Abstract: A therapeutic ointment having wet adherent properties and particularly well suited for delivery of medicaments to mucosal surfaces includes a base material comprising from about 3 to 15% by weight of a water soluble salt of a copolymer of methyl vinyl ether and maleic acid or anhydride in a polyethylene glycol ointment. Formulations of the base material with triamcinolone acetonide and lidocaine are particularly efficacious in the treatment of recurrent aphthous ulcers.
Abstract: A polymeric complex composition comprising a reaction complex formed by the interaction of a polycarbophil component with alginic acid or a salt thereof, said interaction being performed in the presence of a divalent cation and in the presence of an active agent selected from the group consisting of medicinal agents and cosmetic agents. There is also described a method of controlled release treatment comprising the steps of providing such a polymeric complex and an effective amount of an active agent selected from the group consisting of medicinal agents and cosmetic agents contained within said complex, and contacting an area of skin or mucous membrane to be treated with said composition for a sufficient period of time allow a therapeutically effective amount of said active agent to be released from the complex.
Abstract: A sealing resin composition is provided with is useful in the encapsulation of an electronic component and comprises a melt-processable polyester having a weight-average molecular weight of 1000 to 3900 and is capable of forming an optically anisotropic molten phase, and at most 80 percent by weight based upon the total weight of the composition of an inorganic powder which has been surface-treated with an epoxysilane or mercaptosilane coupling agent.
Abstract: A liquid fingernail cosmetic composition is provided containing at least one nail enamel film former resin, at least one organic solvent and at least one essential oil or essence component in an amount sufficient, upon activation, to provide an enhanced fragrance scent for a sustained period of time, e.g., at least about 24 hours, said essential oil or fragrance essence being activated by the formation of a nail enamel film from said coating composition.
Abstract: A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film with a portion of said binder to form agglomerates, is disclosed. Ibuprofen may be fluidized with a portion of the binder in a fluid bed apparatus and sprayed with an aqueous dispersion of polyvinylpyrrolidone and the remainder of the binder. This granulation may be subsequently blended with additional excipients and, optionally, additional active pharmaceutical ingredients for direct compression into tablets.
Type:
Grant
Filed:
January 11, 1990
Date of Patent:
April 14, 1992
Assignee:
Mallinckrodt Specialty Chemicals Company
Abstract: The invention relates to a method of encapsulating biologically active substances by gelling them with intestinal mucus (mucin). The invention is also concerned with a capsule produced by the method, its use as a fodder admixture, and a fodder containing such capsules.
Type:
Grant
Filed:
October 16, 1990
Date of Patent:
April 14, 1992
Assignee:
Valio Meijerien Keskusosuusliike
Inventors:
Hannu Kalsta, Eeva-Liisa Syvaoja, Juha Nousiainen, Jouko Setala
Abstract: Preparation of an effervescent aqueous solution which has an emollient action on the cuticles of the nails, by dissolving the following anhydrous solid compounds substantially simultaneously in water: urea, pyrrolidonecarboxylic acid and an alkali metal and/or ammonium bicarbonate, and additional ingredients, the different compounds being introduced in the form of a mixture or of several separate mixtures prepared in advance. These mixtures are in pulverulent or tablet form.Composition for the preparation of the effervescent aqueous solution.Cosmetic treatment of the cuticle of the nails using the effervescent aqueous solution.
Abstract: A far infrared ray emitting, odor-absorbing material is disclosed. The material comprises cellulose acetate fiber having adhered thereto an ultrafine powder of alumina hydrate or silica hydrate which is chemically produced in an aqueous dispersion of the cellulose acetate fiber. The material possesses a high far infrared ray emitting, odor-absorbing capability as well as many characteristics inherently possessed by cellulose acetate fibers, and can expand the utility of cellulose acetate in such fields as sanitary, health-care, and medical fields.
Abstract: A pharmaceutical composition of the active agent sodium 4-[.alpha.-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoate (a thromboxane synthetase inhibitor for treatment of diseases such as thrombosis and asthma) or its optical isomer or its hydrate with an improved dissolution property, which comprises D-mannitol and/or sodium hydrogencarbonate and at least one water-soluble polymer.The pharmaceutical composition is such that the dissolution of the above-mentioned active agent is free from pH dependency in the digestive tract including the stomach.
Abstract: A pharmaceutical composition useful for treating hypercholesterolemia comprising a bile acid sequestrant resin such as cholestyramine and cholestipol maintained in a semipermeable water-insoluble material; wherein said semipermeable material enables bile acids from the digest tract to contact and bind to said resin while preventing substances having a higher molecular weight than bile acids from contacting said resin material. A method for treating hypercholesterolemia using the inventive composition is also disclosed.
Abstract: Improved odor-reducing compositions, and corresponding methods, are disclosed wherein a substrate or area exhibiting undesirable odors is treated with an odor-reducing composition including respective quantities of citric acid and a salt of citric acid. Preferably, the odor-reducing composition in particulate form includes from about 0.1-20% by weight citric acid, at least about 50% by weight of a salt of citric acid (e.g. sodium citrate) and an anti-caking agent. The compositions of the invention may be used to good effect in the treatment of substrates such as human skin, cloth or other absorbents; or in deodorizing areas exhibiting offensive odors.
Abstract: The oral administration to an animal of sulglycotide `(a sulfoglycopeptide)` together with methylcellulose, pectin or tragacanth gum protects the animal against gastric ulcer.
Type:
Grant
Filed:
March 30, 1990
Date of Patent:
February 4, 1992
Assignee:
Crinos Industria Farmacobiologica S.p.A.
Inventors:
Giancarlo Farolfi, Giovanni Gazzani, Riccardo Niada, Marisa Mantovani
Abstract: An improved method and composition for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. The composition comprises a solution of a polymeric material having a molecular weight of about 500,000 or above having a concentration of from about 0.01 to about 15%, by weight.
Abstract: A controlled release composition comprising an active substance other than a prostaglandin and a polymeric carrier therefor comprising residues having a ratio of number average molecular weight to functionality greater than 1000 which comprises polyethylene oxide and are cross-linked through urethane groups.
Type:
Grant
Filed:
January 2, 1990
Date of Patent:
January 7, 1992
Assignee:
National Research Development Corporation
Abstract: Disclosed is an ophthalmic gel composition of unique rheological and lubricating properties comprising, inter alia, a carboxy vinyl polymer (carbomer) for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising totally administering the composition when indicated for relief of dry eye syndrom, foreign body sensation, burning, hyperemia, corneal straining, and the like.
Abstract: A sustained and controlled release form of iodine is achieved by a complex of polyvinyl alcohol and the iodine characterized by a low water solubility. The polyvinyl alcohol may be reacted to form hydroxylated polyvinyl acetal sponge and the sponge is topically applied as an antimicrobial agent which releases controlled amounts of iodine sufficient to kill germ cells with minimal toxicity to surrounding tissue.
Abstract: A sterile sealed flexible package contains a transparent sheet-form wound dressing which comprises a wholly synthetic hydrophilic water-insoluble cross-linked polymer swollen with an aqueous liquid. The package is formed by introducing the sheet-form polymer and aqueous liquid into the flexible package, sealing the package and then sterilizing it in an autoclave in which the temperature and pressure are independently variable. The polymer is usually formed by polymerizing ethylenically unsaturated monomers, usually acrylic monomers, e.g. hydroxy alkyl (meth) acrylates and/or (meth) acrylic acid, with copolymerizable ethylenically unsaturated cross-linking agent, and is capable of absorbing at least its own dry weight of 0.9% by weight saline. The swollen polymer gel is used as a wound dressing.