Abstract: pH sensitive, reversible gelling erodible drug delivery compositions and methods for their production are disclosed. The compositions are liquid solutions of poly(methylvinylether/maleic acid) having pharmaceutical compounds incorporated therein. The poly(methylvinylether/maleic acid) solutions increase in viscosity with increases in pH. Thus, when the compositions are formulated at a pH lower than physiological pH's, and then delivered to a target physiological site, the liquid solution becomes viscous and adheres to the tissue for a length sufficient to provide prolonged bioavailability of the pharmaceutical compound.
Abstract: The present invention relates to compositions of water dispersible and water soluble carbohydrate polymers and biologically active macromolecules of growth hormones, somatomedins, growth factors, and other biologically active fragments which are suitable for parenteral administration. The present invention also relates to a method for increasing and for maintaining increased levels of growth hormone in the blood of treated animals for extended periods of time, increasing weight gains in animals, and increasing milk production of lactating animals by the administration of the compositions of the invention.
Type:
Grant
Filed:
August 30, 1989
Date of Patent:
November 30, 1993
Assignee:
American Cyanamid Company
Inventors:
Susan M. Cady, Richard Fishbein, Ulf Schroder, Hakan Eriksson, Brenda L. Probasco
Abstract: An antimicrobial, low toxicity, non-irritating composition comprises a blend of several bis-quaternary ammonium compounds coprecipitated with a copolymer of vinylpyrrolidone and an acrylamido or vinyl quaternary ammonium monomer.
Abstract: A composition of three compounds, (E,E)-10,12-tetradecadien-1-ol acetate (I), (Z)-11-tetradecen-1-ol acetate (II), and (Z)-9-tetradecen-1-ol acetate (III), in a weight ratio of about 100:18:4 (I:II:III) is a highly effective sex attractant (pheromone) for the male mint root borer. The composition demonstrates biological activity toward mint root borer males comparable to or greater than that of the mint root borer moth females. By attracting adult males to field traps, the composition provides a means for detecting, monitoring, and controlling this agricultural pest.
Type:
Grant
Filed:
January 28, 1992
Date of Patent:
August 17, 1993
Assignee:
The United States of America as represented by the Secretary of Agriculture
Abstract: Quick miosis with 24 hour control of intraocular pressure of patients undergoing extracapsular cataract extraction surgery is achieved by applying to the eyes of the patient during surgery acetylcholine as a first miotic agent and carbachol as a second miotic agent. Acetylcholine provides quick miosis while carbachol enhances the miotic effect while providing post-surgery control of intraocular pressure. The two miotic agents can be dissolved in a common saline carrier. The two agents can be combined in a unit dosage package by disposing acetylcholine in powder form in a first compartment and a solution of carbachol in a second compartment. The combined miotic agent of the invention is especially useful when substances which raise IOP such as viscoelastic agents are used during ocular surgery and/or with sensitive patients who enter the surgery with elevated pressure such as those suffering from glaucoma.
Abstract: A process for producing a slow-release powder which permit various active ingredients such as perfumes, insect control agents, rust inhibitors, mold inhibitors and antibacterial agents to be slowly released over a prolonged time, the process comprising the steps of mixing a long-chain compound with the ingredients, mixing the resulting mixture with urea, and exposing the resulting urea adduct to radiation.
Abstract: This invention relates to an analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen and a metal carboxymethyl starch present in an amount sufficient for it to function both as a binder and as a disintegrating agent.
Abstract: Perfluoro derivatives of dimethyladamantane; tributylamine; dihexylether; 1-bromooctane; and tetradecahydrophenanthrene, for example, are rendered dispersable colloidally in water or other polar media without the aid of an emulsifying agent by melt spinning a mixture of the compound with a sugar. Thus, a family of new colloidal perfluoro compounds are produced.
Abstract: An aqueous gel based on hyaluronic acid and on deoxyribonucleic acid usable in cosmetics, and a method of preparation.The invention relates to an aqueous gel formed by a homogeneous mix of:a) an alkaline salt or an ammonium salt of hyaluronic acid in the form of an aqueous gel;b) a mineral or organic salt of high molecular weight deoxyribonucleic acid in the form of an aqueous gel;c) at least one hydrophilic polymer having the property of forming aqueous film-forming gels.Application to the preparation of masks in cosmetics.
Abstract: A composition and a method for coating a wound is described. The composition consists of a mixture of 20 parts by weight of polyether polyurethane resin pellets being dissolved in about 80 parts by weight of tetrahydrofuran thereafter mixing the solution in order to provide complete mixing in an air tight container. The composition then being applied to a wound to form a tough but elastic wound coating to promote healing of animal tissue.
Abstract: A penetrable, epoxy resin composition is disclosed which comprises: a liquid, epoxy resin mixture containing a glycidyl ether of bisphenol having an epoxy equivalent of 158-270 and a flexible epoxy resin; a curing agent capable of reacting with the epoxy resin mixture when heated to a curing temperature; an inert organic solvent which does not react with the epoxy resin mixture, which is capable of dissolving the curing agent and which has a boiling point lower than the curing temperature; and an inorganic filler having an average particle size of 0.1-5 .mu.m.
Abstract: Compressed-molded preparations are disclosed. In the preparation coated granules of a pharmaceutical composition are compressed and molded together with non-coated component(s) containing 10% or more by weight of non-swelling polymers. According to the preparation there is little breakdown of the coating of coated granules at the time of compressing and molding, and the rate of disintegration, and in turn, the release rate of the pharmaceutical component, can be freely controlled or modulated.
Abstract: What is described herein is solution polymerization in acetone solvent of a monomer mixture of maleic anhydride, vinyl acetate and isobornyl acrylate or methacrylate.
Abstract: Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker to reduce the production of aqueous humor and carbachol to enhance the outflow of aqueous humor. A method of controlling elevated intraocular pressure with those compositions is also described.
Abstract: A particulate carrier for airborne suspensions of an active agent. The carrier is formed in situ by contacting a spray containing ammonia, a monoalkylamine or dialkylamine with a spray containing acetic acid and/or sulfur dioxide.
Type:
Grant
Filed:
November 9, 1990
Date of Patent:
January 26, 1993
Inventors:
Abelardo A. Portas, Graciela I. O de Portas
Abstract: A method of inhibiting phospholipase A2 in the control of inflammation, wherein delta-6,9,12,15-octadecatetraenoic acid (stearidonic acid) and/or delta-8,11,14,17-eicosatetraenoic acid is administered alone or in a pharmaceutically acceptable diluent or carrier.
Abstract: An emulsion containing a substantially water resistant film-forming copolymer phase and iodine is claimed. The polymer-in-water emulsion forms a film that is a substantially fluid resistant, low tack, flexible film which adheres to skin and releases iodine to skin. The addition of iodate to emulsions having such a film-forming copolymer phase and iodine further enhances stability of the emulsion.
Type:
Grant
Filed:
September 10, 1990
Date of Patent:
December 22, 1992
Assignee:
Minnesota Mining and Manufacturing Company
Abstract: Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone liquid carriers. The suspended drug delivery vehicles may be water labile or water stable and incorporate therapeutic or diagnostic compounds which remain stable and pharmaceutically effective for extended periods. The pharmaceutical compositions possess extended shelf-lives and do not leach the incorporated therapeutic or diagnostic compounds into the liquid carriers making them well suited for multi-dose packaging and administration.
Abstract: A medical material comprising a high-molecular weight material and a heparin derivative is provided, which high-molecular weight material comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, and which heparin derivative comprises heparin and an epoxy compound having at least two epoxy groups part of which is bound to amino groups in the heparin, the amino groups not bound to the epoxy groups in said high-molecular weight material being bound to the epoxy groups not bound to the amino groups in the heparin derivative. Also provided are an intermediate (high-molecular weight material) to be used for said medical material, as well as processes for producing said medical material and said intermediate.