Abstract: The present application provides a method for preparing a probiotic-loaded microcapsule including: (1) dissolving sodium alginate in a solvent to obtain a sodium alginate solution; (2) evenly mixing a probiotic with the sodium alginate solution obtained in step (1) to obtain a probiotic suspension; and (3) spraying the probiotic suspension obtained in step (2) into a salt solution, stirring and curing, to obtain the probiotic-loaded microcapsule. The microcapsule is prepared by a spraying method in conjunction with an ion curing method by using sodium alginate as the wall material of the microcapsule, so that the prepared microcapsule has a good spherical shape, a small particle size, good dispersibility and high pH sensitivity, forms a denser surface under an acidic condition to effectively protect probiotics, and can meet requirements for subsequent in vivo animal evaluations.

Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

Abstract: Ready-to-use (RTU) Sodium Phosphates solutions for phosphorus replacement therapy are presented that include Sodium phosphate with/without sodium chloride at a fixed volume with 6 to 15 mmol/100 mL phosphorus, no more than 20 mEq/100 mL Sodium and less than 25 mcg/L aluminum.

Abstract: A single-dose cosmetic product and process of manufacturing thereof. The single-dose cosmetic product contains a solid portion of parenchyma of an aloe vera plant, a coating with waxy properties completely enclosing the solid portion and at least one tear tape located between the coating and the solid portion. The cosmetic product allows a better handling and application of the aloe vera and also preserves the properties and stability of a 100% aloe vera product without the use of additives. The manufacturing process of this cosmetic product allows the properties of the aloe vera parenchyma to remain intact.

Abstract: An ocular device for placement under an eyelid that includes a plate with a back surface having at least one protrusion having a convex contact surface to contact the sclera of the eye and to provide an offset space. The plate can be connected to an elongated support member. The ocular device can deliver a material to an eye of a user, including, for example, a pharmaceutically active agent. A case for holding and dispensing an ocular device includes a well configured to retain fluid, a stabilizer, and a lid. The lid is connected to the well and rotatable between a position covering the well and a position with the well uncovered. The lid can have a port for adding fluid to the well, and a receiver, which can hold an ocular device, can project from the lid.

Abstract: Hydrogels are blended with water to produce a hydrogel solution. Viscosity of the hydrogel solution is controlled by adjusting the ratio of hydrogel to water and/or by adjusting the blending conditions. The hydrogel solutions may be used to modify the rheology of agricultural compositions. The hydrogel may include lactose, which may be provided by a milk permeate waste stream from the dairy or food processing industry.

Abstract: The present disclosure relates to a method for extracting caffeic acid and rosmarinic acid from Rosmarinus officinalis L., and more particularly, to a method for extracting caffeic acid and rosmarinic acid from Rosmarinus officinalis L., the method comprising the steps of: (S1) preparing an extraction apparatus including an extractor for passing a solution contained in a main body unit through a filtration membrane to obtain a filtered solution, and dropping the filtered solution to the lower outside through a dropping unit connected to a lower portion of the main body unit, and a receiver located in the lower part of the extractor to collect the filtered solution that is dropped from the dropping unit; (S2) putting dried Rosmarinus officinalis L. into the main body unit, and adding a solvent to the main body unit to immerse the dried Rosmarinus officinalis L. at room temperature; and (S3) dropping a solution in which the dried Rosmarinus officinalis L.

Abstract: The present invention provides long-acting parenteral pharmaceutical compositions including a therapeutically effective amount of Cariprazine or salts thereof, in a depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot compositions are preferably in the form of in-situ implants suitable for subcutaneous or intramuscular administration and provide prolonged release of the Cariprazine active ingredient and/or its metabolites desmethyl Cariprazine (DCAR) and didesmethyl Cariprazine (DDCAR) for a period of at least 4 weeks following a single administration. The present invention further provides methods of use of the depot compositions for the treatment of schizophrenia, major depressive disorder, and bipolar disorder.

Abstract: The present invention relates to the production of personal care products that have a high oil content. Specifically the use of a novel combination of starches which allows for the manufacturing of high oil compositions that maintain desirable high quality sensory characteristics. Compositions include cosmetic and personal care items such as lotions and creams.

Abstract: A plunger is described, which is configured for application in a syringe-type pump for a machine for encapsulation of soft capsules, for adjusting the quantity of filler to be injected into said soft capsules, said plunger having an axially developing structure and comprising: a tip (31) and a sealing body (32) connected to the tip, adapted to penetrate into said syringe-type pump (P), a first mechanical abutment ring (33), fixedly positioned, connected to said sealing body, a plunger stopper housing (34), connected to said fixedly positioned mechanical abutment ring, a second mechanical abutment ring (35), axially adjustable, a mechanical dowel (37) protruding from said stopper housing, an adjuster nut (36) adapted to be screwed on said mechanical dowel (37) for adjusting the axial position of the second ring (35) relative to the first ring, so as to adjust the axial position of the plunger in said syringe-type pump (P).

Abstract: The present invention relates to solvent-free aqueous suspension concentrates having high active ingredient concentration, good biological efficacy and good rheological stability, and to processes for production thereof. The formulations of the invention are suitable for the field of plant protection.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Abstract: The present disclosure relates to a herbo-mineral kit for alleviating adverse effects of chemotherapy resulting into improved quality of life of patients. The herbo-mineral kit comprises a first container containing Padmakadi Ghrut (PDG) in a thick, viscous form; a second container containing Mouktikyukta Kamdudha Vati (MKD) in a solid dosage form; a third container containing Praval Pishti Vati (PPV) in a solid dosage form; and a fourth container containing Ananta vati in a solid dosage form. The herbo-mineral kit of the present disclosure can be used for alleviating adverse effects of chemotherapy such as nausea, vomiting, constipation, diarrhea, stomatitis, and skin discoloration in cancer treatment. Use of the herbo-mineral kit of the present disclosure may prove to be beneficial in all types of cancers and diseases for which chemotherapy is treatment of choice.

Abstract: The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.

Abstract: Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.

Abstract: The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.

Abstract: A method for treating a disease condition such as inflammation, arthritis, joint pain, rheumatoid arthritis, osteoarthritis, chronic non-rheumatoid arthritis, and collagen degradation in a patient in need thereof involves administering to the patient an effective amount of a composition: a) a Tamarindus indica seed extract comprising an alcohol or hydroalcohol extract of a Tamarindus indica seed, wherein the alcohol or hydroalcohol extract comprises proanthocyanidins; and b) a Curcuma longa rhizome extract comprising curcuminoids, wherein the Tamarindus indica seed extract and the Curcuma longa rhizome extract are used in a ratio ranging from 1:4 to 4:1.

Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.