Patents Examined by Dong Jiang
  • IFN-? production inducing protein (IGIF, IL-18)
    Patent number: 7758853
    Abstract: A protein which induces the IFN-? production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: July 20, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Haruki Okamura, Tadao Tanimoto, Kakuji Torigoe, Toshi Kunikata, Mutsuko Taniguchi, Keizo Kohno, Masashi Kurimoto
  • Antibodies to IL-17 polypeptides and therapeutic uses thereof
    Patent number: 7749500
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: July 6, 2010
    Assignee: Genentech, Inc.
    Inventors: Jian Chen, Ellen Filvaroff, Audrey Goddard, Austin Gurney, Hanzhong Li, William I. Wood
  • Mutant IL-10
    Patent number: 7749490
    Abstract: IL-10 sequence variants are disclosed that retain the therapeutically desirable anti-inflammatory properties of wild-type IL-10 but do not retain the hemoatopoeitic cell regulatory and cell proliferative activities. The mutant IL-10 polypeptides of the invention are used in methods of treating diseases involving inflammatory response, including neuropathic pain and other neurological disorders.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: July 6, 2010
    Assignee: The Regents of the University of Colorado
    Inventors: Jurg M. Sommer, Raymond A. Chavez, Kirk W. Johnson, Linda May Rothblum Watkins
  • IL-21 production in prokaryotic hosts
    Patent number: 7745176
    Abstract: The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficient E. coli strains transformed with an IL-21 expression vector.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: June 29, 2010
    Assignee: ZymoGenetics, Inc.
    Inventors: Bruce L. Zamost, Douglas C. Covert
  • Neurotransmission disorders
    Patent number: 7732147
    Abstract: There is disclosed a method for diagnosing neurotransmission or developmental disorders in a mammal comprising the step of detecting in a bodily fluid of said mammal autoantibodies to an epitope of the muscle specific tyrosine kinase (MuSK). One such method comprises a) contacting said bodily fluid with said MuSK or an antigenic determinant thereof; and b) detecting any antibody-antigen complexes formed between said receptor tyrosine kinase or an antigenic fragment thereof and antibodies present in said bodily fluid, wherein the presence of said complexes is indicative of said mammal suffering from said neurotransmission or developmental disorders. Also disclosed are kits for use in the diagnosis of neurotransmission and subsequent developmental disorders.
    Type: Grant
    Filed: August 27, 2007
    Date of Patent: June 8, 2010
    Assignees: Isis Innovation Limited, Max-Planck Gesellschaft zur Foerderung der Wissenschaften E.V.
    Inventors: Angela Vincent, Werner Hoch
  • Method of promoting the healing of a chronic wound
    Patent number: 7727520
    Abstract: The present invention provides compositions and methods for promoting the healing of wounds or fibrotic disorders with reduced scarring, comprising inhibitors and inhibiting IFN-?, together with compositions and methods for promoting the healing of chronic wounds, comprising stimulating and stimulators of IFN-?.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: June 1, 2010
    Assignee: Renovo Limited
    Inventor: Mark William James Ferguson
  • Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
    Patent number: 7718397
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: May 18, 2010
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul Godowski, J. Christopher Grimaldi, Austin Gurney, Colin Watanabe, William I. Wood
  • Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
    Patent number: 7704944
    Abstract: The present invention provides a method of treatment or prevention of sepsis and other diseases characteristic to the Systemic Inflammatory Response Syndrome (SIRS), including severe sepsis, septic shock, and sepsis related to cardiac dysfunction.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: April 27, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Giamila Fantuzzi, Leonid L. Reznikov, Boris Schwartsburd
  • IL-18 receptors
    Patent number: 7704945
    Abstract: A novel polypeptide that functions as an IL-18 receptor is disclosed. The receptor is multimeric and includes at least one AcPL polypeptide, or fragment thereof, and at least one IL-1Rrp1 polypeptide, or fraction thereof. The receptor binds IL-18 and finds use in inhibiting biological activities mediated by IL-18.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: April 27, 2010
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • Rescue of gonadotropin releasing hormone receptor mutants
    Patent number: 7695917
    Abstract: Herein disclosed is a method of rescuing gonadotropin-releasing hormone receptor (GnRHR) mutants with IN3 or a mimetic thereof. IN3 significantly rescues 11 missense mutations as assessed by radioligand binding and by IP production. Such rescue occurred despite widely disparate loci along the receptor. In addition, many altered GnRH receptors (terminally truncated, internal deletions, or lacking the ability to form bridges to form tertiary structure) were rescued with IN3.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: April 13, 2010
    Assignee: Oregon Health & Science University
    Inventor: P. Michael Conn
  • Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
    Patent number: 7696154
    Abstract: Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding them. DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided. Therapeutic uses of IL-18 binding proteins and further inhibitors of IL-18 are also provided according to the invention.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: April 13, 2010
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Daniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim, Yolande Chvatchko, Christine Plater-Zyberk
  • N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor
    Patent number: 7696328
    Abstract: This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: April 13, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Venkata B. Nanduri, Ramesh N. Patel, Steven L. Goldberg, Robert M. Johnston
  • Modulation of the activity of an interleukin 17 receptor-related protein, EVI27, and uses thereof
    Patent number: 7696150
    Abstract: The present invention describes the cloning and molecular and cellular characterization of a novel protein with homology to the IL-17 receptor. The gene was cloned by virtue of its proximity to a common site of retroviral integration in a murine acute myeloid leukemia. The gene described herein possibly codes for a novel interleukin receptor that binds an as yet unidentified cytokine ligand, and may be useful in cancer diagnostics and therapies that rely on immune system modulation.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: April 13, 2010
    Assignee: Board of Trustees of the University of Arkansas
    Inventor: John D. Shaughnessy
  • Sitosterolemia susceptibility gene (SSG): compositions and methods of use
    Patent number: 7662376
    Abstract: The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of SSG.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: February 16, 2010
    Assignee: Amgen Inc.
    Inventors: Hui Tian, Joshua Schultz, Bei Shan
  • Use of IL-18 inhibitors for treating head injuries
    Patent number: 7655616
    Abstract: The invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of central nervous system injury, in particular of traumatic head injury.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: February 2, 2010
    Assignee: Ares Trading S.A.
    Inventor: Esther Shohami
  • IL-17-like cytokine binding compounds and antibodies
    Patent number: 7655761
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: February 2, 2010
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, J. Fernando Bazan, Robert A. Kastelein, Gerard Zurawski
  • Purified mammalian cytokine IL-174 polypeptides
    Patent number: 7645445
    Abstract: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: January 12, 2010
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, J. Fernando Bazan, Robert A. Kastelein, Gerard Zurawski
  • DNA molecules encoding ligand gated ion channels from
    Patent number: 7645867
    Abstract: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding D. variabilis LGIC/GluCl channels, substantially purified forms of associated D. variabilis channel proteins and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Dermacentor variabilis LGIC/GluCl, which will be useful as insecticides and acaracides.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: January 12, 2010
    Assignee: Merial Limited
    Inventors: Doris F. Cully, Yingcong Zheng
  • IL-32 monoclonal antibodies and uses thereof
    Patent number: 7641904
    Abstract: The present invention provides monoclonal antibodies specific for interleukin-32 (IL-32, previously referred to as “natural killer cell transcript 4” or “NK4”) and hybridomas secreting monoclonal antibodies specific for IL-32. Also provided are diagnostic methods and kits (e.g., ELISA, Western blot, etc.) which utilize monoclonal antibodies specific for IL-32.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: January 5, 2010
    Assignee: Konkuk University Industrial Cooperation Corp.
    Inventors: Ki-Hong Kim, Jung-Hyun Shim, Min-chul Cho, Jung-Woo Kang, Hee-Sook Choi, Eun-Hee Seo, Eun-young Song, Hee-Gu Lee, Mi-Young Park, Do-Young Yoon
  • Antibodies against interleukin 17 receptor-like protein
    Patent number: 7638603
    Abstract: The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: December 29, 2009
    Assignee: Human Genome Sciences, Inc.
    Inventors: Yanggu Shi, Steven M. Ruben