Patents Examined by Dwayne K. Handy
  • Patent number: 10478820
    Abstract: An article for performing a reaction includes a reagent well having a side wall, a bottom wall and an open upper end. A lyophilized reagent is retained within the well by a non-integral retention feature that is inserted into the open upper end of the well and fixed to a side wall above the reagent. An opening in the retention feature is smaller than the diameter of the reagent, but is sized to permit a pipette tip to be inserted into the well. The retention feature may be a collar fixed to the side wall and may include fingers extending axially into the well. The well and the retention feature may be correspondingly tapered. A method for reconstituting a lyophilized reagent includes the steps of drawing into a pipette tip attached to an automated pipettor an amount of a diluent and dispensing the diluent into the reagent well to thereby reconstitute the lyophilized reagent.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: November 19, 2019
    Assignee: Gen-Probe Incorporated
    Inventor: Byron J. Knight
  • Patent number: 10442995
    Abstract: A system for the production of carbonized biomass that includes an infeed for accepting biomass feed material and an associated twin screw extruder. A water heater is connected with respect to at least one inlet along a length of the twin screw extruder and a pressure sustaining valve is connected at an outlet of the twin screw extruder.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 15, 2019
    Inventors: Larry G. Felix, William E. Farthing, James H. Irvin, Todd R. Snyder, Wei Yan
  • Patent number: 10434436
    Abstract: Provided is a gas-blowing vaporizing and drying device, which includes: a sample tube in the form of a double tube including an inner tube for a solution and an outer tube for a gas, the inner tube protruding from one end of the outer tube by length L; and a collection container including a container body and a lid provided with a protrusion sleeve tube, the protrusion sleeve tube including a coupling portion at an end to be located outside the container body and a sleeve portion of a length equal to or longer than L having an open end to be located inside the container body, the coupling portion being designed to be coupled to the aforementioned one end of the outer tube in an air-tight manner.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: October 8, 2019
    Assignee: Shimadzu Co.
    Inventors: Tomoyuki Yamazaki, Przemyslaw Stasica, Bob Boughtflower
  • Patent number: 10427159
    Abstract: A microfluidic device includes a microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region. The microchannel is formed in a microfluidic chip substrate and configured to accommodate a flow of liquid through the microchannel. The microfluidic device includes a valve operatively coupled to the switching region comprising a sealed reservoir. A side passage extends between the reservoir and the interior of the microchannel via an aperture in the side wall and is configured to accommodate a volume of liquid between the interior of the microchannel and the reservoir. The microfluidic device includes an actuator integrated into the microfluidic chip and configured to increase an internal pressure of the reservoir and move at least a portion of the volume of the liquid from the side passage into the microchannel to deflect a portion of the liquid flowing through the microchannel.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: October 1, 2019
    Assignee: CYTONOME/ST, LLC
    Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
  • Patent number: 10422452
    Abstract: Fluidic connection assemblies, ports, unions and other components are provided that are well-suited for use in HPLC and UHPLC, as well as in other analytical instrument systems. Such assemblies, ports, unions and components can be biocompatible.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: September 24, 2019
    Assignee: IDEX Health & Sciences LLC
    Inventors: Craig Graham, Don Pein
  • Patent number: 10421074
    Abstract: The present invention provides a microplate comprised of multiwell strips connected in such a way as to permit the microplate to unfold and to pass in a linear fashion past a fraction collector and then re-fold back into a microplate configuration. Furthermore, the invention provides for the use of the microplates of the invention in a variety of different laboratory methods.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: September 24, 2019
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Henrik Ostlin
  • Patent number: 10416048
    Abstract: A collecting apparatus comprises: a housing which is long and includes a housing space capable of housing a collecting member, the housing having formed therein an inflow port and an outflow port; a gas flow generator that generates a gas flow within the housing space; and a holding portion that holds the collecting member in a position that the gas flow flows, the inflow port being formed on a more upstream side than the collecting member held by the holding portion, and the outflow port being formed on a more downstream side than the collecting member held by the holding portion, and the outflow port opening toward the downstream side such that air that has flowed out from the outflow port flows along a housing outer surface on a more downstream side than the outflow port.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: September 17, 2019
    Assignees: Sibata Scientific Technology Ltd., Veritas System Ltd.
    Inventors: Masatoshi Shibata, Yoshihiro Suzuki
  • Patent number: 10391030
    Abstract: Device for receiving and draining a high quantity of biopharmaceutical fluid under pressure includes an inner bag, having an inner container for receiving the fluid and provided with a filling port, a drain port, a filling tube having a filling inlet for connection to a filling line, a drain tube having a drain outlet for connection to a drain line, an outer container in which the bag is placed, a compression chamber between the outer container and the bag, an injection port for injecting pressurized draining gas into the chamber, sealed bushings passing through the container via the filling and drain tubes, the deformation capacities of the bag and container being such that, when the draining gas is injected into the chamber, the bag is compressed and the biopharmaceutical fluid is emptied. The outer container includes a receptacle forming the outer chamber, the tubes passing therethrough via permanently fixed connections.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 27, 2019
    Inventors: Cedric Gentile, Maurizio Giovani, Paolo Truzzi, Laurent Aicardi, Sebastien Svete
  • Patent number: 10386323
    Abstract: An improved disposable electrochemical test sensor designed to facilitate sampling of fluid samples. It has a fluid chamber having a novel extra wide sampling entrance. The chamber provides a reservoir from which a sample fluid can be drawn into the chamber through capillary action. The novel extra wide sampling entrance of the test sensor provided by the present invention can draw blood into the chamber not only from the front of the sampling entrance as usual in convenient sensors, but also from the top, bottom, left corner and right corner of the sampling entrance. Thus it allows easy targeting the samples with small volume, picking up smeared samples and it is more tolerant to users who jam the tip of the sensor into users' finger.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: August 20, 2019
    Assignee: Sinocare Inc.
    Inventors: Xiaohua Cai, Hongli Che, Shaobo Li
  • Patent number: 10376878
    Abstract: Method for the treatment of a biological sample comprising at least one cell and a liquid component; according to the method, a force is applied to the sample inserted in an inner chamber of a hollow device towards a filter which has pores with diameters from 2 nm to 1 ?m, so that at least part of the liquid component passes through the filter and the cell remains in the inner chamber, thus obtaining a concentrated sample; the filter has a surface facing the inner chamber of less than 12.6 mm2.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: August 13, 2019
    Assignee: Menarini Silicon Biosystems S.p.A.
    Inventors: Alex Calanca, Gianni Medoro, Nicolò Manaresi, Giuseppe Giorgini
  • Patent number: 10379104
    Abstract: An exposure apparatus for carrying out in vitro experiments with biological test systems, which are perfused with an exposure medium, forming an exposure atmosphere, includes an exposure cap, which is dimensioned in such a manner that it can be set onto a standard multiwell plate and connected with the standard multiwell plate using suitable connecting elements.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: August 13, 2019
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forshcung e.V.
    Inventors: Detlef Ritter, Jan Knebel
  • Patent number: 10377538
    Abstract: A liquid storage and delivery mechanism and method of use are provided. The mechanism comprises shells that include corresponding reservoirs to hold individual quantities of liquid. The shells include filling ends and discharge ends. The filling ends include fill ports that open to the reservoirs in order to receive the corresponding quantity of liquid. The discharge ends are covered with closure lids to seal bottoms of the corresponding reservoirs. A shell management module is provided comprising a cover and a platform. The platform includes shell retention chambers to receive corresponding shells. The shell retention chambers are arranged in a predetermined pattern on the platform. The shell retention chambers are to orient shells with the fill ports exposed from the platform. The cover is mounted onto the platform to close the fill ports. The shells are to move individually, along the shell retention chambers, between non-actuated and actuated positions.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: August 13, 2019
    Assignee: Illumina, Inc.
    Inventors: Paul Crivelli, Gary Watts
  • Patent number: 10369571
    Abstract: A micro-titration vessel may include a plurality of fins protruding outward from an exterior wall of a cup and flush with the bottom of the cup to provide stability to the vessel. Interior walls of the cup are angled inward at multiple points along the body of the cup, resulting in a small surface area at the bottom of the cup where titration occurs.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: August 6, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Tinh Nguyen-DeMary
  • Patent number: 10371677
    Abstract: An odor adsorbent material, an odor detection kit, and a method for using the same for rapidly identifying a facility where binding of an odor component had occurred among facilities used in a distribution route of a commodity. The odor detection kit includes at least two pieces of an odor adsorbent material, a package section that includes at least two storage sections and is configured to store the odor adsorbent material, and a sheet section. The odor detection kit is installed in a facility. At least one of the pieces of the odor adsorbent material is exposed to open space in the facility, recovered therefrom, and sealed and stored. At the time of testing, occurrence of odor emission in the facility is determined by comparing odor components adsorbed by each of the pieces of the odor adsorbent material.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: August 6, 2019
    Inventors: Takiko Nakada, Ryoichi Tajima, Masanobu Yoshinaga
  • Patent number: 10345322
    Abstract: A cartridge for dispensing a fluid is provided, the cartridge comprising: a reservoir chamber configured for receiving the fluid, the reservoir chamber having a fluid outlet and a cover with a first bearing; and a stirring assembly comprising a stirrer located inside the reservoir chamber, the stirring assembly comprising a shaft connected to the stirrer. The stirring assembly can be moved between first and second positions, wherein in the first position the stirring assembly can seal the fluid outlet, the stirring assembly in the first position being configured to form a second bearing with the reservoir chamber or the fluid outlet such that the stirrer can be rotated about an axis defined by the first and second bearing, and wherein if the stirring assembly is in the second position the fluid can pass through the fluid outlet, the shaft being configured to transmit rotational power to the stirrer.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: July 9, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Thorsten Brueckner, Christoph Boehm, Juergen Spinke
  • Patent number: 10335786
    Abstract: A cartridge configured for use in a blood analyzer is provided. The cartridge may include a substantially rigid frame, a flow path within the rigid frame, at least one opening in the substantially rigid frame configured to align and stabilize a capillary tube, and a seal within the flow path. The seal may be configured to temporarily obstruct flow through at least a portion of the flow path. The seal may also be configured to open in response to a force exerted via a capillary tube inserted into the at least one opening.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: July 2, 2019
    Assignee: Pixcell Medical Technologies Ltd.
    Inventors: Avishay Bransky, Liron Shiomo
  • Patent number: 10337967
    Abstract: A magnetic base for a sample plate of a sample processing system is provided comprising a first plate comprising a first top surface; a bottom surface; and a sample plate mounting cavity wall mounted to the first top surface, wherein the first plate and the sample plate mounting cavity wall define a sample plate mounting cavity configured to accommodate a sample plate of a sample processing system. The magnetic base further comprises a second plate extending parallel to the first plate, the second plate comprising a second top surface; and a magnet mounting cavity wall extending between the bottom surface of the first plate and the second top surface of the second plate, wherein the first plate, the second plate, and the magnet mounting cavity wall define a magnet mounting cavity configured to accommodate a free floating magnet.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: July 2, 2019
    Inventors: David John Guckenberger, Mary Christin Regier
  • Patent number: 10335787
    Abstract: An apparatus includes a device for storing a liquid sample, in which the device has a sample acceptance well, one or more storage chambers, and one or more fluidic channels fluidly coupling the sample acceptance well to the one or more storage chambers. The apparatus also includes a well plate having a plate and multiple wells formed in the plate, in which the device and the well plate are configured to be attached to one another.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: July 2, 2019
    Assignee: The General Hospital Corporation
    Inventors: Ramin Haghgooie, Robert Granier, Kenneth T. Kotz, Anne C. Petrofsky
  • Patent number: 10337933
    Abstract: A stirring paddle for isothermal titration calorimetry includes a blade secured to one end of a shaft. The blade has an edge and a pair of opposing surfaces. A lip extends from the edge and forms a non-zero angle with respect to the opposing surfaces. In some embodiments, the blade has a twisted rectangular shape defined by a pair of first opposing edges and a pair of second opposing edges. One of the first opposing edges is oriented at a rotation angle with respect to the shaft axis that is different than an orientation of the other first opposing edge with respect to the shaft axis. Advantageously, the stirring paddle achieves improved turbulent mixing of injections into liquid within a sample cell, resulting in shorter measurement times. The improved mixing efficiency allows the stirring paddle to be operated at a lower rotation rate.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: July 2, 2019
    Inventor: David Serrell
  • Patent number: 10309947
    Abstract: A system and method for performing radiochemical synthesis, analysis and/or dispensing of radiopharmaceuticals using specially designed disposable components: palettes and caddies, the palette being an assembly of containers not connected with each other for direct material transfer; the caddy being a disposable component used to transfer material between containers on the palettes and/or other locations.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: June 4, 2019
    Assignee: Trace-Ability, Inc.
    Inventors: Arkadij Elizarov, Artem Lebedev