Patents Examined by Emily A Cordas
  • Adherent cell culture method
    Patent number: 10655107
    Abstract: Provided are a method capable of evaluating adherent cells under an environment similar to an in vivo environment by a culture method similar to a two-dimensional culture, and applications thereof. An adherent cell culture method uses, as a culture chamber (10), a chamber in which two or more culture spaces each having an equivalent diameter (D) that is 1 to 5 times the diameter of a desired spheroid and each having a height (H) that is 0.3 to 5 times the equivalent diameter are arranged and a surface of each of the culture spaces has a water contact angle of 45 degrees or less. Spheroids of adherent cells are cultured in the respective culture spaces (11) arranged in the culture chamber (10).
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: May 19, 2020
    Assignee: Corning Incorporated
    Inventors: Yoko Ejiri, Satoru Ayano, Masaya Hosoda, Go Tazaki
  • Selective enrichment media and uses thereof
    Patent number: 10619130
    Abstract: Selective enrichment media and methods for selectively growing and detecting Salmonella spp. and/or Shiga toxin-producing E. coli. The media may comprise a carbon and nitrogen source, an inorganic salt, a fermentable sugar, one or more selective agents, and an efflux pump inhibitor. Various selective agents include sulfa drugs, surfactants, aminocoumarins, cycloheximide, supravital stains, ascorbic acid, bromobenzoic acid, myricetin, nitrofurantoin, rifamycins, polyketides, and oxazolidinones. Various efflux pump inhibitors include arylpiperazines, such as 1-(1-naphthylmethyl)piperazine, and quinoline derivatives, such as 4-chloroquinoline. Methods of selectively growing and detecting Salmonella and/or Shiga toxin-producing E. coli are provided.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: April 14, 2020
    Assignee: PARADIGM DIAGNOSTICS, INC.
    Inventor: Alan D Olstein
  • Treating rotator cuff conditions
    Patent number: 10610570
    Abstract: This document provides methods and materials related to treating rotator cuff conditions (e.g., rotator cuff tendonitis or rotator cuff injuries such as partial rotator cuff tears). For example, methods and materials for using BMP-5 polypeptides to treat rotator cuff conditions as well as methods and materials for using inhibitors of SIRT6, SIRT7, and/or HDAC10 polypeptide expression or activity to treat rotator cuff conditions are provided.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: April 7, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Scott M. Riester, John W. Sperling, Andre J. van Wijnen
  • Plant derived cell culture material
    Patent number: 10612003
    Abstract: The present invention relates material that is useful in culturing and transferring cells as well as delivering cells. The material comprises plant derived cellulose nanofibers or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: April 7, 2020
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Marjo Yliperttula, Patrick Laurén, Madhushree Bhattacharya, Yanru Lou, Antti Laukkanen
  • Brown fat cell compositions and methods
    Patent number: 10597638
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 24, 2020
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Cohesive thin liquids to promote safe swallowing in dysphagic patients
    Patent number: 10582722
    Abstract: Nutritional products having improved cohesiveness for promoting safer swallowing of food boluses for patients having swallowing conditions are provided as well as methods of making and using such products. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 10, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Adam Burbidge, Jan Engmann, Simina Popa Nita
  • Extensional viscosity to promote safe swallowing of food boluses
    Patent number: 10583097
    Abstract: Nutritional products having improved cohesiveness of food boluses and methods of making and using same are provided. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products and Trouton ratios of at least 6. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 10, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Adam Stewart Burbidge, Jan Engmann, Simina Popa Nita
  • Methods and devices for analysis of defined multicellular combinations
    Patent number: 10578633
    Abstract: Methods for cell analysis are provided, comprising cell capturing, characterization, transport, and culture. In an exemplary method individual cells (and/or cellular units) are flowed into a microfluidic channel, the channel is partitioned into a plurality of contiguous segments, capturing at least one cell in at least one segment, A characteristic of one or more captured cells is determined and the cell(s) and combinations of cells are transported to specified cell holding chamber(s) based on the determined characteristic(s). Also provided are devices and systems for cell analysis.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 3, 2020
    Assignee: FLUIDIGM CORPORATION
    Inventors: Jason A. A. West, Brian Fowler
  • Fixation devices for tissue repair
    Patent number: 10568993
    Abstract: Fixation devices for tissue repair, for example sutures, surgical arrows, staples, darts, bolts, screws, buttons, anchors, nails, rivets, or barbed devices comprise at least one of angiogenic material; angiogenic precursor material which is capable of breaking down in vivo to form angiogenic material; or tissue-engineered material, which tissue-engineered material is capable of producing angiogenic material. In a preferred form, the material is incorporated into a polymer matrix having predetermined hydrophobicity to allow controlled release of angiogenic materials such as butyric or hydroxybutyric acid or salts thereof. Polymer matrix compositions comprising angiogenic materials and methods for tissue repair are also provided.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: February 25, 2020
    Assignee: Smith & Nephew, Inc.
    Inventors: Nicholas J. Cotton, Emma J. Wright, Steven W. Astorino, Saad Abdul Majeed Ali
  • Polypeptide having xylanase activity
    Patent number: 10550375
    Abstract: The present invention relates to an isolated polypeptide having xylanase activity, selected from the group consisting of: a) a polypeptide comprising an amino acid sequence having at least 87% identity with SEQ ID NO: 1; b) a polypeptide encoded by a polynucleotide having at least 87% identity with SEQ ID NO:2; or c) a fragment of a polypeptide of a) or b) which fragment has xylanase activity.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: February 4, 2020
    Assignee: DuPont Nutrition Biosciences ApS
    Inventors: Rikke Hoeegh Lorentsen, Susan Arent Lund, Svend Haaning, Igor Nikolaev, Sharief Barends, Jan Hendrick A Van Tuijl, Bart Koops
  • Methods for treating osteoarthritis pain
    Patent number: 10537619
    Abstract: Methods for alleviating osteoarthritis-associated symptoms by selecting a treatment-eligible patient and local administration of a clostridial derivative, such as a botulinum toxin, to an osteoarthritis-affected site are disclosed herein.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: January 21, 2020
    Assignee: Allergan, Inc.
    Inventors: Catherine C. Turkel, Guang-Liang Jiang, Ronald E. DeGryse
  • Cell therapy: a method and a composition for treating diabetes
    Patent number: 10507220
    Abstract: A method of increasing beta-islet cells from pancreases of rabbits and a composition for transplantation of beta-islet cells isolated and cultured from rabbit pancreases to promote natural insulin production among diabetic patients.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 17, 2019
    Assignee: Philadelphia Medical Scientific Center L.L.C.
    Inventors: Vladislav Broytman, Nikanor Broytman, Nikolay Skaletskiy
  • Pouch-like construct for preventing heart distension
    Patent number: 10500051
    Abstract: The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: December 10, 2019
    Assignee: UNIVERSITATSKLINIKUM HAMBURG-EPPENDORF
    Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen, Yalin Yildirim
  • Method for producing sheet-shaped cell culture
    Patent number: 10426802
    Abstract: A sheet-shaped cell culture and method for producing a sheet-shaped cell culture are disclosed having a high activity such as high cytokine productivity and a production method thereof. The method for producing a sheet-shaped cell culture can include freezing cells, thawing the frozen cells and forming a sheet-shaped cell culture. A sheet-shaped cell culture which is produced by the production method and which has a high activity and a method for treating a disease associated with an abnormality of a tissue with the sheet-shaped cell culture.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 1, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kenta Sakamoto, Kouichirou Yori
  • Method for preparing an animal decellularized tissue matrix material and a decellularized tissue matrix material prepared thereby
    Patent number: 10426868
    Abstract: A method for manufacturing an animal acellular tissue matrix material and a tissue matrix material manufactured by the same. The tissue matrix material manufactured by the method retains an original basic scaffold structure of a tissue extracellular matrix, with an antigen causing immunological rejection in a human body being effectively removed from the animal tissue. An animal dermal matrix manufactured by the method retains the biological integrity of a natural dermal tissue matrix and can be used for restoration and repair of lesion and missing tissues.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: October 1, 2019
    Assignee: Beijing Ruijian Gaoke Biotechnology Co., Ltd.
    Inventors: Zhi-gang Liu, Xinhua Liu
  • Process for improving the solubility of cell culture media
    Patent number: 10421941
    Abstract: The invention relates to a process for improving the solubility of dry cell culture media. Some dry powder cell culture media show poor dissolving properties and result in turbid solutions when they are dissolved in aqueous solutions. Using a stepwise procedure in which the amino acids present in the non-dissolving part are identified and added to a new batch in other particle sizes significantly reduces that problem.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: September 24, 2019
    Assignee: Merck Patent GmbH
    Inventor: Joerg Von Hagen
  • In vitro method for the label-free determination of a cell type of a cell
    Patent number: 10408735
    Abstract: An in vitro method for the marker-free determination of a cell type of a cell in a biological sample is disclosed, a microscopic device being configured to detect a height profile of the cell with respect to a carrier plate. An embodiment of the method performed by a cell analysis device, include: determining a cell compartment of the cell on the basis of the detected height profile, determining a predetermined quantitative cell feature on the basis of the determined cell compartment, and determining the cell type of the cell on the basis of the determined quantitative cell feature. A correspondingly designed cell analysis device and a corresponding microscopic device are also disclosed.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: September 10, 2019
    Assignee: Siemens Healthcare GmbH
    Inventors: Oliver Hayden, Oliver Schmidt
  • Dermatological, cosmetic or cosmeceutical compositions intended for skin treatment
    Patent number: 10391050
    Abstract: The present invention relates to a product obtained from gastropod spawn, to be used to prepare dermatological, cosmetic or cosmeceutical compositions designed for skin care; said product has the capacity to activate and mobilize skin stem cells, as well as prevent the loss thereof that takes place as a consequence of chronological and premature ageing. The present invention also relates to the process followed in order to obtain said product.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: August 27, 2019
    Assignee: Industrial Farmacéutica Cantabria, S.A.
    Inventors: Marta Dominguez Valdes-Hevia, Aurora Brieva Delgado, Salvador Gonzalez Rodriguez, Eduardo Reyes Martin, Jose Carballeira Morado, Ernesto Quintana Gonzalez, Juan Pablo Pivel Ranieri, Antonio Guerrero Gomez-Pamo, Angeles Juarranz De La Fuente, Jesus Espada Regalado, Francisco Sanz Rodriguez
  • Cells expressing Th1 characteristics and cytolytic properties
    Patent number: 10385315
    Abstract: A novel cell type has been generated that has both Th1 characteristics and cytolytic activity. These Th1/killer cells are CD4+ cells purified from peripheral blood and manipulated to have Th1 characteristics such as production of IFN-gamma combined with cytolytic activity similar to cytotoxic T-cells (CTL). The CTL activity is targeted toward diseased cells, not normal cells. The cytolytic activity of the Th1/killer cells is mediated by Granzyme B-Perforin mechanism and results in apoptotic death of diseased cells. Methods of producing and using these Th1/killer cells include isolating CD4+ cells from peripheral blood, activating the CD4+ T-cells to form Th1/killer cells and administering these Th1/killer cells with the cytolytic activity to a patient wherein the Th1/killer cells are allogeneic to the patient.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: August 20, 2019
    Assignee: IMMUNOVATIVE THERAPIES, LTD.
    Inventor: Michael Har-Noy
  • Stable aqueous spore-containing formulation
    Patent number: 10362786
    Abstract: Stable aqueous spore-containing chemical formulations having a low to medium viscosity profile are provided. The formulations comprise at least one spore in a mixture of water and at least one water miscible solvent, optionally at least one surfactant, optionally at least one stabilizer such as a metal salt, optionally at least one biocide, optionally at least one buffer, and optionally at least one chemical insecticide or fungicide or a mixture thereof. The formulations are particularly suitable as a seed coating and foliar spray. Methods of preparation as well as methods of treating a plant are also provided.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: July 30, 2019
    Assignee: Bayer Intellectual Property GMBH
    Inventors: Chi-Yu Roy Chen, Kevin Bugg, Jennifer Riggs