Patents Examined by Dwayne K. Handy
  • Patent number: 11311874
    Abstract: Embodiments of substrate-based devices disclosed herein comprise a polymeric substrate with a hydrophobic polymer coating that defines wells or openings on the polymeric substrate and/or serves as an adhesive agent between stacked substrates of the device. Also disclosed herein are embodiments of plate frames that can be used to align and hold well plate devices described herein. Methods of fabricating the disclosed devices also are described.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: April 26, 2022
    Assignee: Oregon Slate University
    Inventors: Gayan C. Bandara, Christopher A. Heist, Sumate Pengpumkiat, Vincent T. Remcho
  • Patent number: 11311886
    Abstract: The invention relates to a holding apparatus (100) for sample carriers (200) for use in cryomicroscopy, encompassing: a body having at least one sample carrier receptacle that comprises at least one sample carrier support surface against which at least one sample carrier (200) is abuttable; at least one first sample carrier holding means (121); and at least one second sample carrier holding means (131) that is configured to impinge upon the sample carrier (200) with force against the first sample carrier holding means (121); and to an arrangement having a manipulation container and such a holding apparatus (100), and to methods for introducing and withdrawing a sample carrier (200).
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: April 26, 2022
    Inventors: Reinhard Lihl, Leander Gaechter, Saskia Mimietz-Oeckler
  • Patent number: 11293933
    Abstract: A fully-automatic feces analyzer includes an automatic controller; at least one sample box for containing a feces sample; and a sample box support. A dilution and stirring unit is provided for adding diluent into the feces sample and stirring to obtain feces sample liquid. The analyzer has a physical detection unit for performing a physical detection on the feces sample liquid and at least one chemical detection unit for performing a chemical detection on the feces sample liquid. Each chemical detection unit includes a driving roller and a driven roller, a reagent strip roll wound on the driven roller, an end portion of the reagent strip roll fixed on the driving roller.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: April 5, 2022
    Inventor: Xianglong Li
  • Patent number: 11285487
    Abstract: Apparatuses and associated methods of manufacturing are described that provide a tip resistant optical testing instrument configured to rest on a surface. The optical testing instrument includes a shell defining a cavity for receiving a sample tube. The shell includes a bottom shell surface, wherein the bottom shell surface defines at least one support element, wherein the at least one support element is configured to engage the surface to support the optical testing instrument in a testing position, and a translational surface configured to engage the surface to support the optical testing instrument in an angled position. In an instance in which the optical testing instrument tilts from the testing position to the angled position, the translational surface is configured to engage the surface contacting the translational surface to prevent the optical testing instrument from tipping further and allow the optical testing instrument to return to the testing position.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: March 29, 2022
    Assignee: bioMerieux, Inc.
    Inventors: Jack R. Hoffmann, Jr., Gregory R. Maes
  • Patent number: 11285485
    Abstract: A test tube may include: an annular body having an open first end, a closed second end, a longitudinal surface extending between the open first end and the closed second end and enveloping a hollow interior of the annular body and a central longitudinal axis; wherein the longitudinal surface of the annular body may include: a first longitudinal portion that may include the open first end of the annular body and having a substantially circular cross-section; and a second longitudinal portion that may include: a first longitudinal side having a substantially circular-arc cross-section; and a second longitudinal side tapering in a longitudinal direction of the annular body towards the closed second end of the annular body.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: March 29, 2022
    Inventors: Snir Zano, Daniel Gurevich
  • Patent number: 11255762
    Abstract: A method of classifying sample data for robotically extracted samples is disclosed. A specimen is received from a human subject with a potential infection of a first disease agents or a plurality of disease agents. The specimen includes genetic material collected from a human subject using a collection device and stored in a collection carrier. The specimen includes a unique identifier on the collection carrier. The unique identifier contains human subject descriptive data. The method classifies the human subject descriptive data to identify a second disease agent. The method extracts a sequence of genetic material from the specimen using an automated robot. The method determines a test result for the first disease agent as a function of the sequence of genetic material. A system comprising a computer device configured to classify sample data for robotically extracted samples is also disclosed.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: February 22, 2022
    Assignee: Specialty Diagnostic (SDI) Laboratories, Inc.
    Inventors: Ozman Mohiuddin, Brian T. Sutch, Mohammad Ali Mahmood
  • Patent number: 11241178
    Abstract: A method for inversion counting or phlebotomist monitoring can include identifying, by processing circuitry, whether a blood collection tube is present in image data from a camera situated to capture images of a phlebotomist collecting a sample, in response to identifying the blood collection tube is present in the field of view of the camera based on the image data, identifying whether the blood collection tube includes blood therein, after identifying the blood is present in the blood collection tube, counting, based on the image data, a number of inversions performed on the blood collection tube, and in response to determining the number of inversions performed is less than a required number of inversions, issuing an alert indicating that insufficient inversions were performed.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: February 8, 2022
    Inventor: George S. Cembrowski
  • Patent number: 11235322
    Abstract: The present disclosure relates to an analytical system with at least three components: a multiwell plate on which the wells are included in an optically transparent area; a frame holding the multiwell plate close to its edge while permitting the plate a certain extent of freedom of movement; a baseplate to which the multiwell plate, but not the frame is firmly fixed via a docking mechanism, such that different expansion of plate and frame can be compensated. A second aspect described herein relates to a method of docking a corresponding multiwell plate held by a frame to a baseplate and subjecting the multiwell plate to a step of a biological or chemical assay within this arrangement.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: February 1, 2022
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Lukas Dysli, Christian Thalmann
  • Patent number: 11219875
    Abstract: Disclosed is a device for the synthesis of a radiotracer, including a universal confined enclosure designed for the insertion of a specific synthesis cassette of the radiotracer and the removal of same. The synthesis cassette includes a synthesis module designed to receive reagents and a radioisotope for the synthesis of the radiotracer. An inner connector plate includes at least one inlet, designed to be connected to a radioisotope admission and also to the inlet of the cassette, and an outlet, designed to be connected to a syringe to be filled with the radiotracer and also to the outlet of the cassette. Such a synthesis device can be installed in a facility including, in a confined room, as well as such devices normally arranged in a storage area, a synthesis station, a radioisotope admission, at least one window for communication to the outside, and a manipulator robot.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: January 11, 2022
    Assignee: PMB
    Inventors: Laurent Tanguy, Jerome Corneille, Bertrand Loubaton, Marc Delmas, Alain Perez Delaume
  • Patent number: 11221281
    Abstract: Provided is a heat treatment device for slide specimen testing, and the heat treatment device mainly includes a container, a base, a heater, a liquid outlet, a liquid inlet, a controller and a thermocouple. When such device is used together with devices such as a slide cover plate and a slide rack, a large amount of slide specimens can be carried out steps of reagent loading, cleaning, heat treatment, temperature maintaining and drying inside one same device, especially multi-step operations such as an immunohistochemical testing, an original hybrid gene testing, and other protein testing, DNA nucleotide and gene testing on the slide specimen. All testing on the slide specimen is enabled to be performed in one same device from the beginning to the end, guaranteeing that all slide specimens are completely covered by the reagent from the beginning to the end, and all slide specimens are carried out the heat treatment at a uniform temperature.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: January 11, 2022
    Inventors: James Guo, Derek Guo
  • Patent number: 11192701
    Abstract: A method is provided comprising loading shells into shell retention chambers of a shell management module, the shells including corresponding reservoirs configured to hold individual quantities of liquid, the shell retention chambers arranged in a predetermined pattern on a platform of the shell management module. The method further comprises orienting discharge ends of the shells along an actuation direction within the shell retention chambers, and covering the discharge ends with closure lids to seal bottoms of the corresponding reservoirs.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: December 7, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Paul Crivelli, Gary Watts
  • Patent number: 11135591
    Abstract: A test tube including an annular body having an open proximal end and a closed distal end, and an longitudinal member in a distal portion of an interior of the annular body, the longitudinal member is substantially parallel to a central longitudinal axis of the annular body and is connected to an internal surface of the distal portion of the annular body.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: October 5, 2021
    Inventors: Snir Zano, Daniel Gurevich
  • Patent number: 11116482
    Abstract: Disclosed is a test barrel, to prevent a test liquid in the barrel from sputtering into a connection gap due to shaking of the barrel to hence cause contamination, improve the measurement accuracy in case of multiple tests, and meanwhile improve the operability of screwing on and screwing off the entire device during use of the device. The above technical objective of this utility model is implemented by employing the following technical solution: a test barrel, comprising barrel lid and a barrel body; wherein the threaded rings are arranged on an inner wall of a side face of the barrel lid and an outer wall of an opening of the barrel body, a rotary force applying portion is arranged on an outer wall of the side face of the barrel lid, and during engagement, a liquid blocking washer is arranged between the barrel lid and the barrel body, wherein a radial width of the liquid blocking washer is greater than a thickness of the opening of the barrel body.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: September 14, 2021
    Inventor: Siyu Lei
  • Patent number: 11097277
    Abstract: A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: August 24, 2021
    Inventors: Adam Michael Gray, Michael Stephen Glynn
  • Patent number: 11090655
    Abstract: In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: August 17, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Gary Frenzel, Samartha Anekal, Daniel Young
  • Patent number: 11067565
    Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: July 20, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
  • Patent number: 11045807
    Abstract: An integrated technological platform enabling real-time quantitative multiparameter metabolic profiling, utilizing either or both of extra and intracellular optical sensors, individually or simultaneously. A scalable embedded micropocket array structure, generally fabricated on fused silica substrates, facilitates the integration of multiple, spatially separated extracellular sensors for multiparameter analysis in a container formed with the use of an activation mechanism forming part of a device configured to hold the container during the measurements. The creation of hermetically sealed microchambers is carried out with a pneumatically and/or mechanically and/or electromechanically driven device that is “floating” within the holding device and that is optionally equipped with a vacuum/suction mechanism to hold a component of the container at its surface.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: June 29, 2021
    Inventors: Deirdre Meldrum, Laimonas Kelbauskas, Yanqing Tian, Honor Glenn, Clifford Anderson, Kristen Lee, Ganquan Song, Liqiang Zhang, Jeff Houkal, Fengyu Su, Benjamin Ueberroth, Jacob Messner, Hong Wang, Kimberly Bussey
  • Patent number: 11034495
    Abstract: In some aspects, a keyed cap for a container is provided. Furthermore, in some aspects, a keyed container device including a container and the keyed cap for the container is also provided. Still further, in some aspects, a keyed containing system including a container, keyed cap for the container, and an electronic device having a keying element that is adapted to mate or otherwise fit with a specific keying element on the keyed cap. If a keyed cap has a keying element that does not correctly correspond to a specific keying element on an electronic device, then the keyed cap will not properly mate with the keying element on the electronic device. For example, the two keying elements that do not match may not fit sufficiently far enough within each other to permit the piercing member on the electronic device to reach a septum on the cap.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: June 15, 2021
    Assignee: Abbott Laboratories
    Inventor: Roger W. Accurso
  • Patent number: 11027278
    Abstract: A microfluidic device includes a microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region. The microchannel is formed in a microfluidic chip substrate and configured to accommodate a flow of liquid through the microchannel. The microfluidic device includes a valve operatively coupled to the switching region comprising a sealed reservoir. A side passage extends between the reservoir and the interior of the microchannel via an aperture in the side wall and is configured to accommodate a volume of liquid between the interior of the microchannel and the reservoir. The microfluidic device includes an actuator integrated into the microfluidic chip and configured to increase an internal pressure of the reservoir and move at least a portion of the volume of the liquid from the side passage into the microchannel to deflect a portion of the liquid flowing through the microchannel.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: June 8, 2021
    Assignee: CYTONOME/ST, LLC
    Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
  • Patent number: 11013230
    Abstract: A vial is described herein that comprises a tubular body which comprises an opened end, a closed end, and a cavity, wherein the opened end is located at one end of the tubular body and the closed end is located at an opposing end of the tubular body. The tubular body further comprises a tear line located therein, wherein the tear line extends across at least a portion of one side of the tubular body, across the closed end, and across at least a portion of another side of the tubular body. In addition, the tubular body further comprises two flanges extending from the closed end, wherein the two flanges are configured to separate from one another outwardly from the tubular body and apply a force to break-open at least a portion of the tear line to open at least the closed end of the tubular body.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: May 25, 2021
    Assignee: Corning Incorporated
    Inventor: Michael Kurt Schaefer