Patents Examined by Dong Jiang
  • Lamprey GnRH-III polypeptides and methods of making thereof
    Patent number: 7521057
    Abstract: Lamprey GnRH-III polypeptides for the four species of fish lamprey are disclosed. Also disclosed is a procedure for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing such polypeptides for sterilizing fish.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: April 21, 2009
    Assignee: University of New Hampshire
    Inventors: Stacia Sower, Matthew Silver
  • Vectors encoding interleukin-17 receptor homologue
    Patent number: 7521208
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: April 21, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Steven K. Burkhead, Sarah L. Pownder
  • Interleukin-17 receptor homologue
    Patent number: 7517958
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: April 14, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Steven K. Burkhead, Sarah L. Pownder
  • Antibodies to PRO4349 polypeptides
    Patent number: 7495082
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: February 24, 2009
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Antibodies to T1 receptor-like ligand II
    Patent number: 7495084
    Abstract: The present invention concerns a novel T1R-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: February 24, 2009
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben
  • Methods for promoting growth of bone, ligament, and cartilage
    Patent number: 7491384
    Abstract: Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of a zvegf3 protein in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of a zvegf3 protein.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: February 17, 2009
    Assignee: ZymoGenetics, Inc.
    Inventors: Charles E. Hart, Debra G. Gilbertson
  • Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
    Patent number: 7491512
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: February 17, 2009
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, William I. Wood
  • Human anti-human interleukin-18 antibody, fragment thereof and method for using same
    Patent number: 7491803
    Abstract: A human-derived human anti-human IL-18 antibody of the present invention is an antibody against human IL-18, the antibody including: an H-chain complementarity determining region consisting of (a) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 4 to 6, or (b) a polypeptide which is a mutant of the polypeptide (a) and which serves as the H-chain complementarity determining region; and an L-chain complementarity determining region against human interleukin-18 consisting of (c) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 10 to 12, or (d) a polypeptide which is a mutant of the polypeptide (c) and which serves as the L-chain complementarity determining region. This makes it possible to provide a human anti-human IL-18 antibody and a method for using the antibody.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: February 17, 2009
    Assignees: Japan Science & Technology Agency, Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Kazuhisa Sugimura, Kenji Nakanishi, Toshihiro Nakashima
  • Receptor for IL-17 homologous polypeptides and uses thereof
    Patent number: 7473763
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: January 6, 2009
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, William I. Wood
  • Adenosine receptor
    Patent number: 7465789
    Abstract: The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by adenosine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian adenosine receptor.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: December 16, 2008
    Assignee: Schering Corporation
    Inventors: Joseph A. Hedrick, Jean E. Lachowicz, Wei Wang, Eric L. Gustafson
  • Tango 405 polypeptides and uses thereof
    Patent number: 7459530
    Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: December 2, 2008
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Christopher C. Fraser
  • Method for preparing a physiologically active IL-18 polypeptide
    Patent number: 7442526
    Abstract: The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”).
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: October 28, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Kyung O. Johanson, Robert B. Kirkpatrick, Allan R. Shatzman, Yen Sen Ho, Patrick McDevitt
  • Peptides that induce chondrocyte redifferentiation
    Patent number: 7435793
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: October 14, 2008
    Assignee: Genentech, Inc.
    Inventors: Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
  • Methods of treating asthma by administering interleukin-17 receptor
    Patent number: 7432237
    Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: October 7, 2008
    Assignee: Immunex Corporation
    Inventors: Zhengbin Yao, Melanie K. Spriggs, William C. Fanslow
  • Feline hepatocyte growth factor
    Patent number: 7425536
    Abstract: A feline hepatocyte growth factor gene and a 15 base pairs-deleted feline hepatocyte growth factor gene. These genes encode a protein having an amino acid sequence shown in SEQ ID NO: 2 or 4. The feline hepatocyte growth factor and the 5 amino acids-deleted feline hepatocyte growth factor are useful for the treatment of liver diseases, kidney diseases, lung diseases, digestive diseases, cardiocirculatory diseases or cranial nerve diseases.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: September 16, 2008
    Assignee: Nippon Zenyaku Kogyo Ltd.
    Inventors: Masashi Miyake, Shigehiro Iwabuchi, Yasuyuki Suzuta
  • Antibodies against the PRO4401 polypeptide
    Patent number: 7425621
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: September 16, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood
  • PRO9783 polypeptides
    Patent number: 7371817
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: May 13, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • PRO10284 polypeptides
    Patent number: 7371816
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: May 13, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, William I. Wood
  • Uses of IL-174 for treating helminth infections
    Patent number: 7357924
    Abstract: Use of the cytokine designated IL-174 to treat infectious diseases such as helminth infections.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: April 15, 2008
    Assignee: Schering Corporation
    Inventors: Stephen D. Hurst, Sandra M. Zurawski, Donna M. Rennick
  • PRO9904 polypeptides
    Patent number: 7351796
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: April 1, 2008
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Victoria Smith, Colin K. Watanabe, William I. Wood