Patents Examined by Dominic Lazaro
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Patent number: 12168033Abstract: A method for treating a disease condition such as inflammation, arthritis, joint pain, rheumatoid arthritis, osteoarthritis, chronic non-rheumatoid arthritis, and collagen degradation in a patient in need thereof involves administering to the patient an effective amount of a composition: a) a Tamarindus indica seed extract comprising an alcohol or hydroalcohol extract of a Tamarindus indica seed, wherein the alcohol or hydroalcohol extract comprises proanthocyanidins; and b) a Curcuma longa rhizome extract comprising curcuminoids, wherein the Tamarindus indica seed extract and the Curcuma longa rhizome extract are used in a ratio ranging from 1:4 to 4:1.Type: GrantFiled: September 30, 2021Date of Patent: December 17, 2024Assignee: LAILA NUTRACEUTICALSInventors: Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Kanaka Ranga Raju Gokaraju, Trimurtulu Golakoti, Kiran Bhupathiraju
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Patent number: 12168108Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.Type: GrantFiled: October 12, 2023Date of Patent: December 17, 2024Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett
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Patent number: 12168026Abstract: The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.Type: GrantFiled: October 3, 2023Date of Patent: December 17, 2024Inventors: Nicholas L. Abbott, Jonathan F. McAnulty
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Patent number: 12161685Abstract: A multi-efficacy traditional Chinese medicine compound composition and application thereof in pharmaceutical preparations are disclosed. The traditional Chinese medicine extracts are combined with the glucosamine, the collagen and the chondroitin sulfate, so that the multi-efficacy traditional Chinese medicine compound composition is prepared. The traditional Chinese medicine compound composition starts from improving the health of bone and joint and accompanying cardiovascular disease, selects the medicinal materials, and optimizes the extraction process of the traditional Chinese medicine for the diseases dominated by degenerative osteoarthritis. The disclosure has the efficacious of improving the symptoms of degenerative osteoarthritis, reducing blood pressure, improving the symptoms with osteoporosis, improving the symptoms with cardiovascular disease, improving the symptoms with urinary system disease, etc.Type: GrantFiled: March 26, 2021Date of Patent: December 10, 2024Inventors: Shengcan Zou, Zengliang Zhang, Min Wang, Zhuqing Liu, Sai Lu, Li Li, Shanglong Wang
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Patent number: 12151045Abstract: Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a multifunctionalized polymeric composition (e.g., multifunctionalized polyethylene glycol) functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.Type: GrantFiled: December 27, 2021Date of Patent: November 26, 2024Assignee: Davol Inc.Inventors: Keith Greenawalt, Frederick H. Strickler, Jr.
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Patent number: 12150930Abstract: The present invention relates to oral liquid formulations of Enzalutamide or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipient. Further, the invention relates to providing an economical and technically advanced dosage form over existing dosage forms. In addition, the present invention also provides an improved process for preparation of Enzalutamide oral liquid formulation. The present invention further provides such compositions for the treatment of for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel.Type: GrantFiled: July 31, 2023Date of Patent: November 26, 2024Assignee: BDR Pharmaceuticals Int'l Pvt. Ltd.Inventors: Shah Dharmesh Mahendrabhai, Badiger Aravind Manappa, Sharma Mukeshkumar Subhashchandra, Trivedi Madhavkumar Dilipbhai, Choksi Rakshit Ketanbhai, Vora Pratik Ashwinbhai, Agrawal Vijay Ashok, Gandhi Prashant Kanaiyalal, Panchal Nimitkumar Harishchandra, Mori Nitin Merubhai, Jayaswal Nilay Manikant, Darji Hirenkumar Jitendrakumar
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Patent number: 12121031Abstract: The present invention provides a magnetic biochar-quaternary phosphonium salt bactericidal material, a preparation method therefor and usage thereof, and belongs to the field of water treatment. The preparation method comprises: 1) using corn straw biochar as a precursor to prepare magnetic biochar by a co-precipitation method; and 2) adding the magnetic biochar into deionized water, then adding a quaternary phosphonium salt, performing the magnetic stir at room temperature, raising the temperature after sufficient impregnation, carrying out a hydrothermal reaction, and then cooling to the room temperature to obtain the bactericidal material. The temperature is raised to 60° C.˜70° C.Type: GrantFiled: April 21, 2020Date of Patent: October 22, 2024Assignee: INSTITUTE OF SOIL SCIENCE, CHINESE ACADEMY OF SCIENCESInventors: Fang Wang, Yuhao Fu, Hongjie Sheng, Yongrong Bian, Xin Jiang
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Patent number: 12115235Abstract: The disclosure relates to oral delivery compositions that transition from a flowable state to a hardened or semi-hardened state. The flowable hardening composition may be delivered to oral tissues, including teeth and/or gums, directly or using a barrier strip or a tray-like device. Such compositions may be configured as a multi-part system wherein reactive materials (e.g., catalyst and reactive resins) are kept separate until use. Dispersion of the agents in a viscous carrier within the hardened composition enables a gradual release the desired agent(s) to reduce or eliminate sensitivity that may be caused by certain agents (e.g., dental whitening agents). The hardened delivery composition may include a reverse image of the oral tissue, allowing it to be removed and replaced multiple times during a single use, giving users more flexibility during treatment.Type: GrantFiled: February 1, 2023Date of Patent: October 15, 2024Assignee: ULTRADENT PRODUCTS, INC.Inventors: Brittany Shepler, Andy Kawamoto
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Patent number: 12115286Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.Type: GrantFiled: June 17, 2022Date of Patent: October 15, 2024Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett, David Hendrickson
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Patent number: 12115187Abstract: Ready-to-use (RTU) Sodium Phosphates solutions for phosphorus replacement therapy are presented that include Sodium phosphate with/without sodium chloride at a fixed volume with 1.5 to 15 mmol/100 mL phosphorus, no more than 20 mEq/100 mL Sodium and less than 50 mcg/L aluminum.Type: GrantFiled: May 17, 2024Date of Patent: October 15, 2024Assignee: Nivagen Pharmaceuticals, Inc.Inventors: Niravbhai Jayantibhai Patel, Robert Miller, Maheshkumar Kalubhai Bhalaria, Rucha Abhijit Kelekar, Brijeshkumar B Pandya, Sunil Dnyanu Khandekar, Sudhir Shantarum Jagdale, Dasaradhi Lakkaraju, Jay Shukla
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Patent number: 12108759Abstract: The present invention relates to antibacterial carbon dots, having aminoguanidine functionality on their outermost surface. The invention further relates to the synthesis of said antibacterial carbon dots, and to the uses of these carbon dots for inhibiting a biofilm formation in the presence of said carbon dots and as fluorescent labeling markers for specific bacteria.Type: GrantFiled: October 31, 2019Date of Patent: October 8, 2024Assignee: B.G. NEGEV TECHNOLOGIES & APPLICATIONS, LTD., AT BEN-GURION UNIVERSITYInventors: Raz Jelinek, Sagarika Bhattacharya, Gil Otis
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Patent number: 12104041Abstract: Biodegradable resin particles including a polyhydroxy alkanoate. In the biodegradable resin particles, an amount of a Ca component present in the particles is 10 to 10,000 ppm, the biodegradable resin particles have a volume average particle diameter of 2 to 50 ?m, the biodegradable resin particles have a BET specific surface area of 0.8 to 10 m2/g, and the biodegradable resin particles have a linseed oil absorption of 50 to 300 ml/100 g. The resin particles of the present invention can be suitably used by being included in an external preparation, such as a cosmetic or a quasi-drug.Type: GrantFiled: June 25, 2020Date of Patent: October 1, 2024Assignee: SEKISUI KASEI CO., LTD.Inventors: Kengo Nishiumi, Shinya Matsuno
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Patent number: 12102737Abstract: Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.Type: GrantFiled: June 26, 2023Date of Patent: October 1, 2024Assignee: Urotronic, Inc.Inventors: Lixiao Wang, Peter Barnett
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Patent number: 12083200Abstract: Zinc oxide particles are prepared as a dry powder through a vapor phase formed by a plasma process, or by introducing defects into stoichiometric zinc oxide particles in a liquid carrier through mechanical stress. The zinc oxide has an O:Zn ratio of at least 0.99, an average particle size of 10 to 300 nm, and a sufficient concentration of oxygen vacancies and zinc vacancies to give a dispersion of the particles in C12-C15 alkyl benzoate an orange to tan color corresponding to a ?E value of at least 15 in a Dispersion Color Test. The particles contain no aggregates and have no detectable particles 500 nm or larger, on a number-weighted basis.Type: GrantFiled: April 24, 2023Date of Patent: September 10, 2024Assignee: Nanophase Technologies CorporationInventors: Harry W. Sarkas, Christopher C. Boffa
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Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made
Patent number: 12076463Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 ?m; providing a dispersion of bioactive ceramic particles of particle size at most 10 ?m in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.Type: GrantFiled: June 27, 2022Date of Patent: September 3, 2024Assignee: DSM IP Assets B.V.Inventors: Jens Christoph Thies, Ruud Jozef Regina Wilhelmus Peters, Pieter J. Emans, Jacob Koenen -
Patent number: 12076389Abstract: The invention relates to medicine and veterinary medicine, and more specifically to pharmacology, and can be used to prevent viral infections caused be RNA viruses that have a lipid capcid. An agent for prevention viral infections comprises viral material from RNA viruses that have a lipid capcid and stabilized colloidal selenium at a 1:1 ratio. The viral material from RNA viruses has titres of 6.0-8.0 lg TCD50/ml. To obtain colloidal selenium having particle sizes from 10 to 15 nm the colloidal selenium is stabilized with polyethylene glycol, and for colloidal selenium having particle sizes from 20 to 40 nm, the colloidal selenium is stabilized with cysteine.Type: GrantFiled: April 18, 2019Date of Patent: September 3, 2024Inventors: Vladislav Nikolaevich Laskavy, Sergei Ivanovich Ivanenko
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Patent number: 12064376Abstract: The present disclosure is directed to intracameral implants for treating and/or preventing corneal disorders, diseases, and/or conditions, such as corneal endothelial dystrophies. The intracameral implants can be configured to provide a sustained release of a therapeutic agent, such as a Rho kinase inhibitor, for a prolonged period of time. The intracameral implants can include a non-bioresorbable anchor or a bioresorbable matrix.Type: GrantFiled: June 2, 2021Date of Patent: August 20, 2024Assignee: GLAUKOS CORPORATIONInventors: Tom Burns, Jia-Ying Yang, Patrick Michael Hughes
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Patent number: 12059500Abstract: Disclosed herein are therapeutic constructs including a delivery particle, at least one mitotic kinase inhibitor, and at least one immune checkpoint inhibitor. Also disclosed are therapeutic constructs including a mitotic kinase inhibitor, an immune checkpoint inhibitor, and a chemical linker. These therapeutic constructs cause cancer death by both therapeutic and immune effects and promote targeted delivery of more therapeutics to the surviving cancer cells in a positive feed-back loop. They enhance therapeutic index of free drugs and can be used intratumorally or systemically. This strategy can treat broad cancer types and is particular useful for cancer without obvious receptors for cancer-targeted delivery of otherwise toxic therapeutics.Type: GrantFiled: May 10, 2023Date of Patent: August 13, 2024Assignees: Oregon Health & Science University, PDX Pharmaceuticals, Inc.Inventors: Wassana Yantasee, Moataz Reda, Worapol Ngamcherdtrakul
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Patent number: 12048780Abstract: The technology relates to a 3D printed hydrogel formed from a maleimide containing polymer cross-linked using a bis-thiol containing cross-linking agent having at least two thiol functional groups, processes for preparing the 3D printed hydrogel, and uses thereof.Type: GrantFiled: July 23, 2019Date of Patent: July 30, 2024Assignee: NewSouth Innovations Pty LimitedInventors: Robert Hadinoto Utama, Vincent Tit Guan Tan, John Justin Gooding
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Patent number: 12048726Abstract: The present disclosure provides a method for extracting Gymnadenia conopsea(L.)R.Br., which includes the following steps: (1) the root tuber of Gymnadenia conopsea(L.)R.Br. is soaked in water so that it can be fully infiltrated until having been taken as a sample, no white core is observed; (2) the root tuber of Gymnadenia conopsea(L.)R.Br. is ultrafinely comminuted by wet method to obtain a dispersion slurry; (3) additional water is supplemented into the dispersion slurry to obtain diluted dispersion followed by heating and adding neutral protease, and then extraction is carried out through circulation and homogenization by the homogenization pump to obtain extracted material fluid; (4) heat preservation and enzyme inactivation; (5) coarse filtration to obtain a coarse filtrate; and (6) fine filtration to obtain a fine filtrate. The disclosure also provides a related extract of Gymnadenia conopsea(L)R.Br.Type: GrantFiled: April 1, 2020Date of Patent: July 30, 2024Assignee: Shanghai Hope-Tec Biotechnology Inc.Inventors: Xing Liu, Jibin Wang, Haihua Chen, Zuokun Ding, Chuanhao Wang, Jiwen Wang