Patents Examined by Emily A Cordas
  • Embigin inhibition for promotion of hematopoietic stem and progenitor cell expansion
    Patent number: 10961308
    Abstract: Disclosed herein are methods for enhancing hematopoietic reconstitution of a subject. One method involves administering a therapeutically effective amount of an inhibitor of Embigin to a recipient subject and can also optionally include administering hematopoietic stem/progenitor cells to the subject. Another method involves administering an inhibitor of Embigin to a donor prior to harvest of hematopoietic stem/progenitor cells. Pharmaceutical compositions relating to the methods are also described.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 30, 2021
    Assignees: THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: David T. Scadden, Lev Silberstein, Peter Kharchenko
  • Method for pathogen isolation
    Patent number: 10954546
    Abstract: The present invention relates to methods and apparatus for detecting one or more pathogens in one or more biological samples. The biological sample may be a food sample, a sample of a body fluid, a cell suspension, water, or a combination thereof. The present invention relates also to methods of diagnosing or predicting a disease in an individual.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: March 23, 2021
    Assignee: AIT Austrian Institute of Technology GmbH
    Inventors: Klemens Wassermann, Johannes Peham, Herbert Wiesinger-Mayr, Christa Nöhammer
  • Methods for organ regeneration
    Patent number: 10946066
    Abstract: A method of enhancing or initiating regeneration of an organ in a subject in need thereof comprising the administration of endothelial cells specific to said organ, or inductive endothelial cells specific to said organ, into the area of the body in which organ regeneration is desired in said subject.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: March 16, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Shahin Rafii, Bi-Sen Ding, Sina Y. Rabbany
  • Tissue structure scaffolds
    Patent number: 10940237
    Abstract: A method of forming a scaffold comprises the steps of: preparing a high internal phase emulsion (HIPE) comprising an aqueous solution of: proteins selected from the group consisting of collagen and mixtures of collagen and chitosan; and a cross-linking agent; by addition of an immiscible solvent to the solution to form the HIPE; reducing the temperature of the HIPE to solidify the HIPE; removing water and solvent by vaporisation at a temperature above the melting point of the solvent to form a porous structure; and before or after removal of solvent, causing cross-linking of the protein with the cross-linking agent to form a crosslinked scaffold structure.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: March 9, 2021
    Assignee: UNIVERSITY OF DURHAM (A GB EDUCATIONAL CORPORATION)
    Inventors: Junjie Wu, Ross Carnachan, Stefan Przyborski
  • Functional myelination of neurons
    Patent number: 10920194
    Abstract: Hair follicle bulge region/LLP region CD34(+) MeSCs can be isolated from mammalian skin bearing hair follicles. These cells are multipotent and retain the ability to differentiate into cells of neural crest lineage, including glia-like cells that express the glial marker Gfap, and are able to express myelin basic protein, and to remyelinate naked (unmyelinated or demyelinated) neuronal processes with a functional, dense myelin sheath. These cells of neural crest lineage can be used to produce a dense myelin sheath on neurons which lack myelin due to genetic defect, trauma, toxin, infection, or disease process. Therefore, embodiments of the invention provide methods for preparing such cells, the cells themselves and compositions containing the cells, as well as methods for using the cells.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: February 16, 2021
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Thomas Hornyak, Sandeep Joshi
  • Folding biological tissue via programmed cellular contractility
    Patent number: 10920190
    Abstract: The present disclosure provides methods and systems for generating biological tissues that are configured for folding into a pre-determined three-dimensional form. The present disclosure utilizes contractile cells for folding a biological tissue into a three-dimensional shape. The methods include disposing a pattern of contractile cells on a surface that includes fibers actuated by the contractile cells and folding of the surface by the action of the contractile cells on the fibers. Tissues generated using the methods and systems of the present disclosure are also provided.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: February 16, 2021
    Assignee: The Regents of the University of California
    Inventors: Zev Jordan Gartner, Alex James Hughes
  • Apparatus and method for harvesting and preparing viable stem cells
    Patent number: 10913931
    Abstract: A method of preparing viable stromal and mesenchymal stem cells from adipose tissue that produces high quality and high counts of stem cells with a low risk of contamination. The apparatus provides ultrasonic waves through a constant temperature bath to the tissue held in a sterile sonication container such as a test tube or jar. No sonication probe touches the tissue or the cells during the process. The stem cells produced are ready to be administered to a patient.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: February 9, 2021
    Inventor: Glenn Polansky
  • Method of culturing eukaryotic cells
    Patent number: 10894940
    Abstract: An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: January 19, 2021
    Assignee: GENENTECH, INC.
    Inventors: Dinesh Baskar, Jenny Hsiung, Woon-Lam Susan Leung, Inn H. Yuk
  • Corn blends that include high oil corn and methods of making one or more biochemicals using high oil corn or corn blends that include high oil corn
    Patent number: 10889837
    Abstract: The present invention relates to using high oil corn to make a biochemical such as ethanol. More particularly, the invention relates to methods of making a biochemical using relatively low temperature saccharification followed by fermentation or simultaneous saccharification and fermentation of high oil corn.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: January 12, 2021
    Assignee: POET Research, Inc.
    Inventors: Stephen M. Lewis, John Kenneth Grearson, Neelakantam V. Narendranath, Francis Michael Swain, Brett Yerdon, Camille Kelly Nelson
  • Whole blood separation sampling apparatus
    Patent number: 10883977
    Abstract: The present invention provides systems, devices, kits, and methods for separating blood plasma or serum from whole blood. The present invention further provides systems, devices, and methods for separating a volume of blood plasma or serum from whole blood.
    Type: Grant
    Filed: December 20, 2014
    Date of Patent: January 5, 2021
    Assignee: Spot Bioscience, LLC
    Inventors: Jason Wright, James Hill
  • Cell culture kit, screening method, and method of manufacturing cell culture kit
    Patent number: 10836996
    Abstract: To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers (33) and living cells derived from various donors are adhered to surfaces of the plurality of microchambers (33). Specifically, living cells D1, D2, and D3 derived from various donors are adhered to the plurality of microchambers (33). In each microchamber (33), living cells derived from one donor or living cells derived from various donors may be cultured. The living cells derived from various donors are adhered and cultured in the cell culture kit as a whole, which makes it possible to provide a cell culture kit to conduct a test using cells derived from various donors.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: November 17, 2020
    Assignees: Corning Incorporated, Public University Corporation Yokohama City University
    Inventors: Yoko Itchoda, Go Tazaki, Motohiro Fukuda, Hitoshi Tsuruta, Hideki Taniguchi
  • Lipid membrane structure, lipid-membrane-structure-immobilization carrier, and method of fusing vesicles
    Patent number: 10807061
    Abstract: In methods of separating, moving, and detecting a vesicle of the present invention, either a vesicular-shaped lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane, or a lipid-membrane-structure-immobilization carrier, in which a lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane is immobilized on a carrier, is brought into contact with a sample containing the vesicle such that membrane fusion occurs between the lipid membrane structure and the vesicle.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: October 20, 2020
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Takumi Hirase, Rii Morimura, Masato Nakayama
  • Erythrocyte sedimentation inhibitor
    Patent number: 10788502
    Abstract: The present invention addresses a problem in which, when examining blood properties in measurements of thrombus formation capacity and platelet function or the like, measurement data is changed as a result of sedimentation of blood in reservoirs during measurement. An erythrocyte membrane ion transport inhibitor, such as disodium 4,4?-dinitrostilbene-2,2?-disulfonate (DNDS) or 4,4?-diisothiocyanatostilbene-2,2?-disulfonic acid (DIDS), is used to inhibit erythrocyte sedimentation, and accurate measurement data is obtained.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: September 29, 2020
    Assignee: FUJIMORI KOGYO CO., LTD.
    Inventors: Kazuya Hosokawa, Tomoko Wada
  • Method of producing sugar liquid
    Patent number: 10781466
    Abstract: A method of producing a sugar liquid includes: (A) reacting mannanase with a liquid component obtained by hydrolysis treatment of woody biomass to obtain a saccharified liquid; and (B) filtering the saccharified liquid in Step (A) through a microfiltration membrane and/or ultrafiltration membrane to collect a sugar liquid from a permeate side.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: September 22, 2020
    Assignee: Toray Industries, Inc.
    Inventors: Atsushi Minamino, Yuka Asahi, Hiroyuki Kurihara, Jumpei Kishimoto, Masashi Higasa, Katsushige Yamada
  • Method for rapid testing allergy
    Patent number: 10746722
    Abstract: The present invention provides a method for testing an allergy capable of rapidly and highly accurately testing an allergic reaction. The method can determine whether or not a patient has an allergy or whether or not an agent that may be allergenic to a patient has an allergenicity (an allergic reactivity) in the patient. The method may comprise the steps of causing migration of leukocytes separated from a healthy human or cells of an established cell line with a chemotactic factor contained in a sample such as body fluid or blood of the patient to be tested or a sample stimulated with the agent that may be allergenic to the patient and analyzing the cell kinetics such as migration velocity, migration distance, and migration direction.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: August 18, 2020
    Inventor: Hirotomo Shibaguchi
  • Method for rapid testing allergy
    Patent number: 10746721
    Abstract: The present invention provides a method for testing an allergy capable of rapidly and highly accurately testing an allergic reaction. The method can determine whether or not a patient has an allergy or whether or not an agent that may be allergenic to a patient has an allergenicity (an allergic reactivity) in the patient. The method may comprise the steps of causing migration of leukocytes separated from a healthy human or cells of an established cell line with a chemotactic factor contained in a sample such as body fluid or blood of the patient to be tested or a sample stimulated with the agent that may be allergenic to the patient and analyzing the cell kinetics such as migration velocity, migration distance, and migration direction.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: August 18, 2020
    Inventor: Hirotomo Shibaguchi
  • Process for implementing in vitro spermatogenesis and associated device
    Patent number: 10723999
    Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 28, 2020
    Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
  • Methods for the production and use of mycelial liquid tissue culture
    Patent number: 10709157
    Abstract: A method enhancing the taste of a food product, which includes the steps of culturing a mycelial liquid tissue culture in a media, collecting a mycelium-free portion of the mycelial liquid tissue culture, e.g., the supernatant fluid of the mycelial liquid tissue culture, and adding the collected supernatant fluid to a food product in an amount sufficient to enhance the food product's taste. The mycelial liquid tissue culture may include C. sinensis, and the culture step may be carried out for between about one and sixty days. The food products include non-nutritive sweeteners, alcoholic beverages, teas, coffees, bitter tasting foods such as cranberry, grapefruit, pomegranate, and coconut, as well as dietary supplements, food additives, pharmaceuticals, and nutraceuticals. The present invention also includes compositions of food products in combination with mycelium-free fluids.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: July 14, 2020
    Assignee: MycoTechnology, Inc.
    Inventors: James Patrick Langan, Brooks John Kelly, Huntington Davis, Bhupendra Kumar Soni
  • Herbaceous selenium-enriched SOD non-antibiotic feed additive and method of use thereof
    Patent number: 10709155
    Abstract: A non-antibiotic feed additive including various ingredients, including selenium and superoxide dismutase (SOD). Also provided is a feed including the feed additive.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: July 14, 2020
    Assignee: NE PLUS ENTERPRISES, LLC
    Inventors: Lijun Zhu, Lijun Qing, Qing Yang, Xiang Feng, Wuping Chen, Sixiang Chen
  • Lactic acid bacterium
    Patent number: 10675311
    Abstract: This invention provides lactic acid bacteria that have one or more effects selected from among fatigue-ameliorating effect, blood circulation-improving effect, stool odor-reducing effect, and growth-promoting effect and that can be used with high safety. This invention further provides a pharmaceutical preparation comprising, as an active ingredient, lactic acid bacteria that have one or more effects selected from among fatigue-ameliorating effect, blood circulation-improving effect, stool odor-reducing effect, and growth-promoting effect. According to the invention, novel lactic acid bacteria belonging to the Enterococcus faecium species having particular mycological properties and exhibiting viability of 40% or higher when freeze-dried in the absence of a dispersion medium and viability of 80% or higher in a probiotic preparation when stored at 40° C.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: June 9, 2020
    Assignee: KANEKA CORPORATION
    Inventors: Airo Tategaki, Taizo Kawabe, Hozumi Tanaka