Abstract: An article of manufacture includes an array of distinct and separate regions with respective pharmaceutical compounds located thereon. The array of distinct and separate regions includes a first region with a first set of one or more pharmaceutical compounds located thereon; a second region, that is distinct and separate from the first region, with a second set of one or more pharmaceutical compounds, that is distinct from the first set of one or more pharmaceutical compounds, located thereon; and a third region, that is distinct and separate from the first region and the second region, with a third set of one or more pharmaceutical compounds, that is distinct from the first set of one or more pharmaceutical compounds and the second set of one or more pharmaceutical compounds, located thereon.

Abstract: There is provided methods and systems for disaggregation and deagglomeration of small scale materials such as carbon nanotubes by cavitation of a treatment substance. The treatment substance may be a substance such as CO2 which is capable of undergoing phase changes. Systems must be capable of withstanding high pressures, and cavitation may be done by ultrasound, mechanical agitation, injection of a jet stream, or other methods. Materials treated via the methods of the invention may be removed without the use of chemical surfactants or other chemical modification means, and may be further used in a battery.

Abstract: A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.

Abstract: A surface bio-contamination assay kit (1) comprising a disposable swab cartridge (2) comprising a swab (29); a sampler (3) designed to removably receive the cartridge (2) and to wipe the cartridge swab (29) on a surface to be collect a sampled, along a predetermined sampling path (4) designed to cover a predetermined surface area; and a bio-contamination meter (5) designed to removably receive the cartridge (2) after sampling and to measure bio-contamination of the collected sample on the cartridge (2).

Abstract: A method and device are provided for detecting a target in a biological sample. The target binds to a solid phase substrate. First and second cavities in a plate are filled with an oil. The first and second cavities are in fluid communication with each other. The solid phase substrate is magnetically drawn sequentially from a drop of the biological sample in the first cavity, through the oil, into a drop of the reaction solution in the second cavity. A change in a parameter of the drop of the reaction solution indicates the presence of the target.

Abstract: The methods and systems described herein provide a cell culture platform with an array of tissue modeling environments and dynamic control of fluid flow. The cell culture platform includes an array of wells that are fluidically coupled by microchannel structures. The dynamically controlled flow of fluid interacts with cells grown within the microchannels.

Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.

Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.

Abstract: A biological fluid collection device that allows a blood sample to be collected anaerobically is disclosed.

Abstract: An isolation device includes an isolation chip assembly, a vacuum system, a frequency converting module, and a controller. The isolation chip assembly includes an isolation chip having a first chamber and a second chamber, a first oscillator mounted on the first chamber, and a second oscillator mounted on the second chamber. The frequency converting module causes the vacuum system to generate negative pressure in the first and the second chambers alternately. The controller controls the first and the second oscillators to operate when the vacuum system stops generating the negative pressure in the first chamber and in the second chamber. The first and the second oscillators respectively generate a first and a second oscillation wave when operating, a frequency of the first oscillation wave is greater than a frequency of the oscillation wave, an amplitude of the first oscillation wave is less than an amplitude of the second oscillation wave.

Abstract: The invention provides an analysis plate (10) including at least one analysis zone for receiving a sample to be analyzed by mass spectrometry using the MALDI-TOF technique, the plate being of the type having at least one test face (12) with at least one analysis zone defined thereon and of the type in which the plate includes a support (18) that is plane, the plate being characterized in that the support (18) comprises at least one sheet (20) of paper material comprising cellulose fibers, and in that the analysis plate (10) includes at least one ply (24) of metal material.

Abstract: A technology capable of preventing a sample from being retained is to be provided. Provided are a microchip that includes at least a sample inlet into which a sample is introduced, a sample flow path through which the sample introduced from the sample inlet flows, and a sorting flow path in which a target sample is sorted out from the sample, in which a first tube is inserted into and fixed to the sample inlet, and a sample sorting kit that includes at least the microchip.

Abstract: A method of forming an integrated device includes forming a sample well within a cladding layer of a substrate; forming a sacrificial spacer layer over the substrate and into the sample well; performing a directional etch of the sacrificial spacer layer so as to form a sacrificial sidewall spacer on sidewalls of the sample well; forming, over the substrate and into the sample well, a functional layer that provides a location for attachment of a biomolecule; and removing the sacrificial spacer material.

Abstract: A system, method, and platform for target detection, the system including: a base substrate; a set of sample processing regions defined at a broad surface of the substrate, wherein each of the set of sample processing regions includes: a set of microwell subarrays arranged in a gradient between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions; and a cover substrate configured to mate with the base substrate in a coupled mode, the cover substrate comprising a network of venting channels aligned with the set of sample processing regions upon mating the base substrate with the cover substrate in the coupled mode, the network of venting channels providing gas exchange between the base substrate and an environment surrounding the microwell assembly. The invention(s) can be used for MPN assays.

Abstract: The invention relates to an expandable vacuum chamber (10) having flat frame elements (14) and end plates (12) and to a method for producing such a vacuum chamber (10). The end plates (12) are lined up in front of and behind the frame elements (14) in the axial direction (Ra) and, together with the frame elements (14), delimit a chamber volume of the vacuum chamber (10).

Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.

Abstract: A controller detects an error based on a most recent height of a nozzle at detection of contact of a nozzle with a sample by a liquid surface sensor and a previous height of the nozzle at detection of contact of the nozzle with the sample by the liquid surface sensor, and upon detection of the error, provides an error notification in a manner different from that at detection of another error.

Abstract: A system for processing a sample includes a unitary body. The unitary body including a snap lid, the snap lid having a capillary. The unitary body including a lysing container. The unitary body including a test element and a sliding actuator.

Abstract: A sample collection and detection device includes a collection cavity. The device further includes a sample collector. The sample collector comprises a collection rod and an absorption element, and the absorption element has a hollow cavity. A part of the collection rod is received in the hollow cavity of the absorption element. A first lug for blocking and locating the absorption element is arranged on the collection rod. Also provided is a method for collecting and detecting sample using the sample collection and detection device.

Abstract: A method for inversion counting or phlebotomist monitoring can include identifying, by processing circuitry, whether a blood collection tube is present in image data from a camera situated to capture images of a phlebotomist collecting a sample, in response to identifying the blood collection tube is present in the field of view of the camera based on the image data, identifying whether the blood collection tube includes blood therein, after identifying the blood is present in the blood collection tube, counting, based on the image data, a number of inversions performed on the blood collection tube, and in response to determining the number of inversions performed is less than a required number of inversions, issuing an alert indicating that insufficient inversions were performed.