Patents Examined by Dwayne K. Handy
  • Patent number: 11648565
    Abstract: The equipment item for automatically managing a plurality of biological samples placed in a respective sample jar includes a storage container for sample jars having a plurality of housings, an apparatus with a reader of encoded identification data affixed on the sample jars placed in the container, a device for determining data representative of the position of each sample jar within the container, and a device for rotating the container, and a computer processor connected to the apparatus. The container includes, in the immediate vicinity of each housing, a shape appearing recessed or raised, while the device for determining data representative of the position of each sample jar is defined by a detector for the shape.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: May 16, 2023
    Assignee: DREAMPATH DIAGNOSTICS
    Inventors: Pablo Jordan Navas, Valerie Wilhelm
  • Patent number: 11628436
    Abstract: An assay plate assembly comprising a plurality of microfluidic modules arranged in a rectilinear matrix of rows and columns microfluidic channels. Each microfluidic module has an inlet well leading to a serpentine microfluidic channel that is set at a cant angle. The well is laterally offset from the detection area to avoid optical interference. The geometric center of each detection area is positioned according to ANSI/SLAS standards for well-centers. A drain from each microfluidic channel is located so that it does not interfere with any detection areas. An array of micro-posts are disposed within each microfluidic channel. The micro-posts extend perpendicularly from the top surface of the top plate toward the underside and are equally distributed throughout the entire detection area. The plate assembly provides reduced assay time and sample volume, and increased sensitivity and specificity in biological and chemical assays.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: April 18, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Maung Kyaw Khaing Oo, Xudong Fan
  • Patent number: 11630036
    Abstract: A sample collection and detection device includes a collection cavity. The device further includes a sample collector. The sample collector comprises a collection rod and an absorption element, and the absorption element has a hollow cavity. A part of the collection rod is received in the hollow cavity of the absorption element. A first lug for blocking and locating the absorption element is arranged on the collection rod. Also provided is a method for collecting and detecting sample using the sample collection and detection device.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: April 18, 2023
    Assignee: Assure Tech. (Hangzhou) Co., Ltd
    Inventor: Shi sheng Ling
  • Patent number: 11607690
    Abstract: An applicator or applicator system used for handling samples in an analytical laboratory setting. In particular, the invention the applicator or applicator system is capable of capping an analytical sample tube by applying a capping material to an opening of an analytical sample vessel, the applicator or applicator system including g a dispenser configured to dispense a substantially continuous length of a capping material, such that a region of the substantially continuous length of capping material is located on or about an opening of an analytical sample vessel held in a predetermined orientation.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: March 21, 2023
    Assignee: AIM LAB AUTOMATION TECHNOLOGIES PTY LTD
    Inventors: Damien Braun, Francis Harvey, David Muir-McCarey, Robert Fisher, Sandy Sherry, Zisui Yao, Rainer Novy, Matthew Grant, Peter Dalman, Thomas Knight
  • Patent number: 11591591
    Abstract: Provided herein is a method for isolating high molecular weight (HMW) DNA using beads that are at least 200 ?m in diameter that utilizes a device for retaining the beads and where the purified DNA eluant exits the device without shearing the HMW DNA. In some embodiments, the method comprises precipitating the DNA onto the beads, washing the beads in the device, and then eluting the DNA from the beads therein while substantially avoiding shear. Compositions and kits for practicing the method are also provided.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: February 28, 2023
    Assignee: New England Biolabs, Inc.
    Inventors: Paul A. Koetsier, Barbara W. Taron, Eric J. Cantor
  • Patent number: 11557373
    Abstract: A system for second lab testing of genetic materials is presented. The system includes a computing device configured to receive a specimen from a human subject and perform a smart test on the specimen. The smart test includes a first lab test configured to generate a first lab test identifying a first disease agent and a second lab test configured to generate a second lab test identifying a second disease agent, wherein identifying the second disease agent includes generating a second lab machine-learning model, training the second lab machine-learning model as a function of a second lab test training set, and outputting, as a function of the second lab machine-learning model, the second lab test result using specimen data as an input. The computing device is further configured to generate a smart test result as a function of the smart test.
    Type: Grant
    Filed: December 31, 2021
    Date of Patent: January 17, 2023
    Assignee: Specialty Diagnostic (SDI) Laboratories, Inc.
    Inventors: Ozman Mohiuddin, Sumi Thomas
  • Patent number: 11541393
    Abstract: A sensor for detecting a target pathogen (e.g., a virus or a bacterium) in a specimen is disclosed, which includes at least two sensing units one of which is configured to detect at least one protein (such as a structural protein) associated with the target pathogen and another one is configured to detect at least one genetic component (e.g., an RNA or a DNA segment) associated with that pathogen (e.g., an RNA segment that is unique to that pathogen).
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: January 3, 2023
    Assignee: INNOTECH PRECISION MEDICINE, INC.
    Inventors: Roya Khosravi-Far, Reza Mollaaghababa
  • Patent number: 11517903
    Abstract: A system for collecting, growing, and analyzing biological specimens that may present a health threat. The system includes separate modules for specimen collection, sample isolation, and sample analysis that can be interconnected to safety process, culture, and analyze and unknown specimen. A decapitation module allows a user to safely collect a swab tip containing an unknown sample and transport the sample to a culture module where the sample can be washed from the swab tip and isolated in a cuvette for growth and analysis. The culture module may be coupled to a base station that can provide mixing, heating and cooling, as well as optical and spectral analysis.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: December 6, 2022
    Inventor: Robert B. Silver
  • Patent number: 11513062
    Abstract: It is disclosed a method for calibrating an electronic device for measuring the concentration of a biological compound, in particular bilirubin. The method comprises the step a) of performing (10) a plurality of reflectance measurements for each reference strip of a plurality of reference strips (110-1, 110-2, . . .
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: November 29, 2022
    Assignee: BILIMETRIX S.R.L.
    Inventors: Matteo Mottica, Claudio Tiribelli, Carlos Daniel Coda Zabetta
  • Patent number: 11474009
    Abstract: The present disclosure relates to a sample transfer apparatus (100) for transferring a sample holder (200) into and out of a vacuum chamber (810), comprising: a holding device (110) including at least one cam (120) configured to cooperate with at least one follower (210) of a sample holder (200), wherein the at least one cam (120) includes a curved track having an open end portion (122), a locking portion (126), a locking track portion (124) and a releasing track portion (128), wherein the locking track portion (124) and the releasing track portion (128) respectively connect the open end portion (122) and the locking portion (126), wherein the curved track is configured such that the at least one follower (210) of the sample holder (200) is guided from the open end portion (122) to the locking portion (126) via the locking track portion (124) for attaching the sample holder (200) to the holding device (110), and wherein the curved track is further configured such that the at least one follower (210) of the sa
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: October 18, 2022
    Assignee: KIUTRA GMBH
    Inventors: Alexander Regnat, Jan Spallek, Klaus Eibensteiner
  • Patent number: 11465149
    Abstract: A container cap liner that that facilitates the storage of gases and various volatile organic compounds (VOCs). More particularly, the container cap liner reduces the loss of gases and various volatile compounds thereby providing for relatively longer storage periods with relatively more accurate analytical analysis.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: October 11, 2022
    Assignee: LGC NORTH AMERICA INC.
    Inventors: Thomas M. Rettberg, Kengkaj Sukcharoenphon, Daniel Biggerstaff
  • Patent number: 11459437
    Abstract: A porous polymer monolith comprises a polymer body having macroporous through-pores that facilitate fluid flow through the body and an array of mesopores adapted to bind from the fluid flow molecules of a predetermined range of sizes, wherein the surface area of the monolith is predominantly provided by the mesopores. Also disclosed is a method of making a porous polymer monolith. The method includes forming a polymer body by phase separation out of a solution containing at least a monomer, a crosslinker and a primary porogen, whereby the body contains multiple macroporous through-pores, wherein the solution further contains a secondary porogen comprising oligomers inert with respect to the monomer and cross-linker but chemically compatible with the monomer so as to form mesostructures within the polymer body during said phase separation, and washing the mesostructures from the body to provide an array of mesopores such that the surface area of the monolith is predominantly provided by the mesopores.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: October 4, 2022
    Assignee: Trajan Scientific Australia Pty Ltd
    Inventors: Hans-Jurgen Wirth, Wei Boon Hon
  • Patent number: 11454638
    Abstract: A sample rack transport apparatus for transporting a sample rack to a sample analyser, comprising: a bidirectional transmission track for bidirectionally transmitting a sample rack without passing through the sample analyser; a feed channel in parallel with the bidirectional transmission track, wherein the sample rack may be delivered from the bidirectional transmission track to the feed channel and to the sample analyser; an unloading cache region located between the bidirectional transmission track and the feed channel, the unloading cache region being used for storing the sample tack; and an unloading mechanism for delivering the sample rack in the feed channel to the unloading cache region for storage, or delivering the sample rack stored in the unloading cache region to the bidirectional transmission track. Also provided are a sample analysis device and a sample analysis system using the sample rack transport apparatus.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: September 27, 2022
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Junwei Zhang, Changyin Yan, Changxing Wang, Xuerong Li, Yunfei Wang
  • Patent number: 11448626
    Abstract: An ion exchange chromatographic packing material is described that includes support resin particles and a copolymer grafted to the support resin particles. The copolymer includes polymerized functional monomers such as a first ion exchange group monomer and a second ion exchange group monomer. At a first pH, the first ion exchange group monomer is configured to have a first charge at a first pH, and the second ion exchange group monomer is configured to have a net neutral charge. At a second pH, the first ion exchange group monomer is configured to have the first charge at a second pH, and the second ion exchange group monomer is configured to have a second charge at the second pH where the first charge and second charge both have a same polarity.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: September 20, 2022
    Assignee: DIONEX CORPORATION
    Inventors: Manikandan Jayaraman, Christopher A. Pohl, Charanjit Saini
  • Patent number: 11433392
    Abstract: A microfluidic chip (100), an apparatus, a system, and a control and preparation method therefor. The method comprises: a substrate (101), and an electrode layer (102) and a functional layer (103) sequentially formed on the substrate (101), said electrode layer (102) comprising a plurality of electrode groups (1021) arranged in an array, the electrode groups (1021) being used for converting electrical signals into acoustic signals when an electrode group is activated, and transmitting the acoustic signals to the functional layer (103); and the functional layer (103) being used for carrying a sample to be tested, and for absorbing the acoustic wave signals emitted by the activated electrode group (1021) and converting same into thermal energy for heating the sample to be tested that is carried at the position corresponding to the activated electrode group (1021).
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: September 6, 2022
    Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
    Inventors: Long Meng, Hairong Zheng, Kaiyue Wang, Wei Zhou, Lili Niu, Xiaowei Huang
  • Patent number: 11433355
    Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: September 6, 2022
    Assignee: EMD Millipore Corporation
    Inventors: Kurt E. Greenizen, Christopher A. Scott, Paul Sydlowski, John Doyle, Ryan A. Amara
  • Patent number: 11426733
    Abstract: A sample carrier for assaying can include a plurality of pins having a surface that is capable of picking up at least one substance on the surface. The pins can be arranged such that one or more of the plurality of pins are introduced into a corresponding reaction vessel of a microplate. The sample carrier can be divided into a plurality of modules, with each of the plurality of modules comprising one or more pins of the plurality of pins. Methods of use include placing the sample carrier onto a microplate so that at least the one or more of the plurality of pins extend into the corresponding reaction vessel of the microplate.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: August 30, 2022
    Inventor: Zhaoqiang Wang
  • Patent number: 11420138
    Abstract: A container to be used for preparing a multi-layered blood product by centrifugation comprises a substantially cylindrical body (2) with a closed bottom (3) and a top (4) having a filling opening as well as a filter device (15), which is slidable inside the container (1). The filing opening is closed by means of a penetrable membrane (13), and the filter device (15) comprises a substantially planar mesh (16) and a supporting buoyancy body (18). In addition to this, there are means (35, 36, 39, 40, 42), for releasable fixation of the filter device (15) adjacent to the bottom (3) of the container (1).
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: August 23, 2022
    Assignee: Reapplix APS
    Inventors: Rasmus Lundquist, Niels Erik Holm
  • Patent number: 11420208
    Abstract: Embodiments are directed to a removable cap with a top hole and a seal with a heat induction closure for sealing an opening of a container. Advantageously, the cap and the seal do not need to be removed for a probe to access contents of the container, when used in a diagnostic analyzer, thereby eliminating operator steps of cap removal and seal peeling/perforation. Automated opening of the cap and seal combination is provided by puncturing the seal. The seal retains its opened shape required for unobstructed, non-contact probe access to contents of the container. The seal is comprised of three layers: a first polymer sealing layer capable of being heat-sealed to a container; an aluminum foil layer on top of the first polymer sealing layer, configured to heat seal the first layer by inductive heating; and a second polymer layer on top of the aluminum foil layer for protection.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: August 23, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: James W. Kegelman, Joseph E. Brennan, William E. Hudson
  • Patent number: 11413595
    Abstract: Provided is a fluid flow device having high freedom of choosing means for detecting flow errors. The fluid flow device includes a channel forming body. The channel forming body forms a plurality of fluid channels, a plurality of detection spaces corresponding to the fluid channels, respectively, and a plurality of communication channels providing respective communications between the fluid channels and the detection spaces corresponding thereto, respectively. Each of the detection spaces contains a detection fluid and a detection gas aligned in a longitudinal direction thereof, and an interface is formed therebetween. The detection gas is contained in the detection space so as to allow the position of the interface to be changed with the pressure change of a processing object fluid that flows through the fluid channels.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: August 16, 2022
    Assignee: Kobe Steel, Ltd.
    Inventors: Akira Matsuoka, Koji Noishiki, Tomohiro Ozono