such as nausea, vomiting, constipation, diarrhea, stomatitis, and skin discoloration in cancer treatment. Use of the herbo-mineral kit of the present disclosure may prove to be beneficial in all types of cancers and diseases for which chemotherapy is treatment of choice.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: January 21, 2025
    Inventor: Sadanand Prabhakar Sardeshmukh
  • Patent number: 12186449
    Abstract: The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.
    Type: Grant
    Filed: October 12, 2023
    Date of Patent: January 7, 2025
    Assignee: CollPlant Ltd.
    Inventors: Oded Shoseyov, Nadav Orr, Jasmine Seror Maknouz, Revital Zarka
  • Patent number: 12171909
    Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: December 24, 2024
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Benjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
  • Patent number: 12168026
    Abstract: The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.
    Type: Grant
    Filed: October 3, 2023
    Date of Patent: December 17, 2024
    Inventors: Nicholas L. Abbott, Jonathan F. McAnulty
  • Patent number: 12168033
    Abstract: A method for treating a disease condition such as inflammation, arthritis, joint pain, rheumatoid arthritis, osteoarthritis, chronic non-rheumatoid arthritis, and collagen degradation in a patient in need thereof involves administering to the patient an effective amount of a composition: a) a Tamarindus indica seed extract comprising an alcohol or hydroalcohol extract of a Tamarindus indica seed, wherein the alcohol or hydroalcohol extract comprises proanthocyanidins; and b) a Curcuma longa rhizome extract comprising curcuminoids, wherein the Tamarindus indica seed extract and the Curcuma longa rhizome extract are used in a ratio ranging from 1:4 to 4:1.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: December 17, 2024
    Assignee: LAILA NUTRACEUTICALS
    Inventors: Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Kanaka Ranga Raju Gokaraju, Trimurtulu Golakoti, Kiran Bhupathiraju
  • Patent number: 12168108
    Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.
    Type: Grant
    Filed: October 12, 2023
    Date of Patent: December 17, 2024
    Assignee: Urotronic, Inc.
    Inventors: Lixiao Wang, Peter Barnett
  • Patent number: 12161685
    Abstract: A multi-efficacy traditional Chinese medicine compound composition and application thereof in pharmaceutical preparations are disclosed. The traditional Chinese medicine extracts are combined with the glucosamine, the collagen and the chondroitin sulfate, so that the multi-efficacy traditional Chinese medicine compound composition is prepared. The traditional Chinese medicine compound composition starts from improving the health of bone and joint and accompanying cardiovascular disease, selects the medicinal materials, and optimizes the extraction process of the traditional Chinese medicine for the diseases dominated by degenerative osteoarthritis. The disclosure has the efficacious of improving the symptoms of degenerative osteoarthritis, reducing blood pressure, improving the symptoms with osteoporosis, improving the symptoms with cardiovascular disease, improving the symptoms with urinary system disease, etc.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: December 10, 2024
    Inventors: Shengcan Zou, Zengliang Zhang, Min Wang, Zhuqing Liu, Sai Lu, Li Li, Shanglong Wang
  • Patent number: 12150930
    Abstract: The present invention relates to oral liquid formulations of Enzalutamide or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipient. Further, the invention relates to providing an economical and technically advanced dosage form over existing dosage forms. In addition, the present invention also provides an improved process for preparation of Enzalutamide oral liquid formulation. The present invention further provides such compositions for the treatment of for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel.
    Type: Grant
    Filed: July 31, 2023
    Date of Patent: November 26, 2024
    Assignee: BDR Pharmaceuticals Int'l Pvt. Ltd.
    Inventors: Shah Dharmesh Mahendrabhai, Badiger Aravind Manappa, Sharma Mukeshkumar Subhashchandra, Trivedi Madhavkumar Dilipbhai, Choksi Rakshit Ketanbhai, Vora Pratik Ashwinbhai, Agrawal Vijay Ashok, Gandhi Prashant Kanaiyalal, Panchal Nimitkumar Harishchandra, Mori Nitin Merubhai, Jayaswal Nilay Manikant, Darji Hirenkumar Jitendrakumar
  • Patent number: 12151045
    Abstract: Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a multifunctionalized polymeric composition (e.g., multifunctionalized polyethylene glycol) functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.
    Type: Grant
    Filed: December 27, 2021
    Date of Patent: November 26, 2024
    Assignee: Davol Inc.
    Inventors: Keith Greenawalt, Frederick H. Strickler, Jr.
  • Patent number: 12121031
    Abstract: The present invention provides a magnetic biochar-quaternary phosphonium salt bactericidal material, a preparation method therefor and usage thereof, and belongs to the field of water treatment. The preparation method comprises: 1) using corn straw biochar as a precursor to prepare magnetic biochar by a co-precipitation method; and 2) adding the magnetic biochar into deionized water, then adding a quaternary phosphonium salt, performing the magnetic stir at room temperature, raising the temperature after sufficient impregnation, carrying out a hydrothermal reaction, and then cooling to the room temperature to obtain the bactericidal material. The temperature is raised to 60° C.˜70° C.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: October 22, 2024
    Assignee: INSTITUTE OF SOIL SCIENCE, CHINESE ACADEMY OF SCIENCES
    Inventors: Fang Wang, Yuhao Fu, Hongjie Sheng, Yongrong Bian, Xin Jiang
  • Patent number: 12115187
    Abstract: Ready-to-use (RTU) Sodium Phosphates solutions for phosphorus replacement therapy are presented that include Sodium phosphate with/without sodium chloride at a fixed volume with 1.5 to 15 mmol/100 mL phosphorus, no more than 20 mEq/100 mL Sodium and less than 50 mcg/L aluminum.
    Type: Grant
    Filed: May 17, 2024
    Date of Patent: October 15, 2024
    Assignee: Nivagen Pharmaceuticals, Inc.
    Inventors: Niravbhai Jayantibhai Patel, Robert Miller, Maheshkumar Kalubhai Bhalaria, Rucha Abhijit Kelekar, Brijeshkumar B Pandya, Sunil Dnyanu Khandekar, Sudhir Shantarum Jagdale, Dasaradhi Lakkaraju, Jay Shukla
  • Patent number: 12115286
    Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: October 15, 2024
    Assignee: Urotronic, Inc.
    Inventors: Lixiao Wang, Peter Barnett, David Hendrickson
  • Patent number: 12115235
    Abstract: The disclosure relates to oral delivery compositions that transition from a flowable state to a hardened or semi-hardened state. The flowable hardening composition may be delivered to oral tissues, including teeth and/or gums, directly or using a barrier strip or a tray-like device. Such compositions may be configured as a multi-part system wherein reactive materials (e.g., catalyst and reactive resins) are kept separate until use. Dispersion of the agents in a viscous carrier within the hardened composition enables a gradual release the desired agent(s) to reduce or eliminate sensitivity that may be caused by certain agents (e.g., dental whitening agents). The hardened delivery composition may include a reverse image of the oral tissue, allowing it to be removed and replaced multiple times during a single use, giving users more flexibility during treatment.
    Type: Grant
    Filed: February 1, 2023
    Date of Patent: October 15, 2024
    Assignee: ULTRADENT PRODUCTS, INC.
    Inventors: Brittany Shepler, Andy Kawamoto
  • Patent number: 12108759
    Abstract: The present invention relates to antibacterial carbon dots, having aminoguanidine functionality on their outermost surface. The invention further relates to the synthesis of said antibacterial carbon dots, and to the uses of these carbon dots for inhibiting a biofilm formation in the presence of said carbon dots and as fluorescent labeling markers for specific bacteria.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: October 8, 2024
    Assignee: B.G. NEGEV TECHNOLOGIES & APPLICATIONS, LTD., AT BEN-GURION UNIVERSITY
    Inventors: Raz Jelinek, Sagarika Bhattacharya, Gil Otis