Patents Examined by E. J. Webman
  • Patent number: 5292517
    Abstract: pH sensitive, reversible gelling erodible drug delivery compositions and methods for their production are disclosed. The compositions are liquid solutions of poly(methylvinylether/maleic acid) having pharmaceutical compounds incorporated therein. The poly(methylvinylether/maleic acid) solutions increase in viscosity with increases in pH. Thus, when the compositions are formulated at a pH lower than physiological pH's, and then delivered to a target physiological site, the liquid solution becomes viscous and adheres to the tissue for a length sufficient to provide prolonged bioavailability of the pharmaceutical compound.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: March 8, 1994
    Assignee: Allergan, Inc.
    Inventor: Nienyuan J. Chang
  • Patent number: 5266333
    Abstract: The present invention relates to compositions of water dispersible and water soluble carbohydrate polymers and biologically active macromolecules of growth hormones, somatomedins, growth factors, and other biologically active fragments which are suitable for parenteral administration. The present invention also relates to a method for increasing and for maintaining increased levels of growth hormone in the blood of treated animals for extended periods of time, increasing weight gains in animals, and increasing milk production of lactating animals by the administration of the compositions of the invention.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: November 30, 1993
    Assignee: American Cyanamid Company
    Inventors: Susan M. Cady, Richard Fishbein, Ulf Schroder, Hakan Eriksson, Brenda L. Probasco
  • Patent number: 5242684
    Abstract: An antimicrobial, low toxicity, non-irritating composition comprises a blend of several bis-quaternary ammonium compounds coprecipitated with a copolymer of vinylpyrrolidone and an acrylamido or vinyl quaternary ammonium monomer.
    Type: Grant
    Filed: October 25, 1991
    Date of Patent: September 7, 1993
    Assignee: ISP Investments Inc.
    Inventor: John J. Merianos
  • Patent number: 5236715
    Abstract: A composition of three compounds, (E,E)-10,12-tetradecadien-1-ol acetate (I), (Z)-11-tetradecen-1-ol acetate (II), and (Z)-9-tetradecen-1-ol acetate (III), in a weight ratio of about 100:18:4 (I:II:III) is a highly effective sex attractant (pheromone) for the male mint root borer. The composition demonstrates biological activity toward mint root borer males comparable to or greater than that of the mint root borer moth females. By attracting adult males to field traps, the composition provides a means for detecting, monitoring, and controlling this agricultural pest.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: August 17, 1993
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Leslie M. McDonough, Harry G. Davis
  • Patent number: 5236703
    Abstract: A polymeric substrate such as rubber or latex incorporates povidone-iodine as a control release biologically active agent.
    Type: Grant
    Filed: July 20, 1989
    Date of Patent: August 17, 1993
    Assignee: Virex Inc.
    Inventor: Anton-Lewis Usala
  • Patent number: 5229127
    Abstract: Quick miosis with 24 hour control of intraocular pressure of patients undergoing extracapsular cataract extraction surgery is achieved by applying to the eyes of the patient during surgery acetylcholine as a first miotic agent and carbachol as a second miotic agent. Acetylcholine provides quick miosis while carbachol enhances the miotic effect while providing post-surgery control of intraocular pressure. The two miotic agents can be dissolved in a common saline carrier. The two agents can be combined in a unit dosage package by disposing acetylcholine in powder form in a first compartment and a solution of carbachol in a second compartment. The combined miotic agent of the invention is especially useful when substances which raise IOP such as viscoelastic agents are used during ocular surgery and/or with sensitive patients who enter the surgery with elevated pressure such as those suffering from glaucoma.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: July 20, 1993
    Inventor: James W. McKinzie
  • Patent number: 5211959
    Abstract: A process for producing a slow-release powder which permit various active ingredients such as perfumes, insect control agents, rust inhibitors, mold inhibitors and antibacterial agents to be slowly released over a prolonged time, the process comprising the steps of mixing a long-chain compound with the ingredients, mixing the resulting mixture with urea, and exposing the resulting urea adduct to radiation.
    Type: Grant
    Filed: January 4, 1991
    Date of Patent: May 18, 1993
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Fumio Yoshii, Keizo Makuuchi, Isao Ishigaki
  • Patent number: 5198228
    Abstract: This invention relates to an analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen and a metal carboxymethyl starch present in an amount sufficient for it to function both as a binder and as a disintegrating agent.
    Type: Grant
    Filed: May 15, 1991
    Date of Patent: March 30, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Joseph J. Urban, Richard R. Makowski
  • Patent number: 5196199
    Abstract: Perfluoro derivatives of dimethyladamantane; tributylamine; dihexylether; 1-bromooctane; and tetradecahydrophenanthrene, for example, are rendered dispersable colloidally in water or other polar media without the aid of an emulsifying agent by melt spinning a mixture of the compound with a sugar. Thus, a family of new colloidal perfluoro compounds are produced.
    Type: Grant
    Filed: December 14, 1990
    Date of Patent: March 23, 1993
    Assignee: Fuisz Technologies Ltd.
    Inventor: Richard C. Fuisz
  • Patent number: 5194253
    Abstract: An aqueous gel based on hyaluronic acid and on deoxyribonucleic acid usable in cosmetics, and a method of preparation.The invention relates to an aqueous gel formed by a homogeneous mix of:a) an alkaline salt or an ammonium salt of hyaluronic acid in the form of an aqueous gel;b) a mineral or organic salt of high molecular weight deoxyribonucleic acid in the form of an aqueous gel;c) at least one hydrophilic polymer having the property of forming aqueous film-forming gels.Application to the preparation of masks in cosmetics.
    Type: Grant
    Filed: May 9, 1990
    Date of Patent: March 16, 1993
    Assignee: Pier Auge (Societe Anonyme)
    Inventor: Ricardo Garrido
  • Patent number: 5192536
    Abstract: A composition and a method for coating a wound is described. The composition consists of a mixture of 20 parts by weight of polyether polyurethane resin pellets being dissolved in about 80 parts by weight of tetrahydrofuran thereafter mixing the solution in order to provide complete mixing in an air tight container. The composition then being applied to a wound to form a tough but elastic wound coating to promote healing of animal tissue.
    Type: Grant
    Filed: November 19, 1991
    Date of Patent: March 9, 1993
    Inventor: Carl A. Huprich
  • Patent number: 5189081
    Abstract: A penetrable, epoxy resin composition is disclosed which comprises: a liquid, epoxy resin mixture containing a glycidyl ether of bisphenol having an epoxy equivalent of 158-270 and a flexible epoxy resin; a curing agent capable of reacting with the epoxy resin mixture when heated to a curing temperature; an inert organic solvent which does not react with the epoxy resin mixture, which is capable of dissolving the curing agent and which has a boiling point lower than the curing temperature; and an inorganic filler having an average particle size of 0.1-5 .mu.m.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: February 23, 1993
    Assignee: Somar Corporation
    Inventors: Ichiro Akutagawa, Tsutomu Yamaguchi, Kunimitsu Matsuzaki
  • Patent number: 5186943
    Abstract: Compressed-molded preparations are disclosed. In the preparation coated granules of a pharmaceutical composition are compressed and molded together with non-coated component(s) containing 10% or more by weight of non-swelling polymers. According to the preparation there is little breakdown of the coating of coated granules at the time of compressing and molding, and the rate of disintegration, and in turn, the release rate of the pharmaceutical component, can be freely controlled or modulated.
    Type: Grant
    Filed: January 3, 1989
    Date of Patent: February 16, 1993
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Minoru Okada, Toshiaki Horie, Hirohisa Okuyama, Syuichi Kasai, Akira Iwasa
  • Patent number: 5185143
    Abstract: What is described herein is solution polymerization in acetone solvent of a monomer mixture of maleic anhydride, vinyl acetate and isobornyl acrylate or methacrylate.
    Type: Grant
    Filed: January 13, 1992
    Date of Patent: February 9, 1993
    Assignee: ISP Investments Inc.
    Inventor: Jeffrey M. Cohen
  • Patent number: 5182102
    Abstract: Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker to reduce the production of aqueous humor and carbachol to enhance the outflow of aqueous humor. A method of controlling elevated intraocular pressure with those compositions is also described.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: January 26, 1993
    Assignee: Alcon Laboratories, Inc.
    Inventors: Louis DeSantis, Jr., Rajni Jani
  • Patent number: 5182096
    Abstract: A particulate carrier for airborne suspensions of an active agent. The carrier is formed in situ by contacting a spray containing ammonia, a monoalkylamine or dialkylamine with a spray containing acetic acid and/or sulfur dioxide.
    Type: Grant
    Filed: November 9, 1990
    Date of Patent: January 26, 1993
    Inventors: Abelardo A. Portas, Graciela I. O de Portas
  • Patent number: 5178873
    Abstract: A method of inhibiting phospholipase A2 in the control of inflammation, wherein delta-6,9,12,15-octadecatetraenoic acid (stearidonic acid) and/or delta-8,11,14,17-eicosatetraenoic acid is administered alone or in a pharmaceutically acceptable diluent or carrier.
    Type: Grant
    Filed: May 23, 1991
    Date of Patent: January 12, 1993
    Assignee: Efamol Holdings PLC
    Inventors: David F. Horrobin, Michael J. Finnen
  • Patent number: 5173291
    Abstract: An emulsion containing a substantially water resistant film-forming copolymer phase and iodine is claimed. The polymer-in-water emulsion forms a film that is a substantially fluid resistant, low tack, flexible film which adheres to skin and releases iodine to skin. The addition of iodate to emulsions having such a film-forming copolymer phase and iodine further enhances stability of the emulsion.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: December 22, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Robert H. Brink, Chi-Ming Tseng
  • Patent number: 5173298
    Abstract: Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone liquid carriers. The suspended drug delivery vehicles may be water labile or water stable and incorporate therapeutic or diagnostic compounds which remain stable and pharmaceutically effective for extended periods. The pharmaceutical compositions possess extended shelf-lives and do not leach the incorporated therapeutic or diagnostic compounds into the liquid carriers making them well suited for multi-dose packaging and administration.
    Type: Grant
    Filed: September 27, 1990
    Date of Patent: December 22, 1992
    Assignee: Allergan, Inc.
    Inventor: David L. Meadows
  • Patent number: 5165919
    Abstract: A medical material comprising a high-molecular weight material and a heparin derivative is provided, which high-molecular weight material comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, and which heparin derivative comprises heparin and an epoxy compound having at least two epoxy groups part of which is bound to amino groups in the heparin, the amino groups not bound to the epoxy groups in said high-molecular weight material being bound to the epoxy groups not bound to the amino groups in the heparin derivative. Also provided are an intermediate (high-molecular weight material) to be used for said medical material, as well as processes for producing said medical material and said intermediate.
    Type: Grant
    Filed: September 26, 1990
    Date of Patent: November 24, 1992
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Masatomi Sasaki, Shinichi Kaneda, Nobuyoshi Kashiwagi